JK*A and JK*B Allele Frequency in Southern Thailand Muslim Donors
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Determining of JK*A and JK*B Allele Frequency Distribution among Muslim Blood Donors from Southern Thailand
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Ubonwan Puobon, Kamphon Intharanut, Supattra Mitundee, Oytip Nathalang
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Determining of JK*A and JK*B Allele Frequency Distribution among Muslim Blood Donors from Southern Thailand
Year: 2019 | Doi: 10.21315/mjms2019.26.1.5
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
The Kidd (JK) blood group system plays a significant role in transfusion medicine, with the two primary alleles being JKA and JKB. Understanding the frequencies of these alleles is vital for genetic anthropological studies and improving blood transfusion compatibility. This research aimed to assess the frequencies of the JKA and JKB alleles among Muslim blood donors from Southern Thailand and compare these findings with those from other ethnic populations. The study involved a cross-sectional analysis of 427 samples collected from healthy Thai-Muslim donors across three southern provinces, focusing on demographic data and allele detection through polymerase chain reaction with sequence-specific primers (PCR-SSP).
Significance of JK Allele Frequencies
The analysis revealed that the most prevalent genotype among the southern Thai-Muslims was JKA/JKB, with allele frequencies of 55.2% for JKA and 44.8% for JKB. These frequencies exhibited significant differences when compared to those observed in other populations, such as central Thai, Korean, Japanese, and various African groups. The research highlighted the potential risk of anti-Jk*b alloimmunization due to the high prevalence of the Jk(a+b−) phenotype within the population. The clarity in allele frequency distribution also aids in enhancing transfusion practices and serves as a genetic marker for further anthropological studies concerning population genetics and migration patterns in Southeast Asia.
Conclusion
This study established the JKA and JKB allele frequencies among southern Thai-Muslim blood donors, providing critical data for both transfusion medicine and genetic anthropology. The unique findings and variations in allele frequencies underscore the complexity of population genetics and emphasize the importance of conducting such studies in diverse populations to inform medical practices and genetic research. Future investigations with broader sample sizes and additional blood group alleles are necessary to build upon this foundational research and further explore the relationship between genetic factors and population characteristics.
FAQ section (important questions/answers):
What is the aim of the study on Kidd blood group system?
The study aimed to determine the frequencies of JK*A and JK*B alleles among Muslim blood donors in Southern Thailand and compare these frequencies with those of other populations.
What were the methods used for genetic analysis in the study?
A cross-sectional study involved collecting blood samples from 427 healthy Thai-Muslim donors. JK*A and JK*B allele detections were performed using PCR-SSP, and the frequencies were analyzed statistically.
What were the key findings regarding JK allele frequencies?
The study found that JK*A and JK*B allele frequencies among southern Thai-Muslims were 55.2% and 44.8%, respectively, differing significantly from other populations like central Thai, Koreans, and Japanese.
How can the findings contribute to transfusion medicine?
Determining JK*A and JK*B allele frequencies can help in transfusion medicine by providing compatible blood units for patients, minimizing the risk of hemolytic transfusion reactions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “JK*A and JK*B Allele Frequency in Southern Thailand Muslim Donors”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Tai:
The term 'Thai' refers to the people and culture of Thailand. It is significant in discussions of genetics and population studies, particularly in relation to the Kidd blood group system. The genetic diversity among Thai populations like Thai-Muslims enhances understanding of allele frequencies and transfusion medicine.
2) Blood:
Blood is a vital fluid in the human body, essential for transporting oxygen and nutrients. In the context of transfusion medicine, understanding blood types is crucial for safe blood transfusions. The Kidd blood group system, including alleles JK*A and JK*B, is key for ensuring compatibility in transfusions.
3) Table:
A 'table' in research often presents important data summaries, such as allele frequencies or phenotype distributions. Tables facilitate quick comparisons between different populations, enhancing the clarity of research findings. In this study, tables illustrate the frequencies of the Kidd blood group alleles among various ethnic groups.
4) Study (Studying):
The term 'study' denotes systematic research to explore specific hypotheses or questions. In this context, it pertains to the investigation of Kidd blood group allele frequencies among Thai-Muslims, providing insights for transfusion medicine and genetics. It highlights the importance of collecting and analyzing relevant data.
5) Indian:
In this context, 'Indian' refers to the population of India, particularly in genetic studies. Comparisons are often made between various ethnic groups, such as southern Thai-Muslims and Indians, regarding allele frequencies. Understanding genetic similarities and differences aids in transfusion compatibility and anthropological research.
6) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing diseases. Within the context of blood transfusions, understanding blood group systems, such as Kidd, is critical to ensure safe and effective treatments. Relevant studies contribute to advances in transfusion practices and patient care.
7) Santa (Shanta, Samta, Shamta):
In this context, 'Santa' may refer to Santa Catarina, a state in Brazil where gene frequency studies, like those of the Kidd blood group, have been conducted. The research may include comparisons of different populations, highlighting similarities or differences in allele distributions that are significant for transfusion medicine.
8) Rules:
'Rules' refer to guiding principles or regulations that govern research methodologies or medical practices. In genetics and blood transfusion medicine, established rules ensure ethical compliance and scientific integrity. They guide the comparison of genotype frequencies and allele distributions across various populations.
9) Performance:
The term 'performance' can refer to how effectively different methods or techniques yield results in research. In blood group studies, the performance of genotyping methods like PCR-SSP can be evaluated, impacting the validity and reliability of findings related to Kidd blood group allele frequencies.
10) Disease:
In the medical field, 'disease' refers to pathological conditions that affect the body's systems. Understanding blood group systems helps predict risks of diseases related to blood transfusions, such as hemolytic reactions in patients with specific genotypes. Studies focus on minimizing complications in transfusion practices.
11) House:
The term 'house' could metaphorically refer to groups within populations being studied, similar to clans or familial units. In genetics, understanding how alleles distribute across 'households' (from a broader perspective of kinship) may help elucidate patterns of inheritance and population dynamics.
12) Cina:
In the field of genetics, 'China' represents a population with significant genetic diversity. Comparing Kidd blood group alleles across different populations, including Chinese groups, illuminates variations in allele frequencies. Such comparisons provide insights into migration patterns and historical genetic interactions.
13) Loma (Lomaka):
In this context, 'Loma' may refer to specific ethnic groups or populations being analyzed in relation to genetic studies. The name could represent a geographic or cultural context, contributing to the understanding of genetic diversity and allele frequencies in blood groups across different regions.
14) Musha (Musa, Musá):
In the context of this research, 'Musa' likely refers to an individual contributor to the study or a specific population. Their role may involve participation in data collection, analysis, or interpretation of blood group allele frequencies, offering insights into the genetic characteristics of different populations.
15) Chau:
Similar to 'Musa,' 'Chau' could represent a researcher or a significant population group. Their involvement elucidates aspects of genetic diversity, especially in blood typing and compatibility for transfusions. Analysis of allele frequencies among various ethnicities helps refine medical protocols for better healthcare.
16) Yala:
Yala is a province in Southern Thailand where the study of Kidd blood group frequencies took place. Mentioning Yala emphasizes the regional focus of the research and the importance of understanding how specific populations contribute to broader genetic diversity and transfusion compatibility.
17) Male:
'Male' denotes one of the two primary biological sexes, relevant in genetic studies and transfusion medicine. Gender differences may affect the frequency of certain alleles or phenotypes in populations. Such distinctions are essential for interpreting data and understanding genetic variations across sexes.
18) Calculation:
In research, 'calculation' refers to the quantitative analysis used to determine allele frequencies or statistical comparisons. Accurate calculations ensure valid results, enhancing the reliability of conclusions drawn in studies of genetic diversity and transfusion practices among different populations.
19) Discussion:
The 'discussion' section of a study interprets findings, relates them to existing literature, and identifies implications for practice. It is crucial for contextualizing research outcomes in the field of transfusion medicine and genetics, providing insights into the significance of differences in allele frequencies.
20) Mutation:
A 'mutation' refers to a change in DNA sequences that can lead to variations in traits and characteristics. Understanding mutations in the context of blood group systems is vital, as they contribute to the presence or absence of specific antigens, impacting transfusion compatibility and risks.
21) Marriage:
'Marriage' may symbolize the blending of genetic lineages, influencing allele frequencies in populations over generations. Cross-cultural marriages can promote genetic diversity. This sociocultural aspect plays a role in how blood group frequencies are studied within evolving populations, particularly in anthropological research.
22) Science (Scientific):
'Science' includes the systematic study of natural phenomena, contributing to advancements in knowledge. In the context of this study, scientific methods are applied to examine genetic markers and blood group systems, which are important for medical advancements, particularly in transfusion medicine and genetics.
23) Water:
'Water' is an essential resource for all life forms and plays a significant role in sustaining health. Although not directly related to the genetic study, access to clean water and its implications for health and disease can influence population health, thus indirectly affecting blood group studies.
24) Field:
'Field' can refer to a specific area of study such as genetics or transfusion medicine. This term emphasizes the scope of research, focusing on the Kidd blood group system, its implications for safe transfusions, and the examination of how different populations are impacted by genetic variability.
25) Post:
'Post' typically refers to a message or publication, often related to sharing research findings. In scientific discussions, sharing findings in a post format enables broader dissemination of knowledge, facilitating dialogue and enhancing collaboration within and between scientific fields, especially in medicine and genetics.
26) Ican:
Isan refers to a region in northeastern Thailand, rich in cultural diversity and genetic variation among populations. Understanding the allele frequencies within Isan contributes to insights into the Kidd blood group system and its relevance for transfusion compatibility, while highlighting regional differences within Thai populations.
Other Science Concepts:
Discover the significance of concepts within the article: ‘JK*A and JK*B Allele Frequency in Southern Thailand Muslim Donors’. Further sources in the context of Science might help you critically compare this page with similair documents:
Blood, Blood transfusion, Molecular biology, Statistical analysis, Cross-sectional study, Simple random sampling, Population studies, Interquartile Range, Blood group, Ethnic group, Study objective, Allele frequency, PCR technique, Genomic DNA, Multiplex PCR, Red Blood Cell, DNA sequencing, Genomic DNA Extraction, Monoclonal antibodies, Hardy-Weinberg equilibrium, Blood sample, Molecular technique, Serological test, Allele frequencies, Haemolytic disease, Geographic region, Healthy blood donors, Chi-Squared Test, Genotyping results, Blood donor, Genotyping, South Asian population, Gene polymorphism, Allele-specific PCR, Population genetics, Blood group antigens, Genotype frequencies, Fisher exact test, Study material, Ethnic difference, Red cells.
Concepts being referred in other categories, contexts and sources.
Southern Thailand, Mixed marriage.