Antihyperglycemic and antinociceptive tests of beta vulgaris roots

a preliminary report

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Antihyperglycemic and antinociceptive activity tests with beta vulgaris l. ssp. vulgaris roots
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a preliminary report

Original source:

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Author:

Indrani Mandal, Humayra Jannat, Shahnaz Rahman, Rownak Jahan, Tania Khan,Sadia Moin Mou, Mohammed Rahmatullah


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Antihyperglycemic and antinociceptive activity tests with beta vulgaris l. ssp. vulgaris roots

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


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Summary of article contents:

Introduction

Beta vulgaris ssp. vulgaris, commonly known as garden beet, is a plant cultivated in Bangladesh, valued for its edible roots and leaves. This study aimed to evaluate the antihyperglycemic and antinociceptive properties of the methanol extract of garden beet roots, as previous literature mainly focused on other subspecies of Beta vulgaris.

Antihyperglycemic Activity of Beet Root Extract

The research demonstrated that the methanol extract of garden beet roots significantly lowered blood glucose levels in mice subjected to an oral glucose tolerance test. The extract showed a dose-dependent reduction in blood glucose levels, indicating its potential effectiveness in managing hyperglycemia. The study highlights that garden beet roots could serve as a beneficial natural remedy for lowering blood sugar levels in diabetic patients.

Antinociceptive Effects Observed

In tests conducted to evaluate pain relief, the methanol extract of garden beet roots exhibited significant antinociceptive activity, evidenced by a reduction in abdominal writhings in a pain model induced by acetic acid in mice. This suggests that the extract may be useful in alleviating pain, supporting the traditional use of beet roots in herbal medicine.

Phytochemical Analysis and Safety

Preliminary phytochemical screening of the methanol extract revealed the presence of tannins, alkaloids, and flavonoids, which are compounds known for their medicinal properties. The acute toxicity tests indicated that the extract was safe, showing no adverse effects on mice even at the highest doses tested, suggesting that it may be a non-toxic option for therapeutic use.

Conclusion

This study is the first to report on the antihyperglycemic and antinociceptive activities of garden beet roots, demonstrating their potential as a natural treatment for managing blood sugar levels and pain relief. Given the widespread availability of the plant in Bangladesh, it could provide an accessible and safe alternative for individuals suffering from diabetes and pain conditions. Further research is encouraged to identify the active compounds responsible for these effects and to explore their mechanisms of action.

FAQ section (important questions/answers):

What are the primary benefits of Beta vulgaris roots according to the study?

The study found that methanol extracts of Beta vulgaris roots demonstrated significant antihyperglycemic and antinociceptive properties, potentially helping to lower blood sugar levels and alleviate pain.

How was the antihyperglycemic activity of Beta vulgaris tested?

The antihyperglycemic activity was evaluated using the oral glucose tolerance test (OGTT) on glucose-loaded mice, measuring reductions in blood glucose levels post-administration of various doses of the extract.

What standard drug was used for comparison in the study?

Glibenclamide was the standard antihyperglycemic drug used for comparison, showing a 55.2% reduction in blood glucose levels when administered to the mice.

What method was used to assess antinociceptive activity?

Antinociceptive activity was assessed using an acetic acid-induced pain model in mice, where the number of abdominal writhings was counted after administration of the extract.

What were some significant findings regarding antinociceptive activity?

The methanol extract of Beta vulgaris roots significantly reduced abdominal writhings in mice, with the highest dose reducing writhings comparably to the standard pain relief drug, aspirin.

Were there any toxic effects observed from the extract?

No toxic effects were observed in mice, even at the highest doses tested during the acute toxicity evaluation, indicating the extract's safety at these levels.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antihyperglycemic and antinociceptive tests of beta vulgaris roots”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Blood:
Blood is a vital fluid in the body carrying oxygen and nutrients to tissues and removing waste. In this study, blood glucose levels are measured to assess the antihyperglycemic activity of Beta vulgaris extracts. Proper regulation of blood sugar is crucial for managing diabetes and evaluating therapeutic agents.

2) Activity:
Activity refers to the biological effects or actions of a substance. In the context of this research, it pertains to the antihyperglycemic and antinociceptive effects of the methanol extract of Beta vulgaris roots. Understanding these activities helps in the evaluation of potential treatments for conditions like diabetes and pain.

3) Drug:
A drug is any substance used to diagnose, cure, treat, or prevent diseases. The study compares the effects of the methanol extract of Beta vulgaris to standard drugs like glibenclamide and aspirin, demonstrating the potential of plant-based compounds as alternative treatments in pharmacotherapy.

4) Phytochemical:
Phytochemicals are naturally occurring compounds in plants that contribute to various health benefits. The methanol extract from Beta vulgaris roots contains phytochemicals like flavonoids and tannins, which may have therapeutic properties, including antidiabetic and analgesic effects, thus warranting further study of their health implications.

5) Flavonoid:
Flavonoids are a group of plant metabolites with antioxidant properties and potential health benefits. In the study, the presence of flavonoids in the methanol extract of Beta vulgaris may contribute to its antihyperglycemic and antinociceptive activities, highlighting their importance in traditional and modern medicine.

6) Sugar:
Sugar, particularly glucose, is a key focus in diabetes research, as its regulation is essential for maintaining health. In this study, the effects of Beta vulgaris extract on blood glucose levels are measured, with promising results indicating its potential for lowering high blood sugar in diabetic patients.

7) Toxicity:
Toxicity is the degree to which a substance can harm an organism. The study assessed the acute toxicity of the methanol extract of Beta vulgaris, showing no adverse effects at high doses, which is crucial for determining the safety and viability of using this plant in medicinal applications.

8) Knowledge:
Knowledge refers to the information and understanding gained from research and study. This paper aims to expand knowledge on the pharmacological properties of Beta vulgaris, particularly its effects on blood sugar and pain, contributing to the scientific understanding of traditional medicinal plants in modern healthcare.

9) Pharmacological:
Pharmacological relates to the study of drug action and effects on biological systems. The research investigates the pharmacological effects of Beta vulgaris extracts, aiming to illustrate their potential as antihyperglycemic and antinociceptive agents, which may provide new avenues for treating diabetes and pain relief.

10) Inflammation:
Inflammation is the body's response to injury or infection, often resulting in pain and swelling. Although not the primary focus of this study, understanding anti-inflammatory properties can enhance the overall evaluation of Beta vulgaris extracts, which may have implications in managing pain associated with inflammatory conditions.

11) Alleviation:
Alleviation refers to the reduction or relief of pain, discomfort, or a problem. In this study, the emphasis is on the potential of Beta vulgaris extracts for pain alleviation, indicating its therapeutic properties may provide beneficial effects for patients suffering from acute or chronic pain conditions.

12) Discussion:
Discussion is a critical component of research, where findings are interpreted and contextualized. In this paper, the discussion examines the results of experiments on antihyperglycemic and antinociceptive activities, linking them to existing literature and exploring their implications for future research and therapeutic applications.

13) Irritation:
Irritation is a localized inflammatory response to harmful stimuli. In this study, acetic acid-induced irritation in mice is used to assess antinociceptive activity. Understanding how extracts can modify irritation responses helps evaluate their potential as effective pain relief options in pharmacotherapy.

14) Substance:
A substance is any form of matter with distinct properties. In this research, the methanol extract of Beta vulgaris roots is analyzed as a substance for its pharmacological properties, offering insights into how natural compounds can be leveraged for health benefits, particularly in managing diabetes and pain.

15) Indrani (Imdrani, Indrāṇī):
Indrani refers to the name of one of the authors of the study. The contributions of individual researchers are essential in collaborative research endeavors, where diverse expertise and efforts come together to investigate the scientific properties and health benefits of Beta vulgaris.

16) Edema (Oedema):
Oedema is an accumulation of fluid in tissues, often leading to swelling. While not directly studied in this research, understanding the anti-inflammatory effects of substances can help in presenting them as potential treatments for conditions like oedema, highlighting the broader relevance of the findings.

17) Water:
Water serves as a universal solvent essential for biological processes. In this study, it is used in the preparation and administration of the methanol extract of Beta vulgaris, emphasizing the importance of solvents in extracting compounds for analyzing their potential therapeutic effects.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Antihyperglycemic and antinociceptive tests of beta vulgaris roots’. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical Significance, Phytochemical analysis, Research article, Phytochemical constituents, Antinociceptive activity, Oral glucose tolerance test, Acute toxicity test, Blood glucose level, Dose-dependent reduction, Hyperglycemic patient, Pain relieving drug.

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