Factorial studies on aceclofenac tablets with cyclodextrin and Kolliphor.
Journal name: World Journal of Pharmaceutical Research
Original article title: Factorial studies on formulation development of aceclofenac tablets employing ? cyclodextrin and kolliphor hs15
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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K.P.R. Chowdary, S.Gopinath, C.Uma Maheswara Reddy and S.Umamaheswari
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Factorial studies on formulation development of aceclofenac tablets employing ? cyclodextrin and kolliphor hs15
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Aceclofenac is recognized as an effective anti-inflammatory and analgesic drug but suffers from low and variable oral bioavailability due to its poor solubility in water and aqueous fluids. To enhance its solubility and dissolution rate, which are critical for improving its oral absorption and therapeutic efficacy, this study focuses on the formulation development of aceclofenac tablets using β-cyclodextrin (βCD) and Kolliphor HS15, a non-ionic surfactant. The interaction of these compounds was evaluated through factorial experiments to understand their combined effects on enhancing the drug's solubility and dissolution characteristics.The study highlights the significant role of βCD and Kolliphor HS15 in enhancing aceclofenac's solubility. Individually, βCD and Kolliphor HS15 increased the solubility of aceclofenac by 1.57-fold and 21.72-fold, respectively. However, when combined, they achieved a remarkable increase in solubility of 28.97-fold. This indicates that the combined approach is far more effective than using either component alone, showcasing the potential of using these agents in drug formulation strategies.
Furthermore, the dissolution rates of aceclofenac were considerably improved through the formation of inclusion complexes with βCD and Kolliphor HS15. The dissolution studies demonstrated that the drug released from the complexes showed a drastic enhancement in dissolution profiles compared to the pure drug. The results indicated that the inclusion complex with βCD resulted in an 8.66-fold increase in dissolution rate, further enhanced to 9.85-fold when combined with Kolliphor HS15. This marked improvement emphasizes the importance of formulation techniques that incorporate both solubility and dissolution rate enhancement strategies.
In conclusion, the combined use of βCD and Kolliphor HS15 significantly enhances the solubility and dissolution rate of aceclofenac, thus presenting a promising option for formulating tablets with improved bioavailability. This study recommends further exploration of this combinatorial approach to optimize formulations of poorly soluble drugs, offering insights into effective strategies for addressing similar challenges in pharmaceutical development.
FAQ section (important questions/answers):
What is the primary purpose of this study on aceclofenac tablets?
The study aims to enhance the solubility and dissolution rate of aceclofenac tablets using β-cyclodextrin and Kolliphor HS15, thereby improving oral bioavailability and therapeutic efficacy.
What are the main findings related to solubility enhancement?
The combination of β-cyclodextrin and Kolliphor HS15 resulted in a 28.97-fold increase in the solubility of aceclofenac, significantly higher than the individual increases provided by each component.
How does the dissolution rate of the formulated tablets compare to pure aceclofenac?
Tablets formulated with the inclusion complexes of β-cyclodextrin and Kolliphor HS15 showed a 21.35-fold increase in dissolution rate compared to tablets made with pure aceclofenac.
What methods were used to prepare aceclofenac inclusion complexes?
The aceclofenac-β-cyclodextrin-Kolliphor HS15 inclusion complexes were prepared using a kneading method followed by tablet formulation through wet granulation.
What was the effect of Kolliphor HS15 on dissolution rate?
Kolliphor HS15 individually contributed to a 6.1-fold increase in the dissolution rate of aceclofenac tablets, highlighting its significant role in enhancing drug release.
What recommendation is made for improving aceclofenac formulations?
The study recommends using a combination of β-cyclodextrin and Kolliphor HS15 to effectively enhance the solubility and dissolution rate of aceclofenac tablets for better therapeutic outcomes.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Factorial studies on aceclofenac tablets with cyclodextrin and Kolliphor.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The keyword 'Drug' refers to aceclofenac, an anti-inflammatory and analgesic medication highlighted in the study. The text discusses its characteristics, such as low solubility and variable oral bioavailability, emphasizing the importance of improving its dissolution rate to enhance therapeutic efficacy. This is crucial for effective medication delivery.
2) Water:
The term 'Water' in the context refers to the solvent used in solubility tests for aceclofenac. The study evaluates the drug’s solubility in purified water and other solutions containing β-cyclodextrin and Kolliphor HS15. Water's role as a solvent is fundamental in pharmacological preparations, influencing drug absorption.
3) Science (Scientific):
The word 'Science' encapsulates the systematic and empirical approach used in the formulation development of aceclofenac tablets. The study employs factorial design and analytical techniques to evaluate the impacts of β-cyclodextrin and Kolliphor HS15, aligning with scientific principles to derive conclusions about drug enhancement methodologies.
4) Discussion:
The keyword 'Discussion' signifies the section where results and implications of the study are analyzed. Here, the findings regarding solubility and dissolution rates of aceclofenac in the presence of β-cyclodextrin and Kolliphor HS15 are interpreted, providing insights and recommendations for future formulation strategies based on empirical data.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Factorial studies on aceclofenac tablets with cyclodextrin and Kolliphor.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Therapeutic efficacy, Bioavailability enhancement, ANOVA, Disintegration time, Friability test, Oral bioavailability, Dissolution rate, Pharmaceutical technology, Wet granulation method, Formulation Development, Drug delivery, Compressed tablet.
Concepts being referred in other categories, contexts and sources.
Purified water, Tablet hardness.