Prognostic Factors in Relapsed Myeloma Patients in North East Malaysia

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: Relapsed/Progressive Disease and Its Prognostic Factors among Multiple Myeloma Patients Receiving Novel Agent Treatment in North East Peninsular Malaysia: A Single Centre Experience
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

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Author:

Hany Haqimi Wan Hanafi, Azlan Husin, Najib Majdi Yaacob, Abu Dzarr Abdullah


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Relapsed/Progressive Disease and Its Prognostic Factors among Multiple Myeloma Patients Receiving Novel Agent Treatment in North East Peninsular Malaysia: A Single Centre Experience

Year: 2020 | Doi: 10.21315/mjms2020.27.5.7

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

Multiple myeloma (MM) is a blood cancer characterized by the clonal proliferation of malignant plasma cells, resulting in various complications such as bony lesions and renal injury. Despite advancements in treatment, particularly with novel agents, some patients still experience relapse or disease progression. This study aimed to assess the time to relapse/progression (TTP) in MM patients receiving novel agents at Hospital Universiti Sains Malaysia and identify contributing prognostic factors, particularly focusing on a Malaysian population where data on MM has been sparse.

Importance of Autologous Stem Cell Transplantation

The study found an overall median TTP of 29.33 months, with 64% of patients experiencing a biochemical relapse. Notably, the use of autologous stem cell transplantation (ASCT) emerged as the sole independent prognostic factor significantly associated with longer TTP. Patients who underwent ASCT had a median TTP of 48.16 months compared to just 18.38 months for those who did not. This highlights the critical role of ASCT in MM treatment, emphasizing that it substantially contributes to improved outcomes for patients, further solidified by its statistical significance in the multivariable analysis.

Conclusion

In conclusion, the findings underscore the necessity of regular paraprotein monitoring to detect early relapse features among MM patients, as most exhibited biochemical rather than clinical relapses. ASCT stands out as a pivotal factor in potentially extending TTP in patients receiving novel agents, marking it as an essential consideration in the treatment plan. This research provides valuable insights into the management of MM in Malaysia and offers a foundation for further studies to explore the effectiveness of various treatment regimens and their outcomes in diverse populations.

FAQ section (important questions/answers):

What was the focus of the multiple myeloma study in Malaysia?

The study aimed to evaluate the time to relapse/progression among multiple myeloma patients receiving novel agents and to identify the associated prognostic factors affecting their treatment outcomes.

What were significant findings regarding relapse types in multiple myeloma patients?

The study found that 64% of patients had biochemical relapse/progression, with those having asymptomatic types experiencing a longer time to progression compared to those with symptomatic types.

Which prognostic factor was found to be significant for relapse/progression?

Autologous stem cell transplant (ASCT) emerged as the only significant prognostic factor identified that could influence the risk of relapse/progression in patients receiving novel agent therapy.

What was the median time to relapse/progression for the patients?

The overall median time to relapse/progression among multiple myeloma patients receiving novel agents was 29.33 months, reflecting comparable findings with previous studies in literature.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Prognostic Factors in Relapsed Myeloma Patients in North East Malaysia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In research articles, a 'Table' presents data systematically, allowing readers to quickly grasp complex information. Tables facilitate comparative analysis and aid in illustrating findings clearly. They often summarize results, such as patient demographics or treatment outcomes, making them essential for effective communication in scientific studies, especially within clinical research contexts.

2) Study (Studying):
A 'Study' refers to the structured process of investigation aimed at acquiring knowledge, testing hypotheses, or understanding phenomena. In medical research, studies can validate treatment efficacy, identify prognostic factors, and influence clinical practices. The rigor and design of a study are crucial for credibility and the applicability of its findings.

3) Blood:
In the context of medicine, 'Blood' is vital for understanding multiple myeloma and other diseases. It serves as a medium for transporting nutrients and waste and is essential in evaluating disease progression through various tests. Analyzing blood samples can provide insights into hematologic conditions, informing treatment options in oncology.

4) Disease:
'Disease' encompasses a wide range of health issues that disrupt normal bodily functions. Understanding various diseases, especially cancers like multiple myeloma, is crucial for research and treatment development. Recognizing disease mechanisms enables healthcare professionals to implement effective therapies, ultimately improving patient outcomes and enhancing public health knowledge.

5) Cancer:
'Cancer' indicates a group of diseases characterized by uncontrolled cell growth. It is a leading cause of morbidity and mortality worldwide. Understanding cancer biology helps researchers develop targeted therapies, influencing treatment strategies. Awareness of cancer's complexity underscores the need for continuous research to improve diagnostic, therapeutic, and preventive measures.

6) Chemotherapy:
'Chemotherapy' involves the use of drugs to treat cancer by killing or inhibiting the growth of cancerous cells. It plays a pivotal role in cancer treatment regimens, including multiple myeloma management. Understanding chemotherapy's mechanisms and side effects informs treatment planning and patient care, highlighting its importance in oncology.

7) Kappa:
'Kappa' refers to one of the types of immunoglobulin light chains produced by plasma cells in the body. Its measurement is crucial in diagnosing and monitoring multiple myeloma. Abnormal kappa light chain levels can indicate disease progression, making it an important biomarker in the clinical evaluations of hematological malignancies.

8) Male:
'Male' commonly refers to a biological sex characterized by XY chromosomes, typically producing sperm and having male reproductive anatomy. In medical studies, understanding how male physiology affects health outcomes, particularly in diseases such as multiple myeloma, aids in tailoring effective treatment protocols and improving overall patient care.

9) Rules:
In clinical research, 'Rules' refer to the established guidelines and protocols governing study design, data collection, and analysis. Compliance with these rules ensures scientific rigor, ethical standards, and reproducibility of results. Understanding and adhering to research rules is essential for producing valid and reliable scientific findings.

10) Observation:
'Observation' in research refers to the act of carefully monitoring and recording phenomena to gather data. In clinical studies, observations can involve patient responses to treatments, disease progression, or side effects. This process is fundamental for scientific inquiry, leading to insights that inform therapeutic decisions and enhance patient care.

11) Post:
'Post' often indicates a point in time following a specific event or treatment. In medical research, post-treatment evaluations help assess the effectiveness of interventions and monitor for any adverse effects. Tracking post-treatment outcomes is critical in determining long-term success and refining future treatment strategies.

12) Drug:
'Drug' denotes any chemical compound utilized to diagnose, treat, or prevent diseases. In the context of multiple myeloma, new and novel agents have revolutionized treatment approaches. Understanding the therapeutic use, mechanism of action, and potential side effects of drugs is essential for optimizing patient management in oncology settings.

13) Calculation:
'Calculation' involves mathematical processes used to derive meaningful data from raw information. In clinical research, calculations are fundamental for determining sample sizes, statistical analyses, and treatment dosages. Accurate calculations ensure the reliability of results and help guide clinical decision-making, emphasizing their importance in scientific inquiry.

14) Death:
'Death' is a critical concept in medical research, often serving as an endpoint in clinical trials assessing treatment efficacy. Analyzing mortality rates can provide insight into disease severity and the effectiveness of therapeutic interventions. Understanding factors associated with death inform care strategies and improve health outcomes in patient populations.

15) Fish:
In the medical context, 'Fish' often refers to fluorescence in situ hybridization (FISH), a cytogenetic technique used for identifying chromosomal abnormalities in cells. FISH plays a significant role in diagnosing and monitoring hematological diseases, such as multiple myeloma. Proper usage of FISH allows for improved risk stratification and treatment planning.

16) Measurement:
'Measurement' pertains to the quantitative assessment of variables, essential for scientific research and clinical practice. Accurate measurements of biomarkers, disease progression, or treatment response are crucial for making informed therapeutic decisions. It underscores the importance of standardization in methodologies to ensure comparability and robust data interpretation.

17) Reflecting:
'Reflecting' often denotes the process of considering or analyzing results critically. In the context of research, reflecting on findings aids in identifying patterns, drawing conclusions, and understanding implications for clinical practice. This cognitive process is essential for continuous learning and improving healthcare delivery based on evidence gathered.

18) Kumar:
'Kumar' may refer to an author or researcher noted for contributions in the field of medical research, including studies on diseases like multiple myeloma. Their findings often influence clinical guidelines and improve patient outcomes. Recognition of individual researchers' impacts highlights the collaborative nature of scientific advancement in healthcare.

19) Discussion:
'Discussion' is a section in research articles where authors interpret their findings, compare them with existing literature, and explore implications. This analytical dialogue enhances understanding and situates new knowledge within the broader scientific context. Engaging in meaningful discussions fosters collaboration and paves the way for future research directions.

20) Developing:
'Developing' refers to the process of advancing ideas, treatments, or technologies. In medicine, developing new therapies or protocols is crucial for improving health outcomes. The continuous evolution in treatment strategies, particularly in oncology, reflects ongoing research and innovation aimed at providing better care for patients with complex diseases.

21) Knowledge:
'Knowledge' encompasses the understanding gained through research, experience, or education. In medical contexts, knowledge refers to the expertise needed to inform clinical practice, enhance patient care, and drive innovation in treatment strategies. Continuous knowledge advancement is vital for maintaining high standards in healthcare and improving patient outcomes.

22) Writing:
'Writing' involves the communication of ideas through text. In scientific contexts, writing is essential for publishing research findings, enabling knowledge dissemination, and informing clinical practices. Clear, precise writing enhances understanding and fosters collaboration among researchers and healthcare professionals, ensuring that important findings reach relevant audiences effectively.

23) Account:
'Account' in a research context refers to a report or explanation of events, outcomes, or findings. In healthcare, maintaining accurate patient accounts is critical for monitoring treatment efficacy and understanding disease progression. Detailed accounts inform clinical decisions and contribute to the body of knowledge in medical research.

24) Science (Scientific):
'Science' denotes the systematic study of the natural world through observation and experimentation. In health and medicine, scientific inquiry is fundamental to understanding diseases and developing effective treatments. Science drives innovation and informs evidence-based practices, ultimately improving patient care and promoting public health advancements.

25) India:
'India' refers to a country significant in global health research, including cancer studies. Understanding disease patterns and treatment outcomes in India contributes to a comprehensive understanding of public health issues. The diverse population and varying healthcare access present unique challenges and opportunities for medical research and discovery.

26) Gold (Golden):
'Gold' in a medical context may symbolize the highest standard or a benchmark for treatment, often referred to as 'gold standard.' The gold standard represents the best available care based on evidence, helping guide clinical practice and ensuring that patients receive the most effective and reliable treatments.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Prognostic Factors in Relapsed Myeloma Patients in North East Malaysia’. Further sources in the context of Science might help you critically compare this page with similair documents:

Patient care, Course of treatment, Follow-up, Inclusion criteria, Exclusion criteria, Sample size, Clinical trial, Study population, Patient Monitoring, Complete remission, Cardiovascular disease, Mortality Rate, Symptomatic patients, Renal insufficiency, Serum albumin, Chronic respiratory disease, Study period, Primary endpoint, Lactate dehydrogenase, High risk group, Induction therapy, LDH, Retrospective cohort study, Chinese population, Prognostic value, Survival rate, Conventional chemotherapy, Confidence level, Clinical benefit, Overall survival, Risk stratification, Prognostic Factor, Autologous stem cell transplant, Stem cell transplantation, Type I error, Healthcare cost, Median survival time, Progression-free survival, Standard therapy, Survival analysis, Partial Response, Multiple myeloma, Immunomodulatory drug, Plasma cell leukaemia, Stem cell transplant, Novel agents, Biochemical relapse, Hazard ratio, Target population, Type II error, Novel treatment, Rescue treatment, Asymptomatic patient.

Concepts being referred in other categories, contexts and sources.

O, Ish, Fish.

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