Phytochemical and pharmacological studies of Angiopteris evecta roots.
Journal name: World Journal of Pharmaceutical Research
Original article title: Phytochemical screening and pharmacological studies with angiopteris evecta roots
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Md. Forhad Molla, Shahnaz Rahman, A.B.M. Anwarul Bashar,Mohammed Rahmatullah
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Phytochemical screening and pharmacological studies with angiopteris evecta roots
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study focuses on the phytochemical screening and pharmacological evaluation of Angiopteris evecta roots for their antihyperglycemic and analgesic properties. This plant is known for its medicinal uses, including treatments for digestive issues and pain relief. There is a growing need for alternative remedies for diabetes and pain, especially in regions like Bangladesh where economic constraints limit access to conventional medications.
Antihyperglycemic Activity
The methanolic extract of A. evecta roots was assessed for its ability to lower blood glucose levels in glucose-loaded mice via oral glucose tolerance tests. Doses of 50, 100, 200, and 400 mg/kg resulted in significant reductions in blood glucose levels, with the highest dose achieving a reduction comparable to the standard drug glibenclamide. This finding suggests that the extract has substantial potential as an antihyperglycemic agent.
Analgesic Activity
The analgesic effects of the extract were evaluated using an acetic acid-induced pain model. The results demonstrated a significant, dose-dependent reduction in the number of abdominal writhings, indicating strong pain-relieving properties. The extract's analgesic efficacy at higher doses was found to be comparable to that of aspirin, a common over-the-counter analgesic, highlighting its potential as a natural pain relief option.
Phytochemical Analysis
Preliminary phytochemical screening confirmed the presence of various bioactive compounds in the methanolic extract, including alkaloids, flavonoids, and tannins. These compounds are known for their therapeutic effects, which may contribute to the observed antihyperglycemic and analgesic properties of A. evecta roots. The findings support the need for further investigation into the specific mechanisms and other potential health benefits that these compounds may offer.
Conclusion
The study concludes that the methanolic extract of A. evecta roots possesses significant antihyperglycemic and analgesic activities, which may lead to its development as a natural treatment for diabetes and pain management. Further research is warranted to isolate effective compounds and better understand their mechanisms of action.
FAQ section (important questions/answers):
What is the objective of the study on Angiopteris evecta roots?
The objective was to phytochemically screen and evaluate the antihyperglycemic and analgesic potential of methanolic extract of Angiopteris evecta roots.
What method was used to evaluate antihyperglycemic activity in mice?
The oral glucose tolerance test (OGTT) was used to evaluate antihyperglycemic activity in glucose-loaded mice.
What were the results of the antihyperglycemic activity tests?
The extract significantly reduced blood glucose levels by 11.3% to 46.7% at varying doses, with a maximum reduction comparable to the standard drug glibenclamide.
How was analgesic activity assessed in the study?
Analgesic activity was assessed using an acetic acid-induced pain model, measuring the number of abdominal writhings in mice after treatment.
What preliminary phytochemicals were identified in the extract?
Preliminary screening indicated the presence of alkaloids, flavonoids, and tannins in the methanolic extract of Angiopteris evecta roots.
What are the implications of this study's findings?
The findings suggest that Angiopteris evecta may be useful in developing effective antihyperglycemic and analgesic compounds, warranting further scientific research.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Phytochemical and pharmacological studies of Angiopteris evecta roots.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood is essential for transporting nutrients, hormones, and oxygen throughout the body. In the study, blood glucose levels are measured to assess the antihyperglycemic effects of Angiopteris evecta roots extract. Monitoring blood glucose is crucial for diagnosing and managing diabetes and evaluating the efficacy of antidiabetic substances.
2) Activity:
In pharmacology, 'activity' refers to the effects a substance has on biological systems. This study evaluates the antihyperglycemic and analgesic activities of the methanolic extract from Angiopteris evecta roots. Such activity assessments help determine the potential therapeutic benefits of herbal remedies in treating conditions like diabetes and pain.
3) Drug:
A drug is a chemical substance used for therapeutic purposes. In this study, the standard drug glibenclamide is used for comparison against the plant extract in terms of reducing blood glucose levels. Identifying effective drugs is critical in the context of developing treatments for chronic health conditions.
4) Flavonoid:
Flavonoids are phytochemicals with various health benefits, including antioxidant, anti-inflammatory, and potential antihyperglycemic properties. The presence of flavonoids in the Angiopteris evecta extract suggests a possible mechanism for its therapeutic effects. Flavonoids are often studied for their roles in preventing metabolic disorders and their contributions to human health.
5) Phytochemical:
Phytochemicals are biologically active compounds found in plants that may provide health benefits. The study includes preliminary screening for phytochemicals like alkaloids and flavonoids in the methanolic extract of Angiopteris evecta roots, indicating their relevance to the extract's pharmacological effects and potential therapeutic applications.
6) Toxicity:
Toxicity refers to the degree of harmfulness of a substance to living organisms. In this study, acute toxicity tests show that the methanolic extract of Angiopteris evecta roots exhibited no toxicity in tested mice, highlighting its safety profile for potential therapeutic use and supporting its traditional medicinal applications.
7) Water:
Water is crucial for all biological processes and the solvent in which many phytochemicals and extracts dissolve. In this study, distilled water is used for cleaning roots and preparing extracts, ensuring no contaminants interfere with the measured pharmacological activities of Angiopteris evecta during experimentation.
8) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory condition that causes pain and swelling in joints. The analgesic properties assessed in this study may provide insights for developing herbal remedies to alleviate pain associated with such conditions. Understanding the analgesic potential can contribute to integrative approaches in managing arthritis.
9) Tamarindus indica:
Tamarindus indica is a plant noted for its medicinal properties; its extracts have demonstrated antihyperglycemic activity. In comparison to Angiopteris evecta, this reference highlights the potential of other plants as sources of therapeutic agents for managing diabetes, encouraging exploration of phytochemicals with similar beneficial effects.
10) Pharmacological:
Pharmacological refers to the study of how drugs and herbal substances interact with biological systems. This study's focus on the pharmacological evaluation of Angiopteris evecta's extract underlines the significance of understanding plant-derived substances in developing effective treatments for diseases, including diabetes and pain relief.
11) Antibiotic (Antibacterial):
Antibacterial properties denote the ability to inhibit bacterial growth. Previous studies indicate antibacterial activity of various extracts from Angiopteris evecta, underscoring the potential of this plant in traditional medicine. Such properties expand the plant's relevance beyond diabetes management, suggesting broader applications in treating infections.
12) Agriculture:
Agriculture significantly affects the livelihoods and health of individuals, particularly in rural settings. In the context of this study, understanding the pain experienced by agricultural workers emphasizes the need for effective, safe analgesic remedies derived from plants like Angiopteris evecta, enhancing their quality of life.
13) Discussion:
The discussion section of research papers interprets findings and connects them to existing literature. In this study, the discussion revolves around the implications of the antihyperglycemic and analgesic activities observed in Angiopteris evecta. This analysis informs future directions for research and therapeutic applications.
14) Irritation:
Irritation refers to the discomfort resulting from chemical exposure, often leading to pain. In this study, the acetic acid-induced pain model assesses the analgesic effect of the plant extract. Understanding irritation mechanisms may lead to better pain management strategies through the identification of effective natural analgesics.
15) Science (Scientific):
Scientific denotes an empirical approach to understanding phenomena through structured research. This study employs rigorous methods to evaluate the medicinal properties of Angiopteris evecta, illustrating the importance of scientific inquiry in validating traditional knowledge and contributing evidence-based treatments for health issues like diabetes and pain.
16) Substance:
Substance refers to any material with distinct properties and effects. In this context, Angiopteris evecta extract is studied as a potential therapeutic substance. Identifying effective substances from nature can lead to novel treatments for diseases and enhance the pharmaceutical arsenal available for clinical use.
17) Overuse:
Overuse pertains to the excessive consumption of drugs, leading to adverse effects. This study highlights the rural populations' dependence on over-the-counter pain relievers, promoting the exploration of plant-based alternatives for pain relief. Developing safe herbal remedies can mitigate problems associated with the overuse of synthetic analgesics.
18) Cancer:
Cancer represents a group of diseases characterized by uncontrolled cell growth. Although not the primary focus of this study, understanding pain relief mechanisms is crucial for cancer patients. By exploring natural analgesics like Angiopteris evecta, researchers might identify supportive care options for managing cancer-related discomfort.
19) Misuse:
Misuse refers to inappropriate or incorrect use of medications or substances. The study emphasizes the common misuse of analgesics among urban workers, advocating for the exploration of safe plant-derived options. Identifying effective, safer alternatives can reduce the risks associated with the misuse of synthetic analgesics.
20) Sugar:
Sugar, specifically glucose, is a key focus in this study due to its relation to diabetes management. The extract from Angiopteris evecta is evaluated for its ability to lower blood sugar levels in hyperglycemic mice, highlighting its potential role in managing elevated glucose levels linked to diabetes.
21) Ulcer:
Ulcers are gastrically induced injuries often necessitating pain management. The introduction indicates traditional uses of Angiopteris evecta roots for treating intestinal ulcers. This study's exploration into analgesic properties may reveal additional therapeutic benefits, showcasing the plant's broader relevance in managing gastrointestinal and pain-related disorders.
22) Lemon:
Lemon is cited for its role in traditional medicine, particularly in concoctions for treating conditions such as ulcers. In this study's context, it highlights the cultural and ethnomedical significance of complementary treatments. Investigating plant combinations may lead to enhanced therapeutic effects in managing health conditions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Phytochemical and pharmacological studies of Angiopteris evecta roots.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Indigenous people, Statistical analysis, Significant reduction, Preliminary phytochemical screening, Analgesic activity, Swiss albino mice, Antihyperglycemic activity, Methanolic extract, Acute toxicity test, Blood glucose level, Oral glucose tolerance, Analgesic drug, Ethnomedicinal use.