Antihypertensive effects of Nardostachys jatamansi in rats.
Journal name: World Journal of Pharmaceutical Research
Original article title: Antihypertensive activity of nardostachys jatamansi in hypertnsive rats following renal gold blatt occlusion method.
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
V.Velpandian, N.Anbu, S.Elangovan, M. Mohamed Musthafa
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antihypertensive activity of nardostachys jatamansi in hypertnsive rats following renal gold blatt occlusion method.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
Hypertension is a significant medical condition that can lead to serious health complications, including heart failure and stroke. It is a major public health issue globally, contributing to millions of deaths each year. In India, hypertension is particularly concerning, with projected figures indicating a rapid rise in affected individuals. While various anti-hypertensive medications are available, they often come with side effects, leading to increased interest in traditional systems of medicine such as Siddha, which offers remedies with fewer adverse effects.
Potential of Sadamanjil Chooranam
Sadamanjil Chooranam, derived from the plant Nardostachys jatamansi, is traditionally used to treat conditions including hypertension, headache, and mood disorders. The study investigated its antihypertensive effects using a renal Goldblatt occlusion method in hypertensive rats. Through the administration of Sadamanjil Chooranam at two different doses, results showed a significant reduction in both systolic and diastolic blood pressure in treated rats compared to a control group. The highest dose yielded the most pronounced effects, indicating a dose-dependent relationship.
Acute Toxicity Study
An acute toxicity study was conducted to assess the safety of Sadamanjil Chooranam. Rats subjected to high doses of the drug demonstrated no signs of toxicity or mortality, indicating that even at doses up to 5000mg/kg, the substance is well-tolerated. This suggests the potential for its use as a safe therapeutic option within the appropriate dosage ranges.
Mechanism of Action
The antihypertensive effects of Sadamanjil Chooranam may involve interactions with the renin-angiotensin-aldosterone system, which plays a significant role in regulating blood pressure through mechanisms such as diuresis and vascular relaxation. Active compounds isolated from Nardostachys jatamansi, notably jatamansone, have been linked to these antihypertensive actions, although the specific pathways and mechanisms require further study to elucidate their exact effects in treating hypertension.
In conclusion, the study validates the antihypertensive potential of Sadamanjil Chooranam as an effective treatment option for hypertension, demonstrating significant reductions in blood pressure in hypertensive rats. The safety profile, along with its traditional use, supports the investigation into its broader applications in managing hypertension. Further research is essential to clarify the drug's mechanisms and potentially establish it as a standard treatment in clinical practice.
FAQ section (important questions/answers):
What is the main focus of the research on Sadamanjil Chooranam?
The research investigates the antihypertensive activity of Sadamanjil Chooranam, derived from Nardostachys jatamansi, in hypertensive rats using the renal Goldblatt occlusion method.
How does hypertension affect health according to the study?
Hypertension can lead to serious health issues such as heart failure, stroke, and renal failure. It is a major public health concern, contributing significantly to mortality rates globally.
What methodology was used to induce hypertension in animals?
Hypertension was induced using the Goldblatt method, which involves constricting the renal artery, leading to increased blood pressure due to reduced renal perfusion.
What doses of Sadamanjil Chooranam were tested during the study?
The study administered two doses of Sadamanjil Chooranam: 500 mg/kg and 1000 mg/kg to evaluate its antihypertensive effects in rats.
What were the findings regarding the systolic and diastolic blood pressure?
Sadamanjil Chooranam significantly reduced systolic and diastolic blood pressure in hypertensive rats, demonstrating a dose-dependent effect, especially pronounced at 1000 mg/kg.
What are the potential mechanisms of antihypertensive activity mentioned?
The antihypertensive activity might be due to ACE inhibition, diuretic effects, or antioxidant properties associated with Sadamanjil Chooranam, although the exact mechanisms need further study.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antihypertensive effects of Nardostachys jatamansi in rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' refers to any substance that causes a physiological change in the body upon administration. In this context, 'Sadamanjil Chooranam', derived from 'Nardostachys jatamansi', is investigated for its therapeutic potential as an antihypertensive agent in hypertensive rats, aiming to provide scientific validation for its traditional use in managing high blood pressure.
2) Siddha (Siddhā):
Siddha is a traditional system of medicine that originated in the Indian subcontinent, focusing on holistic healing and natural remedies. This system employs various herbal formulations, such as 'Nardostachys jatamansi', which are believed to have medicinal properties, including antihypertensive activities, making Siddha a relevant approach in contemporary pharmacological research.
3) Blood:
'Blood' is a vital fluid that circulates throughout the body, delivering oxygen and nutrients to tissues and removing waste products. Monitoring blood pressure is crucial in assessing the effectiveness of antihypertensive treatments, like 'Sadamanjil Chooranam', in reducing systolic and diastolic pressure in experimental models of hypertension.
4) Nardostachys jatamansi (Nardostachys jatamamsi):
'Nardostachys jatamansi' is a medicinal plant known for its various therapeutic properties, including its historical use in treating hypertension and neurological disorders. As an active ingredient in 'Sadamanjil Chooranam', this plant has been researched for its antihypertensive effects in rats, validating its place in both traditional and modern medicine.
5) Activity:
'Activity' in this context refers to the pharmacological effects that a substance, such as 'Sadamanjil Chooranam', demonstrates. Here, the focus is on its antihypertensive activity measured through changes in blood pressure, highlighting the importance of documenting the specific actions of the drug in scientific research.
6) Toxicity:
'Toxicity' pertains to the adverse effects a drug may have on biological systems. The study evaluates the acute toxicity of 'Sadamanjil Chooranam' at varying doses, ensuring safety while determining therapeutic efficacy in hypertensive models, reflecting a crucial aspect of pharmacological research.
7) Water:
'Water' is an essential component for biological processes and is used in drug formulation. In the preparation of 'Sadamanjil Chooranam', water is one of the solvents used in the extraction and administration of active compounds, affecting the drug's solubility and, consequently, its bioavailability and efficacy.
8) Post:
'Post' refers to the actions taken after a specific event. In this study, post-operative care for rats after renal artery occlusion is vital for observing the development of hypertension and the subsequent impact of administering 'Sadamanjil Chooranam', making it a significant phase in assessing drug effectiveness.
9) Pharmacology:
'Pharmacology' is the branch of medicine that studies drug action and interactions within biological systems. The research investigates the pharmacological effects of 'Sadamanjil Chooranam' in hypertensive rats, providing insights into its potential therapeutic uses and mechanisms of action within the field of Siddha medicine.
10) Science (Scientific):
'Science' signifies the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. This study demonstrates the application of scientific methods in validating traditional knowledge associated with 'Sadamanjil Chooranam', establishing a scientific foundation for its use in antihypertensive therapy.
11) Pharmacological:
'Pharmacological' relates to the effects and mechanisms of drugs and their interactions with biological systems. The study presents 'Sadamanjil Chooranam's' antihypertensive properties through a pharmacological lens, showcasing its potential impact on blood pressure regulation and contributing to broader pharmacological discussions on traditional medicines.
12) Medicine:
'Medicine' encompasses the field dedicated to the diagnosis, treatment, and prevention of ailments. The research contributes to the understanding of 'Sadamanjil Chooranam' as a possible treatment option for hypertension, bridging the gap between traditional Siddha practices and contemporary medical applications.
13) Salt (Salty):
'Salt' plays a critical role in the body's homeostasis and is directly related to hypertension through mechanisms such as water retention. Understanding the interaction between sodium (salt) levels and blood pressure is essential in evaluating the antihypertensive effects of 'Sadamanjil Chooranam' within the context of renal health.
14) Phytochemical:
'Phytochemical' refers to the chemical compounds produced by plants that may have health benefits. In this research, the presence of active phytochemicals in 'Nardostachys jatamansi' is highlighted, indicating potential mechanisms by which 'Sadamanjil Chooranam' exerts its antihypertensive effects in experimental models of hypertension.
15) Discussion:
'Discussion' in scientific research refers to the section where results are interpreted in relation to existing literature. It is a crucial part of the study on 'Sadamanjil Chooranam' that connects empirical findings to broader implications, exploring how these results align with or challenge existing knowledge in pharmacology.
16) Substance:
'Substance' indicates any material with defined properties. The term is relevant in the research context as it refers to 'Sadamanjil Chooranam', which is scrutinized for its chemical and biological properties leading to its potential use as an antihypertensive agent derived from natural sources.
17) Epilepsy:
'Epilepsy' is a neurological disorder characterized by recurrent seizures. The relevance of mentioning epilepsy in the context of 'Nardostachys jatamansi' lies in the traditional use of this herb in treating various neurological disorders, thus expanding the understanding of its therapeutic applications beyond just hypertension.
18) Hysteria:
'Hysteria' refers to psychological conditions characterized by excessive emotional responses. Traditional medicines, including those from Siddha practices, often include treatments for hysteria, with 'Nardostachys jatamansi' cited for its calming and therapeutic effects, which may contribute to overall health and well-being.
19) Incision:
'Incision' refers to the surgical cut made during experiments such as the Goldblatt method for inducing hypertension in rats. The surgical technique is critical in establishing a model of hypertension in this study, allowing researchers to evaluate the effects of 'Sadamanjil Chooranam' on blood pressure.
20) Diet:
'Diet' refers to the food and nutrients consumed by the experimental animals. The dietary conditions maintained throughout the study are pivotal to ensure consistent and reliable results regarding the antihypertensive effects of 'Sadamanjil Chooranam', as variations in diet can influence health outcomes and drug efficacy.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antihypertensive effects of Nardostachys jatamansi in rats.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Nardostachys jatamansi, Oral administration, Systolic BP, Diastolic BP, Systematic observation, Systolic blood pressure, Diastolic blood pressure, One-way ANOVA, Cardiovascular disease, Drug administration, Anti-oxidant Properties, Hypertension, Acute toxicity study, Institutional Animal Ethical committee, Normal control, Dose-dependent activity, Anti-hypertensive activity, Two kidney one clip model, Renin-angiotensin system, Renin Angiotensin Aldosterone System, Sadamanjil Chooranam, Renal Goldblatt occlusion method, Phytochemical reservoir, Mortal complications of hypertension, Animal experimental design, Hypertension control, CPCSEA guideline, Low dose, Statistically significant decrease, Pharmacological mechanism, Anti-hypertensive drug, Control and Treatment Groups, Hypertensive rats, Experimental hypertension, Gold Blatt occlusion method, Hypertensive model, Mineralocorticoid aldosterone, Anti-hypertensive potential, High dose level.