Endometrial Cancer Survival with Lymphovascular Invasion at USM

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: Median Survival Time of Endometrial Cancer Patients with Lymphovascular Invasion at the Hospital Universiti Sains Malaysia
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Wan Adnan Wan Nor Asyikeen, Ab Hamid Siti-Azrin, Nur Asyilla Che Jalil, Anani Aila Mat Zin, Nor Hayati Othman


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: Median Survival Time of Endometrial Cancer Patients with Lymphovascular Invasion at the Hospital Universiti Sains Malaysia

Year: 2016 | Doi: 10.21315/mjms2016.23.6.5

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

Endometrial cancer is identified as the most prevalent gynecologic malignancy among women globally. This study aims to evaluate the median survival time of endometrial cancer patients at Hospital Universiti Sains Malaysia (USM). Given that much research on endometrial cancer has been conducted outside Malaysia, this study seeks to fill a knowledge gap regarding the specific patient population in the region, analyzing factors that may affect survival and facilitating improvements in treatment and early detection methods.

The Impact of Lymphovascular Invasion on Survival

One critical concept emerging from this study is the significant association between lymphovascular invasion and patient survival. The research found that more than half of the endometrial cancer patients had lymphovascular invasion, a condition where cancer cells infiltrate blood vessels or lymphatic channels, increasing the risk of metastasis. This factor has been highlighted as a strong predictor of poor prognosis, and its presence showed a marked impact on median survival time. Specifically, patients with lymphovascular invasion had a significantly lower median survival compared to those without it, underscoring the need for targeted interventions and close monitoring for this subgroup.

Conclusion

Overall, the survival rates for endometrial cancer patients at USM were found to be low, with a median survival time of 70.20 months. The findings suggest that lymphovascular invasion serves as a crucial prognostic indicator, and further prospective studies are needed to explore effective diagnostic tools for early-stage detection of endometrial cancer. By improving early detection and understanding the impact of specific risk factors like lymphovascular invasion, healthcare professionals may be able to enhance survival outcomes and reduce mortality rates in patients with this type of cancer.

FAQ section (important questions/answers):

What is the purpose of this study on endometrial cancer?

The study aimed to determine the median survival time of endometrial cancer patients at Hospital Universiti Sains Malaysia and identify significant prognostic factors affecting survival.

What demographic was largely represented among the study participants?

The majority of patients included in the study were of Malay ethnicity, with 83.3% being over the age of 50, showcasing the population demographics affected by endometrial cancer.

What was the overall median survival time for patients in the study?

The overall median survival time of the endometrial cancer patients was reported as 70.20 months, indicating a relatively low survival rate in comparison to other studies in different regions.

What factors were found to significantly affect survival rates?

Significant factors affecting survival rates included age, presence of lymphovascular invasion, and the type of treatment received by the patients, highlighting critical areas for patient management.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Endometrial Cancer Survival with Lymphovascular Invasion at USM”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth and division, leading to the formation of tumors. In the context of the study, endometrial cancer is specifically investigated, highlighting its prevalence among women, factors affecting survival, and the need for better detection and treatment strategies to improve patient outcomes.

2) Table:
Tables are utilized to systematically present data, making complex information easier to comprehend. In this study, tables summarize crucial findings regarding patient demographics, clinical presentations, treatment responses, and survival outcomes, facilitating quick reference and clear visualization of patterns and trends in endometrial cancer cases treated at the hospital.

3) Study (Studying):
A study is a detailed investigation or analysis aimed at discovering new insights or validating existing knowledge. This particular retrospective cohort study focuses on endometrial cancer patients, aiming to determine median survival times and associated factors influencing outcomes. The findings aim to enhance understanding and improve care for affected individuals.

4) Radiotherapy:
Radiotherapy involves using high-energy radiation to target and kill cancerous cells. It's often employed as an adjuvant treatment after surgery in endometrial cancer management. This study examines the effects of radiotherapy on survival outcomes, emphasizing its role alongside other treatment modalities in improving the prognosis for endometrial cancer patients.

5) Chemotherapy:
Chemotherapy refers to the use of drugs to kill rapidly dividing cancer cells. In this study, it’s assessed as a treatment method for endometrial cancer, where patients may receive it post-surgery. The study explores associations between chemotherapy administration and patient survival, aiming to identify effective treatment combinations.

6) Disease:
Disease denotes a pathological condition characterized by dysfunction of normal bodily processes. In this context, endometrial cancer is the focus, with the study examining its incidence, clinical progression, and various prognostic indicators influencing outcomes. Understanding the disease aids in tailoring effective interventions to improve patient survival rates.

7) Death:
Death is the cessation of all biological functions that sustain life. In studying endometrial cancer, the timing and circumstances of patient deaths are crucial for understanding prognosis. The study investigates survival time and mortality rates to identify factors that can potentially reduce mortality and improve treatment strategies.

8) Pur:
Poor refers to substandard conditions or inadequate performance. In the context of healthcare, it often describes unfavorable outcomes—such as low survival rates associated with ailments like endometrial cancer. Highlighting poor prognosis factors drives the need for improvements in detection, treatment, and patient management to enhance survival prospects.

9) Rules:
Rules in a medical context often refer to established guidelines or criteria governing diagnosis, treatment, and research methodologies. In studies like this one, adherence to medical rules ensures ethical practices and reliable data collection, vital for drawing valid conclusions about endometrial cancer and the effectiveness of various treatments.

10) Blood:
Blood plays a crucial role in transporting nutrients, oxygen, and immune cells throughout the body. In cancer studies, blood tests help in diagnosing disease conditions, monitoring treatment effectiveness, and assessing health status. The evaluation of hematologic parameters can reveal important insights into a patient's overall condition and prognosis.

11) Life:
Life describes the biological state characterized by growth, reproduction, and self-regulation. In discussing cancer, particularly endometrial cancer, understanding its impact on patients' quality of life is essential. The study aims to explore how different treatments affect not just survival, but also the overall well-being of patients facing this disease.

12) Toxicity:
Toxicity refers to the degree of harmfulness of a substance. In the context of cancer treatment, it often concerns the adverse effects caused by chemotherapy and radiotherapy. Recognizing and managing treatment-related toxicity is vital for improving patient quality of life and ensuring that overall health is not compromised during cancer care.

13) Mutation:
Mutation refers to a change in the DNA sequence that can lead to cancer development. In endometrial cancer, certain genetic mutations may predispose cells to uncontrolled growth. Understanding these mutations aids in identifying risk factors, informing treatment options, and developing targeted therapies to improve patient outcomes.

14) Channel:
In medical terms, channels can refer to structures that transport substances, such as blood vessels or lymphatics. In the context of cancer, lymphatic channels are critical for understanding metastasis and spread of disease. The study's examination of lymphovascular invasion highlights its significance in predicting patient outcomes.

15) Quality:
Quality, particularly in healthcare, denotes the standard of care and outcomes experienced by patients. The study’s findings aim to contribute to improving the quality of life for endometrial cancer patients by identifying effective treatment protocols and care strategies that lead to better survival rates and overall well-being.

16) Family:
Family plays a vital role in the lives of cancer patients, providing emotional support and practical assistance. The impact of cancer on family dynamics can be significant. Understanding these dynamics is essential for developing holistic treatment strategies that consider not just the patient, but their support system as well.

17) Post:
Post refers to the period following a significant event, such as surgery or treatment. In the context of endometrial cancer management, understanding post-treatment recovery, including follow-up care and long-term outcomes, is crucial for ensuring patients receive comprehensive care and support after the initial treatment phase.

18) Tai:
Thai pertains to Thailand, providing a reference for comparison in cancer survival studies. The mention of similar studies from Thailand suggests a broader context for evaluating endometrial cancer outcomes internationally, allowing for insights into regional differences, treatment effectiveness, and prevalence in diverse populations.

19) Ter:
Ther typically refers to therapeutic approaches or treatments. In this study, references to therapeutic strategies such as chemotherapy or radiotherapy indicate an exploration of different treatment options and their roles in managing endometrial cancer, ultimately aiming to identify the most effective care paradigms for improving patient outcomes.

20) Observation:
Observation in a medical context can refer to the monitoring of patient status and response to treatment over time. In the study, censored observations of patients who were lost to follow-up or survived beyond the study period are vital for accurately assessing median survival and evaluating treatment effectiveness.

21) Discussion:
Discussion sections in research articles interpret findings, compare with existing literature, and suggest further research directions. In this study, the discussion presents implications of the findings on endometrial cancer, exploring why certain factors impact survival and emphasizing the need for enhanced early detection and treatment measures.

22) Vomiting:
Vomiting is a common side effect of cancer treatments, particularly chemotherapy. It can severely affect a patient’s quality of life and willingness to continue treatment. Addressing vomiting in treatment protocols is essential for managing side effects and ensuring patients maintain nutrition and compliance with their care plans.

23) Nausea:
Nausea often accompanies chemotherapy and other cancer treatments, impacting patient comfort and treatment adherence. Effective management of nausea is a critical aspect of supportive care, as alleviating this symptom contributes to improved quality of life, better dietary intake, and overall treatment satisfaction for cancer patients.

24) Worry (Worried, Worrying):
Worry reflects the emotional burden experienced by cancer patients and their families, often associated with concerns about diagnosis, treatment, and outcomes. Understanding these worries is essential for healthcare providers to offer adequate psychological support and resources, fostering resilience and coping strategies to navigate the cancer journey.

25) Food:
Food is vital for sustaining health, particularly for cancer patients who may face nutritional challenges due to treatment side effects. Ensuring adequate nutrition can enhance recovery and improve outcomes. Discussions in the study may highlight the importance of dietary considerations for maintaining strength and well-being during cancer treatment.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Endometrial Cancer Survival with Lymphovascular Invasion at USM’. Further sources in the context of Science might help you critically compare this page with similair documents:

Patient care, Diabetes mellitus, Surgical management, Advanced stage, Quality of life, Treatment strategies, Treatment group, Ethical Clearance, Early detection, Clinical presentation, Systematic Review, Mortality Rate, Endometrial Cancer, Retrospective study, Adjuvant Treatment, Prospective study, Chemotherapy and Radiotherapy, Disease free survival, Cancer treatment, Treatment option, Post menopause, Risk factor, Endometrial carcinoma, FIGO staging, Chemo-radiotherapy, Overall survival, Adjuvant chemotherapy, Prognostic Factor, Molecular alteration, Histological grade, Total Abdominal Hysterectomy, Survey results, Surgery and chemotherapy, Lymph node dissection, Socio-demographics, Pleural Effusion, Median survival time, Retrospective cohort, Survival analysis, Type of cancer, Nulliparous, Vaginal brachytherapy, Myometrial invasion, Lymphovascular invasion, Vascular Invasion, Bonferroni correction, Immunohistochemical analyses, Kaplan-Meier survival analysis, Ethnicity, Patient's follow-up, Poor prognostic factor, Stage IV, Significant factor, Gynecologic Oncology Group, Medical record.

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