Antimicrobial Resistance Patterns of Multidrug-Resistant Acinetobacter
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Antimicrobial Susceptibility Patterns of an Emerging Multidrug Resistant Nosocomial Pathogen: Acinetobacter baumannii
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Rachna Tewari, Deepti Chopra, Rushna Wazahat, Shreya Dhingra, Mridu Dudeja
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Antimicrobial Susceptibility Patterns of an Emerging Multidrug Resistant Nosocomial Pathogen: Acinetobacter baumannii
Year: 2018 | Doi: 10.21315/mjms2018.25.3.13
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Acinetobacter baumannii has emerged as a significant nosocomial pathogen worldwide, characterized by its high mortality rates and extensive multidrug resistance (MDR). This study focuses on the antibiotic susceptibility of clinical isolates of Acinetobacter species collected from a teaching hospital, aiming to assess the current resistance patterns. Over a two-year period, a total of 16,452 clinical samples were analyzed, revealing a mere 0.4% positivity rate for Acinetobacter species. The isolates predominantly originated from urine samples, highlighting the need for effective monitoring and management strategies in healthcare settings.
Antibiotic Resistance Patterns
The study demonstrated alarming levels of antibiotic resistance among the isolated Acinetobacter species, with 80.3% exhibiting resistance to three or more classes of antibiotics—classifying them as multidrug-resistant (MDR). Notably, all isolates were found to be susceptible to colistin, while sensitivity rates for tigecycline and carbapenems were 80% and 53.3%, respectively. These findings indicate a critical need for combination therapies, such as colistin and tigecycline, to treat MDR A. baumannii infections effectively, pending the discovery of new treatment options. The study underscores the diversity in antibiotic resistance patterns based on geographic location, contributing to a growing concern about the global management of Acinetobacter-related infections.
Conclusion
The rising incidence of multidrug-resistant Acinetobacter baumannii underscores the challenges faced in treating infections caused by this pathogen. The study found high resistance rates to commonly used antibiotics, advocating for the prudent use of existing antibiotics and the exploration of alternative treatment strategies. With colistin remaining the only effective drug demonstrating 100% sensitivity against Acinetobacter species, the healthcare community must prioritize the development of new antimicrobial agents and combination therapies to address the escalating threat of MDR Acinetobacter in clinical settings.
FAQ section (important questions/answers):
What is the main focus of the study?
The study aimed to assess antibiotic susceptibility levels among isolates of Acinetobacter species from clinical specimens, especially focusing on multidrug-resistant Acinetobacter baumannii and its treatment options.
What was the resistance pattern observed in Acinetobacter isolates?
The results showed that 80.3% of Acinetobacter isolates were resistant to three or more classes of antibiotics, indicating a high prevalence of multidrug resistance, particularly in urine samples.
Which antibiotics were A. baumannii isolates found to be sensitive to?
All A. baumannii isolates were 100% susceptible to colistin. The sensitivity to tigecycline was 80%, while 53.3% showed susceptibility to carbapenems.
What treatment options are suggested for MDR A. baumannii infections?
Combination therapies with colistin and tigecycline are recommended for treating multidrug-resistant A. baumannii until new antibiotics or treatment alternatives become available.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antimicrobial Resistance Patterns of Multidrug-Resistant Acinetobacter”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Antibiotic (Antibacterial):
Antibiotic refers to a type of medication used to treat infections caused by bacteria. They work by killing bacteria or inhibiting their growth. The relevance of antibiotics in the study lies in assessing the resistance patterns of Acinetobacter species, which has become a significant concern in healthcare settings, especially with multidrug-resistant strains emerging.
2) Species:
Species denotes a group of organisms that can interbreed and produce fertile offspring. In the study, the focus is on the Acinetobacter species, particularly Acinetobacter baumannii, known for its role as a nosocomial pathogen. Understanding species-specific behaviors is crucial for targeted treatment and control of infections in clinical environments.
3) Table:
A table serves as a structured way of presenting data, allowing easier comparison and analysis of information. In research, tables summarize findings like the types of clinical specimens and antibiotic susceptibility patterns. They enhance the clarity of the results, facilitating better understanding among healthcare professionals and researchers.
4) Study (Studying):
A study is an investigation or examination to gather insights, test hypotheses, or analyze phenomena. In this context, the study assesses antimicrobial susceptibility among Acinetobacter species. It plays a vital role in identifying resistance trends, ultimately aiding in the development of effective treatment strategies against multidrug-resistant infections.
5) India:
India is the geographical context of the research, representing a significant region in which multidrug-resistant infections pose a substantial public health challenge. The findings from the study reflect the local epidemiology and prevalence of Acinetobacter species in hospitals, essential for formulating effective healthcare policies and intervention strategies within this setting.
6) Drug:
Drug refers to a chemical substance used for medical purposes, often to prevent, diagnose, or treat diseases. The study focuses on various drugs used against Acinetobacter infections, analyzing their susceptibility and resistance. Understanding drug efficacy is critical to making informed choices in antibiotic therapy for serious bacterial infections.
7) Blood:
Blood is a vital fluid in the body responsible for transporting oxygen, nutrients, immune cells, and waste products. Its relevance in the study lies in the analysis of blood samples representing systemic infections caused by Acinetobacter species. Monitoring bloodstream infections is crucial for patient outcomes and effective treatment decisions.
8) Teaching:
Teaching refers to the process of imparting knowledge or skills, typically in an academic setting. In the study, the research was conducted in a teaching hospital, signifying a hub for medical education and training. This institution plays a critical role in shaping future healthcare professionals who will tackle antibiotic resistance in practice.
9) Gupta:
Gupta is likely referring to a researcher or author associated with previous studies in the field of microbiology or infectious diseases. The mention underscores the collaborative nature of research, where findings build upon existing literature and scholarly work, contributing to a holistic understanding of antibiotic resistance in pathogens.
10) Rani:
Rani is another name associated with research, possibly an author of previous publications. This mentions points to the importance of recognizing contributions from multiple researchers in shaping the understanding of antibiotic resistance patterns, advocating for collaborative efforts in the scientific community to combat pressing healthcare issues.
11) Performance:
Performance relates to the efficacy or effectiveness of a procedure or treatment. In the context of antibiotic susceptibility testing, performance standards guide the evaluation of how well specific antibiotics work against bacteria. Monitoring performance is essential for ensuring that treatment strategies are based on reliable and accurate data.
12) Observation:
Observation refers to the act of carefully watching or monitoring a phenomenon or subject. In this study, observations made about the antibiotic resistance patterns among Acinetobacter species are crucial for identifying trends, understanding the clinical implications, and guiding future research and treatment strategies for effective management.
13) Gandham:
Gandham likely refers to a researcher or author who has contributed to the body of knowledge regarding Acinetobacter or antibiotic resistance. Recognizing individual contributions is vital in academia, underscoring the collaboration and collective effort necessary for advancing the understanding of complex medical issues and improving patient care.
14) Mishra (Misra):
Mishra is another author possibly linked to prior research on clinical microbiology or antibiotic susceptibility. Highlighting specific contributors reinforces the collaborative effort in scientific endeavors, crucial for addressing multifaceted health challenges, particularly the growing problem of multidrug-resistant bacterial infections in clinical settings.
15) Sharman (Sarma, Sharma, Sarman):
Sharma might refer to a researcher involved in the study or related works focusing on antibiotic resistance patterns. This acknowledgment of contributors exemplifies the teamwork necessary in scientific research to enhance understanding and devise strategies for controlling infections caused by resistant bacteria in healthcare environments.
16) Rules:
Rules pertain to established guidelines that govern practices, such as clinical standards for antimicrobial susceptibility testing. Understanding rules is essential for standardizing procedures to ensure accurate and reliable laboratory results, promoting effective treatment protocols for patients suffering from infections caused by bacteria like Acinetobacter.
17) Latta:
Latha is likely a reference to a researcher or author in the field of microbiology or medicine. Acknowledging contributors is vital in academic discourse, emphasizing collaborative research efforts to advance knowledge on issues like antibiotic resistance and enhance clinical outcomes through shared insights.
18) Beta:
Beta commonly refers to beta-lactam antibiotics, a class effective against many bacterial infections. In the study, the relevance of beta-lactam antibiotics comes into play when exploring resistance mechanisms within Acinetobacter species. Understanding how these bacteria respond to this antibiotic class is crucial for developing effective therapeutic strategies.
19) Mani:
Mani likely signifies a researcher or collaborator in studies related to antibiotic susceptibility or infectious diseases. Recognizing individual contributions highlights the importance of collective scholarly work in addressing healthcare challenges, particularly the perplexing evolution of antibiotic resistance in hospital-associated pathogens like Acinetobacter.
20) Rice (Rce):
Rice refers to a prominent researcher or scholar in infectious diseases, whose work may have shaped discussions around antimicrobial resistance. Recognizing influential figures in the literature serves to underscore the ongoing discourse in the scientific community about effective responses to challenges posed by multidrug-resistant organisms in clinical settings.
21) Gaura:
Gaur is likely a reference to an author who has contributed research in the field of microbiology or antibiotic resistance. Such individuals often influence future studies, guiding contemporary findings and efforts to mitigate the growing concern of antimicrobial resistance among hospital-associated pathogens.
22) Pharmacology:
Pharmacology is the branch of medicine focused on drugs and their effects. In the context of this study, pharmacology is paramount for understanding the interactions between antibiotics and Acinetobacter species, highlighting the necessity of effective medication strategies to combat infections and guide rational drug use in clinical practice.
23) Transmission:
Transmission refers to the spread of infectious agents, which is integral to understanding the epidemiology of Acinetobacter infections. By assessing transmission pathways, healthcare professionals can better implement control measures in hospital settings, minimizing the risk of spreading drug-resistant infections among vulnerable patient populations.
24) Discussion:
Discussion is a critical component of research, where findings are interpreted and implications for clinical practice are explored. In this study, the discussion elaborates on the significance of antibiotic resistance patterns found, contributing to the broader understanding of public health challenges posed by multidrug-resistant bacteria.
25) Quality:
Quality refers to the standard of healthcare, particularly concerning the effectiveness of treatment protocols. The quality of antibiotic susceptibility testing is fundamental for ensuring accurate clinical decision-making, as obtaining reliable results drives effective choices in managing infections caused by resistant organisms like Acinetobacter.
26) Gelatin:
Gelatin is a substance used in some microbiological media for cultivating bacterial samples. Its relevance in the study relates to specific laboratory techniques used for identifying and differentiating bacterial species like Acinetobacter. Understanding the role of gelatin is vital for ensuring accurate diagnostics in microbiology.
27) Surface:
Surface refers to the external parts of objects or environments. Discussing surfaces is relevant in the context of Acinetobacter, which can persist on hospital surfaces, contributing to infection spread. Understanding contamination routes highlights the importance of rigorous hygiene practices in healthcare settings to prevent nosocomial infections.
28) Aureus:
Aureus generally refers to Staphylococcus aureus, a common bacterial pathogen often discussed alongside Acinetobacter. The relevance lies in the comparison of resistance mechanisms and epidemiology among different bacteria. Understanding the relationship between these pathogens aids in broader public health strategies against antibiotic-resistant infections.
29) Delhi:
Delhi, as a major metropolitan area and the location of the study, signifies regional health challenges relating to antibiotic resistance. Public health policies in cities like Delhi are critically influenced by patterns of infection and resistance, underscoring the importance of localized research to address specific healthcare needs.
30) Linen:
Linen refers to cloth or fabric, which can be contaminated with pathogens like Acinetobacter in healthcare settings. Its relevance highlights the need for stringent cleaning protocols to prevent the spread of infections, raising awareness about transmission routes and infection control measures necessary in hospitals.
31) Genu:
Genu, which may refer to genuineness or legitimacy, highlights the importance of authentic data in scientific research. Ensuring credible sources and accurate methodologies in studies on Acinetobacter resistance is key for generating trustworthy findings that further the understanding of this pressing public health issue.
32) Post:
Post usually refers to after a certain event, particularly the outcomes following interventions. In the context of antibiotic resistance studies, post-treatment observations of patient outcomes are crucial for evaluating the effectiveness of current treatment strategies and informing future clinical practices in managing resistant infections.
33) Male:
Male refers to the male gender, which may be relevant in studies assessing demographic factors influencing antibiotic resistance patterns or infection rates. Understanding gender-related disparities offers insights into susceptibility and treatment responses, guiding personalized healthcare approaches for effectively managing infections among varied patient populations.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antimicrobial Resistance Patterns of Multidrug-Resistant Acinetobacter’. Further sources in the context of Science might help you critically compare this page with similair documents:
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Concepts being referred in other categories, contexts and sources.