Effectiveness of Fixed vs. Non-Fixed Dorzolamide/Timolol in Glaucoma

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: Comparing the Effectiveness and Adherence between Fixed and Non-Fixed Dorzolamide/Timolol Maleate in Open-Angle Glaucoma Patients in Hospital Universiti Sains Malaysia
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Noor-Khairul Rasid, Shelva Meena Gurusamy, Liza-Sharmini Ahmad Tajuddin, Azhany Yaakub


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Comparing the Effectiveness and Adherence between Fixed and Non-Fixed Dorzolamide/Timolol Maleate in Open-Angle Glaucoma Patients in Hospital Universiti Sains Malaysia

Year: 2023 | Doi: 10.21315/mjms2023.30.3.9

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

Glaucoma is a progressive and irreversible eye disease characterized by optic nerve damage and elevated intraocular pressure (IOP), which is a key factor in its management. The study presented aims to evaluate the efficacy of two treatment regimens for patients with open-angle glaucoma (OAG): a fixed combination of dorzolamide/timolol maleate (FCDT) versus a non-fixed combination of dorzolamide and timolol XE (NFDT). The study's primary focus was to compare the IOP-lowering effects of these treatments and assess patient adherence to the prescribed therapies.

Effectiveness and Adherence

One significant finding from the trial is the superior IOP-lowering effect of the FCDT group compared to the NFDT group. Data revealed that both treatment regimens significantly reduced IOP from baseline to months 1 and 3, but FCDT achieved a greater average reduction of 1.02 mmHg compared to NFDT, with statistical significance noted at month 3. In terms of adherence, the FCDT group also demonstrated significantly higher adherence scores based on the weight of medication bottles, indicating better treatment compliance. However, once adherence was accounted for, the differences in IOP reduction between the two groups became non-significant, highlighting that patient compliance is crucial for treatment success.

Conclusion

Both FCDT and NFDT were effective at lowering IOP in patients with OAG, with FCDT showing a greater average reduction. Nonetheless, the study underscores the importance of patient adherence to medication, as it is a critical determinant of treatment effectiveness. To enhance IOP control, strategies aimed at improving adherence among patients should be integrated with pharmacological treatments, emphasizing the need for healthcare providers to focus on both medication efficacy and patient compliance.

FAQ section (important questions/answers):

What is the primary focus of this glaucoma study?

This study aimed to assess the intraocular pressure (IOP) lowering effects and adherence scores of fixed combination dorzolamide/timolol maleate (FCDT) compared to non-fixed combination dorzolamide and timolol XE (NFDT) in patients with open-angle glaucoma (OAG).

How was the trial conducted and what was its design?

A randomized controlled trial was conducted over two years, involving 60 patients with open-angle glaucoma, using a parallel, single-blinded design. Patients were assigned either the FCDT or NFDT groups using a block randomization technique after a two-week run-in period.

What were the key findings related to IOP reduction?

The study showed a statistically significant mean IOP reduction in both FCDT and NFDT groups. However, after adjusting for adherence, the difference in IOP reduction between the groups became non-significant, highlighting the importance of treatment adherence.

What conclusions were drawn regarding medication adherence?

Both groups achieved decreased IOP, but adherence levels were different. The FCDT group demonstrated a significantly higher mean adherence score than the NFDT group, underscoring the need for strategies to improve adherence in glaucoma treatments.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Effectiveness of Fixed vs. Non-Fixed Dorzolamide/Timolol in Glaucoma”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In scientific articles, a 'Table' presents organized data, statistics, or results succinctly for easier interpretation. Tables are vital for summarizing study findings and allowing readers to visualize comparisons and trends across different variables or treatment groups effectively, thereby enhancing comprehension of research conclusions.

2) Study (Studying):
A 'Study' is a systematic investigation designed to test hypotheses, gather data, and derive conclusions. In medical research, studies are crucial for assessing the effectiveness and safety of treatments or therapies, like medications for glaucoma, and contribute to the evidence base guiding clinical practices.

3) Drug:
A 'Drug' is a substance used to diagnose, cure, treat, or prevent disease. In the context of glaucoma, drugs like dorzolamide and timolol play pivotal roles in reducing intraocular pressure (IOP), making them essential components in therapeutic regimens aimed at managing chronic eye conditions.

4) Disease:
A 'Disease' is an abnormal condition affecting the body or mind, often characterized by specific signs and symptoms. In this context, glaucoma is a chronic eye disease leading to progressive optic nerve damage and vision loss, necessitating effective management strategies to mitigate its impacts.

5) Rules:
'Rules' refer to established guidelines or protocols that govern research conduct and methodologies. In clinical trials, adherence to rules ensures ethical standards, participant safety, and the reliability of results, facilitating rigorous comparisons of treatments and their effects on patient outcomes.

6) Ter:
While 'Ther' might refer to 'therapy' in abbreviation form, it encompasses various treatment modalities used in healthcare. In glaucoma management, therapeutic approaches often involve pharmacological agents aimed at lowering IOP, alongside lifestyle modifications to enhance adherence to treatment regimens.

7) Measurement:
Measurement in research pertains to the quantification of variables or outcomes to evaluate effectiveness. In this context, 'Measurement' of intraocular pressure (IOP) serves as a primary endpoint in studies assessing the efficacy of glaucoma treatments, providing critical data for determining treatment success.

8) Cancer:
Though 'Cancer' isn't directly related to the discussed research, it represents a significant health concern. It highlights the importance of research in developing effective therapeutic interventions, ultimately improving survival and quality of life outcomes for patients with various forms of cancer or chronic conditions.

9) Quality:
'Quality' in healthcare and research refers to the standard or grade of care and outcomes achieved. Research focusing on quality allows for ongoing improvements in treatment methodologies, adherence rates, and overall patient experiences, crucial in chronic disease management like glaucoma.

10) Beta:
In a pharmacological context, 'Beta' often refers to beta-adrenergic blockers, which are commonly used in glaucoma treatment to lower IOP. Understanding their mechanism and efficacy is crucial for optimizing treatments and managing conditions effectively.

11) Life:
'Life' encompasses the biological existence and experiences of individuals. In medical research, the quality of life is a significant outcome measure, particularly for chronic diseases, as it reflects the impact of disease and treatments on daily functioning and well-being.

12) Blindness:
'Blindness' refers to the complete or significant loss of vision, often resulting from diseases like glaucoma. Studying risk factors and treatment efficacy is imperative in preventing blindness, thereby enhancing patient quality of life and reducing healthcare burdens.

13) Learning:
'Learning' in a research context pertains to the acquisition of knowledge or skills through study or experience. Continuous learning from clinical trials is vital for evolving treatment approaches, improving patient outcomes, and informing evidence-based practices.

14) Varga:
'Varga' may represent a surname and could potentially relate to a researcher, author, or key figure in the study. Recognizing contributors is crucial in academic writings to acknowledge expertise, knowledge, and influence on the study's design and outcomes.

15) Blood:
'Blood' might refer to systemic conditions affecting ocular perfusion relevant to glaucoma management. Understanding how blood parameters relate to disease outcomes can inform treatment strategies, emphasizing the interconnectedness of systemic and ocular health.

16) Line:
'Line' in research often refers to a protocol or sequence in study design. In clinical studies, following a clear methodology ensures that analyses are structured and results are interpretable, advancing knowledge of treatment effectiveness.

17) Tanu:
'Danu' could potentially refer to a contributor's name in the study. Acknowledging individual contributions within research publications is important for academic integrity, offering insight into the credibility and depth of the research undertaken.

18) Tam:
'Tham' may also symbolize a researcher or author contributing to this field. Identifying key contributors lends weight to the research, allowing readers to trace the foundation upon which current findings are built.

19) Discussion:
'Discussion' refers to the section in research articles where results are interpreted and contextualized. This part is critical for linking findings to existing knowledge, highlighting implications for practice or further research and synthesizing the study's contributions.

20) Account:
'Account' in research often refers to the consideration or acknowledgment of various factors influencing results. In clinical studies, accounting for variables ensures comprehensive analyses, in turn leading to more robust conclusions on treatment efficacy.

21) Burning (Burn, Burned, Burnt):
'Burning' may relate to an adverse effect experienced by participants during treatment. Reporting such events is crucial in medical research to ensure that treatment benefits outweigh side effects, guiding physicians towards the safest and most effective therapies.

22) Science (Scientific):
'Science' embodies the systematic study of the structure and behavior of the physical and natural world through observation and experiment. In healthcare, scientific principles guide the development of effective treatments and enhance understanding of diseases like glaucoma.

23) Surface:
'Surface' may refer to the ocular surface, relevant in evaluating treatments affecting eye health. Investigating the impact of medications on ocular surface health is vital as it influences patient adherence and overall treatment success.

24) Panda (Pamda):
While 'Panda' might not directly align with the context, it could denote a specific study or author's name. Recognizably associating researchers with their contributions fosters a deeper understanding of the research landscape and validates ongoing academic dialogues.

25) Field:
'Field' can refer to an area of study or specialization. In this research context, it implies the field of ophthalmology or glaucoma management, emphasizing the importance of targeted studies to advance knowledge and treatment methodologies in specific medical disciplines.

26) Visit:
'Visit' typically refers to patient consultations or follow-ups in clinical studies. Regular visits allow healthcare professionals to monitor treatment efficacy and patient responses closely, contributing to personalized care strategies and adherence assessments.

27) Food:
While not explicitly related to the primary study context, 'Food' can encompass the dietary factors that may influence systemic health and, indirectly, conditions like glaucoma. Nutrition may play a.role in overall well-being and disease management, indicating the need for holistic treatment approaches.

28) Lamp:
In the medical field, a 'Lamp' can refer to the slit lamp used in eye examinations. This indispensable tool allows ophthalmologists to assess the anterior segment of the eye, essential for diagnosing glaucoma and monitoring treatment.

29) Post:
'Post' typically refers to a communication or report shared after an event. In research discussions, posting results allows for wider dissemination of findings, facilitating knowledge transfer and ongoing academic discourse.

30) Male:
In medical research, 'Male' refers to one of the genders examined as part of study demographics. Gender differences can impact disease prevalence, treatment responses, and adherence rates, essential in tailoring patient care and clinical recommendations.

31) Chan:
'Chan' could be a surname associated with an author or researcher contributing to the study. Highlighting individual contributions aids in recognizing expertise within the research community and acknowledges the collaborative nature of scientific inquiry.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Effectiveness of Fixed vs. Non-Fixed Dorzolamide/Timolol in Glaucoma’. Further sources in the context of Science might help you critically compare this page with similair documents:

Chemotherapy, Eye disease, Medication, Ophthalmology, Blood-pressure, Conflict of interest, Statistical analysis, Research, Significant difference, Treatment group, Clinical trial, Heart rate, Study design, Visual impairment, Treatment effect, Meta analysis, Systematic Review, Medication adherence, Visual field defect, Synergistic effect, Study participants, PMC free article, PubMed, Google Scholar, Primary open angle glaucoma, Intraocular pressure, Clinical profile, Treatment method, Medication regimen, Skin cancer, Ocular examination, Ocular hypertension, Study findings, Adjunctive therapy, Monotherapy, Tertiary care centre, Treatment compliance, Prostaglandin analogue, Anti glaucoma drug, Glaucoma treatment, Preservative free, Patient adherence, Medical therapy, Fixed combination, Global prevalence, Optic Neuropathy, Open-Angle Glaucoma, Randomised controlled trial, Ocular Hypertension Treatment, Logistic Support, Ministry of Health, Adherence to medication, Carbonic anhydrase inhibitor, Clinical practice guideline, Authors contribution, Study material.

Concepts being referred in other categories, contexts and sources.

Fund.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: