Burdock extract effects on hormones and sperm in diabetic male mice.
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Effects of Hydro-alcoholic Extract from Arctium lappa L. (Burdock) Root on Gonadotropins, Testosterone, and Sperm Count and Viability in Male Mice with Nicotinamide/ Streptozotocin-Induced Type 2 Diabetes
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Akram AHANGARPOUR, Ali Akbar OROOJAN, Hamid HEIDARI, Ehsan GHAEDI, Reza TAHERKHANI
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Effects of Hydro-alcoholic Extract from Arctium lappa L. (Burdock) Root on Gonadotropins, Testosterone, and Sperm Count and Viability in Male Mice with Nicotinamide/ Streptozotocin-Induced Type 2 Diabetes
Year: 2015
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Diabetes mellitus, a prevalent endocrine disorder characterized by hyperglycemia, adversely affects various bodily systems, including reproductive function. Men with diabetes commonly experience diminished sexual health, evidenced by decreased testosterone levels and fertility issues such as lower sperm counts and motility. This study investigates the potential of Arctium lappa (burdock) root, known for its hypoglycemic and antioxidative properties, to enhance reproductive health in diabetic male mice. Using a nicotinamide/STZ-induced diabetic mouse model, the researchers aimed to assess the effects of the hydroalcoholic extract of burdock on serum gonadotropins, testosterone levels, and sperm parameters.
Effects of Arctium lappa on Reproductive Health
The findings demonstrated that diabetes significantly lowered the body weight of mice and negatively impacted their reproductive hormone levels (LH, FSH, testosterone) and sperm quality (count and viability). While administration of glibenclamide improved hormonal and sperm parameters in diabetic models, the extract of A. lappa at a higher dose (300 mg/kg) was particularly effective in enhancing sperm viability and increasing hormone levels in nondiabetic mice. These results suggest that A. lappa exhibits anti-infertility effects in healthy mice, but its protective effects against reproductive dysfunction in diabetic mice were less pronounced, indicating the need for further exploration of its mechanisms.
Conclusion
Overall, the study reveals that the hydroalcoholic extract of A. lappa roots could contribute to improved reproductive health, particularly by increasing gonadotropin and testosterone levels in nondiabetic mice. This suggests the potential of A. lappa as a natural therapeutic agent for enhancing male fertility, especially against the backdrop of diabetes. However, the limited impact on diabetic mice's reproductive functions highlights the complexity of diabetes-related reproductive issues and emphasizes the necessity for additional research to elucidate the mechanisms behind the extract's efficacy and its potential role in managing reproductive complications associated with diabetes.
FAQ section (important questions/answers):
What is the objective of the study on Arctium lappa?
The study aimed to investigate the effects of hydro alcoholic extract of Arctium lappa on gonadotropin, testosterone, and sperm parameters in diabetic mice induced by nicotinamide and streptozotocin.
How does diabetes affect reproductive parameters in the studied mice?
Diabetes significantly decreased body weight, serum levels of LH, FSH, testosterone, and reduced sperm count and viability in the mice, indicating reproductive dysfunction linked with diabetic conditions.
What effects did Arctium lappa extract have on the mice?
The extract improved sperm viability and count in diabetic mice and enhanced serum levels of LH, FSH, and testosterone in nondiabetic mice, suggesting potential benefits for fertility.
How was diabetes induced in the mice for the study?
Diabetes was induced through an intraperitoneal injection of nicotinamide followed by streptozotocin, leading to high blood glucose levels, allowing researchers to assess the effects of treatments on fertility.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Burdock extract effects on hormones and sperm in diabetic male mice.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Male:
In the context of the study, 'male' refers to the gender of the mice used as subjects. Male reproductive health is significantly impacted by diabetes, leading to reduced hormone levels and fertility issues. The study aimed to evaluate the effects of treatment on male reproductive parameters under diabetic conditions.
2) Animal:
'Animal' pertains to the type of subjects in the research, specifically adult male NMRI mice. These model organisms are frequently utilized in scientific studies to mimic human disease conditions and evaluate treatment efficacy due to their physiological similarities and ease of handling in a laboratory setting.
3) Table:
'Table' refers to a graphical representation of data that presents results clearly. In the study, tables were used to summarize findings related to body weight, testicular morphology, and various hormonal measurements post-treatment, facilitating comparisons between different groups and experimental conditions for clarity and visual analysis.
4) Study (Studying):
'Study' refers to the overall research project investigating the effects of hydroalcoholic extracts from burdock roots on reproductive health in diabetic mice. It encompasses methodology, data collection, analysis, and the interpretation of results aimed at understanding potential therapeutic benefits for treating male infertility associated with diabetes.
5) Post:
'Post' indicates the time frame after treatment administration. In this study, blood samples and mouse organs were analyzed 24 hours post the last administration of either the hydroalcoholic extract or glibenclamide. This timing is critical to assess the immediate effects and efficacy of the treatments applied.
6) Blood:
'Blood' is a vital component in this research as it contains hormonal levels measured to assess the treatment's effectiveness. Blood samples were collected to analyze serum levels of reproductive hormones like testosterone, LH, and FSH to determine the impact of treatments on the endocrine system in diabetic mice.
7) Drug:
'Drug' refers to pharmacological agents like glibenclamide used in this study. It serves as a control against which the effects of the burdock extract were measured. Evaluating the drug's efficacy in managing diabetes helps contextualize the potential alternative herbal treatment's effectiveness and safety in male reproductive health.
8) Science (Scientific):
'Science' in this context refers to the systematic study of the natural world through observation and experimentation. The research utilizes scientific methods to explore the pharmacological properties of a plant extract, aiming to contribute to understanding and treating diabetes-induced reproductive dysfunction in males.
9) Relative:
'Relative' indicates the comparison made between groups in the study. In the context of diabetes and reproductive health, the term suggests assessing hormone levels and reproductive parameters against control and treated groups to determine the extract's efficacy relative to standard treatments like glibenclamide.
10) Species:
'Species' refers to the specific type of biological organism examined in the study, namely NMRI mice. Studying a specific species allows for a more controlled evaluation of treatment effects and better understanding of diabetes's impact on male reproductive health at a physiological level.
11) Devi:
'Devi' likely refers to a trademark or an author associated with various studies in this research. Authors like Devi contribute to the scientific discourse through collaborative research efforts, enhancing knowledge on the subject matter, such as the reproductive impairments caused by diabetes and their management.
12) Phytochemical:
'Phytochemical' refers to the bioactive compounds derived from plants, which are studied for their health benefits. The research focuses on phytochemicals in burdock root, exploring their potential therapeutic effects on male reproductive health in diabetic conditions, contributing to the broader field of herbal medicine and natural remedies.
13) Medicine:
'Medicine' encompasses the science and practice of diagnosing, treating, and preventing diseases. This study integrates traditional knowledge of herbal treatments with modern scientific approaches, examining the effectiveness of natural extracts in potentially alleviating male reproductive issues associated with diabetes, striving for safe treatment alternatives.
14) Flavonoid:
'Flavonoid' refers to a class of phytochemicals found in plants, known for their antioxidant properties. In the context of the study, flavonoids in burdock root may contribute to ameliorating oxidative stress associated with diabetes, thus potentially improving reproductive health by neutralizing harmful free radicals affecting sperm viability.
15) Kalyani (Kalyanin):
'Kalyani' likely refers to an author who contributed to studies involving diabetes and reproductive health. Authors like Kalyani play a key role in advancing scientific knowledge by conducting research and publishing findings, which informs clinical practices and therapeutic approaches in managing conditions like diabetes.
16) Quality:
'Quality' in the context of this research may refer to the assessment of sperm health and overall reproductive function, focusing on parameters such as count and viability. Evaluating quality helps determine the effectiveness of treatments, such as the burdock extract on enhancing reproductive metrics in diabetic male subjects.
17) Brahmi:
'Brahmi' refers to a plant traditionally used in herbal medicine. In this context, the mention of Brahmi may relate to other studies or comparisons regarding its effects on male reproductive health or fertility, paralleling the investigated benefits of the burdock root extract in managing diabetes-induced infertility.
18) Humana:
'Humana' likely refers to a publisher or a specific scientific text regarding health or reproductive medicine. Their publications contribute to disseminating crucial information on men's health and fertility treatments, expounding on areas relevant to the research conducted in the burdock root extract study.
19) Roman (Roma):
'Roman' may refer to a researcher or scholar associated with studies on reproductive health. Their contributions enhance the understanding of diabetic complications on reproductive parameters, depicting the collaborative nature of research in advancing treatment strategies for male infertility linked to metabolic disorders.
20) Water:
'Water' refers to the solvent used in the extraction process of the burdock root. The preparation of the hydroalcoholic extract employs a mixture of ethanol and distilled water, essential for solubilizing the active compounds, thus enabling the assessment of their potential effects on reproductive health in diabetic mice.
21) Peng:
'Peng' could refer to an author or contributor to the research, highlighting the collaborative efforts in scientific investigations. The involvement of multiple authors demonstrates the teamwork necessary for conducting comprehensive studies that explore the impact of dietary and herbal interventions on health outcomes.
22) Azadirachta indica:
'Azadirachta indica' is a plant scientifically known as neem, recognized for its medicinal properties. While the present study focuses on burdock, referencing azadirachta indica may highlight comparative studies on the efficacy of herbal treatments, enriching the understanding of various plants in managing health challenges, including diabetes.
23) Tribulus terrestris:
'Tribulus terrestris' is a plant known for its potential effects on male reproductive health and testosterone levels. Its mention alongside the study indicates the interest in natural treatment options for enhancing male fertility, underscoring the exploration of various herbal remedies in addressing reproductive dysfunction.
24) Measurement:
'Measurement' refers to the quantitative assessment of variables such as hormone levels and reproductive parameters in the study. Accurate measurement is fundamental to validating the study's findings, allowing for the comparison of effects between treated and control groups in evaluating the efficacy of the burdock extract.
25) Discussion:
'Discussion' is a critical section in scientific research where authors interpret their findings. It connects results with existing literature, explores implications, limitations, and potential areas for future research, providing a platform for understanding the broader context and significance of the study on diabetes and reproductive health.
26) Channel:
'Channel' likely refers to the biological pathways, such as ion channels that mediate various physiological processes. In the context of diabetes and hormone regulation, understanding channel functions is crucial as they may influence hormone secretion and signaling related to reproductive health in the affected individuals.
27) Disease:
'Disease' refers to the pathological condition of diabetes discussed in the study. Diabetes mellitus significantly impacts reproductive health, contributing to infertility and hypogonadism, which were major focuses of the research, emphasizing the need for effective therapeutic interventions to ameliorate these complications.
28) Family:
'Family' in this context could relate to the classification system of plants, indicating the botanical family to which burdock belongs. Understanding its family can provide insights into its properties and potential health benefits, linking it to other plants with similar attributes relevant to diabetes.
29) Powder:
'Powder' refers to the processed form of burdock root after desiccation. The root was ground into powder before extraction, which is a critical preparation step that enhances the efficiency of extracting bioactive compounds, ultimately supporting the evaluation of their therapeutic effects on the studied parameters.
30) Rules:
'Rules' likely refers to the standards and protocols followed in carrying out the experimental procedures outlined in the study. Maintaining rigorous adherence to established rules of scientific investigation ensures the reliability and reproducibility of findings, bolstering the integrity of the research outcomes.
31) House:
'House' may refer to the animal house in which the NMRI mice were maintained before the experiments. Providing a controlled environment is crucial for ensuring the health and welfare of experimental animals, allowing for reliable and valid results in studies investigating physiological and pharmacological effects.
32) Shan (San):
'Shan' likely refers to an author involved in the study or a related research project, contributing to the collective knowledge base in the field. Their participation in research highlights the collaborative effort necessary for advancing scientific inquiry and understanding of complex health issues like diabetes.
33) Rich (Rch):
'Rich' likely describes the chemical composition of the burdock root, indicating a high concentration of bioactive compounds such as antioxidants and phytochemicals. These rich properties may confer health benefits, making burdock an appealing subject for research in the context of managing diabetes-related reproductive dysfunction.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Burdock extract effects on hormones and sperm in diabetic male mice.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Diabetes mellitus, Traditional Chinese medicine, Statistical analysis, Sexual dysfunction, Experimental study, Oxidative stress, Sperm count, Sperm viability, One-way ANOVA, Type 2 diabetes, Oxidative damage, Follicle-stimulating hormone, Hyperglycemia, Body weight, Hydroalcoholic extract, Hydro alcoholic extract, Serum testosterone, Glibenclamide, Experimental protocol, Blood glucose level, Serum FSH, Serum LH, Male infertility, Testicular weight, Hypogonadism, Hypothalamic-pituitary-gonadal axis, Serum testosterone level, Sperm parameters, Reproductive Dysfunction, Testosterone, Free Radical, Androgen deficiency, Plant Extraction, Glibenclamide treatment, Antioxidative properties, Hormonal assessment, Natural antioxidant, Animal Body Weight, Hormonal measurements, Bioactive agent, Hypoglycemic properties, Serum sample, Diabetic mice, Anti-infertility effect, Technical support, Logistic Support, Reference, Serum luteinizing hormone, Administrative support, Serum gonadotropins, Gonadotropin.
Concepts being referred in other categories, contexts and sources.