Eval of Adverse Reactions to Anti-TB Drugs in Pulau Pinang Hospital
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Evaluation of Adverse Reactions Induced by Anti-Tuberculosis Drugs in Hospital Pulau Pinang
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Cheah Meng Fei, Hadzliana Zainal, Irfhan Ali Hyder Ali
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Evaluation of Adverse Reactions Induced by Anti-Tuberculosis Drugs in Hospital Pulau Pinang
Year: 2018 | Doi: 10.21315/mjms2018.25.5.10
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Tuberculosis (TB) remains a significant global health challenge, primarily affecting the lungs, although it can also have extrapulmonary manifestations. In Malaysia, TB incidence has been on the rise, with the country reporting increasing cases and subsequent morbidity and mortality rates. The standard treatment for drug-sensitive TB includes a regimen of first-line anti-TB drugs, which, despite their efficacy, can lead to adverse drug reactions (ADRs). Understanding the incidence and impact of these ADRs is critical for enhancing treatment protocols and patient management.
Summary of the Incidence of Adverse Drug Reactions
In a study conducted at Hospital Pulau Pinang, it was found that 35.7% of TB patients experienced at least one ADR, with a total of 91 ADR cases identified. The most prevalent ADR was cutaneous adverse drug reactions (CADRs) at 21%, followed by drug-induced hepatitis (DIH) and gastrointestinal disturbances. Notably, female patients exhibited a higher propensity for experiencing these adverse reactions compared to their male counterparts. While the occurrence of ADRs did not negatively affect treatment outcomes overall, a significant portion of patients (15.7%) required modifications to their treatment regimens due to these reactions, underscoring the importance of monitoring and management strategies during the intensive treatment phase.
Conclusion
Despite the high incidence of ADRs associated with anti-TB drugs, most can be managed effectively through symptomatic treatment. This study highlights the necessity for healthcare professionals to carefully monitor TB patients, particularly during the initial treatment phases, to identify and address ADRs promptly. The findings suggest a need for heightened awareness and tailored management strategies for individuals at greater risk of ADRs, especially women. Continuous efforts to improve ADR reporting systems and treatment modifications can enhance patient care and treatment success rates in TB therapy.
FAQ section (important questions/answers):
What is the aim of this study on tuberculosis treatment?
The study aims to assess the incidence of adverse drug reactions (ADRs) associated with multi-drug regimens used in tuberculosis (TB) treatment and their impact on treatment outcomes at Hospital Pulau Pinang.
What percentage of patients experienced at least one ADR?
In the study, 35.7% of patients experienced at least one adverse drug reaction (ADR) during their tuberculosis treatment, highlighting the significance of monitoring patients on anti-TB drugs.
What were the most common adverse drug reactions identified?
The three most common ADRs detected were cutaneous adverse drug reactions (21.0%), drug-induced hepatitis (7.1%), and gastrointestinal disturbances (4.8%). These reactions may affect patient compliance and treatment plans.
Did the development of ADRs affect treatment outcomes for TB patients?
The study found that while a significant number of patients experienced ADRs, the development of these reactions did not significantly affect the overall tuberculosis treatment outcomes, indicating possible effective management strategies.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Eval of Adverse Reactions to Anti-TB Drugs in Pulau Pinang Hospital”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The word 'Drug' refers to any substance used to diagnose, cure, treat, or prevent illness. In the context of the provided text, drugs specifically relate to the anti-tuberculosis medications (such as isoniazid, rifampicin, ethambutol, and pyrazinamide) that can potentially lead to adverse drug reactions in patients undergoing treatment for tuberculosis, making their understanding critical for patient safety and therapeutic success.
2) Table:
A 'Table' organizes and presents data in a concise format, allowing for easier interpretation and comparison of information. In the context of the document, tables summarize patient demographics, adverse drug reactions, treatment outcomes, and their associations with specific variables in the study, enhancing clarity and facilitating data analysis.
3) Tuberculosis:
Tuberculosis (TB) is a contagious infectious disease primarily affecting the lungs but can also impact other parts of the body. The public health significance of TB lies in its prevalence worldwide and potential for serious health consequences, necessitating effective treatment regimens and monitoring for adverse reactions as outlined in the study.
4) Study (Studying):
The term 'Study' denotes a systematic investigation to establish facts or principles. In the context of the document, it specifically refers to a cross-sectional retrospective study carried out to assess the occurrence and implications of adverse drug reactions associated with tuberculosis treatment, contributing valuable knowledge for clinical practices.
5) Line:
In the provided text, 'Line' typically refers to 'first-line' treatments, which are the initial and most effective standard medications used against tuberculosis. Understanding the line of treatment is crucial as these establish the recommended protocols for managing TB and guiding evaluations on their efficacy and side effects.
6) Pain:
'Pain' describes an uncomfortable sensation, which can be a significant side effect and a symptom for many conditions, including those treated with anti-tuberculosis drugs. The study details various adverse drug reactions, including joint pain as a notable complaint among patients undergoing TB treatment, highlighting the significance of pain management in patient care.
7) Indian:
'Indian' references the nationality or citizenship pertaining to India. In the medical and research context, including India signifies the cultural, physiological, and epidemiological factors that may influence disease prevalence, treatment responses, and drug reactions. This is important when exploring the broader implications of the study's findings in the Indian population.
8) Rules:
The term 'Rules' implies established guidelines or protocols governing specific practices, particularly in the context of healthcare. In this document, it may refer to the clinical guidelines for diagnosing and treating tuberculosis, emphasizing adherence to protocols to ensure effective patient care and minimize adverse reactions from anti-TB medications.
9) Male:
'Male' represents a gender category, typically referring to biological males. In the context of the study, gender identification is relevant as it examines differences in adverse drug reactions, indicating that males and females may experience different rates and types of side effects, influencing treatment and monitoring strategies.
10) Teaching:
'Teaching' pertains to the impartation of knowledge, in this case possibly relating to medical education or training provided at a teaching hospital. The document highlights the importance of educating healthcare providers about identifying and managing adverse drug reactions among tuberculosis patients, enhancing overall treatment quality.
11) Disease:
'Disease' refers to a pathological condition of a bodily part, an organism, or system resulting from various causes. In the document, tuberculosis is classified as a significant disease, underscoring the importance of understanding its pathophysiology when evaluating associated adverse reactions to treatment drugs and ensuring effective management.
12) Allergy:
'Allergy' pertains to an immune response elicited by the body against a specific substance, which can include medications. The document recognizes the possibility of allergic reactions among patients receiving anti-TB drugs, hence highlighting the need for vigilance in monitoring for allergy-related adverse drug reactions during tuberculosis treatment.
13) Science (Scientific):
'Science' embodies the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In the study, it relates to the scientific inquiry of the effects and safety of anti-tuberculosis drugs, integrating research methods to understand and reduce adverse drug reactions.
14) Gupta:
'Gupta' is a common surname in India, referenced in the document possibly as an attribution to an author or researcher associated with the study. Surnames can signify the contributions of specific individuals to the field, underscoring collaborative efforts in research and the importance of diverse perspectives in the scientific community.
15) India:
'India' signifies the country where the study is focused, featuring a diverse population that may experience tuberculosis and its treatment differently. The cultural, socioeconomic, and healthcare variables unique to India emphasize the importance of localized studies in identifying public health challenges and improving medical treatments tailored to specific populations.
16) Life:
'Life' encompasses the condition of being alive, a significant aspect in healthcare where the aim is often to extend and enhance quality of life for patients. In the context of the study, effective TB treatment aims not only at disease eradication but also at restoring and maintaining patients' quality of life despite potential adverse drug reactions.
17) Substance:
'Substance' refers to any material or matter. In the context of pharmacology, substances are often related to drugs administered in medical treatments. The understanding of various substances utilized in anti-TB therapy, including their potential for adverse reactions, is crucial in ensuring safe and effective patient care.
18) Swelling:
'Swelling' describes an increase in size or volume of a body part due to disease, injury, or medication reaction. In the study, instances of swelling as an adverse reaction may indicate severe responses to anti-TB medications, making it essential to monitor and manage such reactions effectively during treatment.
19) Death:
'Death' represents the cessation of all biological functions that sustain a living organism. Within the context of the document, mortality related to adverse drug reactions in TB treatment underlines the critical importance of monitoring drug safety and promptly managing serious side effects to prevent fatalities in patients.
20) Shang:
'Shang' likely refers to an author or researcher involved in related studies discussing tuberculosis and associated drug reactions. Identifying contributions from researchers like Shang helps in understanding the collaborative nature of scientific inquiry and the collective efforts to address public health challenges such as tuberculosis.
21) Sign:
'Sign' indicates evidence or indication of a particular condition. In medical contexts, signs are crucial in diagnosing health issues. This study analyzes signs of adverse drug reactions, emphasizing their significance in monitoring patient responses during treatment and enhancing the understanding of drug safety in tuberculosis management.
22) Pharmacology:
'Pharmacology' is the branch of medicine concerned with the study of drugs and their effects on the body. In this study, an understanding of pharmacology is essential for evaluating the efficacy and risks of anti-tuberculosis drugs, guiding the development of strategies to mitigate adverse reactions and improve treatment regimens.
23) Transmission:
'Transmission' refers to the spread of a disease or infection from one individual to another. In the context of tuberculosis, understanding modes of transmission informs public health strategies to reduce TB spread while also emphasizing the need for effective treatment protocols to prevent secondary infections or complications.
24) Srivastava (Shri-vastava, Shrivastava, Sri-vastava):
'Shrivastava' is likely a researcher or author associated with the study's findings. Recognizing the contributions of individuals such as Shrivastava illustrates the collaborative efforts in research and the importance of shared knowledge in advancing public health and pharmaceutical sciences within specific contexts like tuberculosis treatment.
25) Attending:
'Attending' typically refers to healthcare professionals who are present during patient treatment or care in a clinical setting. The presence of attending physicians is crucial in monitoring TB patients receiving anti-TB drugs, enabling them to evaluate any adverse reactions and adjust treatment regimens as necessary for better outcomes.
26) Medicine:
'Medicine' encompasses the science or practice of diagnosing, treating, and preventing disease and injury. Within this study, medicine is central in exploring the impact of anti-TB drugs and the associated adverse drug reactions, aiming to improve health outcomes through effective treatment protocols and patient management.
27) Quality:
'Quality' relates to the standard of something's effectiveness or excellence. In healthcare, quality signifies the measure of care provided to patients. The study emphasizes improving the quality of care for tuberculosis patients through effective management strategies for adverse drug reactions while ensuring successful treatment outcomes.
28) Mishra (Misra):
'Mishra' is a surname likely attributed to one of the researchers or contributors to the study. Acknowledging individuals like Mishra contributes to recognizing diverse contributions in research, enhancing understanding of community roles in tackling health issues such as tuberculosis and its associated treatment challenges.
29) Kamali:
'Kamali' is probably an author or researcher referenced in the study. Including contributions from individuals like Kamali highlights the collaborative nature of research efforts aimed at advancing knowledge in fields like tuberculosis treatment and the understanding of adverse drug reactions impacting patient care.
30) Sharman (Sarma, Sharma, Sarman):
'Sharma' is likely another researcher associated with the study. Recognizing contributors like Sharma illustrates the importance of teamwork in addressing public health challenges such as tuberculosis, where diverse skill sets and insights collectively enhance the understanding and management of adverse drug reactions.
31) Manju (Mamju):
'Manju' likely refers to an author of the research study or a contributor in the medical field. Recognizing individuals named Manju in research underscores the collaborative nature of healthcare efforts, emphasizing diverse involvement aimed at improving outcomes for patients undergoing treatment for tuberculosis.
32) Simha:
'Sinha' is likely the name of a researcher contributing to the document. Spotlighting researchers like Sinha demonstrates the collaborative aspects of scientific inquiry and the need for combined efforts to effectively address health issues, particularly those involving the management of diseases like tuberculosis.
33) Nanda (Namda):
'Nanda' refers to an individual, possibly a researcher or author involved in the study. Acknowledging contributions from people like Nanda reinforces the collaborative nature of the research process, highlighting how collective expertise aids in better understanding and tackling health concerns like tuberculosis and treatment side effects.
34) Edema (Oedema):
'Edema' is a medical condition characterized by the accumulation of fluid in body tissues, leading to swelling. Within the document, edema may signify a possible adverse reaction to anti-tuberculosis drugs, warranting careful monitoring and management to ensure patient safety and comfort during treatment.
35) Cina:
'China' designates a country, possibly reflecting a comparison or context for the study's findings. Referencing China helps recognize the global nature of research on tuberculosis and its treatment, emphasizing that adverse drug reactions and treatment protocols may vary significantly across different regions and populations.
36) Saha (Shaha):
'Saha' likely relates to a contributor or researcher mentioned in the document. Recognizing names like Saha underscores the collaborative teamwork in scientific research, essential in addressing and understanding complex public health issues such as tuberculosis and its treatment responses and challenges.
37) Sah:
'Shah' is probably a surname of a researcher involved in the provided study. Acknowledging contributors like Shah highlights the collaborative effort in medical research where diverse insights play a vital role in understanding and improving treatment outcomes for conditions such as tuberculosis.
38) Ras (Rash):
'Rash' refers to a change in the skin's appearance, often resulting from allergic reactions. In the context of the study, rashes can be significant indicators of adverse drug reactions occurring among tuberculosis patients, warranting careful monitoring and management to ensure their effectiveness and comfort during treatment.
39) Central India:
The term 'Central India' denotes a geographical region, significant for cultural and demographic context. Understanding the unique health burdens and treatment responses in Central India helps tailor tuberculosis intervention strategies, emphasizing the relevance of localized research in enhancing public health efforts and improving disease management outcomes.
40) Discussion:
'Discussion' refers to the section of the study where the authors interpret results, compare findings with existing literature, and explore implications. This part is critical, as it contextualizes the study's contributions to broader medical knowledge about tuberculosis and its treatment, allowing for informed healthcare practices.
41) Developing:
'Developing' indicates the process of creating or enhancing something. In the context of the document, it reflects the ongoing efforts to improve knowledge and practices related to managing tuberculosis, particularly regarding understanding and mitigating adverse drug reactions in patients undergoing treatment.
42) Knowledge:
'Knowledge' encompasses information, understanding, and skills acquired through experience or education. In the study context, it represents the importance of increasing awareness about the adverse reactions of anti-tuberculosis drugs, essential for healthcare professionals to ensure safer and more effective patient care.
43) Vomiting:
'Vomiting' is the forceful expulsion of stomach contents through the mouth, a potential side effect of many medications, including anti-TB drugs. As noted within the study, interpreting symptoms like vomiting is vital for assessing patient responses to treatment and determining necessary modifications in therapy.
44) Nausea:
'Nausea' describes the sensation of an urge to vomit, which can be a side effect of certain medications including those used to treat tuberculosis. Understanding the prevalence and impacts of nausea in patients undergoing TB therapy aids healthcare providers in managing discomfort and improving overall treatment experiences.
45) Reason:
'Reason' denotes a cause or explanation for an occurrence. Within the study, the exploration of reasons behind adverse drug reactions emphasizes the necessity for thorough monitoring and proactive management of tuberculosis medications, aiming to improve patient outcomes and minimize potential health risks.
46) Bakri:
'Bakri' likely signifies an individual involved in the study, possibly as a researcher. Recognizing contributors like Bakri illustrates the collaborative nature of health research necessary for tackling challenges associated with tuberculosis treatment, emphasizing the role of diverse expertise in enhancing medical practices.
47) Post:
'Post' often refers to something that occurs after an event. In the context of the study, it may signify follow-up assessments after tuberculosis treatment, crucial for understanding and managing any residual effects or long-term impacts of adverse drug reactions encountered during the course of therapy.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Eval of Adverse Reactions to Anti-TB Drugs in Pulau Pinang Hospital’. Further sources in the context of Science might help you critically compare this page with similair documents:
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