Thyroid Profile and Prolactin in Secondary Amenorrhea Patients
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Sujata Shrestha, Sunita Neupane, Narayan Gautam, Raju Kumar Dubey, Amit Chandra Jha, Nilesh Raj Doshi, Archana Jayan
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea
Year: 2016 | Doi: 10.21315/mjms2016.23.5.7
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Amenorrhea, characterized by the absence of menstrual periods, poses significant social and medical challenges, especially concerning infertility. This case-control study aimed to explore the relationship between thyroid hormone levels and hyperprolactinemia in women experiencing amenorrhea. A total of 50 women diagnosed with secondary amenorrhea were compared with 52 healthy controls, focusing on hormonal evaluations to understand the underlying associations.
Hyperprolactinemia and Thyroid Dysfunction
The study's results highlighted a significant finding: women with amenorrhea exhibited markedly elevated serum prolactin levels compared to the control group. Specifically, the mean prolactin level in the cases was reported at 23.28 ng/ml, against just 6.57 ng/ml in the controls, suggesting a strong correlation between hyperprolactinemia and menstrual disturbances. Additionally, thyroid function was assessed, revealing that mean serum TSH levels were significantly higher in the amenorrheic group compared to controls. Importantly, a positive correlation between prolactin, body mass index (BMI), and TSH levels was noted, indicating that thyroid dysfunction could contribute to elevated prolactin levels, thereby affecting menstrual regularity.
Conclusion
In conclusion, this study found that hyperprolactinemia frequently occurs alongside thyroid dysfunction in women suffering from amenorrhea. The significant elevation of serum prolactin and TSH levels suggests that comprehensive hormonal evaluations, including assessments of fT3, fT4, and TSH, should be integral to the diagnostic process for amenorrhea. Addressing these hormonal imbalances could pave the way for more effective treatment strategies and improved outcomes for women with amenorrhea linked to thyroid disorders and hyperprolactinemia.
FAQ section (important questions/answers):
What is amenorrhea and its social consequences?
Amenorrhea is defined as the absence of menstrual periods, which can lead to significant social consequences, primarily infertility, affecting a woman's emotional and psychological well-being.
What was the objective of the case-control study?
The study aimed to determine the association between thyroid hormones and hyperprolactinemia in women diagnosed with amenorrhea, highlighting hormonal influences on menstrual cycles.
What were the key findings regarding prolactin levels?
Results indicated that mean serum prolactin levels were significantly higher in amenorrheic women. This suggests a potential correlation between high prolactin levels and menstrual dysfunction.
What recommendations were made for diagnosing amenorrhea?
It is recommended that hormonal evaluations of prolactin, fT3, fT4, and TSH be included in diagnostic assessments for patients presenting with amenorrhea.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Thyroid Profile and Prolactin in Secondary Amenorrhea Patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In research studies, 'table' refers to a systematic arrangement of data in rows and columns, which provides a concise representation of findings, facilitating easier comparison and analysis. Tables summarize quantitative data such as mean values, statistical significance, and correlations among variables, thus supporting the overall analysis and conclusions of the study.
2) Study (Studying):
A 'study' refers to a systematic investigation designed to explore specific hypotheses, evaluate relationships, or assess the effectiveness of interventions. In the context of medical research, it often involves the collection of data from subjects to understand health conditions or effects of treatments, thus contributing to scientific knowledge and evidence-based practice.
3) Disease:
'Disease' indicates a pathological condition characterized by a specific set of symptoms and dysfunction within the body. It's critical in medical discourse as it influences diagnosis, treatment choices, and public health initiatives. Understanding disease mechanisms helps clinicians offer optimal care and informs research aimed at curing or managing ailments.
4) India:
'India' signifies the geographical and cultural context in which the study was conducted, offering insights into the population demographics, health trends, and prevalence of conditions such as amenorrhea. Recognizing regional factors is vital for understanding disease patterns and developing targeted interventions that suit specific community needs.
5) Rules:
'Rules' denote the specific guidelines and protocols that govern scientific research methodologies. They ensure ethical standards are maintained, and research is conducted rigorously, facilitating reliable and valid results. Adhering to established rules is essential for gaining credibility within the scientific community and ensuring findings can be generalized.
6) Kumkum:
'Kumkum' refers to a specific author or researcher involved in the study, signifying their contributions to scientific discourse. This acknowledgment is vital in academic contexts as it highlights individual expertise, collaborative efforts, and the importance of shared knowledge in advancing research, particularly in complex fields like endocrinology.
7) Sharman (Sarma, Sharma, Sarman):
'Sharma' represents another author whose work likely provided significant insights or findings relevant to the study. Citing researchers allows for the traceability of ideas and results in academic writing, promoting transparency and accountability while also acknowledging the collective effort in contributing to knowledge in medical research.
8) Science (Scientific):
'Science' encompasses the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. It underpins all research endeavors, ensuring methodologies are rigorous, findings are reproducible, and knowledge is built upon a foundation of empirical evidence, especially relevant in health-related studies.
9) Jasmine:
'Jasmine' likely represents another participant contributing to the research findings. Acknowledging each contributor promotes collaboration and recognizes diverse expertise, essential in multidisciplinary studies. It reflects the collective effort in investigating complex issues, which are often beyond the capabilities of a single researcher or discipline.
10) Lahore:
'Lahore' indicates a specific location that may be associated with relevant research or findings, suggesting potential geographical differences in health issues, prevalence of conditions, or health care accessibility. The city's characteristics may influence study outcomes, thus providing valuable context to the research findings.
11) Gali:
'Gali' might reference another researcher associated with the study, underscoring the collaborative nature of scientific work. Acknowledging each individual's contributions is paramount for building a comprehensive understanding of research while also enhancing credibility and trust in the results.
12) Pari:
'Pari' could signify another element or contributor within the context of the study. Acknowledging such names is essential for recognizing multiple perspectives, experiences, and expertise that enrich the research process, ultimately leading to more robust and comprehensive outcomes.
13) Salt (Salty):
'Salt' might refer to the dietary component essential in health, particularly concerning hormonal balance, thyroid function, and overall metabolism. Its mention could indicate a study aspect related to nutritional factors influencing the conditions being researched, thereby emphasizing the intersection of diet and health outcomes.
14) Observation:
'Observation' is a crucial aspect of scientific research, referring to the systematic and careful monitoring of subjects or conditions to gather data. Observational methods are vital for identifying trends, abnormalities, or responses to treatments, thereby forming a foundation for conclusions drawn in medical research.
15) Discussion:
'Discussion' is a section in research reports where authors interpret the significance of their findings, compare them to existing literature, and explore implications for practice or future research. This critical analysis helps contextualize results and promote dialogue within the scientific community, advancing understanding and clinical application.
16) Medicine:
'Medicine' signifies the science and practice of diagnosing, treating, and preventing illness. This field encompasses a vast range of knowledge, techniques, and therapies, ultimately focusing on improving health outcomes and encompassing various specialties such as endocrinology, which is pertinent to the study's focus.
17) Family:
'Family' may refer to the socio-cultural context impacting health behaviors and choices. Understanding family dynamics is crucial in research as it affects individual health decisions, access to care, and the social determinants of health, thus providing a broader perspective on issues like amenorrhea and thyroid dysfunction.
18) Post:
'Post' could relate to the dissemination of research findings through publications, conferences, and discussions within the scientific community. This aspect is vital for sharing knowledge, fostering ongoing dialogue, and ensuring that research contributes to advancements in medical practice and understanding of health issues.
19) Drug:
'Drug' signifies pharmacological agents that may be referenced concerning treatment options for conditions discussed in the study. Knowledge of drug interactions, impacts on hormonal balance, and potential side effects is essential for managing conditions like amenorrhea, thereby bridging the gap between research findings and clinical practice.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Thyroid Profile and Prolactin in Secondary Amenorrhea Patients’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Menstrual period, Amenorrhea, Menstrual cycle, Statistical analysis, Subclinical hypothyroidism, Thyroid profile, Thyroid dysfunction, Secondary amenorrhoea, Ethics approval, Correlation coefficient, Case-control study, Mean age, Serum TSH, Thyroid hormone, Negative correlation, Positive correlation, Hypothalamic pituitary ovarian axis, Hormonal evaluation, Secondary Amenorrhea, Hypothalamic-pituitary-thyroid axis, Estrogen level, Baseline data, Serum TSH Level, Hyperprolactinemia, Socio-demographic variables, Hyperprolactinaemia, Hormonal change, Clinical tests, Healthy control, Thyroid stimulating hormone (TSH), Serum prolactin, Prolactin level, Diagnostic evaluation, Pituitary hormones, Thyroid disorder, Prolactin secretion, Study material, Gonadotropin, Serum prolactin level, Healthy subject.