Ulva lactuca extract protects against myocardial infarction: Antioxidant, antiapoptotic.

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Journal name: The Malaysian Journal of Medical Sciences
Original article title: Protection by Ethanolic Extract from Ulva lactuca L. against Acute Myocardial Infarction: Antioxidant and Antiapoptotic Activities
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

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Author:

Wahyu Widyaningsih, Suwidjiyo Pramono, Zulaela, Sugiyanto, Sitarina Widyarini


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Protection by Ethanolic Extract from Ulva lactuca L. against Acute Myocardial Infarction: Antioxidant and Antiapoptotic Activities

Year: 2017 | Doi: 10.21315/mjms2017.24.6.5

Copyright (license): CC BY 4.0


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Summary of article contents:

Introduction

Acute myocardial infarction (AMI) is a significant health issue associated with high morbidity and mortality rates globally. Previous research has identified reactive oxygen species (ROS) as a key factor involved in the myocardial damage that occurs during AMI. The present study aimed to evaluate the antioxidant and antiapoptotic effects of an ethanolic extract from Ulva lactuca L. (EEUL) in a rat model of AMI induced by isoproterenol (ISO), thereby exploring its potential as a cardioprotective agent.

Antioxidant and Antiapoptotic Activities of EEUL

The study findings indicated that treatment with EEUL significantly increased the activity of catalase (CAT), an endogenous antioxidant enzyme, compared to the ISO-treated group. Additionally, the EEUL treatment groups exhibited a marked reduction in apical caspase-3 expression, a protein associated with apoptosis, as well as improved myocardial tissue morphology. This protective effect is primarily attributed to the antioxidant properties of EEUL, which aid in attenuating oxidative damage and apoptosis in myocardial cells during an ischemic event.

Conclusion

The results suggest that the ethanolic extract of Ulva lactuca L. provides noticeable protective effects against isoproterenol-induced myocardial infarction in rats, likely due to its antioxidant and antiapoptotic properties. These findings support the potential application of EEUL as a therapeutic agent in the management of cardiac diseases characterized by oxidative stress. Further research could explore the mechanisms underlying these effects and assess the efficacy of EEUL in clinical settings.

FAQ section (important questions/answers):

What is the main focus of the study?

This study investigates the antioxidant and antiapoptotic activities of an ethanolic extract from *Ulva lactuca* L. (EEUL) against myocardial damage caused by acute myocardial infarction (AMI) in a rat model.

How was the experiment conducted on the rats?

Thirty-six male Wistar rats were divided into six groups, with various treatments including isoproterenol (ISO) and different doses of EEUL or melatonin administered for 28 days before inducing AMI to assess protective effects.

What were the significant findings regarding catalase activity?

The administration of EEUL in treatment groups significantly increased catalase (CAT) activity compared to the ISO-treatment group, indicating that EEUL has antioxidant properties that may protect against oxidative stress in myocardial tissue.

What conclusion can be drawn from this study?

EEUL potentially provides protective effects against myocardial infarction via its antioxidant and antiapoptotic properties, illustrating the therapeutic potential of natural extracts for heart health.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Ulva lactuca extract protects against myocardial infarction: Antioxidant, antiapoptotic.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
Table typically refers to a structured arrangement of data, often used in research to present findings in a clear manner. In the context of scientific studies, tables summarize results such as experimental data, statistical analyses, or comparisons, making it easier for readers to interpret the relationship between variables and outcomes.

2) Activity:
Activity in scientific research often refers to the ability of a substance or compound to elicit a biological effect or undergo a specific reaction. In pharmacology, for instance, it can denote the effectiveness of a drug or extract in producing a desired therapeutic effect, such as antioxidant or anti-inflammatory properties.

3) Study (Studying):
A study is a thorough investigation aimed at understanding particular phenomena or relationships in a scientific context. It typically involves systematic research methods, including experiments, observations, or assessments, to gather data that can lead to conclusions about hypotheses, contributing to the broader knowledge in fields like medicine or biology.

4) Animal:
Animal studies are crucial in biomedical research as they help in understanding complex biological processes, including diseases and treatment effects. Animal models, such as rats or mice, are often used to assess the safety and efficacy of new drugs or interventions before proceeding to human trials, providing essential insights into biological reactions.

5) Flavonoid:
Flavonoids are a diverse group of phytonutrients found in many plants, known for their antioxidant, anti-inflammatory, and anti-cancer properties. They play a vital role in human health by protecting cells from oxidative stress and inflammation, often being the focal point in studies exploring natural remedies and dietary supplements.

6) Phytochemical:
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Mada commonly refers to a place or institution, such as Gadjah Mada University. In research, the affiliation with reputable institutions is significant for validation and recognition of studies. Institutions often provide the necessary infrastructure, funding, and intellectual environment for conducting meaningful scientific inquiries and advancing knowledge across disciplines.

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Castor refers to the castor plant, particularly Ricinus communis, known for its seeds that contain ricin and oil. In medicinal research, castor oil has various applications due to its laxative effects and potential benefits in treating skin conditions, making it an important subject of study in pharmacology.

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Sharma likely refers to a collaborator or researcher whose work contributes to the scientific community. Collaborations among researchers like Sharma enrich studies through shared expertise and diversified perspectives, crucial for tackling complex health issues and enhancing the reliability and applicability of research findings.

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Discover the significance of concepts within the article: ‘Ulva lactuca extract protects against myocardial infarction: Antioxidant, antiapoptotic.’. Further sources in the context of Science might help you critically compare this page with similair documents:

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