Standard manufacturing procedure (smp) of kumkumadi ghrita
an ayurvedic formulation
Journal name: World Journal of Pharmaceutical Research
Original article title: Standard manufacturing procedure (smp) of kumkumadi ghrita
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: an ayurvedic formulation
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PK Prajapati , Amrutia A, Rohit Sharma, BJ Patigiri
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Standard manufacturing procedure (smp) of kumkumadi ghrita
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Kumkumadi Ghrita (KG) is a valued Ayurvedic formulation primarily used for treating skin disorders, especially acne vulgaris. Traditionally, saffron (Kesar) is a key ingredient, but due to its high cost and potential for adulteration, Ayurvedic experts suggest using Nagakesar (Mesua ferrea) as a more affordable alternative, possessing similar therapeutic properties. Despite its widespread use, there is a lack of published manufacturing guidelines for KG, motivating this study to establish a standard manufacturing procedure (SMP) for both Kesar-yukta (KKG) and Nagakesar-yukta (NKG) Kumkumadi Ghrita.
Alternative Ingredient Efficiency
The study demonstrated that using Nagakesar as a substitute for Kesar does not compromise the therapeutic efficacy of Kumkumadi Ghrita. Both formulations exhibited comparable results in treating skin disorders, making NKG a cost-effective alternative. The research confirmed that both formulations produced similar therapeutic effects in clinical settings, allowing for more accessible treatment options without sacrificing quality.
Manufacturing Process Insights
The research emphasized the importance of specific manufacturing processes tailored for KG preparation. It highlighted the necessity of using coarse powdered ingredients instead of fine powders to maximize yield, especially for expensive formulations like KG. Additionally, the ideal cooking stage identified was Madhyama Paka, which optimally retains the active constituents without compromising quality. These insights guide future production practices in Ayurvedic pharmaceutical companies.
Economic Considerations
The cost analysis revealed significant differences in the production costs of KKG and NKG, with NKG being notably more economical. This economic advantage, combined with equivalent therapeutic outcomes, positions NKG as a preferable choice for large-scale production, addressing both quality and affordability in Ayurvedic medicine.
Conclusion
The findings of this study indicate that NKG serves as a viable and cost-effective alternative to KKG without sacrificing efficacy. Establishing a standard manufacturing procedure enhances quality assurance in Ayurvedic formulations. The observations and procedures detailed in this study can serve as foundational guidelines for future research and production in the field of Ayurvedic pharmaceuticals.
FAQ section (important questions/answers):
What is Kumkumadi Ghrita and its primary uses?
Kumkumadi Ghrita is an Ayurvedic formulation primarily used for treating skin disorders, particularly Mukhdushika (acne vulgaris). It contains Kesar as a key ingredient, which is known for its therapeutic properties.
What are the two types of Kumkumadi Ghrita mentioned?
The study discusses two types: Kesar yukta Kumkumadi Ghrita (KKG) containing Kesar and Nagakesar yukta Kumkumadi Ghrita (NKG) made with Nagakesar, a cost-effective substitute for Kesar.
What is the primary aim of the study?
The aim is to establish a Standard Manufacturing Procedure (SMP) for KKG and NKG, ensuring uniformity and quality in the preparation of these Ayurvedic formulations.
How do KKG and NKG compare in terms of cost?
KKG is significantly costlier, with a price of 21,086 INR per kilogram, while NKG costs only 3,264 INR per kilogram, making NKG the more cost-effective option.
What is the recommended preparation method for Kumkumadi Ghrita?
The preparation should involve Madhyama Paka stage heating and using coarse powdered ingredients instead of fine powders to maximize yield and therapeutic efficacy.
What were the findings concerning the average loss in final products?
The average loss in the final product during preparation was 10.18% for KKG and 7.58% for NKG, indicating that NKG is more efficient in retaining the final product.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Standard manufacturing procedure (smp) of kumkumadi ghrita”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ghrita (Ghṛta):
Ghrita is a medicated ghee preparation in Ayurveda, which serves as a base for various formulations. It is valued for its ability to facilitate the absorption of lipid-soluble active principles from herbs and improve the bioavailability of medicinal compounds. Ghrita enhances the therapeutic effects of the combined ingredients, acting as both a carrier and preservative.
2) Paka (Pāka, Pakā, Pākā):
Paka refers to the cooking or preparation process in Ayurvedic medicine where herbs are processed with Ghrita or water. The stages of Paka, such as Mridu Paka and Madhyama Paka, indicate varying temperatures and consistencies achieved during the preparation, affecting the efficacy of the final product. Proper Paka ensures optimal extraction of medicinal properties.
3) Murchana (Mūrcchana, Mūrchana, Murcchana, Mūrchanā):
Murcchana is a pretreatment process of Ghrita that involves boiling it with herbs to enhance its absorption and therapeutic qualities. This unique process removes impurities and moisture, allowing the Ghrita to better incorporate the medicinal properties of the added herbs. The Murcchana process is vital in maximizing the health benefits of the preparation.
4) Kalka:
Kalka refers to a coarse paste made from the herbs used in Ayurvedic formulations. It is essential in the preparation of Ghrita, as it optimizes the extraction of active compounds during the cooking process. The quality and consistency of Kalka significantly affect the efficacy and bioavailability of the final product.
5) Drug:
In the context of Ayurveda, a drug refers to any substance used for therapeutic purposes, including herbs, minerals, and animal products. The quality, source, and preparation of these drugs are crucial for maximizing their medicinal effects. Understanding the properties and actions of each drug is key to efficacious treatment.
6) Ghi (Ghī, Ghee):
Ghee, or clarified butter, is a staple in Ayurvedic medicine, prized for its nutritional and therapeutic properties. It serves as a base for many formulations, aiding in the absorption of herbal compounds. Ghee is also lauded for its ability to enhance digestion and support overall health when used appropriately.
7) Ghritapaka (Ghṛtapāka, Ghrita-paka):
Ghrita-paka denotes the cooking process involved in the preparation of Ghrita-based formulations. This method emphasizes reaching specific consistency and temperature stages, such as Madhyama Paka, to ensure the proper extraction of active ingredients. Ghrita-paka is integral to determining the final product's quality and therapeutic efficacy.
8) Murcchita (Mūrcchita):
Murcchita refers to the Ghrita that has undergone the Murcchana process, enriching it with the medicinal properties of the used herbs. The effectiveness of any subsequent Ayurvedic formulation largely depends on the quality of Murcchita, as this initial processing enhances its absorption and therapeutic potential.
9) Quality:
Quality in Ayurvedic formulations is paramount, as it directly affects efficacy and safety. Ensuring the highest quality of ingredients and adherence to standard manufacturing procedures is crucial to providing reliable treatments. Rigorous quality control measures are essential for maintaining the integrity of herbal products in the marketplace.
10) Kalpana (Kalpanā):
Kalpana refers to the concept of pharmaceutical preparations in Ayurveda. It encompasses various forms of drug formulations, such as Ghrita, Churna, and Kwatha, each with specific preparation methods. Understanding Kalpana is essential for practitioners to create effective medicines tailored to individual health needs.
11) Rasashastra (Rasa-shastra, Rasaśāstra):
Rasashastra is an ancient discipline within Ayurveda focusing on the use of metals, minerals, and gemstones for therapeutic purposes. It lays out procedures for preparing potent medicines, emphasizing the importance of quality control and standardization for effective treatment. Expertise in Rasashastra is critical to ensuring safety and efficacy in Ayurvedic practice.
12) Bhaishajya (Bhaiṣajya):
Bhaishajya refers to the branch of Ayurveda that deals with the study and preparation of medicines. It encompasses pharmacology, the therapeutic uses of different substances, and methods of preparation. Knowledge in Bhaishajya enables practitioners to develop effective treatments for various health conditions.
13) Lakshana (Lakṣaṇa, Laksana, Lakṣaṇā):
Lakshana refers to the characteristic signs or markers indicative of quality and readiness in Ayurvedic formulations. Understanding Lakshana helps practitioners assess the efficacy and safety of drugs, guiding optimal usage. Each formulation has specific Lakshanas that signal its appropriateness for therapeutic application.
14) Siddhi:
Siddhi refers to the successful completion or perfection of a pharmaceutical process in Ayurveda. It indicates that a formulation has attained its desired qualities and can be utilized for therapeutic purposes. Achieving Siddhi ensures that the product is effective and safe for consumption.
15) Water:
Water serves as a vital medium in Ayurvedic formulations, often used for decoction or as an excipient during preparations. It facilitates the extraction of active components from herbs and contributes to the overall quality of the final product. The purity and temperature of water are crucial in medicinal preparations.
16) Dravya:
Dravya translates to 'substance' in Ayurveda, referring to both tangible materials (like herbs and minerals) and their therapeutic properties. Understanding various Dravyas and their interactions is fundamental for formulating effective Ayurvedic medicines and tailoring treatments to patient needs.
17) Crocus sativus:
Crocus sativus, commonly known as saffron, is a highly valued ingredient in Ayurvedic formulations. It is known for its antioxidant and anti-inflammatory properties, making it particularly beneficial for skin conditions. Given its high cost and susceptibility to adulteration, its authenticity is critical in Ayurvedic practice.
18) Substance:
Substance encompasses any material used in the preparation of Ayurvedic medicines, including herbs, minerals, and animal products. The quality and characteristics of each substance significantly influence the therapeutic efficacy of any formulation created. Identifying and utilizing high-quality substances is essential for successful treatment outcomes.
19) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is a traditional Indian system of medicine emphasizing balance in bodily systems through diet, herbal treatment, and lifestyle changes. It advocates personalized approaches to health, using botanical and mineral resources. Understanding Ayurveda involves knowledge of its principles, practices, and historical context in medicine.
20) Bitter:
Bitter is one of the six fundamental tastes in Ayurveda that relates to health benefits like digestive enhancement and detoxification. Bitter substances are often utilized in Ayurvedic formulations for their therapeutic properties, influencing appetite and metabolic processes. Recognizing the taste profile is crucial in selecting the appropriate treatments.
21) Mridu (Mṛdu):
Mridu translates to 'soft' or 'gentle' in Ayurvedic terminology. In the context of Paka preparation, it indicates a specific stage where the mixture achieves a softer consistency, which has implications for the efficacy and absorption of the herbal compounds within formulations.
22) Yukta:
Yukta conveys the concept of 'combination' or 'connection' within Ayurveda, referring to the systematic integration of various drug components for creating effective formulations. Understanding Yukta is essential in developing balanced therapies that leverage the synergistic effects of combined substances.
23) Agni:
Agni, or 'digestive fire,' is a central concept in Ayurveda representing metabolic processes. It plays a crucial role in determining digestion and the assimilation of nutrients in the body. Maintaining a balanced Agni is vital for overall health and the effectiveness of administered treatments.
24) Curcuma longa:
Curcuma longa, commonly known as turmeric, is a widely used herb in Ayurveda, celebrated for its anti-inflammatory and antioxidant properties. It is often included in formulations for its therapeutic effects on skin and digestive health. Its active ingredient, curcumin, is responsible for many health benefits attributed to turmeric.
25) Mesua ferrea:
Mesua ferrea, known as Nagakesar, is a significant herb in Ayurveda with properties similar to Crocus sativus. It is commonly used as a substitute due to its relatively lower cost while still offering therapeutic benefits. Knowledge of its potency is essential for practitioners when preparing formulations.
26) Plumbago zeylanica:
Plumbago zeylanica, referred to as Chitrakmoola in Ayurveda, is a vital herb used primarily for its digestive properties. It serves as a key ingredient in formulations, aiding absorption and enhancing the overall therapeutic value of Ayurvedic medicines. Its preparation requires careful consideration to maximize efficacy.
27) Mridupaka (Mṛdupāka):
Mridu-paka refers to the 'soft cooking' stage during Ayurvedic preparation, indicating a specific temperature range and consistency achieved during the formulation process. This stage is critical for ensuring the efficacy of the medicinal properties being extracted and aptly signifies quality in the resulting products.
28) Nikshipta (Nikṣipta):
Nikshipta translates to 'not producing sound' and refers to a quality observed during Ghrita preparation in Ayurveda. This transition signifies the right temperature and consistency, ensuring that active ingredients are appropriately cooked and ready for effective therapeutic use, indicating the optimal completion of the Paka process.
29) Medicine:
Medicine in Ayurveda encompasses various practices and substances aimed at promoting health and treating disease. It integrates the use of herbs, minerals, and techniques such as Panchakarma. The field of Ayurvedic medicine emphasizes personalized treatment based on individual constitutions and balance to restore harmony.
30) Turmeric:
Turmeric is a key ingredient in Ayurveda, known for its diverse medicinal properties, including anti-inflammatory, antimicrobial, and antioxidant effects. Its active compound, curcumin, contributes to its therapeutic benefits in various formulations, particularly those targeting skin conditions and digestive health. Proper preparation and dosage are crucial for maximizing its benefits.
31) Haridra (Hāridra, Haridrā):
Haridra refers to turmeric in Ayurveda and is renowned for its healing properties. It is commonly included in formulations for skin disorders and is praised for its anti-inflammatory and antioxidant effects. The inclusion of Haridra in medicines enhances their efficacy, particularly in skin health treatments.
32) Shabda (Śabda):
Shabda or 'sound' is one of the five perceptions in Ayurveda that plays a role in determining the quality of medicines during preparation. For example, the lack of sound during certain stages indicates that proper characteristics have been achieved, which is essential for ensuring the right consistency and efficacy.
33) Gandha (Gandhā, Gamdha):
Gandha translates to 'odor' in Ayurveda and is a critical aspect of assessing the quality of herbal preparations. The desirable aroma indicates appropriate extraction and processing of active components. Changes in Gandha may reflect chemical changes in the formulation, influencing its therapeutic effectiveness.
34) Dosha (Dosa, Doṣa, Dosā, Doṣā, Ḍosā):
Dosha represents the physiological factors in Ayurveda, fundamental to understanding individual health and imbalances. The balance among the three doshas—Vata, Pitta, and Kapha—determines one's health status. Ayurvedic medicine aims to restore balance among the doshas for optimal health through personalized treatments.
35) Darvi (Dārvī):
Darvi, referring to 'touch' in Ayurvedic medicine, signifies the sensory evaluation of a substance's texture and consistency during preparation. Understanding Darvi is essential for ensuring that medicinal formulations achieve the desired characteristics and efficacy in treatment applications.
36) Varna (Varṇā, Varṇa):
Varna translates to 'color' in Ayurveda, which is an indicator of quality and efficacy for herbal preparations. Observing Varna provides insights into the active components present and their concentration. It is an essential parameter in assessing the readiness and therapeutic potential of formulations.
37) Emblica officinalis:
Emblica officinalis, known as Amla, is an important herb in Ayurveda recognized for its high vitamin C content and antioxidant properties. It is frequently included in formulations for its rejuvenating effects on digestion and skin health. Amla's versatility is essential in creating effective Ayurvedic medicines.
38) Terminalia chebula:
Terminalia chebula, commonly known as Haritaki, is revered in Ayurvedic medicine for its detoxifying properties and role in improving digestive health. Its inclusion in formulations often enhances efficacy, making it a staple herb. Understanding its medicinal qualities is crucial for effective treatment approaches.
39) Berberis aristata:
Berberis aristata, known as Daruharidra, is a significant herb in Ayurveda valued for its antimicrobial and anti-inflammatory properties. It is often used in skin formulations and therapies targeting infections. Knowledge of Daruharidra’s benefits and preparation techniques is vital in crafting effective Ayurvedic remedies.
40) Burning sensation:
Burning sensation refers to an adverse effect that may occur with certain herbal preparations. In Ayurveda, it is important to monitor for such sensations, as they can indicate overheating of active compounds during preparation or inappropriate formulations. Ensuring proper cooking methods helps mitigate this issue.
41) Piper longum:
Piper longum, known as Pippali, is an important Ayurvedic herb recognized for its potent warming and digestive properties. It aids in enhancing the bioavailability of other herbal components in formulations. Understanding its pharmacological actions is critical for crafting effective Ayurvedic treatments.
42) Citrus medica:
Citrus medica, or Matulunga, is a citrus fruit used in Ayurveda for its digestive and flavor-enhancing properties. It complements other ingredients in formulations by adding taste and promoting overall effectiveness. The role of Citrus medica in Ayurvedic therapy impacts herbal combinations positively.
43) Gandhadosha (Gandhadoṣa, Gandha-dosha):
Gandha-dosha refers to the undesirable odor in preparations that can signify poor quality or faulty processing. Managing Gandha-dosha is crucial to ensuring the authenticity and efficacy of Ayurvedic medicines. Attention to processing methods can help eliminate undesirable odors and enhance the therapeutic value.
44) Daruharidra (Dāruharidrā, Daru-haridra):
Daruharidra is a key herb recognized for its medicinal properties in Ayurveda, including its antimicrobial and anti-inflammatory effects. Often used in formulas targeting skin and gastrointestinal health, it exemplifies the importance of integrating such herbs into treatments to achieve desired health outcomes.
45) Perception:
Perception in Ayurveda involves the sensory evaluation of formulations through sight, smell, touch, taste, and sound. These perceptions are vital for determining the quality and readiness of herbal preparations. Recognizing and understanding these perceptions ensures the efficacy and safety of Ayurvedic medicinal products.
46) Discussion:
Discussion in the context of Ayurvedic studies encompasses the analysis and interpretation of research findings related to formulation practices and therapeutic efficacy. Engaging in discussions helps refine practices, ensure better understanding of herbal interactions, and enhance the quality of future research and implementations.
47) Goghrita (Goghṛta, Go-ghrita):
Go-ghrita, or cow ghee, is considered the highest quality of Ghrita in Ayurvedic medicine, attributed to its beneficial properties for preparing medications. The purity, nutritional profile, and therapeutic value of Go-ghrita enhance the efficacy of the formulations made with it, making it integral to Ayurvedic practices.
48) Amadosha (Āmadoṣa, Ama-dosha):
Ama-dosha refers to the toxic metabolic byproducts of incomplete digestion in Ayurveda. It represents a critical imbalance that can lead to health issues. Understanding and addressing Ama-dosha is essential for maintaining health and guiding effective treatments within Ayurvedic practice.
49) Haritaki (Harītakī):
Haritaki, or Terminalia chebula, is revered for its roles in digestive health and detoxification within Ayurveda. Its incorporation in formulations enhances effectiveness, highlighting its beneficial properties. Knowledge of its actions and potential interactions is crucial for practitioners in developing holistic treatments.
50) Activity:
Activity in the context of Ayurveda pertains to the biological effects and therapeutic roles that herbal ingredients induce when administered. Understanding the activity profiles of various herbs supports targeted treatment formulations, helping practitioners select the most effective combinations for patient care.
51) Amalaki (Āmalakī, Āmalaki):
Amalaki, or Emblica officinalis, is a potent herb in Ayurveda renowned for its antioxidant and rejuvenating qualities. It's frequently used in various formulations to promote health and improve digestion. A deeper understanding of Amalaki's properties is crucial for leveraging its benefits in Ayurvedic practice.
52) Pippali (Pippalī, Pīppalī, Pippalin):
Pippali, or Piper longum, is an important Ayurvedic herb noted for its digestive-enhancing and respiratory-supportive characteristics. Including Pippali in formulations serves to optimize the bioavailability of other ingredients, illustrating the importance of synergistic effects in Ayurvedic medicine.
53) Sparsha (Sparśa):
Sparsha translates to 'touch' and is one of the sensory evaluations in Ayurveda, indicating the texture of a formulation. Evaluating Sparsha during preparation can inform practitioners about the quality and characteristics of medicines, ensuring they are appropriate for therapeutic applications.
54) Sharman (Śarma, Sarmā, Sarma, Sharma, Śarman):
Sharma is often a reference to the author or researcher involved in the study or documentation of Ayurvedic formulations. The contributions and expertise of individuals like Sharma demonstrate the importance of scholarly work in advancing the understanding and application of Ayurvedic medicine.
55) Khara (Khāra):
Khara translates to 'hard' or 'dense' in Ayurvedic terminology and is a reference to one of the stages in the Paka process. Understanding Khara is essential for avoiding overcooking or the loss of active properties in formulations, making it an important stage in preparation.
56) Musta (Mustā, Muṣṭa, Mushta):
Musta, or Cyprus rotundus, is an important herb known for its digestive and anti-inflammatory properties in Ayurveda. It plays a significant role in various formulations, particularly those aimed at treating gastrointestinal issues. Knowledge of Musta's properties aids in crafting effective Ayurvedic medicines.
57) Glass:
Glass is used for the storage of Ayurvedic formulations due to its inert properties, which prevent contamination and chemical reaction with the stored substances. Proper storage in glass containers helps maintain the integrity and efficacy of herbal medicines over time.
58) Rasa (Rasā, Rasha):
Rasa translates to 'taste' in Ayurveda, and it is one of the fundamental qualities assessed in herbal preparations. Taste influences not only the palatability of medicines but also their therapeutic effects, as different tastes correspond to specific physiological actions within the body.
59) Rupa (Rūpa):
Rupa means 'form' or 'appearance' in Ayurveda, often referring to the visual aspects of a formulation. Observing Rupa is essential in assessing the quality and readiness of herbal medicines, as significant changes in appearance can indicate variations in active constituents and efficacy.
60) Jala (Jalā, Jālā, Jāla, Jaḷa):
Jala means 'water' in Ayurveda, serving as a critical medium for decoctions and extracts. The quality and purity of Jala used in preparation processes can impact the final product's effectiveness and safety, highlighting the importance of using high-quality water in Ayurvedic formulations.
61) Post:
Post refers to the steps following a particular procedure or preparation in Ayurveda. Attention to post-manufacturing processes, including storage and labeling, is crucial for maintaining the quality, efficacy, and safety of Ayurvedic products before they reach consumers.
62) Inci (Iñci, Imci, Incī):
Inch is a unit of measurement used in the specifications of tools and equipment required for Ayurvedic preparations. Accurate measurements ensure consistency and quality in the preparation processes and contribute to adhering to standard manufacturing practices within Ayurvedic medicine.
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