CNS Depressant and Antinociceptive Effects of Pandanus Foetidus Extract
Journal name: The Malaysian Journal of Medical Sciences
Original article title: CNS Depressant and Antinociceptive Effects of Different Fractions of Pandanus Foetidus Roxb. Leaf Extract in Mice
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Md Mominur RAHMAN, Muhammad Erfan UDDIN, Abu Mohammed Taufiqual ISLAM, Md Ashraf Uddin CHOWDHURY, Md Atiar RAHMAN
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: CNS Depressant and Antinociceptive Effects of Different Fractions of Pandanus Foetidus Roxb. Leaf Extract in Mice
Year: 2015
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Pandanus foetidus, commonly known as kewa kata or keora, is a traditional medicinal plant widely used in Bangladesh for various ailments, including leprosy, syphilis, and heart diseases. Despite its long history of use, there has been limited scientific research investigating its effects on neuropharmacological conditions such as central nervous system (CNS) depression and pain relief. This study aims to evaluate the CNS depressant and antinociceptive effects of P. foetidus leaf extracts through behavioral tests conducted on Swiss albino mice. The research specifically assesses the efficacy of different extracts—methanol, petroleum ether, chloroform, and aqueous—to understand their potential as therapeutic agents.
CNS Depressant and Antinociceptive Effects
The study found that the methanol, petroleum ether, and chloroform fractions of P. foetidus leaf extracts demonstrated significant CNS depressant activities, as indicated by reduced locomotor activity in various tests such as the open field and hole-cross tests. The methanol extract notably increased sleeping time induced by thiopental sodium, suggesting potent sedative properties. Additionally, analgesic effects were confirmed through formalin-induced pain and tail immersion tests. The extract significantly reduced paw licking time in the formalin test, indicating effective pain relief during both the early and late phases of the test. These findings suggest that certain fractions of P. foetidus possess strong CNS depressant and analgesic activities, warranting further investigation into their pharmacological applications.
Conclusion
This research highlights the promising potential of Pandanus foetidus as a source of natural compounds for the treatment of anxiety and pain-related conditions. The various extracts exhibited significant sedative and analgesic properties, particularly the methanol and petroleum ether fractions, which outperformed others. These results support the traditional use of P. foetidus in herbal medicine while also encouraging further studies to elucidate the underlying mechanisms and identify the active phytochemical constituents responsible for its observed effects. Future research could pave the way for developing effective, plant-based therapeutic agents that address CNS-related disorders with minimal side effects.
FAQ section (important questions/answers):
What traditional uses does Pandanus foetidus have in medicine?
Pandanus foetidus is traditionally used to treat ailments like leprosy, syphilis, scabies, and various heart and brain diseases, among others.
What were the main findings of the study on Pandanus foetidus?
The study found that methanol, petroleum ether, and chloroform fractions from Pandanus foetidus exhibited significant CNS depressant and antinociceptive effects in rodents, indicating potential therapeutic uses.
Which animal models were used to test plant extract effects?
Swiss albino mice were utilized for testing the sedative, anxiolytic, and analgesic activities of Pandanus foetidus leaf extracts through various behavioral models.
What potential side effects were observed with Pandanus foetidus extracts?
The study reported that the extracts were non-toxic, meaning no significant side effects were observed due to the doses administered during the research.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “CNS Depressant and Antinociceptive Effects of Pandanus Foetidus Extract”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the performance of a task or function, specifically in biological or pharmacological studies where measurable responses are quantified. In the context of this research, it pertains to the effects observed from the different extracts on central nervous system (CNS) depression and analgesia in animal models, providing insight into their therapeutic potentials.
2) Drug:
Drug signifies a substance designed to have a medicinal effect, typically to diagnose, treat, or prevent disease. In this study, various fractions of the Pandanus foetidus extract are researched as potential drugs, especially focusing on their CNS depressant and analgesic properties, ultimately contributing to the development of new therapeutic agents.
3) Pain:
Pain refers to a complex sensation resulting from the body's protective mechanisms against injury. It serves as a critical outcome measure in pharmacological studies, helping evaluate the efficacy of analgesic agents. The study assesses the analgesic activity of Pandanus foetidus extracts through pain response tests, contributing to understanding pain management.
4) Animal:
In biological and pharmacological research, the term 'animal' represents the living organisms used for experimentation. This study utilized rodents, specifically Swiss albino mice, as models to test the CNS depressant and analgesic effects of the extracts, which aids in extrapolating findings to potential effects in humans.
5) Anxiety:
Anxiety encompasses feelings of unease, such as worry or fear, often related to stress and may require therapeutic intervention. This research focuses on determining the anxiolytic effects of Pandanus foetidus extracts, aiming to identify natural compounds that may alleviate anxiety, thereby contributing to herbal medicine.
6) Study (Studying):
Study denotes a detailed examination or analysis of a particular subject or phenomenon. This research investigates the CNS depressant and analgesic properties of Pandanus foetidus extracts using established behavior models, thus contributing to the body of knowledge on herbal remedies and potential new treatments for neurological conditions.
7) Field:
Field refers to a specific area of study or professional discipline. In the context of this research, it relates to pharmacology, neurology, and botany, which serve as the foundations for exploring the medicinal properties of the plant. It also encompasses how these findings may apply to real-world applications and therapeutic strategies.
8) Toxicity:
Toxicity indicates the degree to which a substance can cause harm to organisms. The study conducted an acute toxicity test on the extracts of Pandanus foetidus, ensuring safety in potential therapeutic applications. Understanding the toxicity profile is critical for evaluating the viability of herbal medicines in treating diseases.
9) Table:
Table often refers to organized data or results presented in a systematic format. In scientific literature, tables summarize experimental findings, making complex data accessible and comparable. This study may include tables that compile the effects of different extract fractions on anxiety and pain responses, facilitating data interpretation.
10) Ter:
Ther might refer to therapeutic measures or therapies aimed at treating health conditions. This study explores the therapeutic potential of Pandanus foetidus extracts, aiming to establish their efficacy as natural alternatives for managing anxiety and pain, thus underscoring the importance of herbal medicine in modern healthcare.
11) Pharmacological:
Pharmacological encompasses the study of drugs and their effects on living organisms. This research examines pharmacological properties of the fractions derived from Pandanus foetidus, particularly focusing on their ability to induce CNS depression and analgesia, providing insights into their mechanism of action and potential therapeutic uses.
12) Phytochemical:
Phytochemical refers to the chemical compounds produced by plants, many of which exhibit biological activity. In this study, the focus on the phytochemical composition of Pandanus foetidus helps identify specific compounds responsible for its CNS depressant and analgesic activities, contributing to the understanding of plant-derived medicines.
13) Chittagong:
Chittagong is a coastal city in Bangladesh, known for its diverse flora. The collection of Pandanus foetidus for this study occurred in this geographical area, highlighting its relevance to local medicinal practices and the importance of exploring ethnobotanical knowledge to discover new therapeutic agents.
14) Depression:
Depression describes a state of low mood and aversion to activity, significantly impacting quality of life. This study addresses the potential anti-depressive qualities of extracts from Pandanus foetidus, contributing to the broader narrative of developing natural therapies in managing mental health issues.
15) Science (Scientific):
Science encompasses the systematic study of the natural world through observation and experimentation. This study exemplifies the scientific approach by utilizing controlled experiments to explore and validate the pharmacological effects of Pandanus foetidus, contributing to the broader scientific discourse on herbal medicine.
16) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant and pharmacological properties. The study may indicate the presence of flavonoids in Pandanus foetidus, applying their known benefits in terms of enhancing cognitive function or reducing anxiety, contributing to the nutritional and therapeutic value of the plant.
17) Water:
Water is a fundamental solvent used in extracting bioactive compounds from plants. In this study, different solvent fractions, including water, were used to prepare extracts of Pandanus foetidus. The properties of these extracts, as influenced by the solvent, impact the efficacy and potency of the bioactive molecules.
18) Observation:
Observation refers to the act of monitoring and recording data during experiments. In pharmacological studies, such as this one, careful observation is necessary to quantify the effects of treatments on behavior and physiological responses in animals, leading to reliable conclusions regarding the efficacy of the extracts.
19) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. This study explores the traditional use of Pandanus foetidus as a medicinal plant, aiming to validate its effectiveness as a treatment for anxiety and pain through scientific investigation, thus bridging traditional and modern medical practices.
20) Disease:
Disease refers to a state of abnormal functioning within the body, often resulting in adverse health outcomes. This study investigates the potential role of Pandanus foetidus extracts in treating conditions like anxiety and pain, reflecting the search for effective botanical treatments for various diseases.
21) Forest:
Forest refers to a natural habitat characterized by the presence of trees and diverse ecosystems. The significance of forests lies in their biodiversity, which is crucial for sourcing medicinal plants like Pandanus foetidus. Conservation and study of these ecosystems are essential for ongoing research in phytotherapy.
22) Food:
Food represents substances consumed for nutrition and sustenance. Herbal remedies like Pandanus foetidus may be integrated into diet, emphasizing its dual role in nutrition and health. Understanding its properties can enhance dietary practices while addressing health issues through naturally derived therapies.
23) Cage:
Cage refers to the enclosure used to house experimental animals. In this study, individually caged mice were maintained under controlled conditions to ensure accurate measurements of behavioral responses to the plant extracts. The cage environment is crucial to minimize stress and variability in results.
24) Pharmacology:
Pharmacology is the study of drug actions and their effects on biological systems. This field is foundational in assessing the therapeutic potential of compounds found in Pandanus foetidus, providing insights into their pharmacodynamic properties and establishing a scientific basis for their use as medicine.
25) Shilpin (Silpin, Silpi, Shilpi):
Shilpi likely refers to one of the authors contributing to the study. Their work in identifying and validating the medicinal properties of Pandanus foetidus highlights the collaborative nature of scientific research, emphasizing the importance of multi-author contributions in undertaking comprehensive studies.
26) Family:
Family often describes a group of related organisms sharing common characteristics. In botanical terms, Pandanus foetidus belongs to the Pandanaceae family, indicating its relationship to other plants within this group. Understanding familial ties can aid in recognizing shared properties and potential uses in traditional medicine.
27) Powder:
Powder refers to the finely ground form of plant materials used for extraction or consumption. The researched extracts of Pandanus foetidus were obtained by grinding dried leaves into powder, which facilitates the extraction of active phytochemicals, enhancing the efficacy of the study's findings.
28) Rekha:
Rekha is likely another author associated with the study. Their collaboration contributes to the collective expertise that enhances the study's design and implementation, emphasizing the multifaceted approach often necessary in conducting comprehensive pharmacological research.
29) Delhi:
Delhi is the capital city of India and a hub for scientific research and education. Mention of Delhi could indicate a connection to broader research networks or institutions involved in medical and pharmacological studies, facilitating knowledge exchange and collaboration.
30) Joshi (Josi):
Joshi refers to a prominent author in the study, suggesting their specialization may contribute valuable insights into the research on Pandanus foetidus. The presence of experienced researchers often enriches the quality and reliability of scientific findings.
31) India:
India is known for its vast biodiversity and rich traditional medicine practices. The relevance of Indian pharmacognosy in the study of Pandanus foetidus highlights the country’s importance as a source of herbal knowledge and potential remedies for various health conditions.
32) Jana:
Jana likely represents another contributor to this research, indicating a collaborative effort. Their involvement reflects the team-based approach prevalent in scientific research, where diverse expertise enhances the depth and breadth of the study, ensuring thorough investigation.
33) Alam (Alaṁ):
Alam may identify yet another researcher contributing to the study. Their participation illustrates the multi-disciplinary nature of pharmacological research, where researchers bring diverse perspectives to explore the properties and applications of medicinal plants like Pandanus foetidus.
34) Tree:
Tree refers to a perennial plant with an elongated stem, or trunk, supporting branches and leaves. Pandanus foetidus is a tree-like plant found in mangrove ecosystems. Its ecological role contributes to biodiversity and serves as a source of medicinal compounds, justifying conservation efforts.
35) New Delhi:
New Delhi, as a location, may indicate the involvement of scientific and medical institutions within the capital of India. Its mention highlights the potential for cross-institutional collaboration that can enhance research quality and facilitate valuable partnerships in exploring herbal medicine.
36) Transmission:
Transmission often describes the process through which signals or substances are carried. In the context of this study, transmission may refer to neurotransmission, relevant in understanding how the compounds from Pandanus foetidus interact with the central nervous system, affecting behavior and physiological responses.
37) Discussion:
Discussion is a crucial part of scientific writing that interprets results in the context of existing knowledge. It provides an opportunity to reflect on findings from the study of Pandanus foetidus, exploring implications for therapeutic applications and future research directions in CNS depression and pain relief.
38) Observing:
Observing pertains to the act of carefully watching and noting phenomena during an experiment. In pharmacological studies, observing behaviors and responses in animal models helps generate data that validate the efficacy of treatments, as seen with the extracts from Pandanus foetidus.
39) Relative:
Relative often denotes a comparison between elements. In this context, it relates to evaluating the effects of different extracts of Pandanus foetidus relative to standard drugs, helping establish their efficacy and safety profile, ultimately guiding therapeutic recommendations.
40) Channel:
Channel generally refers to a route through which substances can pass. In pharmacology, ion channels are critical for neurotransmission. The study may delve into how extracts from Pandanus foetidus can modulate these channels, providing insights into their mechanism of action in CNS effects.
41) Leprosy:
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The mention of leprosy indicates the traditional uses of Pandanus foetidus in treating various diseases, underscoring the need for scientific validation of ethnobotanical remedies in managing health conditions.
42) Surface:
Surface may refer to the external aspects or boundaries of a substance or organism. In laboratory settings, the surface area can influence extraction efficiency and bioavailability of compounds. Understanding surface properties is pivotal in optimizing extraction methods for pharmacological studies.
43) Mishra (Misra):
Mishra likely refers to an author involved in the research. Their contributions may represent collaborative efforts to advance scientific inquiry regarding the efficacy of Pandanus foetidus in therapeutic contexts, showcasing the collective endeavor typical in research environments.
44) Botany:
Botany is the branch of biology concerned with the study of plants. This study on Pandanus foetidus blends botanical research with pharmacology, linking the understanding of plant species to their medicinal properties, emphasizing the relevance of botany in developing natural remedies.
45) Visit:
Visit typically signifies the act of going to a place. In research, it could relate to field visits to collect samples or observe natural habitats. The context of visits emphasizes the importance of fieldwork in understanding the ecological and medicinal aspects of Pandanus foetidus.
46) Cina:
China, a country with rich biodiversity and traditional medicine practices, may indicate a comparison or potential interest in the medicinal plants utilized in Chinese remedies. The mention could suggest the broader scope of research on phytochemical properties globally, highlighting the collaboration in herbal studies.
47) Diet:
Diet refers to the types of food consumed by individuals. The inclusion of herbal extracts in diets may promote medicinal benefits, highlighting the study's potential to integrate findings on Pandanus foetidus into nutritional practices that contribute to health and well-being.
48) Hind:
Hind often refers to the cultural context in which certain medicinal practices are embedded. This study on Pandanus foetidus may reflect traditional uses prevalent in Hind cultures, emphasizing the significance of ethnobotany in understanding plant-based therapies.
49) Fear:
Fear refers to an emotional response to perceived danger or threat. In pharmacological research, understanding fear responses is vital for evaluating anxiolytic effects of substances. The study investigates how extracts of Pandanus foetidus potentially mitigate anxiety-related fear, contributing insights into mental health treatments.
50) Sign:
Sign denotes an indication or mark of something. In scientific studies, signs can refer to observable effects of treatment interventions. This study assesses how the different fractions of Pandanus foetidus induce signs of CNS depression and analgesia in experimental models.
51) Wall:
Wall in a laboratory context may refer to the enclosures within which animal experiments are conducted. In behavioral tests, walls ensure a controlled environment, minimizing external stimuli that could interfere with observing the effects of Pandanus foetidus extracts on animal subjects.
52) Post:
Post often refers to a position or publication of results. In a research context, posting findings is crucial for sharing knowledge with the scientific community, ensuring that conclusions about Pandanus foetidus and its medicinal effects reach a wider audience and inform future investigations.
53) Male:
Male refers to the biological sex of organisms. In this research, male or female mice are utilized as subjects for testing extracts from Pandanus foetidus. Gender considerations are important in pharmacological studies due to potential differences in response to treatments between male and female organisms.
54) Life:
Life represents the condition characteristic of living organisms. In pharmacological research, understanding the life processes of models, like mice used in the study, is essential for accurately interpreting the effects of treatments. This highlights the relationship between biological processes and therapeutic interventions in health sciences.
Other Science Concepts:
Discover the significance of concepts within the article: ‘CNS Depressant and Antinociceptive Effects of Pandanus Foetidus Extract’. Further sources in the context of Science might help you critically compare this page with similair documents:
Therapeutic agent, Traditional medicine, Statistical analysis, Phytochemical screening, Analgesic effect, Animal model, Acute toxicity, Analgesic activity, Elevated Plus Maze, Dose administration, Muscle relaxant, Secondary metabolite, Acetone extract, Locomotor activity, Swiss albino mice, Anxiolytic activity, Neuropharmacological activity, Standard drug, Open arm, CNS depressant activity, Antinociceptive activity, Allergic mediators, Methanol extract, Normal control group, Acute toxicity test, Elevated plus maze test, Analgesic potential, Central nervous system depressant, Open field test, Inflammatory response, CNS Depressant Action, Analgesic properties, Plant Extract, Analgesic Agent, Tail immersion method, Thiopental sodium-induced sleeping time, GABAergic transmission, Petroleum ether fraction, Chloroform fraction, Rodent pellet diet, Department of Botany, Tail immersion test, Formalin-induced pain, Formalin induced nociception, Antinociceptive effect, Hole cross test, Rodent model, Research funding, Sedative activities, Methanol fraction, CNS depressant effect, Cage-side observation.