Conductance of MCM-41, TiO2-MCM-41 with nicotinamide in ethanol.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Conductance measurements of mcm-41 and tio2-mcm-41 in presence of nicotinamide (a hydrotropic agent) in ethanol for partially soluble drugs
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Srabani Swagatika, Suresh Kumar Dash and Upendra Nath Dash.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Conductance measurements of mcm-41 and tio2-mcm-41 in presence of nicotinamide (a hydrotropic agent) in ethanol for partially soluble drugs

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


Download the PDF file of the original publication


Summary of article contents:

Introduction

The use of mesoporous silica materials, particularly MCM-41, as drug carriers presents a promising approach for the delivery of water-insoluble drugs. This study investigates the conductance measurements of MCM-41 and TiO2-MCM-41 modified with different weight percentages, aiming to understand their interactions in the presence of nicotinamide, a hydrotropic agent, in ethanol solution at varying temperatures.

Conductance Measurements and Thermal Effects

Conductance data were analyzed using the Shedlovsky method, revealing that limiting molar conductivity and association constants change with temperature and the material's composition. MCM-41 consistently displayed higher conductance values compared to its TiO2-modified counterparts, underlining the impact of modifications on ionic mobility in solution. This observation highlights the significance of temperature in conducting studies, suggesting that increased thermal energy leads to enhanced ionic movement and reduced solvent interactions.

Thermodynamic Parameters and Ion Interactions

The study computed thermodynamic parameters such as enthalpy, entropy, and Gibbs free energy, indicating that the association processes of the materials in solution are endothermic with decreasing randomness. The analysis suggests that the modification of MCM-41 with TiO2 alters its ion association behavior, impacting the dynamics of solvation. The positive free energy changes for all samples imply that the dissociation process is favored, with implications for drug delivery systems.

Material Characterization and Structural Integrity

Characterization techniques such as SEM and XRD revealed that the modification of MCM-41 with TiO2 does not adversely affect its mesoporous structure. Despite a decrease in the intensity of the XRD peaks due to the introduction of TiO2, the fundamental hexagonal arrangement characteristic of MCM-41 remains intact. This structural integrity is crucial for maintaining the material's efficacy as a drug delivery system.

Conclusion

The study's findings emphasize the potential of MCM-41 and TiO2-MCM-41 as effective carriers for hydrophobic drugs. Enhanced conductance and favorable thermodynamic parameters indicate that these materials can facilitate drug solubilization and delivery. The research provides valuable insights into the interactions and structural integrity of mesoporous materials, contributing to the development of improved drug delivery systems in pharmaceuticals.

FAQ section (important questions/answers):

What materials were used in the study of MCM-41 and TiO2-MCM-41?

The study utilized cetylhexadecyltrimethylammonium bromide (CTAB), tetraethylorthosilicate (TEOS), ammonia solution, nicotinamide as a hydrotropic agent, and various titania sources.

What modifications were made to MCM-41 during the study?

MCM-41 was synthesized with added titania at different weight percentages (10% and 15%) to enhance its drug delivery properties while retaining the mesoporous structure.

How was the conductance measured in the study?

Conductance was measured using a conductivity meter at temperatures ranging from 298.15 K to 313.15 K in ethanolic solutions of nicotinamide at variable concentrations.

What was the significance of measuring thermodynamic parameters?

Determining thermodynamic parameters such as ΔH0, ΔS0, and ΔG0 provided insights into the energy changes and interactions during ion association and solvation processes.

What trends were observed in molar conductance with temperature changes?

Molar conductance increased regularly with temperature for all samples, indicating higher mobility of ions as thermal energy raised their vibrational activity.

What were the conclusions drawn about MCM-41 and TiO2-MCM-41?

MCM-41 exhibited higher conductance values compared to TiO2-MCM-41, indicating superior solvation or ion mobility, crucial for efficient drug delivery systems.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Conductance of MCM-41, TiO2-MCM-41 with nicotinamide in ethanol.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
Drug refers to a substance used for medical treatment, which can be delivered through various systems. The study focuses on enhancing the delivery of water-insoluble drugs using mesoporous materials like MCM-41 and TiO2-MCM-41. Understanding drug behavior in carrier systems is crucial for effective therapeutic outcomes.

2) Water:
Water plays a vital role as a solvent in pharmaceutical studies, such as drug solubility and interaction with hydrotropic agents. In the context of mesoporous materials, water's properties influence the dissolution and delivery of drugs, affecting their pharmacokinetics and pharmacodynamics significantly.

3) Measurement:
Measurement pertains to the quantification of physical properties such as conductance, which is central to the study. Conductance measurements are used to analyze ion interactions and assess the efficiency of drug carriers in solution, providing insights into their behavior under varying conditions.

4) Surface:
Surface characteristics of materials, like MCM-41 and TiO2-MCM-41, are critical for drug interaction and attachment. The modification of these surfaces with functional groups affects drug loading and release, thereby influencing therapeutic efficacy and controlled delivery systems in pharmacological applications.

5) Study (Studying):
Study denotes the systematic investigation undertaken to explore the conductance properties of drug carriers and their interaction with hydrotropic agents. Such research aims to enhance understanding of drug delivery mechanisms and improve formulations for poorly soluble drugs for better clinical outcomes.

6) Table:
A table in the research context organizes and presents data systematically, allowing for easier comparison of conductance values, thermodynamic parameters, and results from different experiments. It serves as a critical tool for data analysis and interpretation within scientific investigations.

7) Nature:
Nature refers to the inherent characteristics of substances and their interactions within the studied system. The research examines the nature of ion associations and solvation phenomena that dictate the behavior of drug carriers in solution, impacting drug delivery mechanisms.

8) Wall:
Wall describes the structural components of mesoporous materials, such as the inner surfaces formed by silica and titania. Understanding the wall characteristics is essential for determining how well drugs can be adsorbed and released from these carriers, affecting therapeutic effectiveness.

9) Bhubaneswar (Bhubaneshvar, Bhubaneśvar):
Bhubaneswar, the capital city of Odisha, India, is the location of the research institution where this study was conducted. The geographical context may influence local research opportunities and collaborations in pharmaceutical sciences and advanced material studies.

10) Composite:
Composite refers to materials made from two or more constituent substances, like TiO2-MCM-41. Investigating these composites allows researchers to explore the combined properties, enhancing drug delivery systems by capitalizing on the strengths of each component in the matrix.

11) Activity:
Activity indicates the effectiveness of the studied materials in drug delivery systems, particularly in the context of solvation and drug interaction. Assessing these interactions helps in optimizing formulations for enhanced therapeutic actions and desirable pharmacodynamic profiles.

12) India:
India represents the geographic and cultural context of the research, which is significant for encouraging local innovation in pharmaceuticals. The country's ongoing advancements in drug delivery technologies contribute valuable insights and applications in the fields of pharmacology and biotechnology.

13) Discussion:
Discussion encapsulates the critical analysis of the study's findings, relating to the experimental data and theoretical implications. It is a vital component of scientific reports, providing insights into the significance of the results and suggesting future research directions.

14) Science (Scientific):
Science encompasses the systematic study of the natural world through observation and experimentation. This research represents the intersection of chemistry and pharmacology, exploring how material properties affect drug delivery and formulating scientific principles that guide therapeutic efficacy.

15) Cancer:
Cancer is a disease potentially addressed by the research through improved drug delivery systems. Utilizing mesoporous materials like TiO2-MCM-41 aims to enhance the delivery of chemotherapeutic agents to targeted sites, thus increasing treatment effectiveness and minimizing side effects.

16) Reason:
Reason pertains to the motivations behind the research, which is to tackle challenges in drug solubility and delivery efficacy. Identifying the underlying causes of these obstacles enables researchers to develop innovative solutions for improving drug formulations.

17) Kumar (Kumār):
Kumar is part of the names of researchers involved in the study, highlighting collaboration in scientific investigation. The contributions from individuals with various expertise enrich the research outcomes, combining knowledge and experience to enhance drug delivery methodologies.

18) Field:
Field refers to the domain of study or research area, here indicating the intersection of chemistry and pharmaceuticals. Understanding interactions and properties within this field is crucial for developing effective drug delivery systems to improve patient care.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Conductance of MCM-41, TiO2-MCM-41 with nicotinamide in ethanol.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Scanning Electron Microscopy, Temperature range, Molecular interaction.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Consider supporting this website: