Nutritional and Antiproliferative Effects of Tamarillo Fractions

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Journal name: The Malaysian Journal of Medical Sciences
Original article title: Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

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Author:

Maisarah Abdul Mutalib, Asmah Rahmat, Faisal Ali, Fauziah Othman, Rajesh Ramasamy


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit

Year: 2017 | Doi: 10.21315/mjms2017.24.5.3

Copyright (license): CC BY 4.0


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Summary of article contents:

Introduction

This study investigates the bioactive constituents and antioxidant activity of various solvent extracts from Cyphomandra betacea (commonly known as tamarillo or tree tomato). The research also examines the potential anticancer effects of these extracts on liver and breast cancer cell lines. Given the rising concerns regarding oxidative stress and its association with various diseases—including cancer—this study highlights the significance of exploring plant-based antioxidants as possible therapeutic agents.

Nutritional Composition and Antioxidant Potential

The findings revealed a moderate nutritional composition in tamarillo, characterized by essential minerals and dietary fibers. Notably, the ethanolic extract of tamarillo exhibited the highest levels of phenolic and flavonoid content, which are compounds recognized for their significant antioxidant properties. Through methods such as GC-MS analysis and FT-IR spectroscopic analysis, twelve bioactive compounds were identified, displaying a range of health benefits, including potential chemopreventive effects against breast and liver cancer cells. The study determined that tamarillo’s significant antioxidant activity could be primarily attributed to its total phenolic content, establishing the fruit as a valuable natural source of antioxidants.

Conclusion

In summary, Cyphomandra betacea demonstrates promising antioxidant and anticancer properties, making it a potential agent for cancer prevention and treatment. Its bioactive components and antioxidant vitamins highlight its health benefits, particularly in relation to oxidative stress and diseases such as cancer. The results underscore the fruit's therapeutic potential, encouraging further research into its applications in nutraceuticals and functional foods. The findings suggest that tamarillo could serve as an effective, non-toxic alternative in health interventions targeting oxidative stress-related diseases.

FAQ section (important questions/answers):

What are the main objectives of the tamarillo study?

The study aims to analyze various solvent extracts of Cyphomandra betacea (tamarillo) for its bioactive constituents, nutritional composition, antioxidant activity, and anticancer effects against liver and breast cancer cell lines.

What methods were used to assess tamarillo’s antioxidant properties?

The researchers evaluated antioxidant activity using methods such as the beta-carotene bleaching assay (BCB), free radical scavenging activity (DPPH), and quantification of total phenolic and flavonoid contents.

What key findings were reported regarding tamarillo's nutritional content?

The study found that tamarillo contains moderate levels of ash, protein, carbohydrates, minerals, and high contents of antioxidant vitamins like beta-carotene and ascorbic acid, suggesting its potential health benefits.

How did tamarillo extract affect cancer cell lines?

The tamarillo extracts exhibited significant cytotoxic effects on liver (HepG2) and breast (MDA-MB-231) cancer cells, indicating its potential as a natural anticancer agent while being non-toxic to normal cells.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Nutritional and Antiproliferative Effects of Tamarillo Fractions”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In scientific literature, a 'Table' refers to a structured arrangement of data presented in rows and columns, which allows for easy comparison and analysis of information. Tables are widely used to summarize results, enabling efficient communication of numerical data or complex information in a clear and concise manner, aiding readers' understanding.

2) Activity:
The term 'Activity' in a scientific context often relates to the functional effectiveness of a substance or process. It may refer to biochemical activities, such as enzymatic reactions, metabolic processes, or physiological effects, and is critical for understanding the potential applications of compounds, such as antioxidants' role in mitigating oxidative stress.

3) Food:
'Food' denotes substances consumed for nutritional support. In the context of health and dietary studies, food is analyzed for its nutrient composition, health benefits, and potential roles in disease prevention. Understanding food’s molecular constituents, like antioxidants in fruits, is vital for promoting health and developing dietary guidelines.

4) Water:
'Water' is a fundamental component of all biological processes, serving as a solvent, nutrient carrier, and vital for cellular function. In studies related to nutrition, it is also examined in the context of hydration and health, playing a critical role in digestion, absorption, and metabolism of nutrients.

5) Beta:
'Beta' often refers to beta-carotene, a precursor to vitamin A, synthesized in plants and responsible for pigmentation in fruits and vegetables. In nutrition science, beta-carotene is noted for its antioxidant properties, contributing to human health by fighting oxidative stress, improving immune function, and supporting vision.

6) Study (Studying):
A 'Study' in scientific research denotes a structured investigation aimed at exploring a specific hypothesis, gathering evidence, and drawing conclusions. Studies can vary in design, including experimental, observational, or clinical trials, and are foundational to advancing knowledge in fields such as nutrition and medicinal properties of plants.

7) Cancer:
'Cancer' refers to a group of diseases characterized by uncontrolled cell growth and division. Research on cancer focuses on understanding its causes, prevention, and treatment strategies. Studies exploring natural compounds, like those from plants, aim to identify potential chemopreventive agents that could inhibit tumor growth and improve outcomes.

8) Mineral:
'Mineral' refers to inorganic nutrients essential for various bodily functions, including bone formation, nerve function, and metabolic processes. Nutritional studies often assess mineral content in foods, emphasizing their importance in diet and health, suggesting that adequate mineral intake helps prevent deficiencies and associated health issues.

9) Flavonoid:
'Flavonoid' describes a class of plant compounds known for their antioxidant properties and role in conveying various health benefits. These compounds are studied for their potential to prevent chronic diseases, such as heart disease and cancer while enhancing overall health through their contribution to the diet.

10) Phytochemical:
'Phytochemical' refers to biologically active compounds found in plants that contribute to health benefits. They can exhibit antioxidant, anti-inflammatory, or anticancer properties and form an essential area of research in understanding how consuming plant-based foods can improve health outcomes and reduce disease risk.

11) Line:
'Line' in a scientific context may refer to cell lines used in research to study cellular behaviors, drug responses, or disease mechanisms. Utilizing specific cell lines allows for controlled experiments, aiding in the understanding of various biological processes relevant to health science and drug development.

12) Rules:
'Rules' in scientific research encompass guidelines or principles that govern experimental design, ethical considerations, and data analysis. They ensure that studies are conducted systematically, promoting reliability and validity in findings, thereby enhancing the integrity of scientific inquiry and the trustworthiness of published results.

13) Powder:
'Powder' often refers to a processed form of a substance, typically generated by grinding or milling. In the context of food and nutritional studies, powdered extracts of fruits or herbs are commonly analyzed for their bioactive compounds, enhancing the concentration of certain health-promoting properties and facilitating their study.

14) Gold (Golden):
In nutritional studies, 'Golden' can refer to a specific variety of a fruit—the golden tamarillo, for example—recognized for its unique health attributes. The term could also metaphorically describe superior quality, indicating certain products or compounds might possess enhanced bioactive properties compared to others.

15) Rich (Rch):
'Rich' typically denotes a high concentration of a specific nutrient or bioactive compound in a food or substance. In nutritional research, being 'rich in antioxidants' implies that a food has substantial levels of these compounds that can provide health benefits, making them desirable in dietary recommendations.

16) Antibiotic (Antibacterial):
'Antibacterial' refers to substances that prevent the growth of bacteria or kill them. Studies investigating the antibacterial properties of phytochemicals contribute to understanding how plant-derived compounds can be integrated into healthcare and food preservation to combat bacterial infections and enhance human health.

17) Species:
'Species' refers to a distinct group of organisms that share common characteristics and can interbreed. In botanical and medicinal research, identifying plant species is crucial for investigating their unique properties, traditional uses, and potential health benefits, influencing conservation and agricultural practices.

18) Ripe:
'Ripe' signifies the stage of fruit development when it is ready for consumption and often at peak nutritional quality. In studies examining fruit, ripeness affects the concentration of vitamins, minerals, and phytochemicals, influencing the health benefits derived from consuming the fruit.

19) Measurement:
'Measurement' denotes the process of quantifying characteristics or constituents, crucial in scientific experiments. Accurate measurement ensures data reliability, allowing researchers to assess nutrient composition, efficacy, and interactions, leading to valid conclusions in studies focusing on health impacts or biological activities.

20) Science (Scientific):
'Scientific' pertains to the systematic study of the natural world through observation, experimentation, and analysis. The scientific approach is foundational in advancing knowledge across disciplines, allowing researchers to validate hypotheses, establish facts, and contribute evidence-based insights into health, nutrition, and biochemistry.

21) Pesticide:
'Pesticide' refers to substances used for controlling pests, including insects, weeds, and diseases in agriculture. The relevance of studying pesticides involves investigating their effects on environmental health, potential residues in food, and exploring natural alternatives that could mitigate risks to human health and ecosystems.

22) Pannala:
'Pannala' references an author or contributor to scientific literature, highlighting the collaboration in research. Recognizing contributors ensures proper attribution of ideas, promotes accountability in scientific communications, and encourages collaboration across multidisciplinary research efforts.

23) Chandra:
'Chandra' may refer to an author associated with research work. Acknowledging contributors like Chandra emphasizes the collaborative nature of scientific investigation, attributing credit and establishing connections to broader research initiatives and advancements in specific fields, such as health and nutrition.

24) Disease:
'Disease' pertains to a pathological condition caused by infection, genetic anomalies, or lifestyle factors. Understanding diseases is essential for identifying prevention strategies, evaluating treatments, and improving overall health outcomes in populations through evidence-based research and public health initiatives.

25) Allergy:
'Allergy' signifies an inappropriate immune response to commonly harmless substances. Research on allergies focuses on understanding triggers, mechanisms, and potential treatments, emphasizing the significance of dietary components, particularly in preventing or managing allergic reactions in sensitive individuals.

26) Avila:
'Avila' likely refers to an author or participant in a scientific study. Citation of contributors like Avila acknowledges their input and efforts in research efforts, fostering a communicative academic culture that recognizes collaborative work in advancing knowledge and scientific literature.

27) Landi (Lamdi):
'Landi' could refer to an author or researcher involved in the scientific discourse. Attribution to contributors like Landi showcases the collaborative nature of research, supporting the sharing and dissemination of ideas, findings, and methodologies in various scientific communities.

28) Patil:
'Patil' is likely a contributor or author in a scientific context. Recognizing individuals such as Patil is crucial in maintaining academic integrity, ensuring proper credit for ideas and work while encouraging collaborative efforts, fostering innovation, and driving future research initiatives.

29) Tree:
'Tree' usually pertains to a perennial woody plant. In the context of plants like 'tamarillo,' the term identifies the species and emphasizes their environmental role and potential applications in food, health, and agriculture, linking botanical characteristics to human uses.

30) Rice (Rce):
'Rice' commonly signifies a staple food grain and is crucial in various dietary studies. Examination of rice varieties often includes their nutritional and health properties, emphasizing its implications for food security, diets, and cultural significance across global populations.

31) Drug:
'Drug' refers to a substance used for medical treatment, diagnosis, or prevention of disease. The research into natural compounds often focuses on their potential therapeutic properties, contributing to the development of new pharmaceuticals while evaluating efficacy against various health conditions.

32) Tai:
'Thai' typically denotes something related to Thailand, including its cuisine, culture, or agricultural products. In nutrition research, Thai fruits and vegetables are often studied for their unique nutritional profiles and health benefits, influencing dietary practices and traditional medicine.

33) Viru:
'Viru' could suggest a classification or reference to a viral component. Exploring viruses contributes to understanding infectious diseases, transmission, and potential natural remedies or preventive measures against viral infections, emphasizing the importance of research in virology.

34) Chemotherapy:
'Chemotherapy' refers to the administration of drugs to treat cancer by killing or slowing the growth of cancer cells. Research into natural compounds for their chemopreventive potential illustrates the dual focus on finding effective treatments while minimizing harmful side effects of conventional therapies.

35) Performance:
'Performance' denotes the effectiveness of a substance in achieving desired outcomes, often assessed in research contexts. In clinical trials, performance measures can determine the efficacy of treatments, informing best practices and guiding future research directions in health and nutrition.

36) Discussion:
'Discussion' refers to the section of a research paper where results are interpreted and contextualized with existing literature. It is essential for explaining implications, limitations, and potential future research directions, fostering knowledge exchange while highlighting the research's relevance in broader scientific discourse.

37) Fragrance:
'Fragrance' signifies a pleasant scent derived from natural or synthetic compounds. In research, fragrances can indicate the presence of certain phytochemicals in plants, contributing to understanding their roles in attraction, deterrence in nature, and potential health benefits associated with aromatherapy.

38) Mutation:
'Mutation' implies a change in the DNA sequence that can lead to altered traits or functions. In medical research, understanding mutations is crucial for explaining the development of diseases like cancer, and the development of targeted therapies aimed at correcting or mitigating their effects.

39) Killing (Killed):
'Killing' in a scientific context often refers to the elimination of harmful cells, such as cancer cells, by therapeutic agents. Understanding the mechanisms by which natural compounds induce cell death is vital for developing effective treatments and enhancing the selectivity and efficacy of anticancer strategies.

40) Family:
'Family' refers to a taxonomic rank in biological classification. In botanical studies, family classification (e.g., Solanaceae for tamarillo) helps in understanding ecological relations, plant characteristics, and potential uses, guiding research into properties that may be shared among related species.

41) Repair:
'Repair' denotes the biological processes that restore function and integrity to cells or tissues. Research often focuses on understanding how certain compounds can aid in healing, emphasizing their potential protective effects against damage caused by diseases or environmental stressors.

42) Medium:
'Medium' indicates a substance or environment in which organisms grow or reactions occur. In culture studies, the choice of medium impacts cell growth and research outcomes, influencing experiments designed to test cellular behaviors or responses to various treatments.

43) Putra:
'Putra' likely refers to a contributor or associated institution in the research sector, highlighting the role of local universities in advancing scientific inquiry. Acknowledging contributors fosters collaboration and promotes the dissemination of knowledge within academic communities.

44) Death:
'Death' signifies the cessation of biological functions. In research, particularly regarding disease, understanding the mechanisms leading to cell death can have profound implications for therapies, particularly in cancer treatment, where inducing programmed cell death is a critical therapeutic strategy.

45) Wall:
'Wall' typically refers to cellular structures, such as the cell wall found in plants. Studies exploring the features of the cell wall in plant cells enhance understanding of physical properties, contributing to nutraceutical and agronomic research emphasizing plant utility and health benefits.

46) Post:
'Post' can refer to the distribution or dissemination of research findings. Ensuring that research is shared 'post-publication' with the community supports transparency, facilitates knowledge exchange, and encourages further exploration and verification of scientific claims.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Nutritional and Antiproliferative Effects of Tamarillo Fractions’. Further sources in the context of Science might help you critically compare this page with similair documents:

Alkane, Ether, Phytochemical, Ripe fruit, Statistical analysis, Antioxidant activity, HPLC analysis, Phytochemical analysis, Oxidative stress, Free radical scavenging, Nutritional composition, Anti-inflammatory, Reactive oxygen species, Beta carotene, Free radical scavenging activity, Anti-inflammatory effect, Antioxidant capacity, Ethanolic extract, MTT assay, Total phenolic content, Cytotoxic activity, DPPH scavenging activity, Antioxidant activities, Flavonoid content, Antioxidant, IC50 value, Total flavonoid content, Ascorbic acid, Total phenol content, Antioxidative activity, Acetic acid, Doxorubicin, IC50, DPPH radical scavenging, Bioactive compound, Anticancer properties, Cancer cell line, Dose response curve, Plant metabolites, GC-MS analysis, Mass spectrum, Total Phenolic Content (TPC), Ethyl acetate fraction, GC-MS, Antioxidant defense, FT-IR analysis, Chemopreventive effect, 1, 3, 4-oxadiazole, Flavonoid compound, Free radical scavenger, Grape seed extract, Anticancer activities, Therapeutic benefit, Antiproliferative activity, Phenol, Enzymatic Antioxidant, Folin-Ciocalteu assay, Carboxylic acid, HEPG2, Hexadecanoic acid, Total phenol, Water fraction, Phytochemical profiling, Atomic absorption spectrometry, Major phytoconstituent, N-butanol fraction, Crude ethanol extract, Functional group, Scavenging effect, Anti-cancer agent, Antioxidant vitamin, N-Hexadecanoic acid, Beta carotene bleaching assay, MDA-MB-231, Non-enzymatic antioxidant, Chemopreventive properties, Evaluation of antioxidant activity, Alcoholic beverage, Total flavonoid content (TFC), Cancer cell death, Food chem, Bioactive constituent, Anticholinesterase activity, J Agric Food Chem, Propanoic acid.

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