Hippocampal Parcellation via Prefrontal Cortex Connectivity in Malays
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Parcellation of the Hippocampus According to Its Connection Probability with Prefrontal Cortex Subdivisions in a Malaysian Malay Population: Preliminary Findings
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Aimi Nadhiah Abdullah, Asma Hayati Ahmad, Rahimah Zakaria, Sofina Tamam, Jafri Malin Abdullah
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Parcellation of the Hippocampus According to Its Connection Probability with Prefrontal Cortex Subdivisions in a Malaysian Malay Population: Preliminary Findings
Year: 2021 | Doi: 10.21315/mjms2021.28.3.6
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
The hippocampus, a crucial structure in the medial temporal lobe, plays an essential role in spatial navigation, learning, and memory. It is involved in distinct functions, with the dorsal subregion primarily linked to processing spatial information while the ventral portion is more associated with emotional and motivational behaviors. The prefrontal cortex (PFC), responsible for higher-order cognitive processes, has subdivisions that interact with the hippocampus. However, the specific structural connectivity between different regions of the hippocampus and the subdivisions of the PFC, particularly in the Malaysian population, has not been thoroughly investigated. This study aims to explore the structural connectivity using diffusion magnetic resonance imaging (dMRI) to understand hippocampal connections with PFC subdivisions in healthy Malaysian subjects.
Connectivity Patterns between the Hippocampus and PFC
The study's findings revealed that the hippocampus connects to all subdivisions of the PFC, with the orbitofrontal cortex (OFC) exhibiting the greatest connectivity. The parcellation of the hippocampus based on connection probabilities showed variability in distribution patterns across subjects, with no definitive distinction between subregions. Notably, individual analyses highlighted that while most subjects exhibited strong connections between the hippocampus and the OFC, one subject displayed a unique connection pattern favoring the dorsolateral prefrontal cortex (DLPFC) in the left hemisphere. These results suggest that the connectivity patterns between the hippocampus and PFC vary significantly among individuals, challenging preconceived notions regarding the structural organization of these regions.
Conclusion
The research underscores the critical role of the OFC in the connectivity between the hippocampus and PFC, reinforcing the idea that both regions contribute to cognitive mapping and decision-making processes. However, the lack of a unifying pattern in hippocampal connectivity emphasizes the complexity of these interactions and suggests that structural connectivity does not strictly conform to established anatomical boundaries of the hippocampus. Given the small sample size in this study, further research with larger cohorts is necessary to confirm these findings and to better understand the intricate relationships between the hippocampus and PFC subregions, which may have implications for understanding various cognitive and emotional processes.
FAQ section (important questions/answers):
What roles does the hippocampus play in the brain?
The hippocampus is crucial for spatial navigation, memory processing, and emotional behavior. Specifically, its dorsal region processes spatial information and memory, while the ventral region is associated with emotions and motivation.
What methods were used to study hippocampal-prefrontal connectivity?
Diffusion magnetic resonance imaging (dMRI) with probabilistic tractography was utilized to examine the structural connectivity between the hippocampus and six prefrontal cortex subdivisions in healthy Malaysian males.
What were the main findings regarding hippocampal connectivity?
The study found that the hippocampus exhibited the highest connectivity to the orbitofrontal cortex (OFC). However, there was considerable variability in connectivity patterns among participants and no clear distinction between hippocampal subregions.
What limitations were noted in this hippocampal connectivity study?
Limitations included a small sample size of four subjects and reliance on probabilistic tractography, which may produce false positives and negatives. Further studies with larger populations and specific region analysis are needed for clearer conclusions.
Glossary definitions and references:
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Other Science Concepts:
Discover the significance of concepts within the article: ‘Hippocampal Parcellation via Prefrontal Cortex Connectivity in Malays’. Further sources in the context of Science might help you critically compare this page with similair documents:
Emotional regulation, Cognitive processes, Cognitive function, Emotional control, Statistical analysis, Human brain, Hippocampus, Disease progression, Long-term potentiation, Magnetic resonance imaging, Dorsolateral prefrontal cortex, Economic value, Neuronal activity, Working memory, Neural circuits, Prefrontal Cortex, Anatomical Connectivity, Emotional behavior, Traumatic brain injury, Cognitive map, Diffusion-weighted imaging, Dopamine neurons, Corticospinal tract, Repeated-measures ANOVA, Amygdala, Episodic memory, Quantitative investigation, Diffusion-weighted MR imaging, Entorhinal cortex, Dentate gyrus.
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