Fast disintegrating lamivudine tablets using basil seed mucilage.
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of fast disintegrating tablets of lamivudine using ocimum basilicum seed mucilage as superdisintegrant
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Dr. M. Sunitha Reddy, Tangella Srividyalalitha
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and evaluation of fast disintegrating tablets of lamivudine using ocimum basilicum seed mucilage as superdisintegrant
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
In recent years, the demand for natural excipients has increased due to their renewable sources, biocompatibility, and eco-friendly characteristics. The Ocimum basilicum plant, commonly known for its medicinal properties, has been used in traditional medicine for various health issues. Lamivudine, an anti-retroviral drug, is utilized in treating both HIV and hepatitis B, making its effective delivery critical for patients, especially pregnant women to prevent mother-to-child transmission.The formulation of fast disintegrating tablets (FDT) of Lamivudine using mucilage derived from Ocimum basilicum seeds serves as an innovative approach to enhance drug delivery. The study showcased well-structured formulations, particularly F2, which demonstrated a rapid disintegration time of 22.79 seconds and a remarkable drug release of 99.4% within 10 minutes. This highlights the potential of natural superdisintegrants in improving the efficiency of drug formulations.
The methodology employed for isolating the mucilage involved rinsing, soaking, high agitation, and subsequent drying of the Ocimum basilicum seeds. Characterization of the mucilage included evaluations of its organoleptic properties, morphology, and physicochemical attributes, confirming its suitability as an excipient. Comprehensive preformulation studies indicated that Lamivudine is soluble in various solvents, ensuring the compatibility of the drug and the extracted mucilage.
Stability studies conducted on the most effective formulation, F2, revealed promising results, with all parameters maintaining consistency after a month of storage under controlled conditions. The findings underscore that the incorporation of Ocimum basilicum seed mucilage in the formulation not only improved the disintegration time but also ensured the stability and efficacy of the Lamivudine fast disintegrating tablets.
In conclusion, the successful extraction and characterization of mucilage from Ocimum basilicum seeds affirm its potential as a natural superdisintegrant. The study effectively demonstrated that incorporating a suitable amount of this mucilage in Lamivudine FDT formulations can significantly enhance drug release and stability, marking a vital advancement in pharmaceutical technology for improving patient treatment outcomes.
FAQ section (important questions/answers):
What is the purpose of the study involving Lamivudine tablets?
The study aimed to formulate and evaluate fast disintegrating tablets of Lamivudine using natural superdisintegrant derived from Ocimum basilicum seed mucilage.
What are the benefits of using natural excipients?
Natural excipients like Ocimum basilicum mucilage are favored for their renewable sources, biocompatibility, biodegradability, low cost, and eco-friendly properties compared to synthetic alternatives.
How was the mucilage extracted from Ocimum basilicum seeds?
Mucilage was extracted by soaking seeds in water, homogenizing to separate the gel, and then precipitating and drying the gel using acetone and ethanol.
Which formulation of Lamivudine tablets showed the best results?
Formulation F2 was the best, disintegrating in 22.79 seconds with a drug release of 99.4% within 10 minutes.
What parameters were evaluated during the formulation study?
Parameters included pre and post compression evaluations like hardness, friability, disintegration time, drug content, wetting time, and dissolution rates.
What does the stability study of the tablets indicate?
The stability study at 40°C and 75% RH for 30 days showed minimal variation in properties, indicating that the formulation is stable.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Fast disintegrating lamivudine tablets using basil seed mucilage.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A drug is a chemical substance used for the treatment, prevention, or diagnosis of diseases. In this study, Lamivudine acts as the active drug in the formulation of fast disintegrating tablets, specifically designed for rapid dissolution and effective delivery, particularly for HIV and hepatitis B treatments.
2) Water:
Water serves as a vital solvent in pharmaceutical formulations. It is used during the extraction of mucilage from Ocimum basilicum seeds and as a medium for solubility studies as well as in wetting tests, demonstrating its importance in ensuring proper drug formulation and absorption rates.
3) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world. This study applies scientific principles in pharmaceutical technology, specifically focusing on drug formulation and the assessment of natural excipients, highlighting the interplay between natural products and medicinal chemistry.
4) Post:
Post refers to the processes and evaluations conducted after the initial formulation of the tablets. In this study, post-compression evaluations assess characteristics like disintegration time, drug release, and stability, ensuring that the manufactured tablets meet quality standards and function as intended.
5) Phytochemical:
Phytochemicals are biologically active compounds found in plants that contribute to their medicinal properties. The mucilage from Ocimum basilicum seeds possesses phytochemical characteristics, which are evaluated in the study to support its application as a natural superdisintegrant in fast dissolving tablet formulations.
6) Swelling:
Swelling refers to the expansion of materials when they absorb water or solvent, which is crucial in tablet disintegration. The study investigates the swelling properties of Ocimum basilicum seed mucilage, emphasizing its role as a superdisintegrant, facilitating rapid dissolution of the tablets.
7) Antibiotic (Antibacterial):
Antibacterial properties refer to the ability to inhibit bacterial growth. This study highlights that the Ocimum basilicum plant has recognized antibacterial properties, which, while not the primary focus of the drug formulation, underpins the notion of utilizing natural plant-derived materials for their therapeutic benefits.
8) Discussion:
Discussion in the context of this study entails the interpretation of experimental results regarding the formulation and evaluation of the tablets. This section often elucidates the significance of findings, explores potential implications for clinical use, and compares results with existing literature to validate the methodology and outcomes.
9) Substance:
A substance denotes a particular kind of matter with uniform properties. In pharmaceutical research, substances include active pharmaceutical ingredients and excipients. This study examines various substances such as Ocimum basilicum seed mucilage, emphasizing their significance in enhancing the properties and effectiveness of drug formulations.
10) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing diseases. Lamivudine, the drug examined in this study, represents an important component in the field of medicine for treating HIV and hepatitis B, emphasizing the need for effective formulations to improve patient adherence and outcomes.
11) Quality:
Quality in pharmaceuticals refers to the attributes of a drug product that ensure its safety, efficacy, and performance. The study conducts numerous evaluations, including stability, disintegration time, and drug release profiles of the formulated tablets, to ensure that they meet required quality standards for clinical use.