The role of acemella oleracea in medicine- a review
Journal name: World Journal of Pharmaceutical Research
Original article title: The role of acemella oleracea in medicine- a review
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Baby Joseph, Jency George, and Jeevitha.M.V.
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Full text available for: The role of acemella oleracea in medicine- a review
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Summary of article contents:
Introduction
The paper discusses the medicinal significance of Acmella oleracea (commonly known as the Toothache plant) which belongs to the Asteraceae family. It is an annual herb used extensively in traditional medicine for a variety of ailments, reflecting the heavy reliance on plant-based treatments in many parts of the world. This review seeks to compile its wide range of applications and justify its use in modern medical contexts.
Biomedical Applications
Acmella oleracea has been utilized for treating several conditions, including toothache, for which the active compound spilanthol is well-known for its pain-reducing properties. Additionally, the plant has diuretic effects, making it useful for treating renal stones. Extracts from the plant serve as a preventive medicine for scurvy and stimulate digestion. It is also used to treat scabies and psoriasis, showing versatility in addressing skin diseases. Furthermore, it's employed in the treatment of malaria due to its effectiveness against Plasmodium falciparum.
Pharmacological Activity
Research has validated the traditional uses of Acmella oleracea by confirming its anti-inflammatory, analgesic, and antioxidant properties. Spilanthol, isolated from the plant, has been shown to reduce inflammation in murine macrophages and exhibit significant analgesic activity in animal models. The methanol extracts of its stem and leaves demonstrate notable antioxidant activity, thereby supporting its potential as a curative agent from natural sources.
Biocidal Activity
The plant also displays significant biocidal properties, including insecticidal and pesticidal activities. Extracts from Acmella oleracea have been proven effective against mosquito larvae and other pests. Spilanthol stands out as a potent insecticide, showing effectiveness comparable to common synthetic pesticides. Additionally, it has demonstrated some antifungal activities, particularly against specific fungal strains affecting humans.
Conclusion
Acmella oleracea is a plant of significant medicinal potential, effective in treating various diseases such as toothache, renal stones, scurvy, skin conditions, malaria, and rheumatisms. Its pharmacological and biocidal activities further emphasize its value. Although traditional uses are well-documented, future research should focus on exploring its molecular mechanisms and interactions using biotechnological tools. This will enhance understanding and potentially expand its application in modern medicine.
FAQ section (important questions/answers):
What is Acemella oleracea commonly known as?
Acemella oleracea is commonly known as the Toothache plant due to its pain-relieving properties.
What are the medicinal uses of Acemella oleracea?
Acemella oleracea has numerous medicinal uses including treating toothache, diuretic and renal stones, scurvy, scabies, psoriasis, hepatoprotection, malaria, rheumatism, and gastrointestinal diseases.
What is the active compound in Acemella oleracea used for toothaches?
The active compound in Acemella oleracea used for toothaches is spilanthol, which has anesthetic properties and induces saliva secretions.
Does Acemella oleracea have anti-inflammatory effects?
Yes, spilanthol from Acemella oleracea exhibits significant anti-inflammatory effects by inactivating NF-κB and reducing pro-inflammatory mediators in murine macrophages.
What are some of the phytochemicals found in Acemella oleracea?
Acemella oleracea contains various phytochemicals like alkaloids, glycosides, flavonoids, tannins, anthraquinones, saponins, and cardiac glycosides, with alkamides being the most abundant.
Are there any known toxicological effects of Acemella oleracea?
Toxicological studies have reported acute toxicity, neurotoxicity, and genotoxicity at certain doses, with symptoms like tremors, convulsions, and cholinergic action on the central nervous system.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “The role of acemella oleracea in medicine- a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the various actions and effects of Acemella oleracea as highlighted in the review. These activities include its use in pharmacological applications like anti-inflammatory effects, analgesic potentials, biocidal activities, and other biomedical uses that contribute to its medicinal value.
2) Medicine:
Medicine signifies the wide range of therapeutic applications of Acemella oleracea, including treatment for toothaches, diuretic and renal stones, scabies, psoriasis, malaria, and gastrointestinal diseases. It underscores the plant's role in traditional and modern medical practices.
3) Drug:
Drug implies that extracts from Acemella oleracea have pharmacologically active compounds used as medicinal substances. These compounds—such as spilanthol—may produce therapeutic effects like pain relief, immune modulation, and anti-inflammatory actions.
4) Toxicity:
Toxicity denotes the adverse effects that Acemella oleracea may cause, as studied through acute, neurotoxic, and genotoxic evaluations. Understanding the toxicity profile of the plant ensures safe usage in pharmacological applications.
5) Water:
Water is significant mainly in the preparation and administration of Acemella oleracea extracts. For example, cold water extracts of the flowers have been identified as having strong diuretic activity when administered orally in rats.
6) Antibiotic (Antibacterial):
Antibacterial refers to the plant’s capacity to inhibit bacterial growth. Studies highlighted in the review indicate that different extracts from Acemella oleracea have been tested against various bacterial strains to determine their antibacterial properties.
7) Salivation:
Salivation is a key effect of Acemella oleracea due to the presence of spilanthol, which stimulates saliva production. This property makes the plant especially relevant in the treatment of conditions like dry mouth and as a stimulant in digestives.
8) Cina (Cīna, Cīnā, Ciṉa, Ciṉā, Cīṉā, Cinā):
China denotes one of the regions where Acemella oleracea is traditionally used in herbal medicine. For instance, in Indo-China, the plant is utilized to treat conditions like dysentery, showcasing its wide geographical application.
9) Tuberculosis:
Tuberculosis is listed among the conditions for which the plant’s extracts are traditionally used. An extract of Acemella oleracea leaves and flowers is employed for treating ailments such as tuberculosis, demonstrating its broad medicinal utility.
10) Science (Scientific):
Scientific pertains to the methodical classification and documentation of Acemella oleracea, establishing its taxonomy and botanical description. It implies the rigorous study and identification of its active compounds, such as spilanthol, through scientific research.
11) Trembling (Tremble, Trembled):
Trembling is an observed symptom in toxicity studies of Acemella oleracea. For example, clinical observations reported trembling in mice following intraperitoneal injection of the plant extract, indicating its potential neurotoxic effects at certain dosages.
12) Pesticide:
Pesticide highlights the biocidal activity of Acemella oleracea, revealing its potential as a natural pesticide. Extracts of the plant have shown significant insecticidal activity against mosquito larvae and other pests, which could be beneficial in agricultural applications.
13) Pungent:
Pungent describes the strong taste of spilanthol, an alkamide found in Acemella oleracea. The pungent taste contributes to the plant’s ability to stimulate salivation and produce localized anesthetic effects, beneficial for dental applications.
14) Bitter:
Bitter characterizes the taste of alkamides, such as spilanthol, found in the plant. This taste quality is linked to the plant’s medicinal impacts, including stimulating saliva production and providing digestive aid.
15) Edema (Oedema):
Edema involves swelling caused by fluid accumulation, which can be mitigated by diuretics. Acemella oleracea exhibits strong diuretic activity that helps in reducing edema by promoting urine formation and removing excess water from tissues.
16) Straw:
Straw refers to the appearance of the receptacular bracts in Acemella oleracea's flower heads. These bracts are described as straw-colored, often tinged with purple-red, contributing to the plant's botanical identification.
17) Moth:
Moth represents one of the insects against which Acemella oleracea exhibits biocidal activity. Studies have shown that extracts from the plant are effective against moth larvae, underscoring its potential as a natural pesticide.
18) Diet:
Diet is relevant in the context of scurvy prevention, where Acemella oleracea flower heads and roots are used as a preventive measure due to their role in stimulating digestion and possibly providing essential nutrients.
19) Post:
Post refers to post-treatment periods in pharmacological studies where the analgesic potential of Acemella oleracea extracts is determined. Different doses were administered to rats, and their pain responses were measured at varied times following treatment.
Other Science Concepts:
Discover the significance of concepts within the article: ‘The role of acemella oleracea in medicine- a review’. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal plant, Phytochemical, Therapeutic effect, Rheumatism treatment, Traditional medicine, Antibacterial activity, Antioxidant activity, Pharmacological activity, Herbal formulation, Acute toxicity, Analgesic activity, Traditional use, In vitro, Immunomodulatory activity, Hepatoprotective activity, Antifungal activity, Anti-inflammatory effect, Neurotoxicity, Immunomodulatory, Antioxidant, Diuretic activity, Genotoxicity, In vivo, Beauty care, Medicinal purpose, Gastrointestinal disease, Micropropagation, Larvicidal activity, Insecticidal activity, Malaria treatment, Biomedical application, Tropical Botanic Garden, Lipopolysaccharide induced, Local anaesthetic effect, Phytochemical constituent.