Anti-diabetic activity of polyherbal formulation on alloxan induced rats

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Anti-diabetic activity of polyherbal formulation on alloxan induced rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the pharmacological actions and effects of the polyherbal formulations being studied. In the context of this research, it specifically denotes the anti-diabetic properties and the responses measured in the alloxan-induced diabetic rats to conclude the formulation's efficacy.

2) Drug:
Drug denotes the substances being tested for pharmacological effects, which in this study are the polyherbal formulations and the standard anti-diabetic drug, glibenclamide. These are evaluated for their potential to control blood glucose levels in diabetic rats.

3) Rekha (Rekhā):
Rekha is the primary researcher, Rajput Rekha, who conducted this study on the anti-diabetic activity of the polyherbal formulation. She is affiliated with Bhagwant University in Ajmer, India, and acted as the main author and correspondent for this research.

4) Water:
Water here is used both as a solvent for extracting active compounds from collected plant materials and as a base for preparing the polyherbal formulation. The use of water-based extracts ensures immediate availability for absorption in the diabetic rat models.

5) Evolution:
Evolution in this context refers to the 'Gas Evolution' parameter in the stability testing of the polyherbal solution. It checks for any gas release during storage, which would indicate chemical instability or decomposition of the herbal formulation over time.

6) Blood:
Blood refers to the biological sample analyzed for glucose levels in the study. Blood glucose levels were measured in alloxan-induced diabetic rats to evaluate the anti-diabetic effectiveness of the polyherbal formulation compared to the standard drug glibenclamide.

7) Toxicity:
Toxicity measures the harmful effects of a substance. In this study, acute oral toxicity tests were conducted according to OECD guidelines to determine the safe dosage range for the polyherbal formulation, ensuring it does not produce adverse effects in the test animals.

8) Science (Scientific):
Science underpins the entire study, involving systematic methodologies to investigate the anti-diabetic effects of polyherbal formulations. It includes pharmacological testing, stability analysis, and standard protocols to ensure the research's reliability and validity.

9) Agra:
Agra is the location where the botanical authentication of the plant materials was done, specifically by Dr. Seema Bhadhauria at the R.B.S College. Specimens of the medicinal plants used were submitted here for confirmation of their identity.

10) Pharmacology:
Pharmacology is the branch of science concerned with the study of drug action. This study assesses the pharmacological effects of the polyherbal formulation on diabetic rats, including its anti-diabetic activity and related pharmacodynamic properties.

11) Flavonoid:
Flavonoid is one of the phytochemical constituents identified in the herbal extracts used in the formulation. These compounds often have beneficial health effects, including antioxidant properties, which may contribute to the anti-diabetic activity observed in the study.

12) Sandhya (Sandhyā, Shandhya, Samdhya):
Sandhya is associated with one of the references cited in the study. N B Yeole and Sandhya P et al. are acknowledged for their work on evaluating the mucilages of different plants as suspending agents, relevant to the formulation aspect of this research.

13) Quality:
Quality refers to the evaluative measures of the polyherbal formulation's characteristics such as pH, flavor, color, and stability. Ensuring high quality indicates that the formulation retains its desired properties and effectiveness throughout its shelf life.

14) Siddha (Siddhā):
Siddha is cited in the reference section of this research. It indicates the traditional Indian medicinal system, and one reference discusses effective Ayurvedic hypoglycemic formulations, which aligns with the polyherbal approach used in this study.

15) Kusuma (Kusumā):
Kusuma is associated with another cited work which looked into the diabetic activity of other herbal extracts. It represents contributions from researchers like Kusuma R, who have explored similar pharmacological properties in medicinal plants.

16) Bitter:
Bitter describes part of the taste profile of the polyherbal formulation. Despite the presence of sweetening agents like sodium saccharin, the solution retains a slightly bitter component, indicating the potent bioactive compounds from the medicinal plants.

17) Botany:
Botany is crucial in this research for the correct identification and use of medicinal plants. Dr. Seema Bhadhauria, as a botanist, authenticated the plant material used, ensuring botanical accuracy and verifying the species involved for efficacy.

18) Gupta (Guptā):
Gupta is part of the reference list and acknowledges contributions to pharmaceutical knowledge, particularly in modern dispensing pharmacy techniques. The citation likely comes from a textbook used to guide the preparation and analysis of the formulation.

19) Khari (Khārī, Khāri, Kha-ri):
Khari Babri is the local market in Delhi where the plant materials were sourced. It implies the importance of local botanical resources and markets in accessing and utilizing indigenous medicinal plants for therapeutic research and formulation.

20) Ravi (Rāvī, Rāvin, Ravin):
Ravi is associated with references discussing antidiabetic effects, possibly Sujatha S and Swaroopa Ravi V et al. Their work on plant extracts complements and supports the background scientific knowledge applied in this study’s research context.

21) Sama (Śama, Sāmā, Sāma, Shama, Samā):
Sama appears in the reference section, specifically in the context of research done by researchers like Sama Venkatesh, who have investigated the anti-diabetic effects of herbal extracts, thus providing a foundation for this study.

22) Hand:
Hand refers to the practical aspect of conducting the methodology described, from preparing extracts to evaluating pharmacological activities. It indicates the hands-on approach required for experimental studies such as this pharmaceutical research.