Review of SCCmec Types in Coagulase-Negative Staphylococci
Journal name: The Malaysian Journal of Medical Sciences
Original article title: A Review of Staphylococcal Cassette Chromosome mec (SCCmec) Types in Coagulase-Negative Staphylococci (CoNS) Species
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Huda Saber, Azmiza Syawani Jasni, Tengku Zetty Maztura Tengku Jamaluddin, Rosni Ibrahim
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: A Review of Staphylococcal Cassette Chromosome mec (SCCmec) Types in Coagulase-Negative Staphylococci (CoNS) Species
Year: 2017 | Doi: 10.21315/mjms2017.24.5.2
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Coagulase-negative staphylococci (CoNS) are generally recognized as low pathogenic organisms; however, their role in serious infections has increased over time, particularly due to their ability to form biofilms and adapt to various antibiotics. This trend is concerning as CoNS have become major nosocomial pathogens, with species like Staphylococcus epidermidis and Staphylococcus haemolyticus at the forefront. Notably, the study of CoNS, particularly their species and gene distributions, remains limited, especially in regions like Malaysia. Understanding these dynamics is essential for better management and treatment of infections linked to these organisms.
The Significance of SCCmec
One crucial element in the pathogenesis of Staphylococcus species is the staphylococcal cassette chromosome mec (SCCmec), which carries the methicillin resistance gene, mecA, and is pivotal in the emergence of methicillin-resistant staphylococci (MRSA). SCCmec comprises the mec gene complex and the ccr gene complex, which allow for the integration and excision of the SCCmec element within the bacterial chromosome. Diverse types of SCCmec (I to VIII) have been recognized, with varying prevalence across different CoNS species. Research undertaken in Malaysia highlighted significant findings regarding the distribution of SCCmec types among CoNS, revealing that they harbor a wide range of types and genetic variety, suggesting the potential for horizontal gene transfer and serving as a reservoir for resistance genes.
Conclusion
The growing prevalence of CoNS as pathogens in both hospital and community settings underscores the urgency for enhanced research and surveillance. The identification of diverse SCCmec types in CoNS is concerning, as it highlights their role as potential reservoirs for antibiotic resistance, which could significantly impact public health. A deeper understanding of the genetic and phenotypic characteristics of CoNS, particularly related to their SCCmec elements, will be vital in informing clinical practices and infection control measures. As the landscape of bacterial resistance continues to evolve, addressing these challenges through targeted research and improved healthcare protocols will be essential in combating infections caused by CoNS.
FAQ section (important questions/answers):
What are coagulase-negative staphylococci (CoNS) and their significance?
CoNS are low pathogenic bacteria that can cause serious infections, particularly in immunocompromised patients. They are known for their ability to form biofilms, increasing their resistance to antibiotics and complicating treatment options.
What role does SCCmec play in Staphylococcus infections?
The staphylococcal cassette chromosome mec (SCCmec) carries the mecA gene, which confers methicillin resistance. This genetic element is crucial for understanding the pathogenicity and antimicrobial resistance of both coagulase-negative staphylococci and Staphylococcus aureus.
Why is further research on CoNS important in Malaysia?
Limited studies on CoNS in Malaysia highlight the need for comprehensive research. This is essential to understand the species distribution, resistance patterns, and potential infection risks associated with these organisms in both hospital and community settings.
How do CoNS contribute to antibiotic resistance in hospitals?
CoNS, particularly those carrying SCCmec elements, can transfer their resistance genes to more pathogenic bacteria like Staphylococcus aureus. Their presence in indwelling medical devices often leads to difficult-to-treat infections, exacerbating antibiotic resistance issues.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Review of SCCmec Types in Coagulase-Negative Staphylococci”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Aureus:
Aureus refers specifically to 'Staphylococcus aureus', a coagulase-positive species of staphylococci known for causing severe infections in humans. Its significance lies in its role as a major pathogen with high resistance to antibiotics, leading to increased morbidity and mortality rates in infected individuals.
2) Species:
Species denotes a group of organisms sharing common characteristics, which can reproduce among themselves. In the context of microbiology, identifying species like coagulase-negative staphylococci (CoNS) helps in understanding infection patterns, epidemiology, and developing targeted treatments to combat resistant strains effectively.
3) Chemotherapy:
Chemotherapy involves using chemical substances to treat diseases, particularly cancer. In relation to bacterial infections, it refers to antimicrobial therapies that target specific pathogens, thus playing a crucial role in combating infections caused by resistant organisms such as Methicillin-resistant Staphylococcus aureus (MRSA).
4) Table:
A table in scientific literature is a structured arrangement of data, often summarizing findings or comparisons. It makes complex information accessible, such as showing the distribution of SCCmec types among various species, aiding researchers and clinicians in analysis, and decision-making for infection control.
5) Blood:
Blood is a critical bodily fluid conveying nutrients, gases, and waste. In microbiological contexts, it's a common source for culture tests to identify infections. The presence of coagulase-negative staphylococci in blood cultures can indicate contamination or true bacteremia, influencing clinical management decisions.
6) Antibiotic (Antibacterial):
Antibiotics are medical drugs used to treat bacterial infections by inhibiting growth or killing bacteria. Their relevance has increased due to rising antibiotic resistance among pathogens like coagulase-negative staphylococci, necessitating ongoing research to develop effective treatment options and manage resistance patterns.
7) Animal:
In biomedical research, animals often serve as models for studying diseases and developing therapies. Identifying antibiotic resistance in animals, such as coagulase-negative staphylococci found in livestock, is vital for understanding zoonotic infections and preventing the transmission of resistant bacteria to humans.
8) Disease:
Disease refers to pathological conditions affecting bodily functions. Understanding how specific bacteria like Staphylococcus species cause disease in various hosts is crucial for developing effective treatments, especially as these pathogens adapt to resist commonly used antibiotics, complicating infection management.
9) Indian:
Indian denotes the nationality or geographical origin related to India. In the context of medical research, it highlights studies conducted in India, focusing on local epidemiological data regarding infections caused by coagulase-negative staphylococci and their resistance patterns, essential for tailoring health policies.
10) Bakri:
Bakri refers to A. G. Al-Bakri, a researcher whose work contributes to understanding microbiological epidemiology, particularly in Staphylococcus species. Their studies often focus on antibiotic resistance and transmission of pathogens in specific populations, which informs clinical practices and public health strategies.
11) Science (Scientific):
Science embodies the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In medical research, scientific principles are foundational for investigating pathogens like staphylococci, understanding their mechanisms, and developing effective treatments and preventive measures.
12) Evolution:
Evolution refers to the process through which species undergo genetic change over time, which in microbiology explains the adaptation of bacteria to resist antibiotics. Understanding the evolutionary mechanisms behind resistance helps in predicting future trends in infection and resistance, guiding therapeutic strategies.
13) Malik:
Malik refers to a researcher or author who contributes to studies in microbial resistance. Their findings can provide insights into the prevalence and characteristics of antibiotic-resistant strains, particularly in animal and human populations, supporting the development of effective intervention strategies.
14) Horse:
Horses are equine animals often used in veterinary research. Their relevance in microbiological studies includes understanding the transmission of methicillin-resistant staphylococci, which affects both animal health and public health, especially concerning zoonotic infections and antibiotic resistance dynamics.
15) India:
India, as a country with diverse populations and health challenges, serves as a significant focus for studying infections caused by coagulase-negative staphylococci. Research from India contributes to global understanding by providing valuable data on local epidemiology, resistance patterns, and effective clinical management.
16) Study (Studying):
A study involves systematic investigation in science to acquire knowledge regarding a specific area or hypothesis. In microbiology, studies on staphylococcal species focus on their pathogenicity, resistance mechanisms, and epidemiological trends, which informs clinicians and public health officials about infection control strategies.
17) Drug:
Drug refers to any substance used for medical purposes, including treatment or prevention of diseases. In the context of staphylococci, understanding how certain drugs interact with bacterial pathogens, particularly in terms of antibiotic resistance, is crucial for developing effective treatments and managing infections.
18) Attending:
Attending refers to individuals involved in a medical practice, often responsible for overseeing patient care. In studies relating to antibiotic resistance in hospitals, attending physicians play a pivotal role in implementing treatment plans and infection control measures to mitigate adverse outcomes associated with resistant infections.
19) Arca:
Arca refers to a genus in the family Arcidae, but in the context of staphylococci-related literature, it might imply relevant research findings or molecular markers being studied. It emphasizes the vast diversity of genetic elements and associations in bacterial evolution and antibiotic resistance.
20) Food:
Food encompasses substances consumed for nutrition. In relation to microbiology, food safety and the presence of resistant bacteria, such as staphylococci, highlight the importance of monitoring food sources for contamination that could spread infections to humans, impacting public health policies.
21) Peng:
Peng refers to a researcher or author who has contributed to studies focused on antibiotic resistance within staphylococci. Their findings often assist in understanding the genetic diversity and epidemiology of resistant strains, thus influencing clinical treatment practices and strategies for infection control.
22) Knowledge:
Knowledge refers to the information and understanding gained through study or experience. In the medical field, increasing knowledge about the mechanisms of antibiotic resistance, particularly among coagulase-negative staphylococci, is essential for developing effective interventions for infectious diseases.
23) Composite:
Composite refers to something composed of various parts. In microbiology, composite structures regarding Staphylococci can relate to genetically diverse elements, including resistant traits, that contribute to complex interactions in pathogenicity, emphasizing the need for comprehensive analysis in resistance studies.
24) Shani (Sani):
Sani refers to N. A. Sani, a researcher who contributed to the understanding of microbial epidemiology in Malaysia. Their research enhances the comprehension of staphylococcal infections and antibiotic resistance patterns, particularly in hospital settings, aiding in the development of effective treatment regimens.
25) Fish:
Fish refers to aquatic animals often studied in the context of bacteriology for understanding zoonotic infections. Investigations into resistant strains in fish highlight the broader implications of antibiotic use in aquaculture on public health, emphasizing the interconnectedness of different ecosystems.
26) Young women (Young woman):
Young women are often highlighted in studies concerning urinary tract infections, where certain staphylococcal species pose significant health risks. Understanding infection trends and resistance patterns among this demographic can directly influence clinical practices and public health strategies targeted towards vulnerable groups.
27) Pharmacology:
Pharmacology is the branch of medicine concerning drugs and their effects. It plays a crucial role in developing and optimizing treatment regimens against bacterial infections, especially as the increasing resistance of strains like MRSA necessitates ongoing research to ensure effective therapeutic options.
28) Teaching:
Teaching involves imparting knowledge and skills, particularly in educational settings. In medical and scientific fields, effective teaching strategies are vital for training healthcare professionals about infectious diseases and antibiotic resistance, thus shaping future approaches to managing pathogenic threats.
29) Chennai:
Chennai, a major city in India, serves as a focal point for research studies examining antibiotic resistance. Its diverse population provides a unique opportunity to conduct epidemiological studies on coagulase-negative staphylococci, yielding insights pertinent for local and global health initiatives.
30) Perumal:
Perumal refers to a researcher whose contributions to the field of microbiology, particularly concerning staphylococci, help to advance understanding. Their work often encompasses antibiotic resistance mechanisms and infection epidemiology, informing clinicians and public health policies for better health outcomes.
31) Writing:
Writing encompasses the act of documenting research findings and ideas clearly and effectively. In scientific communication, well-structured writing is essential for sharing knowledge, facilitating further research, and providing comprehensive insights into antibiotic resistance and infection management strategies in microbial studies.
32) Habitat:
Habitat refers to the natural environment where organisms live. Understanding the habitats of pathogens like coagulase-negative staphylococci is crucial in epidemiology, as it informs about potential infection sources and the ecological factors contributing to their transmission and resistance patterns.
33) Delhi:
Delhi, as a significant urban center in India, serves as an important location for healthcare research and antibiotic resistance studies. Data from Delhi enhances the understanding of the prevalence of resistant strains and informs public health strategies within densely populated regions.
34) Rules:
Rules encompass guidelines or principles governing conduct within a particular sphere. In medical microbiology, establishing clear rules for antibiotic use and infection control is fundamental to combatting the rise of resistance among pathogens, including coagulase-negative staphylococci.
35) Cina:
China represents a major focus for studies related to infectious diseases, including the prevalence of antibiotic-resistant pathogens. Research outputs from Chinese research institutions contribute to the global understanding of resistance patterns, informing infection control policies and therapeutic practices worldwide.
36) Suri (Shuri):
Suri refers to a researcher contributing to staphylococcal studies, particularly in relation to antibiotic resistance. Their findings are significant for understanding the molecular mechanisms involved in resistance among coagulase-negative staphylococci, aiding in developing targeted treatments and infection management guidelines.
37) Paik:
Paik refers to a researcher involved in studies concerning antibiotic resistance among staphylococci. Their work is crucial in identifying resistance trends, understanding genetic variability, and providing evidence that supports the implementation of effective strategies for managing infectious diseases in clinical settings.
38) Bell:
Bell often refers to a researcher or an expert in microbial epidemiology. Their contributions are vital for advancing understanding of the roles that coagulase-negative staphylococci play in infections, particularly regarding their resistance to antibiotics, which informs treatment and preventive measures.
39) Veterinary science:
Veterinary science specializes in animal health and disease. It plays an essential role in understanding transmission dynamics of resistant bacteria in veterinary contexts, thus informing public health strategies and emphasizing the importance of antibiotic stewardship across both human and animal health sectors.
40) Southern India:
Southern India serves as a significant region for studies on antibiotic resistance and infections caused by coagulase-negative staphylococci. Its diverse population allows researchers to explore local epidemiology, paving the way for informed public health policies and targeted interventions against infections.
41) New Delhi:
New Delhi, as the capital of India, is a major hub for medical research and healthcare policy. Research conducted here on antibiotic-resistant staphylococci is crucial for understanding regional infection patterns and devising strategies to mitigate the spread of resistant pathogens.
42) Transmission:
Transmission refers to the transfer of pathogens from one host to another, which is critical in understanding the spread of infections such as those caused by antibiotic-resistant staphylococci. Studying transmission patterns aids in developing effective control measures and interventions to prevent outbreaks.
43) Observation:
Observation entails careful monitoring and recording of phenomena. In scientific research, methods of observation are fundamental for collecting data on infection rates and resistance patterns, leading to informed conclusions about the efficacy of treatments and strategies in managing bacterial diseases.
44) Developing:
Developing involves the process of creating or enhancing methodologies, treatments, or technologies. In the context of infectious diseases, developing new therapeutic approaches is vital for addressing antibiotic resistance, ensuring effective management of infections caused by pathogens like staphylococci.
45) Observing:
Observing includes the act of closely monitoring behaviors or events. In scientific research and clinical practice, observing infection trends helps in understanding antibiotic resistance and efficacy of treatments, thereby guiding healthcare decisions and reinforcing infection control practices.
46) Medicine:
Medicine is the science or practice of diagnosing, treating, and preventing disease. Its relationship with bacterial infections like those caused by staphylococci underscores the need for advancements in treatments, especially those targeting antibiotic-resistant strains prevalent in healthcare settings.
47) Overuse:
Overuse refers to excessive or inappropriate use of resources, often leading to negative outcomes. In the context of antibiotics, overuse contributes to resistance development among pathogens, complicating treatment protocols and necessitating careful adherence to prescribing guidelines to mitigate such issues.
48) Surface:
Surface denotes the outer or topmost layer of an object. In microbiology, the surface of medical devices or skin colonization sites is critical for studying bacterial adhesion and biofilm formation, which play significant roles in the pathogenesis of infections.
49) Family:
In biological classification, family groups together related genera sharing common characteristics. The relevance of families in microbiology aids in understanding evolutionary relationships among bacterial species, including coagulase-negative staphylococci, thereby enhancing knowledge about their pathogenicity and treatment options.
50) Nature:
Nature encompasses the physical world and its phenomena. The study of nature in microbiology examines the interactions between pathogens and their environments, influencing factors like transmission and resistance, which are critical for developing effective public health strategies.
51) Putra:
Putra may refer to institutions or initiatives related to educational research in Malaysia. This context emphasizes the importance of local studies in understanding the dynamics of infections caused by coagulase-negative staphylococci and the implications of antibiotic resistance in Malaysia.
52) Roman (Roma):
Roman often pertains to the classification of types, such as in the naming of SCCmec types using Roman numerals. This standardization is important for consistently identifying and communicating findings related to antibiotic resistance mechanisms in staphylococci across various research contexts.
53) Field:
Field denotes a specific area of study or practice. In scientific research, the field of microbiology is crucial for investigating pathogens, understanding their resistance mechanisms, and developing targeted treatment options, which is especially important for addressing burgeoning health concerns.
54) Hand:
Hand may refer to manual skills or actions taken in clinical practices, including surgical procedures or laboratory techniques. Hand hygiene is vital in preventing the transmission of infections, underscoring the importance of proper practices to limit pathogen spread, especially in healthcare settings.
55) Post:
Post may refer to communications in academic contexts, such as blog posts or publications sharing findings. Effective use of post formats aids in disseminating knowledge about staphylococci, particularly in relation to antibiotic resistance, making research accessible to a broader audience.
56) Pur:
Poor refers to inadequate conditions or lack of resources, often leading to significant health challenges. In the context of infections, poor access to healthcare and antibiotics can exacerbate the spread of resistant strains, thus underscoring the need for improved healthcare access and education.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Review of SCCmec Types in Coagulase-Negative Staphylococci’. Further sources in the context of Science might help you critically compare this page with similair documents:
Clinical significance, Research Studies, Antimicrobial agent, Staphylococcus aureus, Antimicrobial Resistance, Multidrug resistance, Genetic Diversity, Antibiotic resistance, Methicillin resistant Staphylococcus aureus, Tertiary care hospital, Staphylococcus epidermidis, Intensive care unit, Risk factor, S. aureus, Human infection, Nosocomial infection, Methicillin resistance, Horizontal gene transfer, Clinical isolate, S.epidermidis, Nasal carriage, Coagulase negative Staphylococci, Hospital setting, Nosocomial pathogen, Biofilm production, Staphylococcus haemolyticus, MecA gene, Methicillin resistant, Indwelling medical devices, Staphylococcus saprophyticus, Tertiary Hospital, Neonatal sepsis, Blood stream infection, Infection, Epidemiology data, Haematological diseases, Community-acquired infection, Antibiotic resistance gene, Staphylococcal cassette chromosome mec, Molecular epidemiology, Indian journal of medical microbiology, Asian Pacific Journal of Tropical Disease, Journal of Clinical and Diagnostic Research, PLoS ONE, Antimicrobial Agents and Chemotherapy, Community setting.
Concepts being referred in other categories, contexts and sources.