Demographic and Clinical Factors Linked to RA Rheumatoid Factor Positivity
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Correlation of Demographic and Clinical Characteristics with Rheumatoid Factor Seropositivity in Rheumatoid Arthritis Patients
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Maizatul Akmal Othman, Wan Syamimee Wan Ghazali, Nurul Khaiza Yahya, Kah Keng Wong
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Correlation of Demographic and Clinical Characteristics with Rheumatoid Factor Seropositivity in Rheumatoid Arthritis Patients
Year: 2016 | Doi: 10.21315/mjms2016.23.6.6
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic articular symptoms, affecting a significant portion of the global population. The disease is influenced by various risk factors, including genetic predispositions, age, gender, and lifestyle choices. One of the critical markers in diagnosing RA is the rheumatoid factor (RF) test, which detects specific autoantibodies in patients. The study presented examines the demographic and clinical characteristics of 80 RA patients attending Hospital Universiti Sains Malaysia (HUSM) and their correlation with RF seropositivity.
Significant Association with Age
One crucial finding of the study is the significant association between RF seropositivity and older age among RA patients. The results showed that patients aged 50 years and above were more likely to test positive for RF, with a statistical significance of P = 0.032. In this cohort, over 70% of the patients were over 50 years old, and approximately half of them tested positive for RF. This indicates that as age increases, so does the likelihood of RF seropositivity, suggesting that older patients may exhibit more severe manifestations of the disease. The study's findings support the notion that age is an important factor influencing antibody presence and potentially disease progression among RA patients.
Conclusion
In conclusion, the study highlights the demographic characteristics of RA patients, particularly the association of RF seropositivity with older age. This finding underscores the importance of considering age as a factor when diagnosing and managing RA, as older patients may experience more aggressive forms of the disease. Further research is necessary to explore the implications of these findings on treatment strategies and the long-term outcomes for RA patients, particularly in regions like northern Malaysia where age-related trends appear to be pronounced.
FAQ section (important questions/answers):
What is the significance of the rheumatoid factor in rheumatoid arthritis?
The rheumatoid factor (RF) is a blood test used for diagnosing rheumatoid arthritis (RA). Seropositivity for RF may indicate a higher likelihood of developing more severe symptoms in RA patients.
What demographic characteristics were studied in the RA patients?
The study analyzed 80 RA patients aged 18 and older, focusing on their ages, gender, clinical symptoms, RF seropositivity, and laboratory investigations, such as erythrocyte sedimentation rate (ESR). Most patients were female and aged over 50.
Which age group showed a significant association with RF seropositivity?
A significant association was found between RF seropositivity and patients aged 50 years or older, indicating that older RA patients are more likely to be RF positive.
What were the common clinical symptoms experienced by RA patients?
Common clinical symptoms included morning stiffness (52.5% of patients) and joint swelling (35.0%). The involvement of hand joints was particularly frequent among patients, indicating the typical manifestation of RA.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Demographic and Clinical Factors Linked to RA Rheumatoid Factor Positivity”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Rheumatoid arthritis:
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the joints, leading to pain, stiffness, and potential joint damage. Understanding the demographic and clinical characteristics of RA patients, such as seropositivity for rheumatoid factor (RF), is crucial for effective diagnosis and treatment.
2) Table:
In the context of the study, a table is used as a visual tool to present data regarding the demographic and clinical characteristics of rheumatoid arthritis patients. Tables enhance the clarity of complex information and facilitate comparisons between different patient groups or laboratory results.
3) Study (Studying):
A study in this context refers to the systematic investigation conducted to explore the associations between rheumatoid factor seropositivity and various demographic and clinical characteristics in rheumatoid arthritis patients. Studies like this contribute to the scientific understanding of disease mechanisms and factors influencing prognosis and treatment outcomes.
4) Disease:
Disease refers to a pathological condition affecting bodily functions or systems, in this case, rheumatoid arthritis. Understanding features of autoimmune diseases is vital for developing effective care strategies, identifying risk factors, and ultimately improving patient outcomes.
5) Stiffness:
Stiffness is a common symptom in rheumatoid arthritis, often experienced in the morning or after periods of inactivity. It contributes to the patients' discomfort and limits mobility. Identifying and measuring stiffness can aid in assessing disease severity and treatment effectiveness.
6) Male:
In the context of rheumatoid arthritis studies, the term 'male' refers to the demographic category less frequently affected than females. Understanding gender differences in prevalence and disease presentation helps tailor treatment approaches and identify potential biological or environmental factors influencing disease development.
7) Swelling:
Swelling is another hallmark symptom of rheumatoid arthritis, indicating inflammation in the joints. It can significantly impact a patient's function and quality of life. Measuring swelling is essential for assessing disease progression and the effectiveness of therapeutic interventions.
8) Hand:
The hand is often one of the primary sites affected by rheumatoid arthritis. Symptoms such as pain, stiffness, and swelling in hand joints can lead to disabilities. Knowledge of joint involvement patterns, like those in the hands, is critical for diagnosis and treatment planning.
9) Measurement:
Measurement refers to the process of quantifying symptoms or laboratory results associated with rheumatoid arthritis. Accurate measurement of parameters like joint swelling, stiffness, and the presence of markers like RF is crucial in determining disease status and treatment response.
10) Activity:
Activity in rheumatoid arthritis can refer to both the disease's current state and the physical activity level of patients. Monitoring disease activity helps gauge treatment effectiveness and potentially influence future management strategies.
11) Ter:
While 'ther' appears to be an incomplete word, it seems to hint towards therapeutic contexts. Successful management of rheumatoid arthritis often relies on various therapeutic interventions, emphasizing the need for research about drug efficacy on symptoms and disease progression.
12) Inflammation:
Inflammation is a critical aspect of rheumatoid arthritis, underlying the joint damage and symptoms experienced by patients. Research on inflammatory markers and their relation to seropositivity can provide insights into disease mechanisms and help optimize treatment strategies.
13) Syria (Syrian):
Syria may indicate a geographical context relating to rheumatoid arthritis research or prevalence. Understanding how environmental factors might influence disease manifestation aids in examining the global epidemiology of rheumatoid arthritis.
14) Blood:
Blood tests play a significant role in diagnosing rheumatoid arthritis, particularly in measuring rheumatoid factor levels. Analyzing blood samples helps in understanding disease activity and directing appropriate treatment pathways.
15) Cina:
In the context of rheumatoid arthritis research, China may refer to unique genetic or environmental factors influencing the disease among specific populations. Investigating these factors contributes to a more comprehensive understanding of rheumatoid arthritis across diverse ethnicities.
16) Pain:
Pain is a primary symptom experienced by rheumatoid arthritis patients, affecting their daily activities and quality of life. Assessing and managing pain is pivotal in the treatment approach and overall care of these patients.
17) Potter:
Referring to a researcher or study contributor, Potter could symbolize research efforts focusing on the associations between demographic variables and rheumatoid arthritis outcomes. Recognizing key contributors enhances acknowledgment of scientific collaboration and the evolution of knowledge in rheumatology.
18) Rules:
Rules likely pertain to diagnostic criteria, such as the American College of Rheumatology classification guidelines for rheumatoid arthritis. Adhering to established rules fosters consistency and accuracy in diagnosing and managing the disease.
19) Chun:
Chun may refer to a researcher or author involved in studies related to rheumatoid arthritis, especially regarding genetic risk factors or clinical characteristics in different populations. The contributions of such researchers are crucial for advancing understanding in rheumatology.
20) Drug:
The term drug highlights the pharmacological interventions available for treating rheumatoid arthritis. Researching drug efficacy and safety informs clinical practices and treatment guidelines, improving patient care and outcomes.
21) Discussion:
Discussion refers to the section of research articles where findings are interpreted, contextualized, and implications are drawn. It is crucial for synthesizing evidence and offering recommendations for further research or clinical practice in rheumatoid arthritis management.
22) Developing:
Developing can refer to the process of formulating new strategies, treatments, or research findings in rheumatoid arthritis studies. Understanding the dynamics of developing therapies informs ongoing research and potential improvements in patient management.
23) Education:
Education typically underscores the importance of training healthcare providers and increasing patient awareness about rheumatoid arthritis's symptoms, management, and treatment options. Effective education is vital in improving patient adherence and health outcomes.
24) Attending:
Attending relates to healthcare providers actively caring for rheumatoid arthritis patients. The involvement of healthcare professionals in treating patients is paramount to ensure diagnosis accuracy, proactive management, and personalized treatment regimens.
25) Species:
Species may refer to the biological classification relevant in studies exploring genetic risk factors for rheumatoid arthritis. Investigating variations across species may help in understanding genetic predispositions contributing to the disease in different populations.
26) Chinna:
Chinna may denote a researcher who has explored the demographic aspects of rheumatoid arthritis, potentially enhancing understanding of the prevalence and characteristics among different ethnic groups in Malaysia.
27) Indian:
In this context, Indian may highlight the specific demographic contributing to research on rheumatoid arthritis. Understanding ethnic and cultural differences provides insights into genetic susceptibility and varying disease manifestations.
28) Sign:
Sign typically relates to symptoms or clinical indicators observed in rheumatoid arthritis patients. Recognizing significant clinical signs is essential for timely diagnosis, treatment initiation, and monitoring disease progress.
29) Post:
Post can signify the aftermath of treatment or the follow-up phase in managing rheumatoid arthritis. Monitoring post-treatment outcomes is essential for assessing therapeutic efficacy and planning subsequent healthcare strategies.
30) Viru:
Viru might allude to infectious agents associated with rheumatoid arthritis or other autoimmune conditions. Understanding such associations enriches knowledge of potential environmental triggers influencing disease development.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Demographic and Clinical Factors Linked to RA Rheumatoid Factor Positivity’. Further sources in the context of Science might help you critically compare this page with similair documents:
Rheumatoid arthritis, Therapeutic effect, Early stage, Disease diagnosis, Immune system, Clinical feature, Statistical analysis, Medical research, Rheumatoid factor, Clinical study, Autoimmune disease, Morning stiffness, Joint involvement, Clinical trial, Laboratory test, Erythrocyte sedimentation rate, Clinical presentation, Female patient, Laboratory investigation, Combination therapy, Treatment effect, Joint damage, Joint swelling, Immune response, Functional disability, Chronic autoimmune disease, PubMed, Google Scholar, Disease activity, Cross-sectional survey, Female to male ratio, Rheumatoid factor (RF), Statistical analyses, Disease susceptibility, Treatment practices, Inflammatory response, Systemic lupus erythematosus, Autoantibodies, Biologic agents, Small joints, Male to female ratio, Chronic infection, Clinical outcome, Double blind clinical trial, Prolactin, Anti-TNF agents, Rituximab, Methotrexate, Clinical benefit, Rheumatoid arthritis patients, Latex agglutination test, Patient Outcome, Infectious agent, Rheumatic diseases, Prolactin level, RF seropositivity, Disease severity, Seropositivity, Demographic and clinical characteristics, Patient group, Prevalence of Rheumatoid Arthritis, Clinical symptom, Phase III trial, Male patient, Age at onset, Older patients, Immunological investigation, Clinical characteristic, Health data, Acute phase reactant, Double-blind randomized controlled trial, Anti-tumor necrosis factor agents, Anti-TNF therapy, Early rheumatoid arthritis, Demographic characteristic.
Concepts being referred in other categories, contexts and sources.