Macrolide-Resistant Streptococcus pneumoniae Genes and Outcomes in Malaysia
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Detection of Macrolide-Resistant Streptococcus pneumoniae Genes and Its Clinical Outcomes in a Tertiary Teaching Hospital in Malaysia
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Wan Norliyana Wan Mahmud, Siti Asma’ Hassan, Zaidah Abd Rahman, Wan Nor Amilah Wan Abdul Wahab, Nabilah Ismail
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Detection of Macrolide-Resistant Streptococcus pneumoniae Genes and Its Clinical Outcomes in a Tertiary Teaching Hospital in Malaysia
Year: 2024 | Doi: 10.21315/mjms2024.31.2.17
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Streptococcus pneumoniae is a significant global health concern due to its role as a leading cause of mortality and morbidity, particularly in vulnerable populations such as children under 2 years and adults over 65. The increasing resistance of S. pneumoniae to commonly used antibiotics, particularly beta-lactams and macrolides, complicates treatment and poses a public health challenge. This study aimed to assess the rate of drug resistance, evaluate the prevalence of macrolide-resistant genes, and examine the clinical complications associated with pneumococcal infections among patients treated at Hospital Universiti Sains Malaysia (HUSM) in Kelantan, Malaysia.
Macrolide Resistance Determinants
The study found a concerning prevalence of erythromycin resistance among S. pneumoniae isolates, with a resistance rate of 26.5%. Of the 108 isolates tested for macrolide resistance determinants, the mef(A) gene was present in 50.4% of resistant isolates, while the erm(B) gene was found in 20%. Importantly, 16.7% of the isolates carried both resistance genes, highlighting a complex profile of genetic determinants associated with antimicrobial resistance. Despite the high rate of resistance, the study revealed no significant associations between the presence of macrolide resistance determinants and patient mortality or complications, suggesting that clinical outcomes may not worsen solely due to the presence of these resistant strains.
Conclusion
The findings of this study illustrate that while there is a high prevalence of erythromycin-resistant strains of S. pneumoniae, the clinical impact of such resistance on patient outcomes appears limited in this cohort. The majority of isolates retaining susceptibility to other antibiotics indicate the need for continued surveillance of resistance patterns to guide effective treatment strategies. This information is vital for healthcare providers in making informed decisions regarding antimicrobial usage, ultimately aiding in the effective management of pneumococcal diseases and mitigating the potential spread of resistant strains. Continuous monitoring of antibiotic resistance at a national level is essential to adapt treatment protocols and improve patient care.
FAQ section (important questions/answers):
What was the aim of the study on Streptococcus pneumoniae?
The study aimed to describe the drug resistance rate of Streptococcus pneumoniae, assess the prevalence of macrolide-resistant genes, and review the clinical complications of pneumococcal infections among patients at Hospital Universiti Sains Malaysia.
What were the main findings regarding antibiotic resistance rates?
The study found that the penicillin-resistant rate was 7.1%, and the erythromycin-resistant rate was 26.5%. The majority of erythromycin-resistant isolates carried the mef(A) gene, with significant resistance rates highlighted for various antibiotic agents.
Did macrolide resistance affect clinical outcomes in patients?
There was no significant association between the presence of macrolide resistance determinants and mortality or complications in patients, indicating that macrolide resistance did not adversely affect clinical outcomes.
What were the common predisposing factors for pneumococcal infections?
Common predisposing factors included bronchopulmonary diseases (15.9%), underlying malignancy (6.2%), and chronic renal disease (4.4%) among patients diagnosed with pneumococcal infections during the study period.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Macrolide-Resistant Streptococcus pneumoniae Genes and Outcomes in Malaysia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
The keyword 'Table' refers to a structured format used in the article to present data clearly and efficiently. In scientific literature, tables summarize results, making it easier to compare and analyze findings. Tables often include numerical values, statistics, and other important indicators relevant to the study, enhancing understanding of complex information.
2) Study (Studying):
The keyword 'Study' denotes an investigation or research effort aimed at acquiring new knowledge or confirming existing theories. In the context of the article, it indicates a systematic examination of 'Streptococcus pneumoniae' infections, their antibiotic resistance patterns, and associated clinical outcomes. The study contributes to public health understanding and clinical practice.
3) Antibiotic (Antibacterial):
The term 'Antibiotic' refers to substances used to combat bacterial infections. In the article, it highlights the importance of antibiotics in treating pneumococcal diseases caused by 'Streptococcus pneumoniae.' The effectiveness and resistance patterns of various antibiotics, like penicillin and macrolides, are critical for developing effective treatment regimens.
4) Disease:
The keyword 'Disease' outlines a distinct pathological condition typically characterized by specific symptoms and clinical signs. The article discusses 'pneumococcal infections,' leading to conditions like pneumonia, meningitis, and bacteremia. Understanding these diseases helps in better diagnosis and treatment, ultimately contributing to improved patient outcomes and public health strategies.
5) Rules:
The keyword 'Rules' relates to the established guidelines that govern empirical research, such as those outlined by the Clinical and Laboratory Standards Institute (CLSI) in this study. Adhering to these rules ensures accuracy, reliability, and replicability in microbial testing methods, thus validating the study's findings and its contribution to medical science.
6) Drug:
The term 'Drug' indicates pharmacological substances used to treat or prevent diseases. The article explores the implications of antibiotic resistance among drugs like penicillin and erythromycin used against 'Streptococcus pneumoniae.' The focus on drug resistance highlights the challenges in effective treatment and the ongoing need for research in pharmacotherapy.
7) Cina:
The mention of 'China' in the article is relevant in the context of global antibiotic resistance trends. It often serves as a case study for the prevalence of penicillin and macrolide resistance. Attention to data from China helps to compare resistance patterns and informs regional public health responses in Asia.
8) Desha (Desa):
The term 'Desa,' likely part of a name such as 'Mohd Desa,' refers to an author or contributor of the study, indicating their involvement in the research process. Recognizing contributors is essential in academic writing as it grants due credit for insights, methodologies, and data interpretations that facilitate scientific advancement.
9) Species:
The keyword 'Species' refers to distinct organisms classified based on shared characteristics. In microbiology, it is crucial to identify bacterial species such as 'Streptococcus pneumoniae' accurately for effective treatment. The correct identification can influence clinical decisions, guiding appropriate antibiotic use and improving patient management in healthcare settings.
10) Death:
The term 'Death' in the article refers to the mortality outcomes documented among patients with 'Streptococcus pneumoniae' infections. Analyzing mortality rates is essential to understand the severity of infections and the effectiveness of treatment strategies. This data helps healthcare professionals develop better clinical management protocols and allocate resources effectively.
11) Blood:
The keyword 'Blood' relates to clinical specimens from which 'Streptococcus pneumoniae' can be isolated. Analyzing blood samples is vital in diagnosing bacteremia, a severe complication of pneumococcal infections. Understanding blood culture results aids in monitoring treatment efficacy and developing appropriate therapeutic strategies to combat infections.
12) Male:
The term 'Male' refers to the gender designation of a significant portion of patients in the study. Understanding demographic factors, such as higher rates of pneumococcal infections in males, may identify population-specific risk factors. This information can guide targeted prevention measures and enhance overall healthcare management for affected demographics.
13) Evolution:
The keyword 'Evolution' signifies the gradual changes and developments in antibiotic resistance patterns over time among pneumococci. The article discusses how resistance has increased, and understanding the evolution of these changes is crucial for developing new treatment strategies and public health responses that effectively manage bacterial resistance.
14) Natan:
The keyword 'Nathan' likely refers to an author or significant contributor to the research. Citations in scientific literature ensure that those who have offered critical insights, methodologies, or data are recognized. Acknowledging contributions builds credibility and fosters collaboration within the scientific community, enhancing interdisciplinary research efforts.
15) Water:
The term 'Water' serves as a reference point in multiple contexts in health research, including hydration's role during illness and how water-based activities can influence health. While not directly discussed in this study, understanding water's importance in microbial growth and pathogen transmission underpins the overall comprehension of infectious diseases.
16) Jacob:
The mention of 'Jacob,' presumably a reference to a contributor or author, holds relevance in the context of academic acknowledgment. Recognizing key contributors promotes integrity in scientific collaboration, ensuring that all individuals who significantly impacted the research are properly credited for their work, thus enhancing accountability and transparency in scientific communication.
17) Vega:
The term 'Vega' might be included as part of a name associated with the research team or related studies on pneumococcal infections. Acknowledgment of contributors, including individuals like Vega, is essential in academic publishing, as it attributes credit for discoveries and methodologies leading to advancements in medical science.
18) Bile:
The reference to 'Bile' could relate to its significance in microbiological processes, particularly in the identification of bacterial species like 'Streptococcus pneumoniae.' Bile solubility tests help distinguish pneumococci from similar species. Recognizing biochemical characteristics aids in accurate pathogen identification, guiding effective treatment options in clinical settings.
19) Observation:
The keyword 'Observation' signifies the monitoring and assessment strategies employed in the study to capture relevant clinical data. Rigorous observation is critical in research, ensuring accurate documentation of patient outcomes, which informs subsequent analysis and conclusions. This scientific practice strengthens data reliability and supports evidence-based medical decisions.
20) Discussion:
The term 'Discussion' refers to the section in scientific literature where findings are interpreted and contextualized within the broader research landscape. In this article, the discussion analyzes the implications of antibiotic resistance patterns in the context of clinical outcomes, contributing to knowledge expansion on treatment strategies and paving the way for future inquiries.
21) Science (Scientific):
The term 'Science' embodies the systematic study of the natural world through observation and experimentation. In the context of this article, science applies to the investigation of 'Streptococcus pneumoniae' resistance patterns, emphasizing the importance of scientific methods in transforming raw data into actionable knowledge for improving public health outcomes.
22) Similarity:
The term 'Similarity' denotes the comparative analysis between various strains or species in studies. Observing similarities in antibiotic resistance patterns across regions or time frames allows researchers to identify trends and potential public health interventions. Highlighting similarities aids in establishing effective treatment protocols and informs national resistance monitoring efforts.
23) Relative:
The keyword 'Relative' suggests comparative assessments within the research. Understanding the relative rates of antibiotic resistance or illness severity among different populations or strains provides insights crucial for epidemiological studies. This comparative approach allows healthcare providers to adjust strategies based on specific demographics or resistance profiles.
24) Company:
The mention of 'Company' in the context of this study could refer to a pharmaceutical or research entity involved in providing antibiotics or conducting studies. Understanding the role of such companies is vital in improving drug development processes. Company accountability influences public health policies and antibiotic accessibility.
25) Lanka (Lamka, Lànkà):
The term 'Lanka' may refer to Sri Lanka, which is relevant in the context of discussing regional differences in antibiotic resistance patterns. Understanding resistance trends in South Asia, including Sri Lanka, is essential for tailoring public health interventions and improving treatment outcomes for infections caused by resistant pathogens.
26) Money:
The keyword 'Money' likely relates to funding sources for research and public health initiatives. Financial support is crucial for conducting studies aimed at addressing issues like antibiotic resistance. Adequate investment in research facilitates advancements in treatment strategies and ensures the development of effective public health measures.
27) Beta:
The term 'Beta' may refer to a type of lactam antibiotic. The study analyzes resistance concerning beta-lactams, highlighting their effectiveness against 'Streptococcus pneumoniae.' Understanding resistance mechanisms is critical in devising treatment protocols to combat infections, ensuring the continued utility of beta-lactam antibiotics in clinical practice.
28) Miti:
The term 'Miti' appears as part of a name or reference in the context of the research. The recognition of individuals like Miti in scientific writing is essential for proper attribution of ideas, methods, or critical data. Acknowledging team members fosters collaboration and accountability in academic and research environments.
29) Line:
The term 'Line' may refer to a guideline or protocol line in the context of clinical recommendations for treating pneumococcal infections. Establishing clear lines of evidence-based practice helps healthcare providers administer effective treatments, corresponding to the latest research findings on antibiotic susceptibility and resistance among pathogens.
30) Post:
The term 'Post' might refer to scholarly articles or disseminating findings regarding antibiotic resistance and pneumococcal infections. Sharing research outcomes through publications enhances knowledge dissemination, enabling healthcare professionals to stay informed about the latest trends in resistance patterns and facilitating evidence-based decision-making in clinical settings.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Macrolide-Resistant Streptococcus pneumoniae Genes and Outcomes in Malaysia’. Further sources in the context of Science might help you critically compare this page with similair documents:
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