Cytotoxicity of mangroves on A549 and NCI-H522 lung cancer cells

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Cytotoxicity of mangroves on A549 and NCI-H522 lung cancer cells”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Cancer:
Cancer is a leading cause of mortality worldwide, particularly non-small cell lung carcinoma, as highlighted in the study. Understanding cancer mechanisms and exploring potential therapies from natural sources, such as mangroves, is crucial for developing new treatments that may improve patient outcomes and survival rates.

2) Line:
In the context of research, 'line' typically refers to a specific cell line used in experiments. The study utilizes A549 and NCI-H522 cell lines to investigate the cytotoxic effects of mangrove extracts, which are vital for assessing drug efficacy and biological responses in cancer research.

3) Study (Studying):
The study aims to investigate the cytotoxic effects of extracts from mangrove species on lung cancer cell lines. By evaluating the anti-proliferative properties, researchers hope to uncover new therapeutic options and validate traditional use, contributing to the broader scientific understanding of cancer treatments.

4) Drug:
The term 'drug' refers to any substance used to diagnose, cure, treat, or prevent disease. In this study, the focus is on extracting potential anticancer compounds from mangroves, which could lead to the development of new drugs for treating non-small cell lung carcinoma.

5) Activity:
Activity in this context relates to the biological effects of mangrove extracts, particularly their cytotoxic and anti-proliferative actions against cancer cells. The study investigates the extent of these activities, aiming to correlate them with the presence of specific phytochemicals in the extracts.

6) Medium:
Medium refers to the growth environment for cultured cells, such as A549 and NCI-H522, used in this study. The choice of culture media is essential for cellular growth and viability, impacting the outcomes of the cytotoxicity tests performed on the cancer cell lines.

7) India:
India is significant in this study as it is the geographic and cultural context where the mangrove species are studied. The traditional uses of mangroves in Indian coastal communities highlight the potential for discovering pharmacologically active compounds that can contribute to cancer treatment advancements.

8) Table:
Tables in research are used to present data concisely and clearly. In this study, tables summarize the effects of various mangrove extracts and their cytotoxic dosages, providing a visual representation of key findings on cell viability and therapeutic index values for further analysis.

9) Disease:
Disease refers to a pathological condition affecting the body, such as lung cancer. The study emphasizes the need for new therapeutic approaches to combat diseases prevalent in modern society, particularly focusing on the efficacy of mangrove-derived compounds against certain types of cancer.

10) Chemotherapy:
Chemotherapy is a standard treatment for cancer, involving the use of drugs to kill or inhibit the growth of cancer cells. While effective, the adverse effects and resistance issues underscore the importance of exploring alternative therapies, such as those derived from natural sources like mangroves.

11) Observation:
Observation entails the systematic examine of effects during the experiment, allowing researchers to document significant changes in cell morphology or viability due to treatment. This study reports on observable characteristics of cancer cells after exposure to specific mangrove extracts, serving as an important data point.

12) Species:
Species refers to distinct biological classifications of plants or animals. The study investigates specific mangrove species, namely Acanthus ilicifolius, Callophyllum inophyllum, and Excoecaria agallocha, whose extracts are hypothesized to possess anti-cancer properties, contributing to potential drug development.

13) Science (Scientific):
Scientific denotes an evidence-based approach to knowledge accumulation, emphasizing research methodologies, empirical data, and reproducibility. This study embodies scientific inquiry into the anticancer properties of mangrove extracts, contributing to the field of botanical pharmaceuticals with potential clinical implications.

14) Death:
Death is an inevitable outcome associated with terminal diseases like cancer. The study highlights alarming statistics surrounding lung cancer-related deaths, thereby emphasizing the urgency for effective treatment options and the potential role of natural compounds in mitigating disease progression and enhancing survival.

15) New Delhi:
New Delhi, as the capital of India, represents a vital hub for scientific research and policy-making. The study may draw support or collaborations from institutions located in New Delhi, advancing efforts to integrate traditional knowledge of mangroves with modern scientific inquiry.

16) Phytochemical:
Phytochemicals are natural compounds found in plants that may exert health benefits. This study focuses on isolating and identifying phytochemicals from selected mangrove species that exhibit cytotoxic effects against cancer cells, propelling the understanding of plant-based medicine in modern therapeutics.

17) Annamalai (Aṇṇāmalai):
Annamalai refers to Annamalai University, the institution where the study was conducted. The university's facilities and research capabilities provided the necessary environment for exploring the cytotoxicity of mangrove species, reinforcing the role of academic institutions in advancing scientific research.

18) Delhi:
Delhi, similar to New Delhi, serves as a significant academic and research center in India. The proximity to various research institutions allows for collaborative efforts that can further understanding and exploitation of native plant species, including mangroves, for their medicinal potential.

19) Field:
Field refers to the natural environment from which the mangroves were collected. This study contrasts field-grown mangroves with tissue-cultured samples, investigating how growing conditions influence the bioactive compound yield and subsequent cytotoxic effects on cancer cell lines.

20) Tamilnadu (Tamil-nadu, Tamilnāḍu):
Tamilnadu is a state in India that features a rich coastal ecosystem. It is also home to the mangrove species investigated in the study, demonstrating the intersection of local biodiversity, traditional medicine, and scientific research aimed at addressing health challenges like cancer.

21) Medicine:
Medicine represents the science and practice of diagnosing, treating, and preventing illnesses. This study seeks to contribute to the domain of medicine by exploring the therapeutic potential of mangrove extracts, reinforcing the significance of ethnobotanical research for future drug development.

22) Chennai:
Chennai, a major city in Tamilnadu, is near several educational and research institutions. Collaborations from Chennai could enhance the understanding of the therapeutic properties of mangrove species due to its proximity to coastal biodiversity and scientific resources.

23) Habitat:
Habitat refers to the natural environment in which a species lives. The Pichavaram mangrove forest, where the studied species were harvested, provides the necessary conditions for the growth of mangroves, emphasizing their ecological importance and potential bioactive compound production.

24) Account:
In the context of research, account pertains to records or reports of findings. This study accounts for the observed results of cytotoxicity tests, providing scientific data that supports future research into the development of natural cancer treatments derived from mangroves.

25) Surface:
Surface refers to the outer layer of the plant materials being examined. The study emphasizes the importance of surface sterilization in preparing explants for culture, ensuring that the resulting plant tissues are uncontaminated and suitable for subsequent biological testing.

26) Tamil (Tamiḻ):
Tamil, the language spoken predominantly in Tamil Nadu, often ties local cultural and traditional knowledge to bioproduct use. This study connects Tamil heritage with scientific perspectives, underlining the relevance of traditional practices in the exploration of natural resources for medicinal purposes.

27) Nadu (Nāḍu):
Nadu in