Comparative Study of Oral7® vs Salt-Soda Mouthwash in Cancer Patients
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Preliminary Comparative Study of Oral7® Versus Salt-Soda Mouthwash on Oral Health Related Problems and Quality of Life among Head and Neck Cancer Patients Undergoing Radiotherapy
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Norsa’adah Bachok, Biswa Mohan Biswal, Noor Hayati Abdul Razak, Wan Mohd Nazri Wan Zainoon, Kasmawati Mokhtar, Roselinda Abdul Rahman, Mohd Faizal Abdullah, Siti Mimi Nadiya Mustafa, Nawi Noza
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Preliminary Comparative Study of Oral7® Versus Salt-Soda Mouthwash on Oral Health Related Problems and Quality of Life among Head and Neck Cancer Patients Undergoing Radiotherapy
Year: 2018 | Doi: 10.21315/mjms2018.25.5.8
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Head and neck cancers are increasingly prevalent, with an estimated half a million global cases diagnosed annually. The risk is particularly notable in developing countries, where patients often present at advanced stages due to a lack of awareness of early symptoms. Radiotherapy is the standard treatment for these cancers, but it can lead to significant side effects, particularly affecting the salivary glands. This results in xerostomia (dry mouth), which has severe implications for oral health and overall quality of life. In response to these issues, this study aimed to compare the effectiveness of the mucin-based artificial saliva product, Oral7®, against a traditional salt-soda mouthwash in mitigating the adverse effects of radiation therapy on patients with head and neck cancer.
Efficacy of Oral7®
The study found that while there was no significant difference in dental caries development (measured by the Decayed, Missing and Filling Teeth (DMFT) score) between the two groups, patients using Oral7® experienced substantially lower scores for xerostomia and mucositis at various points post-radiotherapy. Furthermore, those using Oral7® reported a better quality of life, specifically in areas related to swallowing, social eating, mouth opening, and overall health perception. These results highlight the potential benefits of using Oral7® as an adjunct treatment for managing xerostomia and improving the quality of life in patients undergoing radiotherapy for head and neck cancers.
Conclusion
The findings of this study suggest that Oral7® may provide clinically meaningful advantages over traditional saline-based mouthwash in managing radiation-induced side effects in head and neck cancer patients. Although the impact on dental caries was not statistically significant, the improvements in xerostomia and quality of life scores underscore the importance of effective management strategies for patients suffering from the oral complications of cancer therapies. Future studies should focus on larger sample sizes and extended follow-up periods to further validate these findings and refine supportive care protocols for this patient population.
FAQ section (important questions/answers):
What was the objective of the study comparing Oral7® and salt-soda mouthwash?
The study aimed to compare the effects of Oral7® and salt-soda mouthwash on dental caries, salivary function, radiation mucositis, xerostomia, and quality of life in head and neck cancer patients undergoing radiotherapy.
What were the main findings regarding xerostomia and quality of life?
Patients using Oral7® reported significantly lower xerostomia scores and better quality of life related to swallowing, social eating, mouth opening, and illness compared to those using salt-soda mouthwash.
How were patients selected for the study?
Patients were included if they had confirmed head and neck cancers, received radiation, were aged 15-60, and had an Eastern Cooperative Oncology Group performance status of 0-1. Exclusions included prior treatments and certain health conditions.
What methodological approach did the study use?
The study was a quasi-clinical trial, utilizing random allocation for treatment groups, with evaluations conducted at baseline, post-radiotherapy, and six months later, while ensuring blinded assessment to eliminate bias.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Comparative Study of Oral7® vs Salt-Soda Mouthwash in Cancer Patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth and division. In the context of the study, it refers specifically to head and neck cancers, which are prevalent globally and can significantly impact patients' health and quality of life, especially following treatments like radiotherapy.
2) Xerostomia:
Xerostomia, or dry mouth, is a common condition after radiotherapy that results from reduced saliva production. It affects oral hygiene, swallowing, and overall quality of life for patients. Understanding and managing xerostomia is crucial for improving patient outcomes and comfort during and after cancer treatment.
3) Salt (Salty):
Salt, in this context, refers to sodium chloride used in the salt-soda mouthwash compared to Oral7®. It plays a role in oral health and salivary function, often considered in treatments for conditions like xerostomia, aiming to alleviate symptoms and enhance patient comfort.
4) Radiotherapy:
Radiotherapy is a primary treatment modality for head and neck cancers that uses ionizing radiation to kill cancer cells. While effective against cancer, it often causes side effects like xerostomia and mucositis, making supportive therapies necessary to manage these adverse effects and improve patients' quality of life.
5) Table:
In the research context, a table refers to a structured presentation of data, summarizing demographic information and clinical findings of study participants. Tables are vital for clear and effective communication of results, enabling comparisons and analyses that support conclusions drawn from the study.
6) Study (Studying):
The study refers to the quasi-clinical trial conducted to compare the effects of Oral7® and salt-soda mouthwash on various patient outcomes, including dental caries and quality of life. It aims to advance knowledge in oncological care, specifically for head and neck cancer patients undergoing radiotherapy.
7) Life:
In this context, 'life' pertains to quality of life, particularly the well-being and daily functioning of patients diagnosed with head and neck cancers. The study emphasizes the importance of treatments that enhance life quality by managing symptoms and side effects associated with cancer therapy.
8) Quality:
Quality refers to the standard of life experienced by patients, focusing on emotional, social, and physical well-being. The research assesses how different mouthwashes can mitigate issues like xerostomia and mucositis, thus directly affecting the overall quality of life for cancer patients.
9) Swallowing:
Swallowing is a key function affected by head and neck cancer and its treatment, including radiotherapy. Difficulty in swallowing, or dysphagia, can lead to nutritional problems and decreased quality of life. The study evaluates how interventions might alleviate these swallowing difficulties for patients.
10) Chemotherapy:
Chemotherapy is another treatment modality often used in conjunction with radiotherapy for cancer patients. It can exacerbate side effects such as xerostomia. The study population included patients who may have undergone chemotherapy, highlighting the need for supportive care to manage their complex symptoms.
11) Post:
Post refers to the period following the initial treatment phase. In the study, it addresses patient outcomes measured six months after radiotherapy. This long-term follow-up is essential to understand the sustained effects of interventions and the trajectory of recovery for cancer patients.
12) Field:
Field often refers to the specific area within which treatment is applied, such as the field of radiotherapy targeting head and neck cancers. The study discusses how different fields of treatment can influence patient outcomes and necessitate supportive measures for managing side effects.
13) Pain:
Pain is a significant symptom many cancer patients experience, especially following treatments like radiotherapy. The study addresses various methods of managing pain associated with oral mucositis, emphasizing the need for effective pain relief strategies to enhance the quality of life for patients undergoing cancer treatment.
14) Performance:
Performance, particularly in terms of Eastern Cooperative Oncology Group (ECOG) status, indicates how well patients can carry out daily activities. The study assesses the impact of oral treatments on the performance status of head and neck cancer patients during and post-radiotherapy.
15) Hygiene (Hygienic):
Hygiene refers to oral hygiene practices which are crucial for cancer patients, particularly those undergoing radiotherapy, to prevent complications such as oral infections and dental caries. The study explores the effectiveness of different mouthwash treatments in maintaining oral hygiene and health during therapy.
16) Reason:
Reason relates to the rationale behind conducting the study, which is to identify and compare effective methods for managing oral health issues in head and neck cancer patients. Understanding reasons for treatment choices informs clinical practices and enhances patient care strategies.
17) Pur:
Poor refers to the negative outcomes affecting patients with head and neck cancer, particularly due to treatments that lead to complications like xerostomia and mucositis. The study aims to identify effective interventions to mitigate these conditions, improving patients' overall health and well-being.
18) Measurement:
Measurement involves assessing and quantifying patient outcomes, such as xerostomia and mucositis severity in this study. Reliable measurements are crucial for drawing valid conclusions about the effectiveness of treatments like Oral7® and salt-soda mouthwash in improving patient health post-treatment.
19) Language:
Language in this context refers to the language of the quality of life questionnaires used in the study, which were translated into Malay. Utilizing preferred languages ensures better comprehension by patients and enhances the quality and reliability of their responses in assessments.
20) Filling (Filled):
Filled often describes the state of dental cavities treated with fillings, an important aspect of assessing oral health. The research investigates the relationship between oral care products and the maintenance of dental health in head and neck cancer patients during treatment.
21) Avatara (Avatar):
Avatar can refer to a user or representation in the context of medical simulations or digital health tools. While not extensively covered in the study, understanding patient behavior and treatment adherence in the digital age can inform future interventions and educational strategies.
22) Joshi (Josi):
Joshi is mentioned as an author in the study, contributing to research on dental treatment planning and management for mouth cancer patients. The inclusion of diverse expertise enhances the study's credibility and integration of interdisciplinary knowledge in patient care.
23) Rules:
Rules may refer to the guidelines or protocols established for conducting the research, ensuring ethical standards and scientific rigor. Adhering to these rules is crucial for the integrity of the study and the reliability of its findings in oncological care.
24) Ship:
Ship refers to a co-author of the study who has contributed to understanding management strategies for salivary hypofunction. Their expertise and collaboration emphasize the interdisciplinary nature of cancer treatment, integrating medical and dental knowledge to optimize patient outcomes.
25) Male:
Male denotes a gender demographic among study participants. Analyzing gender differences can provide insights into how treatment effects may vary, influencing the development of targeted approaches for both male and female patients undergoing cancer therapies.
26) Calculation:
Calculation refers to the statistical processes used to analyze data collected during the study, including evaluating salivary gland function and quality of life scores. Accurate calculations are vital for drawing meaningful conclusions regarding the effectiveness of treatment interventions.
27) Discussion:
Discussion is a critical section in research papers where results are interpreted and contextualized within existing literature. In this study, the discussion highlights the implications of findings, potential limitations of the study, and recommendations for future research directions in oncological care.
28) Developing:
Developing generally pertains to countries or regions where healthcare resources may be limited. This study's context considers how head and neck cancers are especially prevalent in developing regions, emphasizing the need for effective treatment strategies and supportive care to improve patient outcomes.
29) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. In this context, it relates to the discussions around the management of cancer therapies and their side effects, highlighting multidisciplinary approaches in treating complex health issues.
30) Disease:
Disease refers to the abnormal condition affecting body functions. In the study, it primarily addresses head and neck cancer as the focal disease and discusses associated complications like xerostomia and mucositis, which significantly impact patients’ health and quality of life.
31) Science (Scientific):
Science involves the systematic study of structure and behavior of the physical and natural world through observation and experimentation. The research discussed employs scientific methods to evaluate the effectiveness of different treatments in managing side effects of head and neck cancer therapies.
32) Water:
Water is a crucial component of hydration and oral health, especially relevant for patients experiencing xerostomia. The study might consider the role of water intake and oral care products in alleviating dry mouth symptoms, contributing to patient comfort and overall health.
33) Food:
Food plays a vital role in the nutrition and well-being of cancer patients. The study explores how treatment-related complications like swallowing difficulties impact food intake and nutrition, emphasizing the importance of supportive care strategies to maintain dietary habits.
34) Burning (Burn, Burned, Burnt):
Burn refers to the sensation experienced by patients, particularly in the context of using certain mouthwashes or treatments following radiation therapy. Protecting sensitive oral tissues from burning sensations is essential for improving quality of life and adherence to prescribed oral care regimens.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Comparative Study of Oral7® vs Salt-Soda Mouthwash in Cancer Patients’. Further sources in the context of Science might help you critically compare this page with similair documents:
Alcohol, Chemotherapy, Radiotherapy, Xerostomia, Palliative care, Coughing, Oral hygiene, Sodium chloride, Supportive care, Treatment regimen, Preventive measure, Mouth-opening, Dry mouth, Quality of life, Social Contact, Inclusion criteria, Treatment group, Sample size, Clinical trial, Dysphagia, Weight gain, Mouthwashes, BMI, Dental caries, Chi square test, Nutritional supplement, Oral cavity, Sample size calculation, Follow-Up Assessment, Taste sensation, Radiation induced mucositis, Head and neck cancer, Mucositis, Antimicrobial, Weight loss, Confounding variables, Confidence interval, Conflicts of interest, Statistical analyses, Eastern Cooperative Oncology Group, Eastern Cooperative Oncology Group (ECOG), Radiation therapy, Dental problems, Oral microorganism, Quality of life questionnaire, Speech problems, Head and neck, Topical therapies, Multidisciplinary management, Palliative measure, Oral hygiene practice, Sodium bicarbonate, Artificial saliva, Palliative chemotherapy, Oral gels, Preventing complications, Body weight assessment, Cancer awareness, Salivary gland, Mouthwash, Quality of life score, Clinical oncologist, Neo-adjuvant Chemotherapy, Taste bud, Salivary flow, Non-significant Result, Systemic therapies, Oral tissues, Oral hygiene protocol, Natural enzyme, Radiation dose, Oral infection, Unstimulated saliva, Salivary gland function, Placebo lozenge, Dental assessment, Research grant, Socio-demographic background, Radiation effect, Feeding tube.