Verification of the Caretium XC-A30 ESR Analyser Method

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Journal name: The Malaysian Journal of Medical Sciences
Original article title: Method Verification of the Caretium XC-A30 Automated Erythrocyte Sedimentation Rate Analyser for Erythrocyte Sedimentation Rate
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

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Author:

Soemwit Khongwichit, Menapha Saelim, Yanisa Na-Songkhla, Hansuk Buncherd, Chawadee Nopparatana, Kanitta Srinoun


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Method Verification of the Caretium XC-A30 Automated Erythrocyte Sedimentation Rate Analyser for Erythrocyte Sedimentation Rate

Year: 2022 | Doi: 10.21315/mjms2022.29.5.5

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

The erythrocyte sedimentation rate (ESR) test is a widely used laboratory examination to assess inflammation in the body. Traditionally, the Westergren method serves as the gold standard for measuring ESR; however, this method is characterized by limitations, including lengthy analysis time and substantial blood volume requirements. Recent advancements have led to the development of automated and alternative methods for ESR measurement, aiming to improve efficiency, reduce sample volume, and provide timely results. This study focuses on evaluating the analytical performance of the Caretium XC-A30 automated ESR analyser in comparison with the Westergren method.

Precision and Accuracy of the Caretium XC-A30

The Caretium XC-A30, an automated ESR analyser, employs infrared photometric aggregometry to quantify sedimentation rates in less time than the conventional methods. In a comparative study involving 125 patient samples, the Caretium XC-A30 exhibited a high correlation with the Westergren method, with an overall correlation coefficient of 0.97. However, subgroup analysis revealed notable variations based on sedimentation rates, especially in the upper analytical range, which exhibited a significant mean bias of 16.4 mm between the two methods. Precision studies indicated that while the Caretium XC-A30 produced acceptable precision values, there were higher variability levels associated with abnormal controls compared to normal controls, highlighting the need for careful interpretation of results in clinical applications.

Conclusion

The findings demonstrate that the Caretium XC-A30 provides reliable and rapid ESR measurements, making it a viable alternative for laboratories seeking to enhance their workflow and efficiency. Despite this, the significant discrepancies at higher ESR values relative to the traditional Westergren method warrant cautious clinical interpretation. Future research involving larger sample sizes and varying clinical conditions is necessary to further validate the accuracy and potential impacts of this automated technology on patient management and diagnosis.

FAQ section (important questions/answers):

What is the purpose of the Caretium XC-A30 ESR analyser?

The Caretium XC-A30 ESR analyser is designed to automate the measurement of erythrocyte sedimentation rate (ESR), improve laboratory workflow, and reduce blood volume requirements, providing a more efficient testing process compared to traditional methods.

How does the Caretium XC-A30 compare to the Westergren method?

The Caretium XC-A30 exhibited a high correlation coefficient of 0.97 when compared to the Westergren method, indicating that the automated analyser can reliably deliver ESR results, though a notable mean bias was observed at higher sedimentation values.

What methods were used to evaluate the Caretium XC-A30's performance?

The evaluation included precision studies using control samples, patient sample analysis, method comparison with the Westergren method, and stability tests to confirm the reliability and accuracy of the Caretium XC-A30 ESR analyser.

What were the conclusions about the Caretium XC-A30's accuracy?

The Caretium XC-A30 analyser demonstrated satisfactory precision and accuracy for ESR measurements, making it a suitable instrument for routine analysis, but results, especially at higher ESR values, should be interpreted with caution due to potential biases.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Verification of the Caretium XC-A30 ESR Analyser Method”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A table is an organized arrangement of data, usually in rows and columns, which simplifies the presentation of complex information. In the context of scientific studies, tables display experimental results, making it easier for researchers to compare and analyze findings. They serve as a vital component for effective communication of results.

2) Measurement:
Measurement refers to the process of quantifying attributes or characteristics of variables, such as time, length, mass, or in this case, the erythrocyte sedimentation rate (ESR). Accurate measurement is crucial in scientific research as it provides evidence to support conclusions and allows for reliable comparisons between different studies.

3) Blood:
Blood is a vital fluid in the human body, containing red blood cells, white blood cells, platelets, and plasma. It plays essential roles in transporting oxygen, nutrients, and waste materials. In the context of the study, blood samples analyzed for the ESR provide essential diagnostic information on inflammatory conditions.

4) Study (Studying):
A study is a detailed investigation and analysis of a specific subject or phenomenon. In scientific research, studies aim to generate new knowledge, validate existing information, or explore relationships between variables. The referenced study assesses the performance of automated ESR analyzers, contributing to the understanding of their reliability in clinical settings.

5) Medium:
Medium can refer to an intermediate state, substance, or a way of conducting measurements. In the context of the research, different ESR measurement techniques can be categorized into medium effectiveness concerning accuracy and convenience. This study compares various methods, assessing how medium precision impacts clinical diagnostics.

6) Performance:
Performance refers to how effectively and accurately a method, instrument, or system operates. In the medical field, assessing the performance of diagnostic tools like the ESR analyzer is vital to ensure reliability and clinical effectiveness. Enhanced performance can lead to quicker diagnoses and more effective patient management in healthcare.

7) Rules:
Rules often refer to established protocols or guidelines that dictate how experiments should be conducted or data should be interpreted. Following rules ensures standardization, enhances reproducibility, and validates results in scientific studies. In ESR testing, adhering to international guidelines helps maintain testing accuracy and comparability.

8) Gold (Golden):
The term 'gold standard' signifies the most reliable and authoritative benchmark against which other methods are compared. In medical diagnostics, the Westergren method is considered the gold standard for measuring the erythrocyte sedimentation rate. Other testing methods are validated based on their agreement with this standard practice.

9) Inflammation:
Inflammation is a biological response to harmful stimuli such as pathogens, damaged cells, or irritants. It is characterized by redness, swelling, and heat, and can indicate underlying health conditions. The ESR test is primarily used to assess inflammation levels, providing critical information for diagnosing various inflammatory disorders.

10) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory disorder affecting joints, causing pain, swelling, and potential joint damage. The ESR is commonly used in diagnosing and monitoring this condition, as its levels indicate inflammation. This connection underscores the relevance of reliable ESR measurement methods in managing rheumatoid arthritis.

11) Reliability:
Reliability refers to the consistency and dependability of a measurement or method over repeated trials. In medical testing, high reliability decreases the risk of misdiagnosis and enhances patient care. This study evaluates the reliability of a new automated ESR analyzer, comparing it against the traditional Westergren method.

12) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illnesses. Advancements in medical technology, including automated testing methods, allow healthcare providers to deliver more efficient care. This study on ESR analyzers contributes to the evolving landscape of diagnostics and improves clinical decision-making processes.

13) Quality:
Quality reflects the degree of excellence of a product or process, which in healthcare translates to the accuracy and reliability of diagnostic tests. High-quality measurements in clinical laboratories improve patient outcomes and ensure trustworthy results. The study emphasizes quality assessments in comparing automated ESR analyzers to traditional methods.

14) Catta:
Chatta likely refers to a geographical or cultural context, but its specific relevance isn't clear within the medical or scientific framework related to the study. If it alludes to a contributor or researcher, it highlights collaborative approaches in scientific investigations. Further context is necessary to establish its role.

15) Cina:
China is a country where significant advancements in medical technology are being made. The Caretium XC-A30, an automated ESR analyzer developed in China, represents innovations emerging from this region. This technology plays a crucial role in modernizing laboratory procedures, emphasizing the global nature of healthcare advancements.

16) Kuti:
Kuti refers to a potential contributor or researcher associated with the study or relevant findings. Highlighting various contributors reflects the collaborative efforts necessary in scientific research, drawing on diverse expertise to validate methodologies and results, thereby enhancing the reliability of the conclusions drawn in studies.

17) Kaya:
Kaya might refer to another researcher or contributor that took part in the study or relevant findings. The mention of individual contributors illustrates the collaborative nature of scientific endeavors. Acknowledging their contributions is essential in valuing the multifaceted approach necessary to achieve reliable research outcomes.

18) Sah:
Similar to other names listed, Shah likely refers to an individual involved in the study. The inclusion of names emphasizes the teamwork behind research activities and highlights different expertise that contributes to the validation and development of medical instruments like the ESR analyzer.

19) Peng:
Peng, as with the other names mentioned, likely identifies a researcher or contributor relevant to the study. Recognizing the individuals behind scientific contributions reinforces the collaborative effort in developing reliable methodologies and interpreting results. Each contributor plays a vital role in advancing medical research.

20) Calculation:
Calculation refers to the mathematical process used to derive results from raw data, essential in determining metrics like the erythrocyte sedimentation rate. Accurate calculations are pivotal in clinical diagnostics to ensure that test outcomes are valid and useful for patient management, guiding healthcare providers’ decisions.

21) Discussion:
Discussion is the section of a research paper where authors interpret their findings, relate them to existing literature, and explore implications for future research or clinical practice. It is crucial for contextualizing study results, elaborating on their significance, and suggesting directions for further investigation.

22) Science (Scientific):
Scientific pertains to the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. This framework is foundational in developing reliable testing methods, such as automated ESR analyzers, ensuring that medical practices are evidence-based and grounded in rigorous research.

23) Knowledge:
Knowledge refers to the understanding gained through study, experience, or education. In the context of medical sciences, accumulating knowledge informs clinical practices, improves diagnostic methods, and ultimately benefits patient care. Research contributions such as this study augment the collective knowledge base necessary for advancing healthcare.

24) Swelling:
Swelling pertains to the enlargement of body parts due to inflammation or injury. It is often a clinical sign that can relate to underlying conditions being investigated through tests like the ESR. Understanding the causes and implications of swelling is crucial for accurate diagnosis and effective treatment.

25) Post:
Post can denote an aftereffect, such as procedures or conclusions after an experiment. In a scientific context, it can refer to discussions or publications that follow research activities. Furthermore, it emphasizes the importance of disseminating findings to enhance understanding and spur further inquiry in the medical community.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Verification of the Caretium XC-A30 ESR Analyser Method’. Further sources in the context of Science might help you critically compare this page with similair documents:

Clinical evaluation, Clinical condition, Erythrocyte sedimentation rate, Correlation coefficient, Sample collection, Acute phase response, Coefficient of Variation, Sample stability, Routine Analysis, Spearman's rank correlation, Analytical performance, Patient Samples, Control sample, Westergren method.

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