Swellable Controlled Porosity Osmotic Pump Tablets of Metoprolol and Ramipril
Journal name: World Journal of Pharmaceutical Research
Original article title: Development and evaluation of swellable controlled porosity osmotic pump tablets of metoprolol succinate and ramipril
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Padma priya S , Ravichandran V,Suba V
World Journal of Pharmaceutical Research:
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Full text available for: Development and evaluation of swellable controlled porosity osmotic pump tablets of metoprolol succinate and ramipril
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Hypertension is a prevalent cardiovascular risk factor necessitating effective treatment strategies. Fixed-dose combinations of antihypertensive drugs offer multiple benefits, including reduced costs, side effects, and improved patient adherence. This study focuses on developing and evaluating swellable controlled porosity osmotic pump (SCPOP) tablets containing Metoprolol Succinate and Ramipril, aimed at achieving a controlled release over 24 hours independent of pH and agitation intensity.
Swellable Controlled Porosity Osmotic Pump Tablets
SCPOP tablets utilize osmotic pressure and polymer swelling to deliver drugs consistently over 24 hours. Various formulations were tested using different concentrations of osmopolymers like PEO, Carbopol, PVA, and SCMC. The formulations (MRSC1-MRSC9) were analyzed for drug release rates, showing that higher polymer concentrations generally decreased release rates due to the polymers' solubility-modulating properties. The optimized formulation, MRSC7, achieved nearly complete drug release for both Metoprolol and Ramipril, demonstrating stability and consistent drug delivery.
Pre and Post Compression Characteristics
The powder blends used in SCPOP tablets exhibited satisfactory precompression parameters including bulk density, tapped density, and flow properties, indicating good compressibility. The post-compression characteristics such as tablet thickness, hardness, friability, weight variation, and drug content were also found to be within acceptable limits. These rigorous evaluations ensured the tablets' structural stability and drug content uniformity necessary for consistent therapeutic effects.
Drug-Excipients Compatibility Study
Compatibility between the active drug substances and excipients was confirmed through IR and DSC analyses. The characteristic spectral bands of Metoprolol and Ramipril were retained in the physical mixtures with excipients, indicating no significant interactions. This assurance of compatibility is crucial for the stability and effectiveness of the final SCPOP formulations.
Conclusion
The developed SCPOP tablets for Metoprolol and Ramipril demonstrated reliable, pH-independent drug release controlled by the osmotic and swelling properties of polymers. The optimized formulation, MRSC7, adhered to zero-order kinetics, emphasizing the potential of SCPOP systems in providing stable and controlled drug delivery over extended periods. Stability studies corroborated the formulations' robustness, making them promising candidates for clinical use in managing hypertension and related conditions.
FAQ section (important questions/answers):
What are SEOP tablets used for?
SEOP tablets deliver Metoprolol and Ramipril to manage hypertension in heart failure patients continuously for 24 hours using osmotic pressure and polymer-swelling forces.
Which drug combination is used in SCPOP?
The SCPOP tablets contain Metoprolol Succinate and Ramipril, drugs commonly used for treating hypertension and heart failure.
What materials are used in the SCPOP formulation?
Materials used include Metoprolol, Ramipril, mannitol, PEO, carbopol, PVA, SCMC, MCC, talc, magnesium stearate, aerosol, and the coating of cellulose acetate.
How is drug release controlled in SCPOP?
Drug release is controlled by the swellable polymer and osmogen, which manage the release for 24 hours at a zero-order rate.
Does SCPOP drug release depend on pH?
The release from optimized SCPOP formulations is independent of pH and agitation intensity, making it reliable under various gastrointestinal conditions.
What is the role of polymers in SCPOP?
Polymers like PEO, carbopol, PVA, and SCMC control the drug release rate by affecting the swelling and osmotic pressure within the tablet.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Swellable Controlled Porosity Osmotic Pump Tablets of Metoprolol and Ramipril”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The study focuses on the development of a controlled porosity osmotic pump designed to release metoprolol and ramipril, both of which are drugs used in managing hypertension and heart failure. The term 'drug' is integral to the research as it centers around drug release mechanisms and optimization.
2) Swelling:
Swelling: The core mechanism in the development of the swellable controlled porosity osmotic pump. It refers to the absorption of water by polymers in the tablet, which then swell, creating pressure that aids in the controlled release of the drugs from the tablet.
3) Padma (Padmā, Pādma):
Refers to Padma priya S, the lead researcher and author of the study. Her work involves the formulation and evaluation of a new drug delivery system aimed at controlled drug release. Her affiliation and correspondence details are provided at the beginning of the article.
4) Priya (Priyā):
This is part of the name of the lead author, Padma priya S, who conducted the research. It is relevant as it identifies the main contributor to the study and her academic background, which adds to the credibility of the research.
5) Water:
Essential in the mechanism of drug release in the osmotic pump system. Water diffuses through a semi-permeable membrane into the tablet, causing the polymers to swell and create osmotic pressure that pushes the drug out in a controlled manner.
6) Post:
Refers to 'Post compression', which is part of the evaluation process for the developed tablets. Post compression parameters such as hardness, friability, weight variation, and drug content are evaluated to ensure the quality and functionality of the tablets.
7) Blood:
Mentioned in the context of blood pressure, as the drugs metoprolol and ramipril are used to manage hypertension, which involves controlling high blood pressure. The study aims to develop a system that maintains consistent drug levels in the blood for effective hypertension management.
8) Substance:
Used in the context of the active drug substance and other excipients that are part of the tablet formulation. Compatibility and consistency of these substances are crucial for the stability and efficacy of the final pharmaceutical product.
9) Pharmacological:
Refers to the study of the effects and mechanisms of the drug combination used in the formulation. The term highlights the importance of combining agents with different pharmacological profiles to achieve improved treatment outcomes for hypertension and heart failure.
10) Activity:
Connected to the pharmacological activity of the drugs used (metoprolol and ramipril). It refers to their therapeutic effects, such as lowering blood pressure and managing heart failure, achieved through the controlled release system described in the study.
11) Siddha (Siddhā):
Refers to the National Institute of Siddha, one of the affiliations of the co-author Suba V. This institution is reputable in traditional Indian medicine systems, bringing additional credibility and a multi-disciplinary approach to the pharmaceutical research done in the study.
12) Inci (Iñci, Imci, Incī):
Inch: Related to the technical specifications of the tablet-punching machine used in the study. It denotes the size of the punch, which is critical for ensuring uniformity and proper dosing in the tablet formulation process.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Swellable Controlled Porosity Osmotic Pump Tablets of Metoprolol and Ramipril’. Further sources in the context of Science might help you critically compare this page with similair documents:
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