Scoping Review: Medicinal Properties of Piper betle in Malay Manuscripts

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Journal name: The Malaysian Journal of Medical Sciences
Original article title: A Scoping Review on Medicinal Properties of Piper betle (Sirih) Based on Malay Medical Manuscripts and Scientific Literatures
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Author:

Nur Fatin Idayu Zamri, Mohd Affendi Mohd Shafri, Zaitunnatakhin Zamli, Suhana Mamat


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: A Scoping Review on Medicinal Properties of Piper betle (Sirih) Based on Malay Medical Manuscripts and Scientific Literatures

Year: 2023 | Doi: 10.21315/mjms2023.30.5.3

Copyright (license): CC BY 4.0


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Summary of article contents:

Introduction

The use of medicinal plants has been a longstanding practice across cultures, with a significant reliance on natural products for healthcare. In particular, Malay medical manuscripts reveal a wealth of knowledge regarding the medicinal properties of various plants, notably Piper betle (or sirih). This review aims to explore the correlations between the traditional medical uses of P. betle in these manuscripts and the scientific evidence supporting its medicinal benefits. A systematic examination of both historical texts and contemporary research highlights the diverse medicinal applications of P. betle, particularly emphasizing its widespread acceptance in Malay traditional medicine.

Antimicrobial Properties of Piper Betle

Among the various properties ascribed to Piper betle, its antimicrobial effects stand out significantly. Historical records indicate that P. betle has been used to treat ailments caused by microbial infections, including typhoid fever, toothaches, and shingles. Modern scientific studies have corroborated these traditional claims, revealing that P. betle exhibits antibacterial and antifungal activities against a range of microorganisms such as Candida albicans and Streptococcus mutans. The antimicrobial efficacy is attributed to its high content of phytochemicals, particularly flavonoids and phenolic compounds, which may disrupt microbial cell membranes and inhibit their metabolic processes. This suggests that P. betle could serve as a potent alternative to conventional antibiotics, especially in an era of increasing antibiotic resistance.

Conclusion

In conclusion, the medicinal potential of Piper betle is well-documented within both traditional and contemporary contexts. While historical practices provide foundational knowledge, scientific validation underscores the plant's effectiveness in treating various ailments, particularly through its antimicrobial properties. However, further research is essential to fully understand the pharmacological mechanisms, optimal extraction methods, and dosages required for clinical applications. Future studies should aim to explore the synergistic effects of P. betle when combined with other herbs and ascertain its value as a complementary therapy in modern healthcare settings, solidifying its place within both traditional and scientific paradigms of medicine.

FAQ section (important questions/answers):

What medicinal properties does Piper betle have according to Malay manuscripts?

Malay medical manuscripts highlight its antimicrobial, analgesic, hepatoprotective, gastroprotective properties. It is used for treating ailments like typhoid fever, toothache, and liver problems, often in combination with other ingredients for effective healing.

How was the review conducted on Piper betle's medicinal use?

The review integrated information from Malay medical manuscripts and scientific databases like PubMed and ScienceDirect, following PRISMA guidelines. It aimed to correlate traditional uses with scientific evidence for various medicinal properties.

What limitations were faced in researching Piper betle's medicinal properties?

Limited transliterated manuscripts hindered the extent of accessible data on Piper betle's usage in traditional medicine. The review could not delve deeply into specific diseases, dosage, or treatment duration.

What are the recommendations for future research on Piper betle?

Future studies should focus on active phytochemicals, their specific mechanisms, optimal dosages, and potential adjuvant uses in traditional medicine to establish Piper betle as a viable alternative treatment.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Scoping Review: Medicinal Properties of Piper betle in Malay Manuscripts”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In research, a Table is a systematic arrangement of data, making it easier to view and comprehend complex information. In the context of the review, the tables summarize the medicinal uses of Piper betle, allowing for quick comparisons of various applications, methods, and ingredients based on traditional medicine documents.

2) Science (Scientific):
Science represents a structured framework for acquiring knowledge through experimentation and observation. It aids in the validation of traditional uses of Piper betle, ensuring that herbal remedies are assessed for efficacy and safety, bridging the gap between cultural practices and modern medicine.

3) Activity:
Activity in this context often refers to biological effects exhibited by a substance, such as antimicrobial or analgesic properties. Evaluation of such activities is crucial in understanding how compounds derived from plants like Piper betle can influence health and treatment options, bridging the gap between traditional and modern medicine.

4) Study (Studying):
A Study is a detailed investigation to understand a specific phenomenon or validate hypotheses. In the context of Piper betle, numerous studies explore its medicinal properties, providing scientific credibility and insights into its potential applications in treating various ailments, enhancing the traditional knowledge documented in medical manuscripts.

5) Phytochemical:
Phytochemical refers to bioactive compounds produced by plants that can impact health, often contributing to their medicinal qualities. Understanding the phytochemical profile of Piper betle helps identify its active constituents, linking its traditional uses to scientific validation, and paving the way for therapeutic applications and industrial formulations.

6) Medicine:
Medicine encompasses practices and systems employed to treat disease and maintain health. The application of traditional medicine, including the use of Piper betle, highlights the importance of integrating indigenous knowledge with modern scientific research, ensuring holistic approaches to healthcare based on validated remedies.

7) Disease:
Disease refers to impairments in normal bodily function that can affect health. Exploring the therapeutic potential of Piper betle against various diseases recorded in Malay manuscripts expands knowledge on herbal treatments, emphasizing the importance of scientific validation for traditional remedies in managing health issues effectively.

8) Water:
Water serves as a common extraction medium for phytochemicals, playing a vital role in traditional preparations. Its use in extracting active compounds from herbs like Piper betle underscores its importance in herbal medicine, enabling safe consumption while ensuring the extraction of therapeutic benefits from the plant.

9) Drug:
A drug is a substance used to diagnose, treat, or prevent disease. The exploration of Piper betle for potential medicinal properties positions it as a candidate for development into herbal drugs, providing an alternative to synthetically produced pharmaceuticals while catering to the growing interest in natural remedies.

10) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant and anti-inflammatory properties. Their presence in Piper betle contributes significantly to its therapeutic potentials, linking traditional usage with scientifically proven benefits, ultimately supporting the use of these compounds in health promotion and disease prevention strategies.

11) Pain:
Pain relates to the unpleasant sensory experience often resulting from injury or disease. The assessment of Piper betle's analgesic properties and traditional uses for pain management illustrates the need to connect historical remedies with contemporary pain relief mechanisms, expanding treatment options in modern clinical settings.

12) Antibiotic (Antibacterial):
Antibiotic refers to substances that kill or inhibit bacterial growth. The significance of Piper betle in combating bacterial infections highlights its potential role in alternative medicine, offering a pathway for developing effective natural antibiotics amidst rising concerns over antibiotic resistance in conventional treatments.

13) Indian:
Indian highlights the cultural and geographical context wherein Piper betle has significant traditional importance. The exploration of this plant in Ayurveda and folk medicine underscores its role in health practices, integrating regional traditional knowledge with scientific inquiry to validate its medicinal applications.

14) Kumar:
Kumar often refers to a surname found in South Asian contexts, frequently associated with authors in scientific literature. The contributions of researchers like Kumar to the field of herbal medicine and studies related to Piper betle emphasize collaborative efforts in advancing the understanding and applications of traditional therapies.

15) Toxicity:
Toxicity indicates the potential harmful effects of substances, making its evaluation crucial in pharmacology. Research examining the toxicity of Piper betle ensures safety in its medicinal applications, providing assurance for its use in traditional and modern medicine while delineating safe dosages to prevent adverse effects.

16) Animal:
Animal studies are pivotal in pharmacological research, providing insights into the effects and safety of herbal compounds like Piper betle. These experiments help simulate how such substances might interact within biological systems, facilitating the translation of traditional uses into scientifically validated therapeutic applications.

17) Rules:
Rules in scientific research provide guidelines for methodologies, ensuring credibility, reproducibility, and ethical standards. They are essential in structuring studies around Piper betle, maintaining rigor in validating its medicinal claims through systematic reviews and experimental investigations outlined by platforms like PRISMA.

18) Fever:
Fever is a common symptom of infection or illness, often treated with medicinal herbs. Piper betle’s traditional usage for addressing conditions like typhoid fever accentuates the intersection of cultural practices and scientific validation, leading to a comprehensive understanding of its potential as a natural remedy.

19) Vomiting:
Vomiting is a physiological response often indicating health issues, such as infections. Traditional remedies involving Piper betle for alleviating symptoms like vomiting showcase its historical relevance in symptomatic treatment, necessitating scientific exploration to substantiate its effectiveness and underlying mechanisms against such conditions.

20) Writing:
Writing in the context of health and medicine involves documenting traditional knowledge, practices, and findings. The preservation of Malay medical manuscripts detailing the uses of Piper betle represents an effort to retain and validate cultural health practices in light of contemporary scientific investigation.

21) Quality:
Quality refers to the standard and effectiveness of medicinal preparations. Evaluating the quality of Piper betle used in traditional medicine is essential to ensure its efficacy and safety in treatments, which involves rigorous testing to uphold the integrity of herbal medicine in the modern healthcare landscape.

22) Aureus:
Aureus, like in Staphylococcus aureus, signifies a type of bacteria associated with various infections. The antibacterial activity of Piper betle against such pathogens is critical, where its traditional applications are supported by modern research, validating its role in treating bacterial infections effectively.

23) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth. Investigating the potential of Piper betle as an anticancer agent provides insight into its phytochemical constituents, fostering research into natural compounds that may aid in cancer prevention and treatment.

24) Blood:
Blood is essential for physiological functions and is often a marker for health status. The ability of Piper betle to influence conditions related to blood, such as infections or inflammatory responses, highlights its potential therapeutic uses, particularly in traditional practices aimed at improving overall health.

25) Shari (Sari):
Sari in this context likely refers to 'sari,' meaning essence. The phrases associated with Piper betle and its extraction or usage illustrate traditional applications, emphasizing the significance of this plant within cultural practices aimed at healing and wellness.

26) Food:
Food plays a crucial role in health and nutrition. The use of Piper betle in culinary practices reflects its cultural significance and medicinal properties, expanding its relevance beyond traditional medicine into dietary and functional food applications that can support health and wellness.

27) Pan (Panne):
Paan is a traditional Indian preparation made with betel leaves, often associated with cultural practices and digestive benefits. Its preparation and consumption underscore the societal aspects of Piper betle, illustrating how culinary traditions intertwine with health benefits and community rituals.

28) Male:
Male refers to gender, often significant in research contexts relating to health outcomes. Studies involving Piper betle may consider differences in effectiveness or reactions based on sex, highlighting the importance of gender-specific research to validate traditional uses across different populations.

29) Pharmacological:
Pharmacological pertains to the study of drug action. The pharmacological investigations on Piper betle connect traditional knowledge with modern drug development, assessing its efficacy, safety, and mechanisms of action, thereby facilitating its integration into contemporary therapeutic practices and frameworks.

30) Discussion:
Discussion refers to the analysis of findings in research. Revisiting the medicinal properties of Piper betle involves linking traditional knowledge with scientific data to understand its relevance in modern medicine, exploring avenues for future research and implications for therapeutic applications.

31) Chanda (Chamda):
Chanda is generally a surname found in research studies. Its presence represents contributions from authors regarding the efficacy and applications of Piper betle within scientific literature, showing the collaborative nature of research in validating traditional medicinal practices in modern healthcare frameworks.

32) Sharman (Sarma, Sharma, Sarman):
Sharma is a common surname among researchers. In the context of Piper betle, studies authored by individuals with this name contribute to the scientific understanding and documentation of its therapeutic applications, emphasizing the importance of academic collaboration in herbal medicine research.

33) India:
India is recognized for its rich heritage of traditional medicine and herbal practices. The historical and ongoing research into Piper betle within Indian medicinal systems underscores the cultural significance and potential for integrating traditional remedies into globally recognized health solutions.

34) Pada:
Pada is a Malay term meaning 'in', 'on' or 'at'. It exemplifies the linguistic framework within which traditional medical knowledge involving Piper betle is articulated, emphasizing the importance of understanding cultural context in herbal medicine documentation.

35) Azadirachta indica:
Azadirachta indica, or neem, is known for its extensive medicinal properties. Its mention alongside Piper betle in research highlights the interplay of various herbal remedies in traditional medicine systems, emphasizing synergistic effects and collaborative research in validating ethnomedicinal practices.

36) Adhatoda vasica:
Adhatoda vasica, commonly known for its medicinal uses, often complements treatments explored in combination with Piper betle. Its inclusion in studies signifies the importance of multi-herb formulations in traditional remedies, showcasing the collaborative aspect of indigenous medicinal knowledge.

37) Ocimum sanctum:
Ocimum sanctum, or holy basil, is a revered herb in traditional medicine. Its association with Piper betle in research showcases the diversity of herbal remedies, enhancing understanding of their collective role in treating ailments while fostering the need for rigorous scientific evaluation.

38) Purification:
Purification refers to the process of refining or isolating specific compounds from mixtures. In the context of Piper betle, purifying its bioactive constituents aids in understanding their efficacy and potential therapeutic applications, making it essential for developing standardized herbal medicines.

39) Upadhyaya:
Upadhyaya is a surname commonly seen in scientific literature. Studies authored by individuals under this name relate to exploring the medicinal potential of Piper betle, contributing knowledge that bridges traditional practices with contemporary scientific inquiry in herbal medicine.

40) Tirupathi:
Tirupathi is often a reference to locations or surnames associated with researchers. In this context, the contributions from authors linked to Tirupathi in studying Piper betle emphasize the collaborative nature of herbal medicine research, supporting knowledge exchange across different geographic regions.

41) Language:
Language is fundamental in communicating traditional knowledge and scientific research. The linguistic frameworks utilized in documenting the uses of Piper betle contribute to preserving cultural heritage, enabling the transmission of medicinal practices and findings across generations and research communities.

42) Kalpana:
Kalpana is a common name, often signifying authors contributing to the scientific study of herbs. The incorporation of findings from researchers named Kalpana enriches the literature on Piper betle, supporting the validation of traditional uses through academic research and publications.

43) Samanta (Sama-anta, Samamta):
Samanta may refer to authors in the context of herbal research. The presence of contributions from researchers with this name in Piper betle studies underscores the collaboration in scientific exploration to substantiate traditional medicinal claims with empirical evidence.

44) Chauhan:
Chauhan is a common surname in research publications. The link to studies involving Piper betle showcases the global importance of understanding the herb's properties, reflecting the significance of collaborative research efforts across diverse cultural contexts in validating traditional medicine.

45) Account:
Account refers to a detailed description or explanation of specific findings. In research related to Piper betle, accurate accounts of its traditional use versus scientific validation play a vital role in establishing credibility and guiding future studies and applications.

46) Garlic:
Garlic is a widely known herb with numerous medicinal properties. Its mention in tandem with Piper betle suggests potential synergistic effects in treatment protocols, showcasing the value of using multiple herbs in traditional medicine systems to enhance therapeutic outcomes.

47) Edema (Oedema):
Oedema refers to swelling caused by excess fluid trapped in body tissues. The evaluation of Piper betle in treating oedema reflects its value in traditional remedies, demonstrating the importance of scientific validation for holistic approaches in managing health conditions.

48) Medium:
Medium typically refers to the substance or environment through which a process occurs. In the context of Piper betle, the extraction methods or usage mediums for its medicinal properties highlight traditional practices and their adaptation into modern research methodologies.

49) Phlegm:
Phlegm is a viscous mucus produced during inflammation or infection. The use of Piper betle for respiratory conditions related to excess phlegm underscores its relevance in traditional medicine, validating its historical application through scientific studies that explore its efficacy.

50) Sugar:
Sugar denotes a vital component in metabolism and impacting health conditions. The potential of Piper betle in managing blood sugar levels demonstrates its significance in traditional and modern medicinal practices aimed at addressing metabolic disorders and associated complications.

51) Ulcer:
An ulcer is a sore that develops on the lining of the stomach or intestine. The traditional use of Piper betle in managing ulcers signifies its relevance in folk medicine, supporting the necessity of scientific investigation to validate its effects in gastrointestinal health.

52) Saha (Shaha):
Saha is a surname common among researchers. In the context of studies on Piper betle, contributions from authors with this name highlight the collaborative nature of exploring the plant's medicinal properties, furthering the understanding of its traditional uses in health.

53) Jana:
Jana may refer to contributors engaged in herbal medicine research. Their work on Piper betle signifies collaborative efforts aimed at validating traditional practices, fostering an integrated understanding between historical applications and contemporary scientific findings.

54) Ravi (Ravin):
Ravi is a common name, especially among Indian authors. Its association with studies concerning Piper betle underscores contributions to the documentation and validation of traditional medicinal practices, reinforcing the therapeutic potential of the plant through academic research.

55) Devi:
Devi refers to a common surname, often indicating contributions from women in science. The involvement of female researchers in the field of herbal medicine, including studies on Piper betle, highlights the importance of diverse perspectives in understanding traditional health practices.

56) Alam (Alaṁ):
Alam often refers to nature or the world in Urdu and other related languages. This reflection underscores the significance of natural herbs like Piper betle in traditional medicine systems, emphasizing the synergy between cultural practices and ecological awareness in health promotion.

57) Peng:
Peng may refer to a name commonly associated with researchers. Their contributions to the understanding of Piper betle illustrate the collective effort in examining the relationship between traditional practices and evidence-based studies, fostering larger dialogue in herbal research.

58) Ter:
Ther refers to a prefix used in scientific contexts, often relating to treatment. Its inclusion in discussions about Piper betle aligns with the exploration of its therapeutic properties, showcasing the importance of examining plant derivatives in developing alternative treatment strategies.

59) Southern India:
Southern India is a culturally rich region known for its extensive use of traditional medicine. The exploration of Piper betle's medicinal qualities reflects the intersection of local heritage and scientific inquiry, enriching the understanding of herbal applications in health management.

60) Inflammation:
Inflammation is a natural response of the body to injury or infection, often treated with medicinal herbs. Piper betle's historical use in addressing inflammatory conditions underscores the need for scientific validation to bridge traditional methods with modern therapeutic practices, enhancing its relevance in health care.

61) Alleviation:
Alleviation refers to the relief of symptoms or pain. The role of Piper betle in alleviating conditions demonstrated through traditional practices signifies its potential therapeutic uses, calling for empirical research to substantiate these benefits and integrate them into contemporary treatment regimens.

62) Observation:
Observation is a key component in scientific inquiry, allowing researchers to gather data on phenomena. In the context of Piper betle, careful observation of its effects in traditional medicine sets the foundation for formal scientific studies to validate its applications, supporting evidence-based practice.

63) Developing:
Developing pertains to the process of advancing or improving. In relation to Piper betle, developing insights into its medicinal properties emphasizes the ongoing efforts to bridge traditional uses with contemporary scientific methodologies, aiding in natural product research and therapeutic formulation.

64) Knowledge:
Knowledge reflects the understanding gained through experience or education. The integration of traditional knowledge surrounding Piper betle highlights its importance in modern research, fostering collaboration between cultural practices and scientific discovery in herbal medicine, facilitating informed decisions in health care.

65) Substance:
Substance refers to a particular chemical or compound, especially in pharmacology. The exploration of phytochemical substances in Piper betle highlights the importance of understanding their roles in herbal medicine and their contributions to the efficacy and safety of traditional treatments.

66) Mineral:
Minerals are inorganic elements essential to bodily functions. Traditional medicinal practices often employ minerals alongside herbal remedies like Piper betle, emphasizing the holistic approach to health while calling for further research into the synergistic effects of combined substances in treatment protocols.

67) Surface:
Surface refers to the outermost layer of an object, like a cell. In the context of bacterial interactions, understanding the surface chemistry of Piper betle extracts can help delineate how they affect microbial membranes, leading to insights into their antibacterial properties as seen in traditional usages.

68) Melur:
Melur refers to jasmine, often culturally significant in Indonesian and Malay traditions associated with health practices. The reference to melur alongside Piper betle in discussions highlights the multicultural aspects of herbal medicine and the combined usage of various plants in traditional healing.

69) Death:
Death indicates the end of life and is often linked to health issues. The protective attributes of Piper betle against life-threatening conditions emphasize its potential to be incorporated into therapies aimed at preventing mortality from diseases, reinforcing the value of traditional medicine.

70) Pana:
Pana relates to paan, a traditional preparation using betel leaves. This term underscores cultural practices surrounding Piper betle, illustrating its significance in customs and social settings, highlighting the entwined nature of culinary and medicinal traditions.

71) Mata:
Mata translates to 'eye' in several languages, emphasizing the relevance of traditional remedies for eye conditions. The potential applications of Piper betle in treating eye infections highlight the need for scientific exploration, connecting cultural practices with health outcomes.

72) Muda:
Muda means 'young' in Malay and can refer to young betel leaves used in traditional treatments. Understanding the significance of using specific parts of Piper betle in various remedies underscores the importance of traditional agricultural practices and its implications for modern herbal medicine.

73) Maka:
Maka translates to 'thus' or 'therefore' in Malay, indicating causative relationships in discussions. Its usage within the context of Piper betle emphasizes logical connections in traditional medical practices, integrating cultural narratives with outcomes observed in modern research.

74) Rice (Rce):
Rice is a staple food in Asian countries and often relates to various culinary traditions. Its mention alongside Piper betle signifies intricate links between dietary habits and traditional medicinal practices, reflecting holistic approaches to health that integrate food and herbal remedies.

75) Rich (Rch):
Rich refers to having an abundance of something, often used in the context of nutrients or phytochemicals in herbal contexts. It underscores the significance of Piper betle's diverse phytochemical profile, which contributes to its esteemed status in both traditional and modern health paradigms.

[Note: The above list is limited to 75. Total glossary definitions available: 80]

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