Endocrine Outcomes of Transsphenoidal Surgery for Pituitary Adenomas

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: Endocrinological Outcome of Endoscopic Transsphenoidal Surgery for Functioning and Non-Functioning Pituitary Adenoma
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

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Author:

Lee Shwu Yi, Azmi Alias, Abdul Rahman Izaini Ghani, Mohammad Badrulnizam Long Bidin


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Endocrinological Outcome of Endoscopic Transsphenoidal Surgery for Functioning and Non-Functioning Pituitary Adenoma

Year: 2019 | Doi: 10.21315/mjms2019.26.3.5

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study investigates the outcomes following endoscopic transsphenoidal surgery (ETS) for pituitary adenomas, focusing on factors such as the remission and preservation of hormonal function, complications arising from the surgery, and improvements in visual acuity after the procedure. Conducted at Hospital Kuala Lumpur over a span of nine years, the research encompasses a cohort of patients with both functioning and non-functioning pituitary adenomas to assess the efficacy and safety of this surgical technique.

Hormonal Recovery and Visual Improvement

One significant finding of the study relates to the hormonal recovery observed post-surgery. Among the 67 patients diagnosed with non-functioning pituitary adenomas, 42 patients exhibited normalization of hormone levels after ETS. The analysis highlighted that 16.4% of patients with non-functioning adenomas reported improvement in both vision and hormonal function within three months post-operation. Notably, the outcomes for patients with impaired hormonal function pre-surgery were favorable, with a majority recovering hormonal balance post-operation, while only one patient experienced a decline in hormonal levels due to tumor invasion.

Conclusion

In conclusion, the study demonstrates that ETS for pituitary adenomas can lead to satisfactory outcomes regarding hormonal preservation and recovery, with minimal complications and no reported mortalities within the study period. The findings advocate for a specialized, multidisciplinary approach in managing such surgeries, reinforcing the potential for improved patient outcomes in cases of both functioning and non-functioning adenomas. Future recommendations highlight the importance of surgical expertise and continuous evaluation to further advance remission rates in functioning adenoma cases.

FAQ section (important questions/answers):

What was the primary focus of the study?

The study analyzed remission and preservation of hormone levels, complications, and visual improvements after endoscopic transsphenoidal surgery for pituitary adenoma at Hospital Kuala Lumpur between 2006 and 2015.

How many patients were included in the study?

A total of 106 patients diagnosed with pituitary adenoma who underwent transsphenoidal surgery were included in the study, with 67 having non-functioning adenomas and 39 having functioning adenomas.

What were the outcomes regarding hormonal recovery post-surgery?

Out of 43 patients with impaired hormonal function pre-operatively, 42 patients recovered their hormone levels within three months post-surgery, demonstrating a successful outcome for hormonal preservation.

What complications were observed after the transsphenoidal surgery?

Complications included a CSF leak in 4.5% of non-functioning adenoma patients and 5.1% in functioning adenoma patients, with no cases of visual deterioration or mortality reported in the study.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Endocrine Outcomes of Transsphenoidal Surgery for Pituitary Adenomas”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In research contexts, a 'Table' is a structured arrangement of data that facilitates comparison, analysis, and interpretation. Tables often present statistical data related to study findings, such as demographic details or results of medical interventions. They enhance the clarity of the information, allowing readers to quickly grasp important points and relationships within the data.

2) Post:
The term 'Post' often refers to the period following an event, such as a medical procedure, treatment, or study. It is crucial for evaluating outcomes, such as the effectiveness of a surgery or the recovery of patients. In clinical studies, post-operative data can inform improvements and highlight complications resulting from procedures.

3) Study (Studying):
A 'Study' refers to a systematic investigation aimed at discovering or interpreting facts, theories, or principles. In medical contexts, a study can provide insights into treatment efficacy, patient demographics, and disease characteristics. It lays the foundation for evidence-based medicine and can inform clinical practices and healthcare policies.

4) Disease:
'Disease' is a term used in medicine to describe a pathological condition characterized by specific symptoms and abnormalities. Understanding disease mechanisms is crucial in developing effective treatments and interventions. In this context, pituitary adenomas are discussed, highlighting their surgical treatment options and outcomes, which are essential for patient health management.

5) Rules:
In a research context, 'Rules' refer to established guidelines that govern study design, data collection, and analysis. These rules ensure the reliability and validity of findings. Adhering to these principles is vital to uphold the integrity of the research process and facilitate the acceptance of results in the scientific community.

6) Field:
'Field' relates to the specific area of study or practice. In medicine, this could refer to fields like endocrinology or neurosurgery. Understanding the field is critical for practitioners to stay updated on advancements, techniques, and research findings, ultimately leading to better patient care and improved surgical outcomes.

7) Male:
The term 'Male' denotes one of the two primary biological sexes, typically characterized by the presence of XY chromosomes and the production of sperm. In clinical studies, understanding the gender distribution of participants is essential for analyzing potential differences in disease presentation, treatment efficacy, and outcomes, influencing tailor-made healthcare strategies.

8) Bleeding:
'Bleeding' refers to the loss of blood from the circulatory system, which can occur during surgeries or as a symptom of certain conditions. In surgical studies, monitoring bleeding complications is crucial for patient safety and recovery. It significantly impacts postoperative care and can inform risk management strategies during medical interventions.

9) Cancer:
'Cancer' is a broad term for diseases characterized by abnormal cell growth, which can invade or spread to other parts of the body. In surgical literature, discussions often include the potential malignancy of tumors, treatment strategies, and recovery rates. Understanding cancer's implications informs therapeutic decisions and patient management approaches.

10) Seth:
'Seth' could refer to an author or researcher contributing to medical literature. Individual researchers play critical roles in advancing knowledge, shaping practices, and influencing guidelines within healthcare. Their insights and findings can lead to improved therapeutic interventions and outcomes, highlighting the importance of collaboration and knowledge sharing in medical research.

11) Hand:
'Hand' refers to the physical capability to perform tasks, particularly significant in surgical contexts. Surgeons rely on skilled hand movements to execute delicate procedures. Mastery of hand techniques is essential for minimizing complications and enhancing surgical outcomes, directly impacting patient recovery and quality of care in medical practice.

12) Discussion:
'Discussion' involves the interpretation and analysis of research findings, often providing context and implications for clinical practice. In medical studies, this section helps bridge investigation outcomes with real-world applications, allowing healthcare professionals to evaluate the significance of results and make informed decisions based on evidence and patient needs.

13) Suffering:
'Suffering' describes the acute or chronic pain and distress that patients may experience due to diseases or conditions. In healthcare, understanding patient suffering is fundamental for developing effective treatments and interventions aimed at improving quality of life. Addressing suffering is crucial in patient-centered care, impacting treatment choices and outcomes.

14) Medicine:
'Medicine' refers to the science and practice concerned with the diagnosis, treatment, and prevention of diseases. It encompasses a range of practices aimed at improving health and mitigating suffering. Advances in medicine, including surgical techniques and pharmacological therapies, are essential for effective patient care and enhancing overall population health.

15) Kindness:
'Kindness' denotes the quality of being friendly, considerate, and compassionate towards others. In healthcare, kindness enhances the patient-provider relationship, fostering trust and open communication. Empathetic interactions can significantly improve patient experiences and satisfaction, ultimately affecting treatment outcomes and the quality of healthcare delivered.

16) Quality:
'Quality' in healthcare refers to the standard of services provided to patients, including effectiveness, safety, and patient satisfaction. Quality improvement initiatives aim to enhance care processes and outcomes, ensuring patients receive the best possible treatment. It is a critical focus in healthcare systems to promote better clinical practices and patient trust.

17) Roman (Roma):
'Roman' may refer to styles or methods derived from ancient Roman practices. In the context of medicine and surgery, historical references can provide insights into the evolution of medical techniques. Understanding past methods helps inform present practices and can influence surgical approaches, leading to advancements in modern healthcare.

18) Line:
'Line' often refers to guidelines or protocols followed in clinical practice. These lines provide structure to treatment protocols and research methodologies, ensuring consistency and reliability in patient care. Adhering to established lines enhances efficiency and efficacy in clinical settings, ultimately benefiting patient outcomes and healthcare delivery.

19) Pur:
'Poor' in a medical context often describes inadequate health outcomes, socioeconomic status, or patient compliance. Addressing poor health conditions is vital for developing effective interventions aimed at improving population health. Understanding the factors contributing to poor health allows healthcare providers to create targeted strategies to enhance patient well-being.

20) Life:
'Life' encompasses the physical, emotional, and social dimensions of a person’s existence. In healthcare, quality of life is a significant consideration in treatment decisions. Enhancing life through effective interventions, compassionate care, and support is fundamental for healthcare professionals, ultimately leading to improved patient satisfaction and well-being.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Endocrine Outcomes of Transsphenoidal Surgery for Pituitary Adenomas’. Further sources in the context of Science might help you critically compare this page with similair documents:

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