Serum Prolactin and TSH Correlation in Infertile Women: Meta-Analysis

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: Correlation of Serum Prolactin and Thyroid Stimulating Hormone Concentration in Infertile Women: A Systematic Review and Meta-Analysis
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Delini Devi Ramadras, Noor Azlin Azraini Che Soh@Yusof, Najib Majdi Yaacob, Wan Azman Wan Norlina, Abdul Hamid Hanisah


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Correlation of Serum Prolactin and Thyroid Stimulating Hormone Concentration in Infertile Women: A Systematic Review and Meta-Analysis

Year: 2024 | Doi: 10.21315/mjms2024.31.1.2

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

Infertility is a global challenge affecting millions of individuals of reproductive age. This systematic review and meta-analysis focus on the relationship between serum prolactin (PRL) and thyroid stimulating hormone (TSH) in women facing infertility issues. Both hormones play critical roles in reproductive health, and their interactions may influence fertility outcomes. The review involved a thorough search of online databases to identify relevant studies, culminating in the inclusion of 11 eligible articles that contributed to evaluating the correlation between PRL and TSH in the context of infertility.

The Correlation Between Serum PRL and TSH

The meta-analysis revealed a significant positive correlation, with a pooled estimate of 0.431 (95% CI: 0.251, 0.582) among infertile women. This indicates that changes in serum PRL levels correspond with changes in serum TSH levels, highlighting an interconnected relationship between hyperprolactinemia and hypothyroidism. Notably, the analysis found that hypothyroidism can adversely affect ovulation, and elevated PRL levels might inhibit the hypothalamic-pituitary-gonadal axis, further complicating fertility. This relationship supports the hypothesis that evaluating both hormones is crucial for understanding the causes of infertility and guiding treatment options.

Conclusion

In conclusion, this meta-analysis underscores the vital connection between serum PRL and TSH in infertile women, suggesting that hyperprolactinemia frequently accompanies hypothyroidism. Given the observed correlation, it is essential for healthcare providers to assess both hormone levels in women experiencing infertility. By recognizing and addressing the hormonal interplay, effective treatment strategies can be implemented to improve reproductive outcomes for affected individuals. Overall, the findings contribute valuable insights that could enhance infertility management practices.

FAQ section (important questions/answers):

What is the relationship between serum PRL and TSH in infertile women?

The meta-analysis found a significant positive correlation of 0.431 between serum prolactin (PRL) and thyroid stimulating hormone (TSH) in infertile women, indicating that as one hormone increases, the other typically does as well.

How was the meta-analysis conducted on PRL and TSH?

A systematic search of online databases was performed from inception until March 2021, identifying 822 articles. After screening, 11 studies were included based on eligibility criteria, assessing the correlation between PRL and TSH.

What factors did not influence the correlation between PRL and TSH?

The correlation estimates were not influenced by study region, types of infertility, sample size, or the year of the study, indicating a consistent relationship across various conditions.

What implications do PRL and TSH levels have for infertility management?

Elevated serum PRL and TSH levels can affect fertility. Thus, monitoring these hormone levels is essential for diagnosing and managing infertility in women, as effective treatments can reverse these hormonal imbalances.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Serum Prolactin and TSH Correlation in Infertile Women: Meta-Analysis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The term 'Study' is a fundamental concept in research, representing systematic inquiry aimed at discovering new knowledge or validating existing information. In the context of the systematic review and meta-analysis described, it pertains to analyzing correlations between serum prolactin and thyroid stimulating hormone levels in infertile women. Studies help derive evidence-based conclusions that can influence clinical practices and guidelines in reproductive health.

2) Table:
A 'Table' serves as a concise method to organize and present data visually, making it easier for readers to comprehend key information effectively. In scientific papers, tables summarize results, characteristics of study participants, and methodologies, allowing for quicker comparison and retrieval of relevant data regarding correlations observed in the reviewed studies.

3) India:
The mention of 'India' underscores the geographical and cultural context of several studies included in the meta-analysis. Understanding regional variations in fertility, hormonal profiles, and healthcare practices is crucial in comprehensively addressing infertility issues. India, having diverse populations, provides significant insight into hormonal interactions and infertility management.

4) Sharman (Sarma, Sharma, Sarman):
'Sharma' refers to one of the authors of a study included in the meta-analysis, which explored the correlation between prolactin and thyroid stimulating hormone (TSH) levels. The findings of Sharma's study presented a negative correlation, thereby providing important context and contrasting results that enrich the overall discussion about hormonal interplay in infertility.

5) Saxena (Sakshena, Saksena):
'Saxena' signifies another contributing author involved in research concerning the correlation of serum hormones affecting infertility. This reference highlights collaborative efforts within the scientific community aiming to enhance understanding of how thyroid hormones and prolactin influence reproductive health, ultimately guiding clinical practices for treating infertility in women.

6) Quality:
In research, 'Quality' pertains to the methodological rigor and reliability of studies included in analyses. A high-quality study ensures valid results, influencing clinical decisions reliably. The systematic review assessed the quality of included studies using criteria ensuring that the findings regarding hormone correlations are robust and trustworthy, aiding better healthcare delivery.

7) Indian:
'Indian' denotes the national context impacting study populations and findings. Many studies included in the analysis originate from India, offering insights into hormone levels and reproductive health concerns typical to this region. Cultural and socioeconomic factors relevant to Indian women can considerably influence fertility issues and treatment approaches.

8) Nahi:
'Nahi' is a reference to 'Al-Nahi', another author in the cited studies addressing hormonal levels in infertile women. Including various authors signifies collaborative research efforts and the importance of diverse perspectives in comprehending hormonal interactions. Each author's contributions add depth to the overall findings presented in the systematic review.

9) Disease:
'Disease' encompasses various health conditions, including hormonal disorders like hypothyroidism and hyperprolactinemia that significantly impact fertility. The systematic review discusses how these diseases correlate with hormonal profiles in women, emphasizing the need for awareness and treatment options to improve reproductive health and address infertility effectively.

10) Forest:
'Forest' often refers to 'forest plots', a graphical presentation method used in meta-analyses to display the results of multiple studies comprehensively and visually. These plots help visualize the variance among studies and the overall correlation, enhancing understanding of the pooled data in research concerning serum prolactin and TSH levels.

11) Reason:
'Reason' highlights the underlying factors that necessitate a study, including medical, hormonal, and social influences on infertility. In this context, the review investigates various reasons for hormonal imbalances and infertility, enhancing our understanding of the interplay between hormonal levels and reproductive health among women.

12) Rules:
'Rules' refer to the methodological standards and guidelines that govern clinical studies and systematic reviews. Adhering to established rules, such as PRISMA guidelines, ensures that research is conducted ethically, reducing bias and enhancing the validity of findings, which ultimately contributes to reliable outcomes in infertility research.

13) Sage:
'Sage' may refer to the SAGE publishing platform known for hosting academic articles. Access to a wide array of studies through such platforms is crucial for comprehensive literature reviews. Researchers rely on digital libraries like SAGE to authenticate existing literature and extend their inquiries into hormone interactions affecting fertility.

14) Discussion:
'Discussion' is a critical section in research papers where the authors interpret results, contextualize findings, and suggest implications for clinical practice. It allows for the exploration of the study's broader impact, synthesizing insights gained from analyzing thyroid-stimulating hormone and prolactin, ultimately enhancing infertility management approaches.

15) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
'Srivastava' refers to one of the authors involved in the studies included in the meta-analysis, contributing to the analysis of serum hormone levels and female infertility. Author contributions like Srivastava's are pivotal in advancing research outcomes, providing collaborative insights into clinical practices related to reproductive health and hormonal interactions.

16) Teaching:
'Teaching' underscores the importance of educational initiatives in disseminating knowledge derived from research findings. The implications of studies regarding hormonal levels and infertility impact clinical practices not only by guiding treatment but also by informing healthcare professionals about the significance of hormone assessment in reproductive health managing.

17) Lakshmi (Laksmi):
'Lakshmi' denotes a name associated with the authorship of studies contributing to the research on correlations between prolactin and thyroid-stimulating hormone levels. Each author’s work, including Lakshmi's, adds valuable knowledge to systematically understand hormonal impacts on female fertility, contributing to advancements in reproductive healthcare practices.

18) Jasmine:
'Jasmine' is associated with an author whose contributions to research offer insights into infertility and hormonal balances. The inclusion of diverse perspectives from authors like Jasmine enriches the understanding of hormonal influences in reproductive health and reinforces the importance of collaborative research in addressing complex infertility issues.

19) Kumkum:
'Kumkum' signifies another author contributing to the body of knowledge surrounding hormonal interactions in infertility studies. Referring to various authors contributes to the credibility of research findings and emphasizes the collaborative nature of scientific inquiries aimed at improving infertility assessments and treatments based on hormonal evaluations.

20) Nature:
'Nature' in a research context often refers to a high-impact scientific journal but can also imply the inherent characteristics of biological systems. Discussing the nature of hormonal interactions emphasizes their critical role in reproductive health, underpinning the theoretical basis for understanding conditions like hyperprolactinemia and hypothyroidism in relation to infertility.

21) Gupta:
'Gupta' highlights another contributor in the published studies. The collaboration among researchers with varying expertise enriches the comprehensive analysis of hormonal levels and their connection to infertility, thereby enhancing the quality of research insights that can positively influence clinical applications in managing reproductive health.

22) Kumar:
'Kumar' refers to an author who contributed to understanding correlations between prolactin and thyroid hormone levels in infertility research. The recognition of individual author contributions emphasizes how multidisciplinary collaboration enhances the depth and breadth of research, ultimately improving methodologies and treatments surrounding female hormonal health and fertility.

23) Patel:
'Patel', like other author names, contributes to collective research efforts investigating hormonal influences on fertility. Recognition of diverse authors helps reinforce the shared responsibility of the scientific community in advancing knowledge on infertility, fostering a deeper understanding and effective strategies in diagnosis and treatment relying on hormonal assessments.

24) Annal:
'Annal' usually signifies a historical record or account but, in this context, could refer to a journal in which findings were published. Scientific publications play a crucial role in sharing research results, allowing the community to build on existing knowledge and further explore impacts of hormones like prolactin and TSH on fertility.

25) Gali:
'Gali' represents a contributing author whose research efforts intersect with studies regarding hormonal balance and infertility. Inclusion of multiple authors heightens the credibility of the findings, indicating collaborative approaches to researching complex issues, ultimately influencing medical practices in addressing female hormonal health related to infertility.

26) Sood:
'Sood' specifies one of the authors whose work has contributed to understanding the dynamics of prolactin and TSH levels in infertility. Each author's insights enhance the overall narrative of the study, providing unique perspectives leading to improved understanding of the association between hormonal imbalances and reproductive health.

27) Transformation (Transform, Transforming):
'Transformation' in a research context often refers to a methodological change or a metaphorical change of perception regarding study findings. It may signify the statistical transformation applied to correlation coefficients for meta-analyses, highlighting the importance of rigorous methods to consolidate results from diverse studies on hormonal correlations and infertility.

28) Knowledge:
'Knowledge' encompasses the insights gained through research activities, particularly regarding the interactions between hormones like prolactin and TSH in infertility. Enhanced knowledge contributes to improved clinical practices, informing healthcare professionals of potential hormonal impacts on reproductive health and guiding intervention strategies for infertility treatments.

29) Language:
'Language' pertains to the terminology used in scientific communication, ensuring clarity and accuracy in conveying research findings. The appropriate articulation of hormone correlations and their clinical implications is crucial for effective dissemination of information within the medical community and to the general public in lifestyle management related to infertility.

30) Family:
'Family' may refer to the fundamental unit affected by infertility issues, emphasizing the emotional and social implications of hormonal dysfunctions. Childbearing and reproductive health are critical to family dynamics, highlighting the necessity of addressing hormonal imbalances in women to assist families in achieving their desired reproductive outcomes.

31) Animal:
'Animal' signifies references to studies involving animal models in hormonal research. Animal studies serve as important preliminary investigations, enabling scientists to understand endocrine functions before human studies, thereby contributing to advancements in infertility treatment strategies based on hormonal interactions and their physiological effects.

32) Blood:
'Blood' plays a vital role in assessing hormone levels, as hormonal analysis is typically conducted through blood samples. Understanding the blood concentrations of hormones like prolactin and TSH is crucial for diagnosing endocrine disorders affecting fertility, effectively linking laboratory assessments to clinical treatments in reproductive health.

33) Cutan:
'Sudan' points to another geographical context potentially linked to studies regarding hormonal levels and fertility in women. Global diversity in research contributes to a thorough understanding of how various populations experience infertility, enhancing insights into hormonal interactions across different cultures, which may aid in customizing treatment approaches.

34) Hand:
'Hand' could signify a thematic reference in a contextual analysis or be metaphorical, emphasizing the collaborative nature of research, where many individuals contribute their expertise toward understanding complex issues like infertility. Successful studies often require a 'hand' from various fields to address multifaceted hormonal relations effectively.

35) Post:
'Post' may refer to the dissemination of research findings via publications or online platforms, indicating the significance of sharing scientific knowledge. Such dissemination plays a crucial role in informing healthcare providers and the public about the importance of hormone assessments in managing infertility, thereby enhancing community awareness.

36) Pir:
'Peer' highlights the crucial aspect of peer-review in scholarly research. The peer-review process ensures that studies published are critically evaluated by experts in the field, enhancing the credibility and reliability of findings concerning hormonal levels in infertility research, guiding future studies and clinical practices.

37) Male:
'Male' signifies the aspect of fertility that relates to men, emphasizing the importance of considering both male and female factors in reproductive health discussions. While this study focuses on hormonal interactions in women, acknowledging male fertility factors is crucial as infertility is a shared concern, necessitating comprehensive evaluation.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Serum Prolactin and TSH Correlation in Infertile Women: Meta-Analysis’. Further sources in the context of Science might help you critically compare this page with similair documents:

Reproductive age, Original research, Statistical analysis, South Asia, Peer-reviewed journal, Infertility, Inclusion criteria, Exclusion criteria, Sample size, Study population, Female infertility, Primary infertility, Secondary infertility, P Value, Study design, Infertility management, Anovulation, Meta analysis, Data extraction, Systematic Review, Thyroid stimulating hormone, Thyroid profile, Hypothyroidism, Follicle Stimulating Hormone (FSH), Gonadotropin Releasing Hormone, Publication bias, Serum TSH, Thyroid hormone, Negative correlation, Positive correlation, Hypothalamic pituitary ovarian axis, Cross-sectional studies, Sex hormone binding globulin, Infertility in women, Correlation, Hypothalamic-pituitary-thyroid axis, Subgroup analysis, Hyperprolactinaemia, Gonadotropin-releasing hormone (GnRH), Sensitivity analysis, Systematic review and meta-analysis, Search strategy, Thyroid stimulating hormone (TSH), Serum prolactin, Infertile women, TSH, Case control studies, Negative feedback loop, Ovarian Function, Global population, Study Characteristics, Mediterranean region, Eastern Mediterranean Region, Effect Size, Risk of bias, Heterogeneity, Random effect model, Methodological quality assessment, Steroid hormone, Data source, FSH and LH, Gonadal steroid hormones, Online Database, GnRH secretion.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: