Dietary Acid Load and Cardiometabolic Syndrome Effects on Bone Resorption

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: Combined Effect of Dietary Acid Load and Cardiometabolic Syndrome on Bone Resorption Marker among Post-Menopausal Women in Malaysia
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

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Author:

Sook Yee Lim, Yoke Mun Chan, Yit Siew Chin, Mohd Shariff Zalilah, Vasudevan Ramachandran, Manohar Arumugam


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Combined Effect of Dietary Acid Load and Cardiometabolic Syndrome on Bone Resorption Marker among Post-Menopausal Women in Malaysia

Year: 2024 | Doi: 10.21315/mjms2024.31.2.10

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

This study investigates the factors influencing bone resorption status in post-menopausal women, specifically examining the independent and interactive effects of dietary acid load (DAL) and cardiometabolic syndrome (CMS). Bone health is critically important as osteoporosis, characterized by decreased bone density and increased fracture risk, affects millions worldwide, particularly post-menopausal women who experience significant hormonal changes that exacerbate bone loss. The research recruited 211 community-dwelling post-menopausal women in Malaysia, collecting data through dietary assessments, sleep quality evaluations, and various serum tests to understand relationships between lifestyle, dietary habits, and bone resorption markers.

Impact of Dietary Acid Load on Bone Resorption

One of the key findings highlights that higher dietary acid load (DAL) correlates positively with bone resorption, as indicated by increased levels of serum C-terminal telopeptides of type I collagen (CTX1), a marker for bone turnover. Specifically, age and sleep quality were significantly linked to CTX1 levels, with younger individuals demonstrating higher rates of bone resorption. Conversely, CMS showed no significant association with bone resorption or CTX1 levels. This suggests that while a high DAL may be a risk factor for increased bone resorption, CMS might not have the same effect, indicating a need for further investigation into how dietary choices can impact bone health in this demographic.

Conclusion

In summary, the study concludes that high dietary acid load poses a potential risk to bone resorption rates in post-menopausal women, while cardiometabolic syndrome does not demonstrate significant influence. The interactions between DAL and other potential factors warrant further exploration to better understand their collective impact on bone health. These findings underscore the importance of dietary habits in maintaining skeletal integrity and offer valuable insights for public health strategies aimed at preventing osteoporosis among post-menopausal women. Future research should consider longitudinal designs to establish causal relationships and explore interventions that could modify dietary patterns to promote better bone health.

FAQ section (important questions/answers):

What was the main objective of the study?

The study aimed to investigate factors associated with bone resorption and evaluate the independent and interactive effects of dietary acid load and cardiometabolic syndrome on bone resorption in post-menopausal women.

How was dietary acid load assessed in participants?

Dietary acid load was estimated using the potential renal acid load calculated from a food frequency questionnaire completed by the participants to determine their dietary intake.

What were the significant findings related to age and sleep quality?

The study found that younger age was negatively associated, while poorer sleep quality was positively associated with higher levels of bone resorption marker CTX1 in post-menopausal women.

What conclusion can be drawn about dietary acid load?

The findings suggest that a high dietary acid load is a potential risk factor for bone resorption; however, no significant interactive effects with cardiometabolic syndrome were observed in the study.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Dietary Acid Load and Cardiometabolic Syndrome Effects on Bone Resorption”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
Tables are visual representations that organize data, making it easier to read and comprehend complex information. In the context of research studies, tables summarize key findings, variables, and statistical results. This allows readers to quickly grasp trends and relationships relevant to the study's objectives, facilitating an understanding of the results.

2) Study (Studying):
Studying represents the act of examining subject matter in detail. In this research context, studying the impacts of dietary factors on bone health elucidates understanding of osteoporosis risk among post-menopausal women, allowing for evidence-based interventions.

3) Quality:
Quality in research refers to the reliability and validity of the methods, data, and analysis conducted. High-quality research is crucial for drawing accurate conclusions that can impact public health recommendations, particularly in studies related to nutrition, metabolic health, and conditions such as osteoporosis among post-menopausal women.

4) Food:
Food is essential for nutrition, providing the energy and nutrients necessary for growth and health. In this study context, the type of food consumed—specifically, the balance between acidic and alkaline foods—can influence health outcomes like bone density and resorption, highlighting the importance of dietary choices.

5) Diet:
Diet encompasses the collection of foods and beverages consumed by an individual, impacting overall health. The study emphasizes how dietary patterns, particularly dietary acid load (DAL) from various foods, affect bone health, underscoring the role of diet in managing osteoporosis risk in post-menopausal women.

6) Post:
The term 'post' in this context usually refers to events or conditions occurring after a particular point—in this study, post-menopause. Understanding the physiological changes and health risks that arise in post-menopausal women is crucial for targeting interventions, especially concerning bone health and related metabolic conditions.

7) Blood:
Blood is a vital fluid that circulates in the body, delivering essential nutrients and oxygen to cells while removing waste products. In this study, blood measurements are critical as they help assess biomarkers such as vitamin D levels and markers of bone resorption, both important for evaluating health status.

8) Activity:
Activity refers to physical movement and exercise, which plays a vital role in maintaining health and preventing disease. The study investigates the relationship between physical activity levels and bone resorption in post-menopausal women, highlighting its importance in enhancing bone health and managing conditions like osteoporosis.

9) Mineral:
Minerals are inorganic substances essential for various bodily functions, including bone health. Calcium, a key mineral, is crucial for bone density. This study discusses the influence of dietary acid load on mineral balance and bone resorption, illustrating the significance of minerals in nutrition and health management.

10) Chan:
Chan is referenced as an author, indicating involvement in the study or research. Authors contribute their expertise, methodologies, and interpretations to the work, fostering scientific collaboration that drives advancements in understanding health issues—particularly concerning bone resorption and dietary influences among post-menopausal women.

11) Education:
Education refers to the formal process of acquiring knowledge and skills. Higher educational attainment may positively correlate with health outcomes and awareness of dietary impacts. The study considers education's role in affecting health behaviors and outcomes, suggesting that it may influence dietary choices and overall health status.

12) Disease:
A disease is a pathological condition of a bodily part, an organism, or system resulting from various causes. This text discusses diseases associated with metabolic syndrome and osteoporotic conditions. Understanding the connection between lifestyle, dietary factors, and disease prevalence is essential for developing preventive strategies.

13) Measurement:
Measurement refers to the methods of quantifying variables in research. Precise measurements are vital for assessing factors such as dietary intake, blood markers, and physical health indicators. The study employs various measurement techniques to determine associations and outcomes related to diet and bone resorption in the population studied.

14) Rules:
Rules in research pertain to the established guidelines or criteria used in methodological frameworks. These can include statistical rules for data analysis and criteria for including study participants. Adhering to rules helps ensure research integrity, reproducibility, and the validity of findings related to health outcomes.

15) Milk:
Milk serves as a significant dietary source of calcium and other nutrients essential for bone health. This study may discuss the role of dairy consumption in providing these nutrients and how milk intake potentially influences bone density and resorption, particularly in post-menopausal women.

16) Pur:
The term 'poor' typically denotes suboptimal conditions or results. In the context of this study, poor sleep quality or inadequate nutrient intake may be referenced, highlighting their associations with adverse outcomes such as increased bone resorption and heightened risk of osteoporosis among post-menopausal women.

17) India:
India is highlighted as a geographical context with specific relevance to the prevalence of conditions such as metabolic syndrome. By comparing different populations, researchers can understand cultural and dietary differences affecting bone health and the broader impacts of lifestyle-related diseases in varied demographics.

18) Beta:
Beta refers to coefficients in statistical analyses representing the degree of influence variables have on outcomes. In the context of this study, beta values indicate the strength and direction of relationships between independent variables (like dietary acid load) and dependent outcomes (such as bone resorption markers).

19) Hand:
Hand could refer to manual data collection or participant activities such as filling out questionnaires. In research, many tasks require direct human involvement, such as document administration or performing physical measurements, which contributes to the richness and validity of the study's findings.

20) Discussion:
Discussion constitutes a critical section of research where authors interpret findings, contextualize results within existing literature, and draw conclusions. This segment often evaluates the implications of the research, helps identify future areas for study, and reassesses hypotheses based on the collected data.

21) Mahadeva (Maha-deva):
Mahadeva is referenced as an author, which signifies crucial contributions to the research study. The presence of multiple authors often indicates a collaborative approach, combining diverse expertise and perspectives to deepen the understanding of complex issues like bone health and related risk factors.

22) Medicine:
Medicine encompasses the science of diagnosing, treating, and preventing illness. This study has intersections with medicine as it focuses on osteoporosis risk factors, offering insights into dietary implications and lifestyle adjustments essential for improving health outcomes in post-menopausal populations.

23) Science (Scientific):
Scientific pertains to the systematic approach employed in conducting research. This study embodies scientific inquiry by adhering to research methodologies that emphasize evidence-based findings on the relationships between diet, bone health, and relevant physiological outcomes.

24) Rampal:
Rampal is cited as an author in this research, implying significant scholarly contributions. Each author's work adds breadth to the study, facilitating a multi-faceted perspective on intricate health issues like metabolic syndrome and bone health in diverse populations.

25) Bengal (Bemgal):
Bengal alludes to a specific geographical area, which may be relevant in the context of the study regarding dietary habits and health outcomes. Understanding regional differences in diet and lifestyle can inform targeted health interventions tailored to specific populations everywhere.

26) Animal:
The term 'animal' can relate to dietary sources, such as animal proteins, which influence dietary acid load. The study may evaluate the role of animal-based foods versus plant foods in affecting bone health outcomes, shedding light on dietary guidelines for post-menopausal women.

27) Valley:
Valley may signify a specific locality pertinent to the study's population. The environmental context can greatly influence lifestyle choices, dietary habits, and thus health outcomes. Understanding geographical variances aids in comprehending how local factors contribute to health disparities.

28) Saha (Shaha):
Saha is mentioned as an author, indicating collaboration in the research. Authors represent their collective expertise, bringing individual insights that enhance the depth and reliability of the study's conclusions regarding dietary impacts on bone health among post-menopausal women.

29) Khaw:
Khaw's mention reflects active participation in the research team's work. Each author’s contribution not only helps shape the research design and findings but also validates the results through various expert lenses that encourage robust and well-rounded academic discourse on the research topic.

30) Meat:
Meat, as a source of protein, can significantly impact dietary acid load. This study possibly examines the effects of high meat consumption on bone health, investigating how dietary components influence metabolic processes and influence conditions like osteoporosis in post-menopausal women.

31) Rich (Rch):
Rich typically describes the abundance of a certain nutrient in foods. In this study, it may refer to diets rich in calcium or alkaline foods, emphasizing their roles in maintaining bone health and potentially counteracting the effects of high dietary acid loads.

32) Male:
Male denotes a gender distinction that may be addressed in the research findings. The study primarily targets post-menopausal women, but including data on males can enhance understanding of gender differences in dietary impact on health outcomes, particularly in relation to bone resorption.

33) Life:
Life refers to the biological existence and activities of organisms. In research, understanding the life stages and experiences of participants—like women in post-menopausal stages—is essential for tailoring interventions that cater to their unique health needs and dietary behaviors.

34) Calculation:
Calculation is vital in research for deriving meaningful statistical results from raw data. In this context, calculations might involve determining dietary acid load or assessing health indicators, providing a quantitative basis for conclusions regarding bone health and nutritional status.

35) Observation:
Observation refers to the process of monitoring and assessing data and behaviors within a study. It's crucial for identifying patterns and establishing relationships in research, especially in health-related studies where behavior and dietary intake directly influence health outcomes like osteoporosis.

36) Developing:
Developing signifies the processes involved in creating interventions or strategies. In the context of this study, developing effective nutritional guidelines is crucial for promoting better bone health among post-menopausal women, targeting modifiable risk factors through evidence-based recommendations.

37) Knowledge:
Knowledge encompasses the insights gained through research, contributing to the broader field of health sciences. The findings from this study enhance understanding of the dietary influences on bone health, particularly in post-menopausal women, aiding in public health strategy development.

38) Relative:
Relative may signify the connections or comparisons between variables within the study. Understanding relative associations, such as between dietary acid load and bone resorption, helps contextualize findings within existing literature and informs interpretation related to women's health.

39) Meeting:
Meeting can reference gathering researchers or participants to discuss findings. Collaborative meetings facilitate knowledge sharing, promoting coherent understanding of data outcomes and advancing strategies to mitigate health risks, particularly those related to bone resorption and disease management.

40) Citizen:
Citizen can refer to participants in the study. The inclusion of citizens emphasizes the importance of community engagement in research, ensuring demographic representation and enhancing the applicability of findings to real-world public health challenges.

41) Filling (Filled):
Filling involves the completion of forms or questionnaires in research. Accurate filling is crucial for obtaining reliable data, providing insights into participant behaviors, health status, and dietary habits that are integral to the study's conclusions.

42) Hygiene (Hygienic):
Hygiene denotes the conditions and practices that promote health through cleanliness. In research, ensuring appropriate hygiene standards in data collection is essential for minimizing contamination risks and ensuring the accuracy of health-related measurements.

43) Pujari:
Pujari is cited as an author, underscoring collaborative work within the research study. Each author's input contributes to the overall integrity and depth of the study, particularly in analyzing dietary impacts on health outcomes in diverse populations.

44) Medium:
Medium can relate to methods or pathways of communication. In research, it may refer to the mediums (like surveys) employed to gather data, so choosing appropriate mediums is pivotal for capturing accurate representations of participant experiences and health behaviors.

45) Indian:
Indian signifies relevance to the study's context, as it may represent dietary patterns, health issues, or population characteristics specific to Indian communities. Understanding these factors allows tailoring interventions and health strategies to address unique health challenges.

46) Kappa:
Kappa typically refers to a statistical measure of agreement. In this context, kappa may be relevant for validating the reliability of tools, such as questionnaires used in the study to assess dietary habits and health outcomes among participants.

47) Putra:
Putra is mentioned in the context of financial support or institutional backing for the study. Recognizing the role of such funding sources is essential for understanding how research is facilitated, enabling advancements in public health and nutrition science.

48) Salt (Salty):
Salt, as a dietary component, can influence health in varying ways. In the study's context, examining the consumption of salt-rich foods impacts dietary acid load and overall nutrition, potentially affecting bone health and resorption rates among post-menopausal women.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Dietary Acid Load and Cardiometabolic Syndrome Effects on Bone Resorption’. Further sources in the context of Science might help you critically compare this page with similair documents:

Physical activities, Physical activity, Scientific research, Blood-pressure, Sedentary lifestyle, Main effect, Environmental factor, Obese, Sample size, Lifestyle Factors, World Health Organization, Dietary Intake, Insulin resistance, Post-menopausal women, HDL-C, Metabolic syndrome, Systolic blood pressure, Diastolic blood pressure, Lipid profile, Serum lipid profile, Cross-sectional study, Cardiovascular disease, BMI, Type 2 diabetes, Calcium intake, Glomerular Filtration Rate, Calcium absorption, Pittsburgh Sleep Quality Index, Sleep quality, Bone health, Fasting blood glucose, Self-reported questionnaire, Body weight, Marital Status, Google Scholar, Peak bone mass, Bone mineral density, Menopausal women, Serum ferritin level, Significant correlation, Osteoporosis, Statistical analyses, Postmenopausal osteoporosis, Nutritional intervention, Physical activity level, Genetic factor, Kidney function, Elevated blood pressure, Weight Management, Menopause, Hyperglycaemia, Metabolic Acidosis, Anthropometric measurement, BMD, Risk factor, Postmenopausal women, Bone fracture, Triglyceride, Metabolic factors, Metabolic disease, Fracture risk, Food composition, Bone resorption, Multiple linear regression, Gastrointestinal absorption, Bone loss, Biochemical marker, Education Level, Calcium homeostasis, Pro-inflammatory cytokine, Blood sample, Endocrine dysfunction, Public health implication, Global adult tobacco survey, Endocrine Disease, Public Health Research, Muscle mass, Acid base balance, Biochemical Measurement, Age-related bone loss, Household income, Sedentary behavior, Risk factors of osteoporosis, Overweight and obese, Type 1 collagen, Food frequency questionnaire, Gene-Gene interaction, National Health and Morbidity Survey, Intracellular calcium, Sleep Restriction, Bone turnover, Interaction Effect, Poor sleep quality, Study variables, Bone quality, Oestrogen deficiency, Ministry of Health Malaysia, Bone turnover marker, Osteoclast activity, Hypertriglyceridaemia, Vitamin D intake, Ethnic difference, Non-smoker.

Concepts being referred in other categories, contexts and sources.

Tall stature, Younger age.

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