Quercus infectoria Galls: Anti-parasitic Agents Study Review

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Journal name: The Malaysian Journal of Medical Sciences
Original article title: A Review of Quercus infectoria (Olivier) Galls as a Resource for Anti-parasitic Agents: In Vitro and In Vivo Studies
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Author:

Nik Nor Imam Nik Mat Zin, Wan Nur Addiena Wan Mohd Rahimi, Nurhidanatasha Abu Bakar


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: A Review of Quercus infectoria (Olivier) Galls as a Resource for Anti-parasitic Agents: In Vitro and In Vivo Studies

Year: 2019 | Doi: 10.21315/mjms2019.26.6.3

Copyright (license): CC BY 4.0


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Summary of article contents:

Introduction

Parasitic diseases pose significant challenges to global public health, economics, and the environment, exacerbated by the emergence of drug-resistant parasite populations, high drug development costs, and ongoing threats from vectors. Traditional anti-parasitic treatments are becoming increasingly ineffective, which underscores the importance of exploring alternative sources, particularly medicinal plants. This paper focuses on Quercus infectoria (commonly known as the oak galls), a plant traditionally used in various cultures for medicinal purposes, including the treatment of parasitic infections. A systematic review was undertaken to evaluate the anti-parasitic efficacy of Q. infectoria through both in vitro and in vivo studies, revealing its potential as a source of new anti-parasitic agents.

Summary of One Important Concept: Potential Anti-Parasitic Properties of Quercus infectoria

The systematic review identified a total of four relevant studies that demonstrated the anti-parasitic properties of Q. infectoria. The studies highlighted its effectiveness against various protozoan parasites such as Entamoeba histolytica, responsible for amoebic dysentery, and Blastocystis hominis, which can cause gastrointestinal disturbances in immunocompromised individuals. In vitro assays indicated a significant inhibition of parasite growth, with certain concentrations of methanol extracts achieving notable success in dose-dependent effects. For instance, extracts from Q. infectoria were found to kill 67% of B. hominis and significantly reduce the viability of E. histolytica in treated mice. These findings suggest that the plant's rich bioactive compounds, primarily phenolic compounds, play a vital role in its anti-parasitic mechanisms.

Conclusion

While the data on Quercus infectoria suggests promising anti-parasitic potential, particularly against Leishmania major and intestinal protozoa, the evidence remains insufficient for conclusive therapeutic endorsement. Further research is needed to validate these results, explore additional parasites, and elucidate the exact mechanisms by which Q. infectoria exerts its effects. This review highlights the necessity for comprehensive phytochemical analyses and standardization of extraction methods to optimize the medicinal properties of Q. infectoria. By addressing these research gaps, Q. infectoria may serve as a viable candidate for future anti-parasitic drug development.

FAQ section (important questions/answers):

What are the health impacts of parasitic diseases globally?

Parasitic diseases result in significant economic, environmental, and public health challenges worldwide. They lead to high morbidity and mortality rates, particularly in vulnerable populations, and contribute to healthcare burdens in many regions, necessitating effective treatment solutions.

What is the significance of Quercus infectoria in treating parasitic diseases?

Quercus infectoria galls are recognized for their potential anti-parasitic properties. Studies suggest that they exhibit activities against parasites such as Leishmania and Blastocystis, providing a promising direction for developing new treatment options from natural sources.

What methods were used to evaluate the efficacy of Q. infectoria?

A systematic review of literature from databases like PubMed demonstrated the anti-parasitic efficacy of Quercus infectoria extracts through in vitro and in vivo studies, focusing on various parasitic infections.

What challenges exist in developing new anti-parasitic drugs?

Challenges include the emergence of drug-resistant parasites, high costs of development, and the complex biological interactions between parasites and hosts, hindering the progress of new therapeutic options.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Quercus infectoria Galls: Anti-parasitic Agents Study Review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In scientific literature, a table is a structured way to present data, summarizing key findings from research. Tables allow for efficient comparison of results across different studies or experimental conditions, helping the reader to quickly understand the relevant information and draw conclusions about the efficacy or characteristics of the studied subjects.

2) Activity:
Activity in pharmacology often refers to the functional response of a compound or extract, such as its biological or therapeutic effects. Understanding the activity of a substance, particularly in medicinal plants, is essential for determining its potential use in treating diseases, guiding future research, and validating traditional remedies.

3) Drug:
A drug is any substance that causes physiological changes in the body. In the context of parasitic diseases, drugs aim to eliminate or inhibit the growth of parasites. The search for new and effective drugs, particularly from natural sources, is critical due to the emergence of drug-resistant strains and the toxicity issues of existing medications.

4) Disease:
Disease refers to a disorder of structure or function in a living organism. Understanding diseases, especially those caused by parasites, is crucial for developing effective treatments and interventions. Parasitic diseases can lead to significant public health issues, and the search for new solutions, including herbal remedies, is essential for addressing these challenges.

5) Study (Studying):
A study is a systematic investigation intended to establish facts and reach new conclusions. In the context of this research, studies examining the efficacy of medicinal plants like Quercus infectoria provide valuable insights into their potential roles in treating parasitic infections, highlighting the importance of evidence-based approaches in herbal medicine.

6) Toxicity:
Toxicity refers to the degree to which a substance can cause harm to organisms. In pharmacology, evaluating the toxicity of potential treatments, especially herbal extracts, is essential to ensure safety for human use. Understanding toxicity helps in safer drug development and identifying acceptable dosages to minimize adverse effects.

7) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing disease. It encompasses a wide range of health care practices, including the use of pharmaceuticals, surgeries, and natural remedies. The use of medicinal plants, such as Quercus infectoria, reflects the importance of exploring alternative treatments in response to resistant infections.

8) Science (Scientific):
Scientific refers to methods and principles grounded in empirical evidence and rational inquiry. In the context of this review, scientific approaches ensure that research on medicinal plants follows rigorous standards, leading to credible findings. This credibility is essential for integrating traditional knowledge and modern medicine in therapeutic development.

9) Flavonoid:
Flavonoids are a group of natural substances with variable phenolic structures that are found in many plants. They exhibit various biological activities, including anti-inflammatory, antioxidant, and anti-cancer properties. The presence of flavonoids in medicinal plants like Q. infectoria contributes to their therapeutic effects, emphasizing the potential health benefits of dietary phytochemicals.

10) Species:
Species refers to the basic unit of biological classification, consisting of individuals that can interbreed. The identification of species is crucial in parasitology, as different parasites (e.g., Plasmodium, Leishmania) may require specific treatments. The focus on species helps target research and treatments to combat specific types of infections effectively.

11) Phytochemical:
Phytochemicals are bioactive compounds produced by plants that have health benefits. They play a vital role in the medicinal properties of plants like Quercus infectoria. Understanding phytochemicals aids in recognizing their mechanisms of action and how they can support health, particularly in the treatment of parasitic diseases.

12) Kumar:
Kumar is a common South Asian surname; in scientific literature, specific authors such as those named 'Kumar' often contribute to research on medicinal plants and their applications. Recognizing the contributions of these researchers is important for tracing the development of knowledge and advancements in herbal medicine.

13) Food:
Food refers to any substance consumed to provide nutritional support for an organism. In terms of health, the nutritional value of food can play a role in disease prevention and treatment. Investigating antimicrobial properties of food plants, like Q. infectoria, can lead to identifying dietary interventions that promote health or combat infections.

14) Antibiotic (Antibacterial):
Anti-bacterial refers to substances that can combat bacterial infections. The increasing prevalence of antibiotic resistance drives the search for alternative treatments, particularly from natural sources. Investigating the anti-bacterial properties of plants like Q. infectoria can yield new compounds for treating infections that are resistant to conventional antibiotics.

15) Killing (Killed):
Killed refers to the action of causing death or extermination. In medical research, particularly regarding treatments, determining whether a substance kills pathogens helps assess its effectiveness. The capability of a compound to kill harmful organisms is a significant aspect of evaluating its overall therapeutic potential.

16) Animal:
Animals serve as crucial subjects in biomedical research, notably in studies investigating disease mechanisms and treatment efficacy. Animal models can provide insights into how a potential drug or treatment might perform in humans, making them vital for validating findings from in vitro studies before moving towards human trials.

17) Powder:
Powder typically refers to a finely ground substance. In herbal medicine, powdered extracts are commonly used to harness the bioactive compounds of the plant for therapeutic applications. The preparation of plant extracts in powdered form is essential for dosage standardization, facilitating research and clinical usage of medicinal plants.

18) Rules:
Rules in scientific research refer to established guidelines or principles that govern the methodology and conduct of studies. Following strict rules ensures that research findings are valid, reliable, and reproducible. Adhering to rules during systematic reviews and studies is essential for producing credible evidence regarding the efficacy of medicinal plants.

19) Chemotherapy:
Chemotherapy is a type of cancer treatment that uses drugs to kill cancer cells. In parasitology, it refers to the use of antimicrobial agents to treat parasitic infections. Understanding chemotherapy's role in treating diseases is pivotal, especially as researchers explore natural alternatives to conventional drugs, including plant-based treatments.

20) Performance:
Performance evaluates how well a particular treatment or extract achieves its intended effects. In the context of herbal research, performance is typically assessed through the efficacy of extracts against specific pathogens. Evaluating performance provides insight into the potential clinical applications and benefits of using herbal medicines.

21) Roman (Roma):
Roman may refer to the ancient civilization known for its innovations in many fields, including medicine. The study of ancient medicinal practices, including the use of plants, can inform modern approaches to herbal medicine. Understanding historical context may enhance current medicinal practices and encourage research on traditional remedies.

22) Wall:
In biological terms, a wall can refer to various types of barriers, such as cell walls in bacteria that can influence a pathogen's susceptibility to treatment. In the context of this research, understanding the structural aspects like cell walls helps in determining how plant extracts may disrupt pathogen growth.

23) Male:
Male refers to the sex of certain organisms, including humans, that produce small, mobile gametes (sperm). In research studies, specifying gender can be crucial since males and females may respond differently to treatments, potentially influencing the outcomes in efficacy studies of herbal medicines or pharmaceuticals.

24) Life:
Life refers to the condition that distinguishes organisms from inorganic substances, characterized by various biological processes. Understanding the life cycles of parasites is crucial in developing effective treatments. Studying how plants influence the life processes of pathogens provides insights into potential therapeutic mechanisms.

25) Indian:
Indian refers to anything related to India, a country with a rich tradition of herbal medicine. Understanding the historical and cultural contexts of Indian medicinal practices can inform contemporary research on plants such as Quercus infectoria, bridging traditional knowledge and modern scientific inquiry in pharmacology.

26) Adana:
Adana is a city in Turkey known for its historical significance and biodiversity. The geographical diversity of regions like Adana contributes to a variety of medicinal plants, including Quercus infectoria. Researching locally sourced plants aids in understanding their specific applications and benefits in regional medicine.

27) India:
India is a country with a long history of using herbal medicine and biodiversity. The vast array of medicinal plants found in India highlights its significance in traditional medicine. Exploring the local herbal remedies can lead to discovering new drugs and therapeutic agents for various diseases.

28) Death:
Death refers to the cessation of biological functions that sustain an organism. In a medical context, understanding mortality rates and causes of death, particularly from diseases like malaria or leishmaniasis, is vital for public health initiatives. Research focusing on treatment efficacy seeks to reduce mortality associated with infections.

29) Cina:
China is significant in medicinal herbal studies, having a vast reservoir of traditional medicine knowledge. Research on plants like Q. infectoria often incorporates data from different cultures, including Chinese medicine, enriching the understanding of herbal remedies. By integrating traditional wisdom and modern science, innovative treatments may emerge.

30) Alam (Alaṁ):
Alam, which means 'world' in various languages, is often used in literature and research to encompass a broader context of study. In pharmacological research, understanding the global implications of medicinal plants, including Q. infectoria, can inform practices and regulations in herbal medicine across different regions.

31) Tree:
A tree represents a significant source of biodiversity and medicinal compounds. Many trees are known for their therapeutic benefits and serve as vital components of traditional medicine. Examining the medicinal properties of trees like Quercus infectoria can unveil new treatments and contribute to preserving traditional practices.

32) Mast:
Mast might refer to mast cell, which plays a role in the immune response. Understanding the interaction between mast cells and parasites or antimicrobial treatments is crucial in developing effective therapies. The study of plant extracts on mast cells could lead to new insights into their antiparasitic properties.

33) Horn:
Horn can refer to various subjects, including authors, techniques, or parts of plants. In literature, authors with the surname 'Horn' can contribute to research with significant implications in medicinal practices. Acknowledging diverse contributions is essential to paint a comprehensive picture of advancements in herbal pharmacology.

34) Rich (Rch):
Rich typically refers to abundant resources or substances. In pharmacology, a rich content often denotes high levels of beneficial compounds in plants, which can enhance their therapeutic potentials. The richness of phytochemicals in plants such as Q. infectoria can influence their efficacy in treating various diseases.

35) Post:
Post refers to processes that occur after a certain event has transpired, such as post-treatment evaluations in clinical studies. Understanding post-treatment effects is essential to gauge the effectiveness of interventions and may impact future research directions in the study of medicinal properties of herbs.

36) Tai:
Thai is a reference to Thailand, a country recognized for its rich tradition of herbal medicine. The influence of Thai traditional medicine often shapes the study of local plants, including investigations into their therapeutic effects. Documentation of these practices can lead to enhanced understanding and preservation of valuable medicinal heritage.

37) Viru:
Viru may refer to viruses or viral infections. Understanding the interactions between herbs and viral pathogens can help in developing complementary treatments. Exploring how certain plants may inhibit virus replication could lead to alternative therapies, adding depth to the study of antiviral properties in natural products.

38) Soil:
Soil is essential for plant growth and health, influencing the availability of nutrients needed for medicinal plants. The quality and composition of soil can impact the phytochemical profiles of plants, affecting their therapeutic properties. Knowledge of soil composition is vital for sustainable herbal plant cultivation and utilization.

39) Pur:
Poor refers to substandard conditions or deficiencies, often associated with health and socioeconomic issues. Understanding the root causes of poor health outcomes related to parasitic infections highlights the importance of addressing both medical and societal factors. Research on effective treatments must consider these challenges to improve public health.

40) Terminalia chebula:
Terminalia chebula is a medicinal plant well-known in traditional medicine for its health benefits. Recognizing its uses alongside plants like Q. infectoria is vital in understanding broader ethnobotanical practices. Researching its pharmacological properties may reveal insights into synergistic effects when combined with other herbal treatments.

41) Piper longum:
Piper longum is a medicinal plant used traditionally for its many health benefits, including respiratory and digestive ailments. Understanding its therapeutic properties in relation to other plants like Q. infectoria can foster comprehensive knowledge of their potential effectiveness for treating various diseases, enriching the field of herbal medicine.

42) Inflammation:
Inflammation is a biological response to harmful stimuli, playing a crucial role in various diseases, including infections. Understanding the anti-inflammatory properties of herbal extracts helps delineate their therapeutic roles in managing conditions associated with inflammation. Studying plants like Q. infectoria for their anti-inflammatory effects could lead to new treatments.

43) Measurement:
Measurement in scientific research pertains to the process of quantifying variables, which is essential for objectivity and reproducibility. Accurate measurements of treatment efficacy, toxicity, and bioactive compound concentrations are vital, ensuring that conclusions drawn from studies are valid and applicable in clinical settings, facilitating advancements in herbal pharmacology.

44) Discussion:
Discussion in academic papers serves to analyze findings, providing insights and interpretations of results. This section critically examines the implications of data collected during research. Engaging in discussions enhances understanding of plant efficacy, helping position the study within the larger context of herbal medicine and its applications.

45) Harvesting (Harvest):
Harvesting refers to the process of collecting plants for medicinal use. The timing and method of harvesting influence the quality and concentration of phytochemicals in plants. Proper harvesting practices are vital to ensure sustainability and potency, impacting the overall effectiveness of herbal remedies in treating diseases.

46) Knowledge:
Knowledge encompasses the understanding and information acquired through study and experience. In herbal medicine, knowledge about the medicinal properties of plants, their active compounds, and proper usage guides effective treatment approaches. Preserving and enhancing this knowledge base is essential for advancing integrative medicine practices and improving health outcomes.

47) Evolution:
Evolution pertains to the gradual development of organisms over time, including their adaptation to environments. In medicine, understanding the evolution of parasites is crucial for developing treatments; evolving drug resistance highlights the need for new therapeutics. Researching the evolutionary aspects of parasites informs strategies to counteract these challenges.

48) Blindness:
Blindness refers to the loss of vision, which can result from various conditions, including diseases caused by parasites. Understanding the relationships between parasitic infections and their potential to cause blindness is critical for developing preventative and therapeutic measures, ultimately guiding public health strategies to reduce disease incidence and complications.

49) Suffering:
Suffering refers to the negative experiences associated with illness or disease. This term encompasses the physical, emotional, and social impacts of illness on individuals. In medicinal research, particularly concerning parasitic diseases, addressing suffering is paramount, as effective treatments can significantly enhance quality of life and lessen the burden on affected populations.

50) Mutation:
Mutation refers to changes in the DNA sequence of an organism, which can lead to the development of resistance in parasites against treatments. Understanding mutation mechanisms is critical in the field of pharmacology to predict and counteract resistance development, allowing researchers to develop more effective and adaptable therapeutic strategies.

51) Vomiting:
Vomiting is a symptom that can be related to various diseases, including those caused by parasitic infections. Understanding the causative factors of vomiting is essential for developing comprehensive treatment approaches. Exploring herbal remedies that alleviate nausea and related symptoms can provide holistic solutions in managing parasitic diseases.

52) Language:
Language refers to the system of communication used by humans. In scientific literature, language is crucial for disseminating findings effectively, enabling the sharing of research insights across cultures. Effective communication in conveying the benefits and challenges of medicinal plant use fosters collaboration in global health communities.

53) Richness:
Richness pertains to the abundance of resources or species in a specific area. In pharmacology, it refers to the variety of bioactive compounds present in medicinal plants. Higher phytochemical richness in plants suggests greater potential for therapeutic applications, underlining the importance of biodiversity in discovering effective medicinal resources.

54) Writing:
Writing is the act of composing text, essential for documenting research findings and sharing knowledge. In academic and scientific contexts, writing effectively allows researchers to communicate their ideas, methodologies, results, and conclusions clearly. High-quality writing enhances the accessibility and impact of research findings in the field of herbal medicine.

55) Village:
A village is a small community in a rural area. Understanding the traditional practices and medicinal knowledge specific to villages can enrich research on herbal medicine. Local practices often incorporate the use of native plants for health, providing valuable insights for scientific studies investigating medicinal efficacy and cultural importance.

56) Quality:
Quality refers to the standard of something, including its performance, reliability, and safety. In medicinal plant research, ensuring the quality of extracts is critical for efficacy assessments, influencing treatment outcomes. Rigorous standards in quality evaluation foster trust and integrity in research findings, ensuring safety for human use.

57) Account:
An account refers to a detailed report or description of an event or research study. In scientific literature, providing a thorough account of methods, results, and discussions contributes to transparency and reproducibility. This is essential for the credibility of research, particularly in studies on herbal remedies.

58) Greece:
Greece is geographically significant due to its ancient history of herbal medicine. Many traditional practices and plants originating from Greece contribute to modern herbalism. Studying the historical context of these practices enriches the understanding of their applications and may inspire contemporary research into therapeutic benefits.

59) Weapon:
Weapon refers to tools or means used for attack or defense. In the context of medicine, particularly in fighting diseases, effective treatments can be seen as 'weapons' against pathogens. Understanding how different remedies, including herbal extracts, function as therapeutic agents gives insight into their roles in disease management.

60) Family:
Family in biological terms refers to a classification group that includes related organisms. In pharmacology, understanding the family of plants can provide insights into shared characteristics or therapeutic potentials. Investigating related species within the same family can enhance knowledge about medicinal properties and potential applications in herbal medicine.

61) Medium:
Medium refers to the substance in which organisms grow or develop. In microbiological and pharmacological studies, selecting the appropriate growth medium for pathogens is crucial for determining the effects of various treatments. Understanding the interactions between the medium and herbal extracts is essential for evaluating therapeutic efficacy.

62) Insect:
Insects can be vectors for various diseases, playing critical roles in the life cycles of many parasites. Studying the interactions between insects and medicinal plants can unveil novel aspects of disease transmission and potential remedies derived from plant materials, enhancing our understanding of the ecological dynamics in disease management.

63) Water:
Water is essential for life, facilitating numerous biological processes. In herbal medicine, the quality and presence of water in plant growth can impact the concentration of bioactive compounds. Understanding the role of water conservation and quality in herbal cultivation can facilitate better practices for sustainable herbal resource management.

64) Ulcer:
An ulcer refers to a sore that develops on the skin or mucous membranes. In medicine, ulcers can result from infections, including those caused by parasites. Understanding the relationship between parasitic infections and ulcer formation is vital for developing effective treatment protocols, particularly when considering herbal remedies for management.

65) Syria (Syrian):
Syria is a historically rich region with diverse flora utilized for traditional medicine. Acknowledging the contributions of various cultures, including Syrian practices in herbal medicine, can inform modern medicinal research. Understanding local uses of plants can inspire further studies into their therapeutic properties and applications in health care.

66) Blood:
Blood is a vital fluid in organisms, responsible for transporting nutrients, gases, and waste products. In the context of parasitic infections, understanding blood interactions is crucial, as many parasites rely on blood for sustenance. Research on herbal treatments often evaluates their effects on blood-related conditions, enhancing therapeutic insights.

67) Genu:
Genu often pertains to the knee or region of the body in anatomy. In research contexts, references to specific body parts can aid in understanding the symptoms associated with various diseases, including those caused by parasites where bodily locations are affected. Clarifying these aspects contributes to better-targeted therapies.

68) Line:
Line often refers to a sequence, such as in lineage or classifications. In biological research, understanding lineage helps trace the evolution of organisms and diseases. Establishing lines of descent for pathogens can provide insights into treatment resistance and inform strategies for combating emerging infectious diseases.

69) Pain:
Pain is a complex experience that can be a symptom of various health conditions, including those caused by parasitic infections. Understanding how herbal remedies can alleviate pain is crucial for improving patient comfort and quality of life. Studies focusing on pain relief highlight the therapeutic potential of medicinal plants.

70) Shand (Sand):
Sand refers to the granular material found in various natural environments. In the context of tropical diseases, sand may indicate places like deserts or beaches where certain parasitic infections could be prevalent. Understanding the ecosystems and habitats associated with sand can inform research on disease transmission and control measures.

Other Science Concepts:

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