In vitro antibacterial activity of cleome gynandra linn
Journal name: World Journal of Pharmaceutical Research
Original article title: In vitro antibacterial activity of cleome gynandra linn
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
A. Annadurai, S. Ahmed John
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: In vitro antibacterial activity of cleome gynandra linn
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study investigates the antibacterial activity of crude extracts from the leaf, stem, and root of Cleome gynandra L. using different solvents against selected Gram-positive and Gram-negative bacteria. Cleome gynandra, known in India as ‘Hurhur’ and ‘Karaila’, is recognized in traditional medicine for various ailments and possesses significant potential for developing herbal drugs.
Antibacterial Efficacy
The research found that extracts from the leaf, stem, and root exhibited varying degrees of antibacterial activity against pathogens such as Pseudomonas, Escherichia coli, Salmonella, and Staphylococcus aureus. The leaf extracts, particularly those in acetone and chloroform, demonstrated the highest inhibitory action against Pseudomonas and Staphylococcus aureus. These findings suggest that Cleome gynandra may serve as a source of natural antimicrobial agents.
Therapeutic Potential
Cleome gynandra has been associated with several therapeutic properties in Ayurveda, including anti-inflammatory and immune-enhancing effects. Previous studies indicated that its ethanolic extract could modify lysosomal membrane behaviors, leading to reduced inflammatory responses. This reinforces the plant’s value in traditional medicine and its relevance for developing holistic treatment options.
Pharmaceutical Applications
The study emphasizes the significance of plant-based antimicrobials, showcasing their potential as alternatives to synthetic drugs, which often come with undesirable side effects. The efficacy of Cleome gynandra extracts highlights the importance of exploring natural products in the quest for new therapeutic compounds.
Conclusion
The findings suggest that Cleome gynandra possesses notable antibacterial properties and can serve as a natural therapeutic agent with minimal side effects. The study validates the traditional uses of the plant and advocates for further research to isolate and characterize its bioactive compounds for potential pharmaceutical applications, reinforcing its status as a valuable resource in herbal medicine.
FAQ section (important questions/answers):
What are the antibacterial activities of Cleome gynandra extracts?
The extracts of Cleome gynandra, particularly the acetone and chloroform extracts from leaves, stem, and root, exhibited significant antibacterial properties against both Gram positive and Gram negative bacteria, notably Pseudomonas, Escherichia coli, Staphylococcus aureus, and Salmonella.
Which parts of Cleome gynandra were tested for antibacterial activity?
The study investigated the antibacterial effects of extracts from the leaves, stems, and roots of Cleome gynandra. Each part was tested separately to evaluate its inhibitory potential against various bacterial strains.
How was the antibacterial activity of the extracts measured?
The antibacterial activity was evaluated using the Agar Disc Diffusion method, where filter paper discs impregnated with the extracts were placed on bacterial-inoculated plates to measure the zones of inhibition around the discs.
What microorganisms were used in the antibacterial activity tests?
The study tested the extracts against several microorganisms: Pseudomonas, Escherichia coli, Staphylococcus aureus, and Salmonella, to determine their effectiveness as antibacterial agents.
What conclusions were drawn from the study on Cleome gynandra?
The study concluded that Cleome gynandra extracts demonstrated significant antibacterial activity, suggesting its potential as a natural therapeutic agent with fewer side effects compared to synthetic antibiotics. Further research is necessary to identify its bioactive compounds.
What is the significance of using traditional medicinal plants like Cleome gynandra?
Traditional medicinal plants like Cleome gynandra are significant as they offer alternative therapeutic solutions derived from nature, potentially reducing reliance on synthetic drugs and minimizing side effects, which align with ancient medicinal practices and modern health trends.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “In vitro antibacterial activity of cleome gynandra linn”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Antibiotic (Antibacterial):
The term 'antibacterial' refers to substances that inhibit bacterial growth or kill bacteria. In the context of this research, it is pivotal as the study evaluates the antibacterial properties of various extracts from Cleome gynandra against specific Gram positive and Gram negative bacterial strains, demonstrating potential therapeutic benefits.
2) Activity:
In this context, 'activity' pertains to the effectiveness of the extracts from Cleome gynandra in combating bacterial pathogens. It denotes how these extracts can exert their antibacterial effects, showcasing the significance of their biochemical properties in preventing or slowing bacterial proliferation essential for developing new medicinal applications.
3) Medicine:
The term 'medicine' refers to substances used to diagnose, treat, or prevent illnesses. This study highlights the importance of traditional and herbal medicines derived from plants like Cleome gynandra, which serve as alternative therapeutic agents in managing infections and promoting health, emblematic of the shifting focus towards natural medicine.
4) Drug:
A 'drug' is a chemical substance used for medical purposes to treat, cure, or prevent diseases. The research emphasizes the potential of Cleome gynandra as a source of novel drugs, enhancing the understanding of how natural compounds can be effective in pharmaceutical applications, especially in combating resistant bacterial strains.
5) Water:
In this research, 'water' is significant as it is used for washing and sterilizing plant materials, ensuring the purity of extracts. Furthermore, water acts as a solvent in which extraction processes occur, underscoring its essential role in traditional medicine preparation and enhancing the efficacy of bioactive compounds from the plant.
6) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda, the ancient Indian system of medicine, emphasizes holistic health through natural means. The study connects Cleome gynandra to Ayurvedic practices, where it is acknowledged for its therapeutic properties, validating traditional knowledge and encouraging further investigation into its bioactive compounds to support contemporary health paradigms.
7) Botany:
The term 'botany' refers to the scientific study of plants, which forms the foundation for understanding the medicinal uses of plant species like Cleome gynandra. This research falls under botany as it explores the plant’s chemical constituents and their potential pharmacological applications, bridging traditional knowledge and modern science.
8) Pharmacological:
The word 'pharmacological' relates to the study of drugs and their interactions within biological systems. In this research, it indicates an investigation into the medicinal properties and therapeutic potentials of Cleome gynandra, supporting the premise that plants can lead to the discovery of new antibacterial agents.
9) Discussion:
The 'discussion' refers to the section of the study where the implications of the findings are analyzed and interpreted. It allows for a deeper understanding of the results, fostering critical thinking about the antibacterial efficacy of Cleome gynandra extracts and their relevance in modern medicinal practices.
10) Scorpion:
The mention of 'scorpion' highlights the traditional medicinal applications of Cleome gynandra, particularly in treating scorpion stings. This illustrates the plant's potential as an alternative therapeutic agent in traditional medicine, emphasizing its historical and cultural significance in managing traumatic incidents and promoting local health practices.
11) Glass:
The term 'glass' is relevant as it pertains to laboratory equipment used in the study, specifically during the preparation and transfer of plant extracts. Its mention underscores the importance of maintaining sterile conditions in biomedical research, ensuring accurate and reproducible results while isolating bioactive compounds effectively.
Other Science Concepts:
Discover the significance of concepts within the article: ‘In vitro antibacterial activity of cleome gynandra linn’. Further sources in the context of Science might help you critically compare this page with similair documents:
Narayanachurna, Medicinal plant, Natural product, Therapeutic agent, Traditional medicine, Ayurvedic medicine, Ayurvedic pharmacopoeia, Antibacterial activity, Therapeutic potential, Antimicrobial activity, Dimethyl sulfoxide, Disc diffusion method, Zone of inhibition, Antimicrobial agent, Staphylococcus aureus, Escherichia coli, Cell-mediated immunity, Humoral immunity, Phagocytosis, Bioactive compound, Gram positive, Gram negative, Nutrient broth, Inflammatory activity, Chemical constituent, Cleome gynandra L, Agar Disc Diffusion assay, Pseudomonas, Salmonella, Inhibitory potential, Sterilization of Plant Materials, Active antimicrobial agents, Crude extract, Bioactive principle, CRUDE PLANT EXTRACT, Pharmacological science, Indian medicinal plant, Plant based antibacterial, Synthetic chemotherapeutic agents, Industrial drug formulation, New and novel bioactive Compounds, Selected plant essential oil.