Meningioma Grade and Resection: Impact of Peritumoral Edema
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Prediction of Histological Grade and Completeness of Resection of Intracranial Meningiomas: Role of Peritumoural Brain Edema
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Kamalanathan Palaniandy, Mohammad Saffari Mohammad Haspani, Norzaini Rose Mohd Zain
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Prediction of Histological Grade and Completeness of Resection of Intracranial Meningiomas: Role of Peritumoural Brain Edema
Year: 2017 | Doi: 10.21315/mjms2017.24.3.5
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Meningioma is the most common primary intracranial tumor in adults, comprising approximately 33.8% to 34.4% of all such tumors. These tumors arise from the arachnoid layer of the meninges and are categorized into three histological grades, with low-grade meningiomas typically being curable through surgical resection. Conversely, high-grade meningiomas require additional treatments due to a higher likelihood of recurrence. A particularly important feature associated with the presence and severity of meningiomas is peritumoral brain edema, which can present diagnostic and surgical challenges. This study aims to explore the relationship between peritumoral edema and histological grading of meningiomas, as well as its potential impact on surgical outcomes.
Peritumoral Edema and Tumor Grading
One significant finding in the study is the statistically significant relationship between peritumoral brain edema and high-grade meningiomas. Analysis revealed that patients with high-grade tumors were more likely to have associated edema, with a 40.7% rate of residual tumors in those reported to have undergone gross resection. Although univariate analysis indicated that both peritumoral edema and tumor volume were strong predictive factors for high-grade meningioma, the relationship did not hold up under multivariate analysis, suggesting that these factors alone may not be solely responsible for predicting tumor grades. Notably, no substantial impact of edema on surgeons' judgment regarding resection completeness was found, indicating that while edema is related to tumor grade, it does not significantly complicate surgical resection.
Conclusion
The study concludes that while there appears to be a correlation between peritumoral brain edema and high-grade meningiomas, the predictive reliability of these factors is diminished when subjected to multivariate analysis. This implies that although edema plays a role in the existing understanding of meningiomas, it should not be regarded as a definitive determinant in isolation. Future studies should further examine the implications of edema and tumor volume on meningioma prognosis, and consider integrating these factors into revised classifications and assessment metrics. The complexities surrounding the surgical management of meningiomas underscore the necessity of multi-faceted evaluations to guide treatment effectively.
FAQ section (important questions/answers):
What is the prevalence of meningiomas among adult brain tumors?
Meningiomas account for 33.8% to 34.4% of primary intracranial tumors in adults, making them more common than glial tumors, which represent 31.1%.
How does peritumoral brain edema relate to meningioma grading?
The study found a statistically significant association between peritumoral brain edema and high-grade meningiomas, indicating that higher-grade tumors are more likely to be associated with greater edema.
What are the treatment options for low-grade versus high-grade meningiomas?
Low-grade meningiomas are typically cured through surgical excision, while high-grade meningiomas may require additional adjuvant therapy post-surgery due to a higher likelihood of recurrence.
How do surgeons assess the completeness of meningioma resection?
Surgeons assess resection completeness using their experience and intraoperative judgment, although the study indicates that peritumoral edema does not significantly impact this judgment.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Meningioma Grade and Resection: Impact of Peritumoral Edema”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Edema (Oedema):
Oedema is another term for edema, describing fluid retention that leads to swelling of body tissues. In cases of meningioma, it can signify increased pressure on surrounding brain tissues. Its presence indicates potential complications in managing tumours and influences surgical approaches and post-operative care strategies.
2) Table:
In a medical study, tables organize and present data succinctly, making it easier to compare results and analyze findings. They play a critical role in conveying statistics including patient demographics, tumor characteristics, and treatment outcomes. Effective data representation enhances comprehension for clinicians and researchers alike.
3) Study (Studying):
A study in the medical context refers to systematic research aimed at understanding a health condition, treatment efficacy, or patient outcomes, utilizing methods such as observational or experimental designs. In relation to meningiomas, studies investigate correlations between peritumoural edema and tumor grades, thereby informing clinical practice.
4) Epilepsy:
Epilepsy is a neurological disorder that results in recurrent seizures due to sudden, excessive electrical activity in the brain. Its relevance arises in patients with meningiomas, where seizures may present as a symptom. Understanding the link between meningioma and epilepsy helps in assessing prognosis and treatment strategies.
5) Cancer:
Cancer denotes an uncontrolled growth of abnormal cells in the body. Meningiomas, typically benign, can exhibit malignant behavior in high-grade cases. Understanding the cancerous potential of meningiomas and their classification according to the World Health Organization is essential for effective treatment planning and patient prognosis.
6) Rules:
In a medical research context, rules can refer to guidelines or protocols that dictate study design, execution, and analysis. Adhering to established research rules ensures the integrity and validity of clinical findings, ultimately helping clinicians in making informed decisions based on robust and reproducible data.
7) Post:
The term 'post' often denotes subsequent events or evaluations following a specific medical intervention, such as post-operative assessments in patients who underwent tumor resection. This phase is essential for monitoring recovery, detecting complications, and determining the success of the surgical procedures conducted on meningioma patients.
8) Radiotherapy:
Radiotherapy is a treatment that uses high doses of radiation to kill cancer cells or shrink tumors. In the context of meningiomas, especially higher grade types, it serves as an adjunctive treatment following surgery, assisting in minimizing recurrence risks and managing residual tumor tissues effectively.
9) Calculation:
Calculation in a medical context often involves quantifying various measures, such as tumor volume or edema indices. Accurate calculations facilitate objective assessment of patient conditions and contribute to treatment planning, ensuring that surgical interventions are tailored appropriately based on precise measurements and statistical data.
10) Surrounding:
Surrounding tissue refers to the areas adjacent to a tumor, which can be affected by the tumor's presence and subsequent treatment. In meningiomas, assessing the impact on surrounding brain structures is vital as it informs surgical approaches, potential complications, and post-operative recovery strategies.
11) Observation:
Observation in a clinical setting involves closely monitoring patients to gather information on symptoms, effects of treatment, and overall health. In research, it refers to a method of collecting data about patients' conditions and responses to treatment, particularly concerning how meningioma affects neurological function.
12) Medicine:
Medicine is the field focused on the diagnosis, treatment, and prevention of disease. In relation to meningioma studies, advancements in medicine inform clinicians on the best practices for managing complex conditions, engaging with current literature and outcome studies that influence patient care strategies.
13) Training:
Training refers to the preparation and education of medical professionals regarding techniques, surgical procedures, and patient management. For neurosurgeons, training is essential to develop skills for operating on complex cases like meningiomas and understanding the implications of inter-operative findings and patient outcomes.
14) Samtana (Santana):
Santana here likely refers to a researcher or author contributing to the body of work concerning meningiomas. The reputation and findings of such individuals are significant in advancing understanding of tumor behaviors, treatment strategies, and the relationship between edema and tumor grading.
15) Challa:
Challa may refer to a contributor or relevant figure in the context of research surrounding meningiomas. The studies, potentially authored or co-authored by such individuals, may include tales of scientific inquiry that investigate critical correlations in brain tumors and treatment methodologies.
16) Family:
Family history can play a crucial role in understanding genetic predispositions to certain health conditions, including meningiomas. A thorough family medical history can aid in risk assessment, providing insights into potential hereditary links and guiding surveillance strategies in susceptible individuals.
17) Nagel:
Nagel might refer to an author or contributor within the realm of meningioma research, indicating their work's influence on current medical knowledge. Their insights may shape clinical understanding and practices regarding tumor management or, specifically, the interplay of edema and tumor grade.
18) Blood:
Blood tests may serve to evaluate overall health or identify specific markers suggestive of tumor presence or progression. In the context of meningiomas, understanding blood-related disorders or abnormalities can offer insights into treatment impacts and potential complications post-surgery or during therapy.
19) Shila (Sila):
Sila could denote an author or key figure contributing to meningioma research. Their body of work aids in providing vital information and insights that contribute to the scientific dialogue surrounding the management and understanding of such tumors and related conditions.
20) Male:
The term 'male' often appears in epidemiological studies, particularly concerning gender predisposition to specific conditions like meningiomas. The differences in incidence rates between genders inform clinical perceptions and considerations regarding treatment and expected outcomes in male versus female patients.
21) Measurement:
Measurement refers to determining the magnitude or size of a particular variable, such as tumor volume or extent of edema. Accurate measurements are crucial in clinical studies as they directly inform treatment strategies, prognostic evaluations, and surgical planning for conditions like meningiomas.
22) Discussion:
Discussion in a study examines findings in the context of existing literature, exploring implications and conclusions drawn from data. It's a critical component of research papers that elucidates how results interact with broader medical and scientific knowledge, helping to refine clinical practices.
23) Inference:
Inference in medical research allows practitioners to draw conclusions from data, such as associating peritumoural edema with high-grade meningiomas. Making informed inferences based on robust evidence is crucial in guiding treatment decisions and understanding underlying pathophysiological mechanisms.
24) Activity:
Activity in a medical context may refer to the biological processes or patient movements relevant to health outcomes. In studies involving conditions like meningioma, assessing patient activity levels and neurological functions can provide insights into recovery trajectories and treatment effectiveness.
25) Dividing:
Dividing entails categorizing or separating components within a study, such as grouping patient populations by tumor grade or treatment type. It aids in clarifying results and analyzing data significance, allowing for a more nuanced understanding of how different factors affect outcomes.
26) Relative:
Relative measures allow for comparisons between groups, such as assessing the significance of findings in meningioma research. Relative terms help in understanding how one variable influences another, particularly in assessing risks or predicting outcomes based on various clinical characteristics.
27) Disease:
Disease refers to a pathological condition affecting the body. In relation to meningiomas, categorizing them correctly according to their grade and behavior is essential for implementing appropriate treatment strategies and improving patient prognosis through an understanding of disease dynamics.
28) Nature:
Nature can refer to the inherent qualities and characteristics of a condition, such as the biological behavior of meningiomas. Understanding the nature of a tumor assists medical professionals in predicting behavior, customizing treatment plans, and anticipating potential complications during therapy.
29) Indian:
Indian likely denotes the demographic representation in studies, especially relevant in research involving localized populations. Acknowledging racial and ethnic backgrounds in meningioma research can provide insights into how genetic, environmental, and lifestyle factors influence tumor characteristics.
30) Water:
Water is fundamental to the concept of edema, as it signifies fluid accumulation in tissues. Understanding the balance of water within the brain and its role in edema formation around tumors is crucial for diagnosing and treating conditions like meningiomas effectively.
31) Visit:
Visit typically refers to a follow-up appointment in a medical context, essential for monitoring post-operative outcomes. Regular visitation ensures that patients receive timely evaluations regarding their recovery status, potential complications, and the effectiveness of treatments applied after meningioma surgeries.
32) Wall:
Wall may refer to structural barriers in the context of tumors, such as the dural wall surrounding meningiomas. The relationship between these structures and tumor behavior is significant for surgical approaches, as these anatomical details must be thoroughly understood for optimal patient management.
33) Line:
Line may denote boundaries or distinctions in clinical classification or the progression of a disease. Understanding these lines, particularly concerning tumor grading, is essential in forming treatment plans that align with the best practices recognized universally by the medical community.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Meningioma Grade and Resection: Impact of Peritumoral Edema’. Further sources in the context of Science might help you critically compare this page with similair documents:
Central nervous system, Statistical Significance, Significant effect, Multivariate analysis, Blood brain barrier, Surgical resection, Surgical Procedure, Adjuvant therapy, Prospective study, Statistically insignificant, Odds ratio, Confidence interval, Male to female ratio, WHO Classification, Magnetic Resonance Imaging (MRI), Median age, MRI imaging, Molecular marker, Histological grading, Tumour volume, Institutional ethical approval, Surgeons' experience, Cerebral edema, Binary Logistic Regression, Age risk factor, Radiation treatment, Predictive value, Influencing factors, Authors contribution, Racial Variation.