Evaluation of antihyperglycemic and analgesic activity of Raphanus sativus
Journal name: World Journal of Pharmaceutical Research
Original article title: Antihyperglycemic and analgesic activity evaluation of methanolic extract of raphanus sativus l. aerial parts
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Tania Khan, Shahnaz Rahman, Mohammed Rahmatullah
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antihyperglycemic and analgesic activity evaluation of methanolic extract of raphanus sativus l. aerial parts
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Raphanus sativus L. is a plant cultivated worldwide, primarily for its edible roots and also for its aerial parts, which are consumed as salads. The red root variety, known as radish, has various medicinal uses, and the aerial parts contain several bioactive compounds including glucobrassicin and phenolic acids. The rise of diabetes, particularly in Bangladesh due to changes in diet and lifestyle, has prompted interest in alternative treatment options, especially for those in rural areas lacking access to modern medicine. Pain management is also critical, with traditional pain relievers often having side effects.
Antihyperglycemic Activity of Methanol Extract
The study evaluated the antihyperglycemic effects of methanolic extract of R. sativus aerial parts in Swiss albino mice. The extract was administered at varying doses, showing a dose-dependent decrease in blood glucose levels, with the highest dose achieving a reduction similar to that of a standard anti-diabetic drug, glibenclamide. This suggests that the aerial parts of R. sativus possess significant potential for managing blood sugar levels.
Analgesic Effects of Methanol Extract
The extract also demonstrated notable analgesic properties through the acetic acid-induced abdominal writhing test. The reduction in the number of abdominal constrictions at different doses indicates that the methanol extract can provide pain relief, outperforming aspirin at higher doses. The presence of phytochemical constituents such as flavonoids and saponins may contribute to these analgesic effects.
Phytochemical Constituents and Their Potential
Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and tannins in the extract, which are known for their antihyperglycemic and analgesic properties. The study highlights that these components may work individually or synergistically to exhibit the observed biological activities, indicating a pathway for further research into their mechanisms of action.
In conclusion, the methanolic extract of R. sativus (red variety) aerial parts shows promise as a natural alternative for lowering blood glucose levels and offering pain relief. The study suggests potential health benefits for populations in rural areas where access to modern medicine may be limited, underscoring the need for further investigation into this plant's therapeutic applications.
FAQ section (important questions/answers):
What was the objective of the Raphanus sativus study?
The study aimed to evaluate the antihyperglycemic and analgesic effects of methanolic extract of Raphanus sativus aerial parts in Swiss albino mice.
How was the antihyperglycemic activity measured in mice?
The oral glucose tolerance test was conducted, measuring blood glucose levels in glucose-loaded mice after administering the methanolic extract at various doses.
What were the key findings on blood glucose reduction?
The extract demonstrated significant blood glucose reduction, achieving a maximum reduction of 49.2% at 400 mg/kg, comparable to the standard drug glibenclamide.
How was analgesic activity assessed in the study?
The analgesic activity was evaluated using an acetic acid-induced pain model, counting abdominal constrictions in treated mice compared to control groups.
What phytochemical components were present in the extract?
Preliminary screening identified the presence of alkaloids, flavonoids, saponins, and tannins in the methanolic extract of Raphanus sativus.
What potential applications does this study suggest for Raphanus sativus?
The findings suggest that Raphanus sativus aerial parts could be beneficial for managing diabetes and alleviating pain, making it a viable dietary supplement.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of antihyperglycemic and analgesic activity of Raphanus sativus”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood refers to the vital fluid in the body that transports oxygen and nutrients to cells while removing waste products. In the context of diabetes and the study, blood glucose levels are a critical parameter, as maintaining proper glucose levels is essential for managing diabetes and preventing complications associated with high blood sugar.
2) Activity:
Activity refers to the physiological or biological functions and effects of a substance, often measured in studies to assess benefits or therapeutic efficacy. In this study, the activities evaluated include antihyperglycemic and analgesic activities of Raphanus sativus extract, indicating its potential health benefits.
3) Drug:
A drug is a substance that alters physiological functions when administered. In this research, the standard drugs glibenclamide and aspirin are compared to the methanolic extract of Raphanus sativus to evaluate its hypoglycemic and analgesic effects, illustrating the search for effective treatments.
4) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant properties and potential health benefits, including anti-inflammatory, antihyperglycemic, and analgesic effects. The presence of flavonoids in the methanolic extract of Raphanus sativus suggests they may contribute to its observed pharmacological activities in the study.
5) Phytochemical:
Phytochemicals are bioactive compounds found in plants that can have health-promoting effects. The study screened the Raphanus sativus extract for several phytochemicals like alkaloids, flavonoids, saponins, and tannins, which are believed to be responsible for its antidiabetic and analgesic properties.
6) Sugar:
Sugar, specifically glucose, is a simple carbohydrate that serves as an essential energy source for the body. Elevated blood sugar levels are a hallmark of diabetes, making the regulation of sugar levels vital. The study evaluates the extract's ability to lower blood sugar in hyperglycemic mice.
7) Raphanus sativus:
Raphanus sativus, commonly known as radish, is a vegetable belonging to the Cruciferae family. Its aerial parts are used in this study, which investigates their antihyperglycemic and analgesic potential, highlighting the plant's versatility and possible health benefits beyond its traditionally consumed root.
8) Toxicity:
Toxicity refers to the harmful effects of substances on living organisms. In this study, the methanolic extract of Raphanus sativus was tested for acute toxicity, confirming its safety even at high doses, an important consideration when evaluating natural products for medicinal use.
9) Pharmacological:
Pharmacological pertains to the actions and effects of drugs and substances on biological systems. This study assesses the pharmacological effects of Raphanus sativus extract, demonstrating its potential as a natural remedy for managing diabetes and pain, supporting its therapeutic applications.
10) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing diseases. This study involves evaluating a plant extract for antihyperglycemic and analgesic properties, contributing to the larger field of herbal medicine as an alternative or complementary treatment for common ailments.
11) Tamarindus indica:
Tamarindus indica, commonly known as tamarind, is a tropical tree whose pods are used in cooking and traditional medicine. Like Raphanus sativus, tamarind has shown medicinal properties, including antihyperglycemic effects, making it relevant in the discussion of plant-based treatments for diabetes.
12) Syzygium cumini:
Syzygium cumini, known as jamun, is a tropical fruit tree whose seeds and other parts have antidiabetic properties. Mentioned in the study, its relevance lies in its traditional use in managing diabetes, paralleling the investigation of Raphanus sativus as a similar therapeutic option.
13) Discussion:
Discussion is a section in research papers where results are interpreted in context. In this study, the discussion addresses findings regarding the antihyperglycemic and analgesic effects of the Raphanus sativus extract, situating them within existing literature and implications for future research.
14) Irritation:
Irritation refers to the sensation of discomfort or pain often due to chemical exposure or injury. The study uses acetic acid to induce pain in mice to evaluate the analgesic effect of Raphanus sativus extract, using this model to measure the extract's efficacy in alleviating pain.
15) Substance:
A substance is any material with a definite composition. In this study, both the methanolic extract of Raphanus sativus and standard drugs are considered substances whose biological activities are evaluated, demonstrating the importance of substance characterization in pharmacological research.
16) Debility:
Debility refers to physical weakness or infirmity often linked with various health conditions. The ethnomedicinal use of Raphanus sativus seeds for treating sexual debility illustrates its historical application in traditional medicine, highlighting the perceived health benefits associated with the plant.
17) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth. Although the study does not focus on cancer, the discussion of pain management and potential natural remedies relates to the need for safer alternatives to conventional treatments often used in cancer care.
18) Thirst:
Thirst is a physiological urge driven by the body's need for hydration, often heightened in individuals with diabetes due to elevated blood sugar levels. The mention of thirst relates to the diabetes context, emphasizing the importance of effective blood sugar management in reducing related symptoms.
19) Water:
Water is essential for life, facilitating numerous bodily functions and maintaining homeostasis. In diabetic patients, hydration levels can be affected by elevated blood sugar, making it crucial to manage both glucose levels and adequate hydration; this context reinforces the study's relevance to health.
20) Hand:
Hand is not explicitly discussed in the study but often represents physical action or manual skills in administration or healthcare. In broader terms, understanding how herbal remedies can be prepared and applied connects to traditional healing practices still prevalent in many cultures.
21) Cita:
Sida refers to the genus of flowering plants, some of which are studied for their medicinal properties. Its mention in the study underscores the focus on natural sources as potential alternatives for pain relief and other health issues, highlighting the ongoing research into plant-based therapies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Evaluation of antihyperglycemic and analgesic activity of Raphanus sativus’. Further sources in the context of Science might help you critically compare this page with similair documents:
Pain, Raphanus sativus, Painful condition, Significant reduction, Statistical Significance, Preliminary phytochemical screening, Phytochemical screening, Analgesic activity, Analytical grade, Swiss albino mice, Antihyperglycemic activity, Ethnomedicinal plant, Methanolic extract, Antinociceptive activity, Oral glucose tolerance test, Anti-hyperglycemic activity, Glibenclamide, Acute toxicity test, Blood glucose level, Ferulic acid, Phenolic acid, Ethnomedicinal use, Department of Pharmacy, Aerial part, Standard analgesic drug, Phyto-constituent, Competing interests, Behavioral change, Bioactive constituent.