TMS for Depression: Second Courses for Initial Responders/Non-Responders
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Second Courses of Transcranial Magnetic Stimulation (TMS) in Major Depressive Episodes for Initial Responders and Non-Responders
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Saxby Pridmore, Sheila Erger, Tamara May
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Second Courses of Transcranial Magnetic Stimulation (TMS) in Major Depressive Episodes for Initial Responders and Non-Responders
Year: 2019 | Doi: 10.21315/mjms2019.26.3.8
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Transcranial Magnetic Stimulation (TMS) has emerged as an effective treatment for people experiencing major depressive episodes (MDE). Despite this success, many individuals face chronic relapse, often leading to insufficient response from an initial course of TMS. This study aims to explore the outcomes of a second course of TMS in such patients, assessing their mood through various standardized measures. The research scrutinizes the impact of TMS treatment on individuals who previously experienced either remission followed by relapse or who did not respond effectively to the initial course.
Efficacy of Second TMS Courses
The findings indicate that a second course of TMS can considerably benefit patients struggling with MDE, demonstrating promising rates of remission. Among the 30 participants, 87% achieved remission after their first course, and 73% did so following the second course. For patients who had not remitted after their first TMS treatment, a notable 75% achieved remission with the second course. The study utilized several measurement scales, including the Hamilton Depression Rating Scale, Clinical Global Impression-Severity, and a Visual Analogue Scale, to quantify changes in depressive symptoms, thus highlighting the notable effectiveness of TMS even after prior unsuccessful attempts.
Conclusion
This research illustrates that offering a second course of TMS presents a valuable treatment option for individuals facing challenges with major depressive episodes, specifically those who relapse after an initial response or remain resistant to treatment. The significant results underline the potential for ongoing investigation into TMS as a reliable intervention for MDE, especially in chronic and treatment-resistant cases. The findings contribute to a growing body of literature supporting TMS's adaptability and efficacy in managing depression, warranting further trials to solidify these outcomes and explore optimal treatment strategies.
FAQ section (important questions/answers):
What is transcranial magnetic stimulation (TMS) and its effectiveness?
TMS is a non-invasive treatment for major depressive episodes that is effective in alleviating symptoms. Studies have shown that a significant percentage of patients achieve remission after TMS treatment.
What was the objective of studying second courses of TMS?
The study aimed to investigate the effectiveness and outcomes of second courses of TMS for patients who either relapsed after an initial course or did not achieve remission initially.
What were the findings regarding remission rates after TMS courses?
After the first TMS course, 87% of patients achieved remission. Following a second course, 73% of patients who had relapsed or not responded initially again achieved remission.
What limitations were noted in the TMS study?
Limitations included a lack of placebo control, potential confounding variables from ongoing medications, and the small sample size. These factors may affect the generalizability of the findings to broader populations.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “TMS for Depression: Second Courses for Initial Responders/Non-Responders”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Post:
The term 'Post' refers to a period after an event, often relevant in clinical research to analyze outcomes following interventions like Transcranial Magnetic Stimulation (TMS). In studies, tracking post-treatment effects helps understand the effectiveness and duration of treatments for conditions such as Major Depressive Episodes (MDE).
2) Table:
Tables are critical in research for presenting data in an organized manner. They allow for quick reference and comparison of results, aiding in the interpretation of findings, such as changes in depression ratings pre- and post-treatment. Tables support the clear communication of complex data.
3) Depression:
Depression is a significant mental health disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest, impacting daily functioning. It is crucial to study depression, as it affects a considerable population and has profound effects on overall health, relationships, and quality of life.
4) Study (Studying):
A study refers to a systematic investigation designed to test hypotheses and gather knowledge. In medical research, studies like the one evaluating TMS aim to assess treatment outcomes for depression, contributing to a better understanding of effective mental health interventions in clinical settings.
5) Carpenter:
Carpenter is likely a reference to an author or researcher involved in studies on mental health treatments, particularly using Transcranial Magnetic Stimulation (TMS). Acknowledging contributors is essential in academic work, as their research enhances the understanding of effective treatments for conditions like depression.
6) Mud:
Mood pertains to an individual's emotional state, influencing their experience and behavior. In the context of depression, fluctuations in mood are critically observed to assess treatment effectiveness. Measuring mood changes pre- and post-intervention helps evaluate the impacts of therapies like TMS on emotional health.
7) Anxiety:
Anxiety is a common mental health condition characterized by excessive worry, nervousness, or fear, often co-occurring with depression. Understanding anxiety’s relationship with depression is vital as it complicates diagnosis and treatment, necessitating integrated therapeutic approaches to address both conditions effectively.
8) Rules:
Rules might refer to guidelines or protocols in clinical studies. Establishing rules for treatment and evaluation ensures consistency, reliability, and ethical standards in research. Following these rules is crucial for valid results and ensures the accountability of researchers and the safety of participants.
9) Mental health:
Mental health encompasses emotional, psychological, and social well-being, affecting how individuals think, feel, and behave. Addressing mental health is essential for overall health and well-being, and research into treatments like TMS provides insights into effective interventions for enhancing mental health outcomes.
10) Measurement:
Measurement in research refers to the systematic quantification of variables, such as depression severity. Accurate measurement is crucial for evaluating treatment outcomes, allowing researchers to assess the effectiveness of interventions like TMS and to compare results across studies to draw meaningful conclusions.
11) Account:
An account in research often refers to a detailed report of findings or experiences. Documenting patient outcomes, like those in TMS studies, provides valuable insights for clinicians and researchers, contributing to the broader understanding of treatment efficacy and patient management in depression.
12) Medium:
Medium can refer to various dimensions in research contexts, such as the size of the sample or the type of interventions used. Understanding medium effects in treatment outcomes, like TMS for depression, helps determine the strength of interventions and their applicability to broader populations.
13) Male:
Male refers to the gender identity of participants in studies. Demographic factors like gender often influence mental health outcomes, treatment responses, and symptoms. Recognizing male representation in studies facilitates the understanding of gender-specific treatment efficacy in conditions such as depression.
14) Arrangement:
Arrangement can refer to the systematic organization of treatment schedules or protocols in clinical research. How TMS treatments are arranged influences patient experiences and the effectiveness of the intervention, highlighting the importance of well-structured clinical trials in assessing therapeutic methods.
15) Observation:
Observation in research involves watching and recording behaviors or outcomes to gather data. In the context of TMS for depression, systematic observation provides insights into treatment effects, participant responses, and the overall trajectory of mental health improvements, aiding in quality assessment and adjustment.
16) Discussion:
Discussion involves analyzing and interpreting research findings, contributing to the understanding of treatment impacts and future directions. In TMS studies, the discussion section synthesizes results, contextualizes them within existing literature, and highlights implications for clinical practice and further research.
17) Knowledge:
Knowledge is the accumulation of facts and insights gained through research. Increasing knowledge about effective treatments, such as TMS for depression, is essential for advancing mental health practices and improving patient outcomes, fostering informed decision-making among clinicians and policymakers.
18) Education:
Education refers to the process of acquiring knowledge. In mental health, educating patients about treatment options, including TMS, empowers them to make informed choices about their care. Education also extends to professionals, ensuring they are up-to-date with current practices and evidence-based treatments.
19) Suffering:
Suffering in the context of mental health relates to the pain and distress experienced by individuals with disorders like depression. Addressing suffering through effective treatment strategies is essential for improving quality of life, underscoring the importance of researching and implementing therapeutic interventions.
20) Field:
Field refers to a specific area of study or practice. In the context of mental health, it encompasses research, treatment, and interventions for disorders. Advancements in the field of psychiatry and psychology are crucial for developing effective treatment methodologies for conditions like major depression.
21) Pulse:
Pulse may refer to the rhythmic signal in brain stimulation therapies like TMS, where pulses are delivered to stimulate neural activity. Understanding the mechanics of pulse delivery in TMS is critical to ensuring therapeutic outcomes and optimizing treatment protocols for patients experiencing depression.
22) Line:
Line is often used metaphorically in research to indicate a pathway or sequence of reasoning. In TMS studies, establishing a clear line of inquiry helps in formulating hypotheses and designing experiments that accurately address mental health treatment outcomes and patient care strategies.
23) Drug:
Drug pertains to pharmaceutical interventions used in treating depression, often alongside or instead of therapies like TMS. Understanding the role of drugs in mental health treatment is vital, as they often influence patient management strategies and can complement non-pharmaceutical therapies for better outcomes.
24) Pur:
Poor typically describes suboptimal outcomes or conditions, such as low response rates to treatment. In mental health contexts, assessing poor responses to therapies like TMS is essential to identify effective strategies for improving treatment efficacy and addressing the needs of patients with resistant depression.
Other Science Concepts:
Discover the significance of concepts within the article: ‘TMS for Depression: Second Courses for Initial Responders/Non-Responders’. Further sources in the context of Science might help you critically compare this page with similair documents:
Mental health, Medical treatment, Treatment, Subjective experience, Long-term treatment, Patient, Inclusion criteria, Clinical studies, Pilot study, Clinical Practice, Treatment period, Visual analogue scale, Significant improvement, Treatment outcome, Relapse prevention, Treatment effect, Meta analysis, Systematic Review, Clinical application, Hamilton Depression Rating Scale, Major depressive episodes, Major depressive disorder, Antidepressant effect, Treatment Course, Prospective study, Significant decrease, Open-label study, Mean age, Symptom score, Standard deviation, Treatment option, Depression Rating Scale, Clinical Judgment, Depressive disorder, Beck Depression inventory, Relapse frequency, Clinical outcome, Residual symptoms, Private hospital, Major depression, Post treatment, Hospital setting, Side effect, Clinical benefit, Repetitive transcranial magnetic stimulation, Patient Outcome, Treatment of depression, Antidepressant medication, Relapse, Remission, Electroconvulsive therapy, Transcranial magnetic stimulation, Secondary analysis, Initial treatment, Partial Remission, Subjective symptom, Treatment-resistant depression, Effect Size, Depression rating, Symptomatic response, Pharmacoresistant, Maintenance treatment, Neuropsychopharmacology.
Concepts being referred in other categories, contexts and sources.
Course, Time, First course, Week.