Expression of Circulating MicroRNA-141 in Epithelial Ovarian Cancer
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Expression of Circulating MicroRNA-141 in Epithelial Ovarian Cancer
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Akbar Satria Fitriawan, Aprilia Indra Kartika, Siti Nur Chasanah, Teguh Aryandono, Sofia Mubarika Haryana
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Expression of Circulating MicroRNA-141 in Epithelial Ovarian Cancer
Year: 2020 | Doi: 10.21315/mjms2020.27.6.4
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Epithelial ovarian cancer (EOC) is a significant health challenge for women worldwide, primarily due to its high mortality rate linked to late-stage diagnosis. Early detection is complicated by the asymptomatic nature of the disease and the inadequacy of existing screening methods. Recent research highlights the potential role of microRNA (miR) as non-invasive biomarkers for cancer detection. The current study focuses on evaluating the expression of miR-141 in the blood plasma of EOC patients compared to healthy individuals, aiming to determine its viability as a biomarker associated with the cancer's clinical stage.
Upregulation of miR-141 in EOC
The study revealed a notable upregulation of miR-141 in the blood plasma of EOC patients, with an increase of 8.41 times compared to healthy controls (P < 0.001). In addition, the expression of miR-141 was significantly higher in patients diagnosed at advanced stages of the disease, marked by a 4.2-fold increase compared to those in the early stages (FIGO stages I and II; P < 0.001). These findings indicate that miR-141 might serve not only as a potential biomarker for EOC detection but also as a reflective measure of disease progression, suggesting its relevance in identifying patients with more severe disease at diagnosis.
Conclusion
In summary, the research underscores the promising role of circulating miR-141 as a minimally invasive biomarker for EOC, demonstrating its higher expression levels in patients compared to healthy controls and its association with advanced disease stages. The findings support the idea that miR-141 could be integrated into screening protocols to enhance early detection efforts for EOC, ultimately aiming to improve patient outcomes and reduce mortality associated with this deadly cancer. Further investigations are warranted to evaluate the sensitivity and specificity of miR-141 in clinical settings.
FAQ section (important questions/answers):
What is the significance of miR-141 in ovarian cancer?
MiR-141 is implicated in ovarian carcinogenesis and shows potential as a non-invasive biomarker for detecting epithelial ovarian cancer (EOC), especially correlating with disease stages.
How was the study on miR-141 conducted?
The study involved blood plasma samples from 30 EOC patients and 25 healthy controls. miR-141 expression was analyzed using quantitative PCR to assess its potential as a biomarker.
What were the main findings regarding miR-141 expression?
MiR-141 was significantly upregulated in EOC patients, showing an 8.41-fold increase from healthy controls. In advanced-stage patients, it was also upregulated 4.2 times compared to early-stage patients.
What is the urgent need identified in the study?
There is a need for effective and minimally invasive screening methods for early detection of ovarian cancer, as late diagnosis often leads to poor prognosis.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Expression of Circulating MicroRNA-141 in Epithelial Ovarian Cancer”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Cancer:
Cancer refers to a group of diseases characterized by the uncontrolled proliferation of abnormal cells. It can arise in various tissues and is often classified into types based on the origin. Early detection and effective treatments are crucial for improving survival rates, and biomarkers, such as miRNAs, play a role in diagnostics.
2) Table:
In scientific literature, a table is a structured format used to present data clearly and concisely. Tables allow researchers to summarize findings, comparisons, or statistical analyses visually, aiding in the understanding of complex information such as demographics, experimental results, or other quantitative data essential for research interpretation.
3) Study (Studying):
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Disease encompasses a wide range of health conditions characterized by physiological dysfunction, especially those categorized as acute or chronic. Understanding disease mechanisms, risk factors, progression, and effects on quality of life is vital in medicine, leading to targeted treatments, preventive measures, and improved patient care outcomes.
5) Blood:
Blood is a vital bodily fluid responsible for transporting nutrients, oxygen, and waste products throughout the body, playing a crucial role in maintaining homeostasis. In medical research, blood samples are invaluable for identifying biomarkers, detecting diseases like cancer through abnormalities in components like microRNAs, and assessing physiological states.
6) Relative:
Relative refers to the comparison of quantities or values in relation to one another. In research, such as the context of miRNA expression, relative measures are essential for understanding changes due to specific conditions, enabling effective statistical analyses and providing insights into biological significance and clinical relevance in studies.
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Tuberculosis (TB) is an infectious disease primarily affecting the lungs, caused by the bacterium Mycobacterium tuberculosis. Understanding TB's etiology, symptoms, diagnosis, and treatment is fundamental in public health, as its impact on populations can be severe. TB can also complicate the diagnosis of other conditions, like ovarian cancer.
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Other Science Concepts:
Discover the significance of concepts within the article: ‘Expression of Circulating MicroRNA-141 in Epithelial Ovarian Cancer’. Further sources in the context of Science might help you critically compare this page with similair documents:
TRANSLATION, Early stage, Advanced stage, Early diagnosis, Physiological condition, Pathological condition, Statistical analysis, Different diseases, Control group, Healthy subjects, Sample size, Early detection, Clinical Practice, Cross-sectional study, BMI, Gene expression, Histological examination, Mortality Rate, Sample size calculation, Tumor suppressor gene, Clinical stage, Molecular genetics, Real-time PCR, Pelvic examination, DNA methylation, Statistical analyses, Patient characteristics, Pelvic organs, Plasma samples, Mann-Whitney test, Tumor microenvironment, Congestive Heart Failure, Prostate cancer, Cancer progression, Poor prognosis, Epithelial Cells, Hepatocellular Carcinoma, Global Incidence, Clinical outcome, Cell migration, Benign Ovarian Masses, Biomarker, CDNA synthesis, Sensitivity and Specificity, FIGO staging, Real-time quantitative PCR, Molecular mechanism, Paclitaxel, Histological type, Transvaginal Ultrasonography, Gastric cancer, Therapeutic target, Ovarian cancer, Tumor marker, RNA extraction, Ovarian Volume, Chronic Lymphocytic Leukemia, Healthy control group, High sensitivity, Fold change, Tumor suppressor, Early stage disease, Oncogene, Blood sample, Cancer development, Nanodrop spectrophotometer, Molecular biomarkers, High mortality rate, Epithelial Ovarian Cancer, CA-125, Ovarian Cancer Detection, High specificity, Disease severity, Cancer metastasis, Cross-sectional design, Clinical sample, MicroRNA, Reverse transcription, Tumour microenvironment, Tumor Metastasis, Screening method, Clinical sample collection, Serous type, Carboplatin, Blood plasma, MicroRNA (miRNA), MicroRNA expression, Detection method, Blood plasma samples, Nasopharyngeal carcinoma, CDNA, Clear cell carcinoma, Histological subtype, Non-coding RNA, Non-invasive biomarker, DNA hypomethylation, Endometrioid carcinoma, Tumour suppressor protein, Relative gene expression, Real-time quantitative polymerase chain reaction, Cancer-epigenetics, DNA hypermethylation, Human cancer, Genetic alteration.
Concepts being referred in other categories, contexts and sources.