HAV and HBV Prevalence among Jaundice Patients in Mombasa, Kenya
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Gordon Ochieng’ Kasera, John M Maingi, Omondi Kevin Onyango, Anthony Kebira Nyamache
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya
Year: 2021 | Doi: 10.21315/mjms2021.28.3.5
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Hepatitis A and B viruses (HAV and HBV) pose significant health risks worldwide, particularly in sub-Saharan Africa where they contribute to considerable morbidity and mortality. The study conducted at Coast General Hospital in Mombasa County, Kenya, sought to determine the prevalence of HAV and HBV among jaundice patients and to explore the genetic diversity of HBV in the region. Ethical approval was obtained for this cross-sectional study, which analyzed samples from 222 patients between February and August 2018, focusing on the demographic characteristics and clinical history associated with hepatitis infections.
Predominance of HBV A1 Genotype
A key finding from this study was the significant prevalence of HBV, with 21.2% (n = 47) of patients testing positive for the virus, and notably no presence of HAV detected among the participants. The results showed a marked predominance of the HBV A1 genotype, which accounted for 74.5% (n = 35) of the analyzed strains. The study also identified the presence of other genotypes, including A2, A3, B, and C2, which were less frequent. The high transmission potential of HBV, particularly in males and among individuals aged 25 to 38 years, suggests that specific behavioral and social factors may be influencing the spread of this virus in the region.
Conclusion
The findings of this study reveal a significant public health concern regarding HBV in Mombasa County, highlighting both a concerning prevalence and previously unrecorded genotypes circulating in the region. The absence of Hepatitis A, following an outbreak in 2016, denotes the potential for community immunity; however, the presence of HBV underscores the necessity for ongoing surveillance and intervention strategies. The study emphasizes the need for further research into the epidemiological factors driving HBV transmission, and the importance of public health initiatives aimed at reducing infection rates among vulnerable populations in Kenya.
FAQ section (important questions/answers):
What is the purpose of the study conducted at Coast General Hospital?
The study aimed to determine the proportion of hepatitis A and B viruses among jaundice patients and to analyze the genetic diversity of hepatitis B virus among those infected at the Coast General Hospital, Mombasa County, Kenya.
What were the findings regarding hepatitis A infections in the study?
The study found no cases of hepatitis A (HAV) among the 222 patients screened, suggesting a low prevalence possibly due to previous outbreaks and public health awareness.
What was the overall prevalence of hepatitis B among the patients?
The overall prevalence of hepatitis B virus infection (HBV) among the 222 patients was 21.2%, with a higher prevalence observed among males compared to females.
Which hepatitis B virus genotypes were detected in this study?
The study revealed that HBV A1 genotype was the most predominant, followed by A2, and newly detected genotypes A3, B, and C2 were also noted, indicating diversity.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “HAV and HBV Prevalence among Jaundice Patients in Mombasa, Kenya”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Viru:
The term 'Viru' appears to refer to viruses, particularly hepatitis viruses like Hepatitis A (HAV) and Hepatitis B (HBV). Viruses are crucial in the context of this study as the research assesses the prevalence and genetic diversity of these pathogens among jaundice patients in Kenya, informing public health strategies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘HAV and HBV Prevalence among Jaundice Patients in Mombasa, Kenya’. Further sources in the context of Science might help you critically compare this page with similair documents:
Age, Gene, Discussion, Keyword, Conclusion, Pregnant women, Jaundice, Introduction, Group, Result, Statistical analysis, Patient, Occupation, Age-group, Sample size, Statistical Significance, Study population, Public Health Problem, Hepatitis B surface antigen, Hepatitis B Virus, P Value, Study design, Cross-sectional study, Chi square test, Viral Infection, Hepatitis B, Genetic Diversity, HIV infection, Study participants, Clinical history, Marital Status, Odds ratio, Confidence interval, Mean age, Standard deviation, Human immunodeficiency virus, Ethical approval, Risk factor, Viral hepatitis, High risk group, Purposive Sampling, Prevalence, PCR amplification, Phylogenetic tree, Chi-square, Phylogenetic analysis, Faecal-oral route, Hepatitis C virus, PCR, Venous blood sample, Risk, Hepatitis B infection, HBsAg, Blood sample, Genotype, Viral DNA Extraction, Ethical Review Committee, Antenatal clinic, HIV infected adults, Sub-Saharan Africa, Body fluid, Viral genotype, Technical support, Outbreak, Logistic Support, High risk population, Viral strain, HIV Negative, Infection, HBV infection, HIV-positive, Self-structured questionnaire, Administrative support, Abstract background, Serological analysis, Continuous surveillance, HIV-infected individuals, Human immunodeficiency virus infection, Infected blood, Study material, PLoS ONE, Ethidium bromide staining, Viral DNA, Demographic characteristic.
Concepts being referred in other categories, contexts and sources.
Sex, Male, Study, Region, Test, Old, Diversity, Status, New, Analysis, Case, High, Method, Female, Area.