Efficacy of Topical Coriander Extract for Infants' Diaper Dermatitis

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: Efficacy of Topical Coriandrum sativum Extract on Treatment of Infants with Diaper Dermatitis: A Single Blinded Non-Randomised Controlled Trial
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Ladan Dastgheib, Narjes Pishva, Nasrin Saki, Soghra Khabnadideh, Bahareh Kardeh, Fatemeh Torabi, Shahram Arabnia, Alireza Heiran


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Efficacy of Topical Coriandrum sativum Extract on Treatment of Infants with Diaper Dermatitis: A Single Blinded Non-Randomised Controlled Trial

Year: 2017 | Doi: 10.21315/mjms2017.24.4.11

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

Diaper dermatitis, a prevalent skin disorder among infants, arises mainly due to over-hydration and elevated temperatures in the diaper area, leading to skin vulnerability. Standard treatments often include oils and powders, but these can cause irritation while topical steroids can have adverse side effects. In this context, the study investigates the potential of Coriandrum sativum (coriander) extract, known for its anti-inflammatory, analgesic, and antioxidant properties, as an alternative treatment for diaper dermatitis compared to the conventional hydrocortisone ointment.

Efficacy and Side Effects of Treatment

In a non-randomized clinical trial involving 58 infants diagnosed with diaper dermatitis, the efficacy of topical coriander extract cream was compared with hydrocortisone 1% ointment. The intervention group received coriander cream, while the control group was treated with hydrocortisone. After a 10-day treatment period, results showed 54.1% of infants in the coriander group were cured, compared to 90.5% in the hydrocortisone group, indicating a statistically significant difference. Additionally, 27% of infants using coriander experienced side effects, including irritation. This suggests that while Coriandrum sativum has benefits, its effectiveness in treating diaper dermatitis alone is not as robust as hydrocortisone.

Conclusion

The findings of this study do not support the efficacy of Coriandrum sativum as a treatment for diaper dermatitis when compared to hydrocortisone. Nevertheless, it points to the potential for improving outcomes with modifications, such as combining the extract with soothing agents to minimize irritation. Future research should consider randomized trials with larger sample sizes and longer follow-up periods to better assess the benefits of coriander extract and the possible alleviation of its side effects for treating diaper dermatitis.

FAQ section (important questions/answers):

What is the common treatment for diaper dermatitis in infants?

Common treatments include topical steroids, oils, soaps, and powders. However, these can cause complications like irritation and may not always be effective.

What is Coriandrum sativum and its effects?

Coriandrum sativum, or coriander, is a herbal remedy known for its anti-inflammatory, analgesic, antimicrobial, and antioxidant properties, potentially beneficial for treating skin conditions.

How effective is topical Coriandrum extract compared to hydrocortisone?

In a study, hydrocortisone showed significantly higher cure rates and fewer side effects compared to topical Coriandrum extract for diaper dermatitis in infants.

What suggestions were made for future studies on Coriandrum?

Future studies should consider using soothing compounds with Coriandrum, randomization to prevent bias, and extended follow-up periods to assess efficacy and safety more conclusively.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Efficacy of Topical Coriander Extract for Infants' Diaper Dermatitis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
Study refers to a systematic investigation designed to establish facts or principles or collect information on a subject. In this context, the study aimed to evaluate the efficacy and safety of Coriandrum sativum extract in treating diaper dermatitis in infants, providing evidence to support or refute its medicinal use.

2) Table:
A table is a systematic arrangement of data, usually in rows and columns, allowing for easy comparison and analysis. In this research, tables likely present clinical characteristics, cure rates, and side effect occurrences between the intervention and control groups, aiding in visualizing results for efficient understanding.

3) Disease:
Disease signifies a pathological condition characterized by a specific set of signs and symptoms. In the discussed context, diaper dermatitis (a common disease in infants caused by prolonged exposure to moisture and irritants) was the focal point, validating the need for effective treatment methods to alleviate suffering.

4) Activity:
Activity refers to the state of being active or engaging in a specific action. Here, it relates to the activities of Coriandrum sativum, which exhibits various pharmacological properties, including anti-inflammatory and antimicrobial effects, possibly playing a role in mitigating symptoms associated with diaper dermatitis.

5) Food:
Food denotes any nutritious substance consumed to sustain life, growth, and health. In relation to Coriandrum sativum, it is not only significant as a culinary herb but also as a potential source of nutraceuticals, which contribute to health beyond basic nutrition, highlighting its dual role in diet and medicine.

6) Irritation:
Irritation is the state of being provoked or inflamed, characterized by redness, swelling, and discomfort. In this study, the adverse effects associated with the application of Coriandrum extract, such as irritation, were crucial in evaluating its tolerability and safety compared to standard treatments like hydrocortisone.

7) Science (Scientific):
Science is the systematic pursuit of knowledge about the natural world through observation and experimentation. The scientific approach used in this study emphasized rigorous methods to assess the efficacy of herbal treatments, illustrating the importance of evidence-based practice in validating traditional remedies within contemporary healthcare.

8) Antibiotic (Antibacterial):
Antibacterial refers to the quality of a substance that destroys or inhibits the growth of bacteria. Coriandrum sativum has demonstrated antibacterial properties, which are relevant in treating infections associated with skin conditions like diaper dermatitis, showcasing its potential utility in therapeutic formulations beyond conventional treatments.

9) Inflammation:
Inflammation represents the body’s protective response to injury or infection, involving the activation of immune pathways. In the context of diaper dermatitis, inflammation exacerbates the condition, making treatments that effectively reduce this response essential for improving patient outcomes and alleviating discomfort in affected infants.

10) Substance:
Substance is a physical material with specific characteristics, such as composition and properties. In pharmacological studies, the identification and evaluation of substances like Coriandrum sativum are fundamental in determining their therapeutic applications and potential benefits for skin ailments, supporting further research on their efficacy and safety.

11) Attending:
Attending relates to the act of being present or involved in an event, particularly in medical contexts referring to healthcare providers or specialists attending to patients. This term underscores the importance of professional oversight in clinical trials and the provision of care in medical settings focused on pediatric patients.

12) Toxicity:
Toxicity refers to the degree to which a substance can harm humans or animals. In research involving herbal remedies like Coriandrum sativum, assessing toxicity is vital to ensure patient safety and determine appropriate dosage levels, as it plays a significant role in the risk-benefit analysis of alternative treatments.

13) Itching:
Itching is an uncomfortable sensation that provokes the desire to scratch. It is a common symptom of diaper dermatitis, and understanding its triggers is crucial in formulating effective treatments. Addressing itching in therapeutic protocols enhances patient comfort and improves overall treatment adherence in managing this condition.

14) Aureus:
Aureus, particularly as in Staphylococcus aureus, pertains to a species of bacteria known for causing skin infections. This term is relevant in dermatological studies as it draws attention to the need for effective antimicrobial treatments in conditions like diaper dermatitis, shaping the discussion around the efficacy of herbal alternatives.

15) Water:
Water is an essential substance for all living organisms and plays a crucial role in human physiology. In terms of diaper dermatitis, over-hydration in the diaper area contributes to skin vulnerability, making the management of moisture levels paramount in devising treatment strategies for affected infants.

16) Carin (Cari):
Saari references one of the authors of the study, indicating collaboration within the research framework. Author names in scientific publications lend credibility, highlight interdisciplinary approaches, and showcase contributions that collectively advance knowledge on treatments for conditions such as diaper dermatitis through shared research efforts.

17) Wall:
Wall refers to another author involved in the study. The mention of specific authors underscores the collaborative nature of scientific research, indicating that collective expertise and contributions from various professionals are essential in developing sound conclusions and advancing clinical practices regarding pediatric skin care.

18) Burning (Burn, Burned, Burnt):
Burn denotes damage to the skin caused by heat, chemicals, or radiation. Although it may not be directly related to diaper dermatitis, understanding skin healing and treatment parallels can provide informative insights into the management strategies for all types of skin injuries, underlining the importance of effective topical applications.

19) Male:
Male refers to the gender of subjects involved in the study. Gender distribution is essential in clinical trials as it may influence results and treatment responses, ensuring that findings are applicable and generalizable, thus contributing to a comprehensive understanding of pediatric health issues across demographics.

20) Pharmacological:
Pharmacological pertains to the study or use of drugs and their effects on biological systems. Understanding the pharmacological properties of Coriandrum sativum is crucial in evaluating its potential as an alternative treatment for diaper dermatitis, opening pathways for future research in herbal medicine and pediatric care.

21) Agriculture:
Agriculture relates to the science or practice of farming, including the cultivation of plants. This term is relevant in discussions about Coriandrum sativum as it signifies its use as an agricultural product with health benefits, highlighting the intersection of agricultural practices and medicinal plant applications in healthcare.

22) Discussion:
Discussion reflects the sections of a research paper where results are interpreted, implications are drawn, and further research is suggested. Engaging in discussion about findings related to Coriandrum sativum and diaper dermatitis helps inform actionable insights and future studies, bridging gaps in existing literature.

23) Developing:
Developing refers to the process of growth, advancement, or evolution. In medical research, developing effective treatments for conditions like diaper dermatitis involves understanding existing remedies and innovating new formulations that enhance healing and reduce side effects, ultimately improving patient care and health outcomes.

24) Language:
Language denotes the method of communication used in conveying information. In scientific articles, precise language is vital to ensure clarity and understanding in reporting research findings, enabling effective dissemination of knowledge regarding treatments for conditions such as diaper dermatitis among healthcare professionals and the public.

25) Account:
Account refers to a narrative or report of events or conditions. In the research context, providing detailed accounts of study findings, methodologies, and patient experiences is crucial for transparency, reproducibility, and informing healthcare practices in managing conditions like diaper dermatitis effectively.

26) Family:
Family refers to a classification in biological taxonomy. In this context, it highlights Coriandrum sativum's classification within the family Apiaceae, underscoring the importance of botanical knowledge in understanding the characteristics and potential applications of plants used in traditional and modern medicinal practices.

27) Powder:
Powder typically refers to a solid substance reduced to fine particles. In dermatology, powders are often used in the management of diaper dermatitis to absorb moisture and reduce friction. Understanding the properties of various topical forms enhances treatment strategies for achieving effective management of skin irritations.

28) Desire:
Desire indicates a strong feeling of wanting to have something. In clinical studies, patients' desires for treatment options can influence their choices and adherence to therapies. Understanding the desires of parents regarding their infants' treatment can help tailor effective and acceptable care plans for managing diaper dermatitis.

29) Rules:
Rules refer to prescribed guidelines or principles governing activities. In clinical research, adherence to rules, such as ethical considerations, methodological standards, and regulatory compliance, is imperative for ensuring the integrity of the study and the safety of participants, ultimately contributing to credible findings and conclusions.

30) Ras (Rash):
Rash denotes a change in the skin's condition, often characterized by redness, irritation, or inflammation. In the context of diaper dermatitis, recognizing and appropriately managing rashes is essential for pediatric care, emphasizing the need for effective treatment interventions to alleviate symptoms and promote skin healing.

31) Hand:
Hand relates to the physical manipulation or application of treatments. In clinical settings, practitioners often use their hands for examinations, diagnoses, and care delivery. Understanding the tactile approach in assessing skin conditions like diaper dermatitis underscores the importance of hands-on assessments in pediatric healthcare.

32) Post:
Post refers to the position after or following an event. In research publications, post may indicate intervals of assessments or follow-up evaluations after interventions. Tracking post-treatment outcomes is crucial for understanding the efficacy of therapies and refining treatment protocols based on longitudinal data collected through studies.

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