Magnesium, Lung Function, and Asthma Control in Children
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Relationship between Intracellular Magnesium Level, Lung Function, and Level of Asthma Control in Children with Chronic Bronchial Asthma
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Htwe Htwe SEIN, CHEAH Whye Lian, KOK Juan Loong, Josephine SL NG, Andy RAHARDJAI, Mohamed Ameenudeen SULTAN
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Relationship between Intracellular Magnesium Level, Lung Function, and Level of Asthma Control in Children with Chronic Bronchial Asthma
Year: 2014
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Bronchial asthma is a chronic inflammatory condition affecting the airways and is a leading cause of morbidity among children globally. In the United States, approximately 7.1 million children under 18 suffer from asthma, with many experiencing attacks that can significantly impact their daily lives. Given the existing literature highlighting the potential link between magnesium levels and asthmatic exacerbations, this study seeks to investigate intracellular magnesium concentrations in children with chronic bronchial asthma. Additionally, the research aims to explore the relationship between magnesium levels, peak expiratory flow rate (PEFR), the type of asthma treatment, and the level of asthma control among the pediatric population.
Importance of Intracellular Magnesium
The study revealed that 95% of participants had normal intracellular magnesium levels, with a mean of 2.27 mmol/L. Furthermore, despite varying treatment regimens—where approximately 85% were using both reliever and controller medications—no significant correlations were found between magnesium levels and factors such as age, gender, asthma duration, PEFR, or treatment types. The research supports the notion that intracellular magnesium levels can be stable in chronic, well-controlled asthma, indicating that, unlike acute asthma attacks which may lead to magnesium depletion, controlled asthma may not significantly impact magnesium homeostasis among children.
Conclusion
In conclusion, this study indicates a lack of significant intracellular magnesium deficiency in children with chronic bronchial asthma. The findings suggest that therapeutic interventions for asthma do not adversely influence magnesium levels, implying that magnesium homeostasis remains stable in this population. Future research with larger cohorts is recommended to further clarify the relationship between intracellular magnesium levels and asthma control, as well as the potential influence of dietary habits on magnesium status among asthmatic children.
FAQ section (important questions/answers):
What was the focus of the study on magnesium levels?
The study aimed to evaluate intracellular magnesium levels in children with chronic bronchial asthma, investigating their relationship with peak expiratory flow rate (PEFR), asthma treatment types, and asthma control levels.
What were the main findings regarding magnesium deficiency in subjects?
The study found no significant intracellular magnesium deficiency in 95% of participants, suggesting that normal magnesium levels are prevalent in children with chronic asthma. No significant relationship was observed between magnesium levels and other measured factors.
How was the intracellular magnesium level measured in the study?
Intracellular magnesium levels were measured using venous blood samples, employing a GBC Avanta Flame Atomic Absorption Spectrophotometer specific for measuring red blood cell magnesium concentration.
What implications do the study results have for asthma treatment?
The study suggests that asthma treatment medications do not significantly affect intracellular magnesium levels, indicating magnesium status may not be directly influenced by asthma therapy, and further investigation is warranted with larger populations.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Magnesium, Lung Function, and Asthma Control in Children”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table references are important in studies to summarize and present data in a clear, organized manner. In research, tables often display demographics, participant information, and statistical outcomes, which allow readers to quickly grasp findings, compare results between groups, and see the significance of data supporting the study’s conclusions.
2) Study (Studying):
A study is a systematic investigation to discover or revise facts, theories, or applications. In the context of health and medicine, studies are essential to understanding disease mechanisms, treatment outcomes, and epidemiology. They provide crucial evidence that informs clinical practice, enhances public health, and shapes health policy.
3) Bronchial asthma:
Bronchial asthma is a chronic inflammatory disease of the airways characterized by airway hyper-responsiveness, obstruction, and manifestations like wheezing and coughing. It affects individuals' quality of life and may lead to severe complications. Understanding its prevalence, risk factors, and treatment options is crucial for effective management and prevention strategies.
4) Disease:
Disease refers to a pathological condition characterized by a dysfunction in body systems. In the medical context, diseases can affect various organs and processes, causing physical, emotional, and social implications. Identifying diseases, their causes, and treatment options is essential for improving health outcomes and advancing medical knowledge.
5) Blood:
Blood is a vital fluid in the body, transporting oxygen, nutrients, hormones, and waste products. It plays a crucial role in maintaining homeostasis and supporting immune function. Studying blood components, such as cells and electrolytes, can provide insights into health, disease states, and the efficacy of treatments.
6) Male:
Male refers to one of the two primary biological sexes in humans, characterized by XY chromosomes and specific reproductive anatomy. In medical research, sex-based differences are important for understanding disease susceptibility, response to treatment, and behavioral factors. Analyzing male participation in studies contributes to gender-specific medical insights.
7) Measurement:
Measurement refers to the process of quantifying variables or outcomes. In medical research, accurate measurement tools and methods are essential for obtaining reliable data on health indicators, such as lung function, blood pressure, and intracellular elements. This data supports the validity of research findings and informs clinical decision-making.
8) Rules:
Rules are guidelines or principles that govern behavior or practices. In research, rules may refer to ethical guidelines, protocols for studies, or statistical methods for data analysis. Adherence to rules ensures the integrity of the research process, the validity of results, and the protection of participants’ rights.
9) Food:
Food refers to any substance consumed for nutritional support. In health research, understanding dietary patterns is crucial as certain foods influence health outcomes, nutritional status, and disease risk. Investigating food sources, dietary habits, and their relationship to conditions like asthma aids in developing effective prevention and management strategies.
10) Inflammation:
Inflammation is the body's response to harmful stimuli, such as pathogens or irritants, characterized by redness, swelling, heat, and pain. It is a crucial aspect of many diseases, including asthma. Understanding inflammatory processes can aid in identifying mechanisms of disease progression and developing targeted treatments to alleviate symptoms.
11) Education:
Education involves the systematic imparting and acquiring of knowledge, skills, and values. In health contexts, educational programs are vital for promoting awareness about diseases, treatment options, and preventative measures. Effective education empowers individuals to make informed health choices and enhances overall public health through increased awareness.
12) Quality:
Quality refers to the standard or degree of excellence of something. In medical research, quality indicators can evaluate healthcare services, treatments, or patient outcomes. Quality measures promote adherence to best practices, enhance patient safety, and improve health outcomes, ensuring that healthcare services effectively meet patients' needs.
13) Species:
Species, in a biological context, refers to a group of organisms that can interbreed and produce fertile offspring. In health studies, addressing species diversity and interactions can reveal important environmental and genetic factors related to diseases, informing public health responses and conservation strategies for biodiversity.
14) Allergy:
Allergy is a hypersensitive immune response to specific allergens, resulting in symptoms such as sneezing, itching, and anaphylaxis. Allergies significantly affect individuals' quality of life and health. Researching the mechanisms of allergic reactions helps in developing interventions and understanding the links between allergies and other health conditions.
15) Indian:
Indian pertains to anything associated with India, including its culture, people, and medical practices. In health research, studying Indian populations and their unique health challenges can provide valuable insights into disease patterns, treatment responses, and healthcare efficacy, fostering culturally competent health interventions and policies.
16) India:
India is a country in South Asia characterized by vast cultural and ethnic diversity. In a medical context, understanding India's healthcare challenges, epidemiology, and healthcare systems is essential for addressing public health issues, developing effective policies, and improving health outcomes in its diverse populations.
17) Kumar:
Kumar is a common surname in India often linked to various prominent figures in academia, politics, and health research. In medical literature, studying individuals such as Dr. Kumar can provide insights into their contributions, research findings, and impact on public health, particularly in specific fields of study.
18) Divi:
Divi may refer to a specific individual associated with health research, particularly in studies involving asthma or magnesium levels. Understanding contributions from researchers like Divi can offer context on study methodologies, findings, and advancements in specific areas of study, enhancing the overall body of health knowledge.
19) Shari (Sari):
Sari refers to a traditional garment worn by women in India and other South Asian countries. While its primary context is cultural, understanding ethnic and cultural backgrounds, like those of sari wearers, contributes to the appreciation of diverse perspectives in health research, particularly in female-dominant studies.
20) Bota (Boti):
Bota may refer to a specific individual involved in health research or significant contributions in related fields. Acknowledging the work of researchers like Bota enhances the body of medical literature, highlighting diverse contributions to asthma research and related studies, ultimately informing treatment and preventative strategies.
21) Chau:
Chau, often associated with individuals contributing to the fields of medicine or health sciences, plays a role in knowledge dissemination through research. Recognizing contributors like Chau encourages collaborative efforts and highlights multidisciplinary approaches essential for advancing health studies and improving clinical outcomes.
22) Diet:
Diet refers to the sum of food and drink an individual consumes. In health research, diet plays a pivotal role in determining long-term health outcomes. Investigating dietary habits and their impacts can inform public health strategies, policy development, and nutritional education aimed at disease prevention.
23) Rice (Rce):
Rice is a staple food for a significant portion of the world's population, particularly in Asia. Its nutritional value and role in diet can significantly influence health outcomes. Researching rice consumption patterns is essential for understanding dietary health, potential deficiencies, and cultural dietary practices in certain populations.
24) Rich (Rch):
Rich, in the context of nutrition or minerals, refers to foods that contain high amounts of specific nutrients. Food that is rich in vitamins and minerals can enhance overall health. Understanding the nutrient profile of various foods aids in developing dietary recommendations for disease prevention and health enhancement.
25) Life:
Life encompasses the existence and biological functions of living organisms. In health contexts, understanding life through health studies focuses on promoting well-being, preventing disease, and addressing health disparities. Research contributes to knowledge that enhances quality of life, guiding public health initiatives and healthcare decisions.
26) Redistribution:
Redistribution refers to the movement or reallocation of substances within the body, such as minerals or nutrients. In medical contexts, studying the redistribution of elements like magnesium can explain physiological responses, disease progression, and treatment effects, helping to elucidate mechanisms behind conditions like asthma.
27) Discussion:
Discussion in research involves analyzing and interpreting study results in the context of existing literature. This section provides critical insights into findings, limitations, and implications for future research. Engaging in productive discussions enhances collaboration and knowledge sharing, which are vital for advancing scientific understanding and clinical practice.
28) Science (Scientific):
Scientific pertains to the systematic study of the natural world through observation and experimentation. This methodical approach underlies medical research, fostering evidence-based practices and innovations in healthcare. Scientific rigor ensures that findings contribute to reliable, reproducible knowledge, providing a solid foundation for advancements in health sciences.
29) Activity:
Activity refers to any action or performance that has a specific function. In health contexts, understanding the level of physical activity is crucial for assessing health status, disease risk, and effectiveness of interventions. Regular activity promotes physical and mental well-being, essential in preventing lifestyle-related diseases.
30) Relative:
Relative describes a relationship between entities or conditions based on a comparative basis. In medical research, understanding relative risk factors assists in evaluating the likelihood of developing diseases compared to control groups. This comparative analysis aids in risk assessments, informing patients and guiding clinical practices.
31) Soya:
Soya refers to soybeans and their products, known for their protein content and health benefits. Incorporating soya into diets can enhance nutritional profiles, particularly in vegetarian populations. Investigating soya’s role in health research sheds light on its impact on various conditions, such as cholesterol levels and overall wellbeing.
32) Hand:
Hand can refer literally to the human hand, or metaphorically, as in managing or performing tasks. In health research, assessing hand function is crucial for understanding physical capabilities, rehabilitation needs, and quality of life. Studies might evaluate hand dexterity and strength in relation to various conditions and treatment outcomes.
33) Post:
Post typically refers to a position or placement following an event. In medical literature, post often appears in contexts such as post-operative care, addressing factors affecting recovery after surgery. Understanding post-event outcomes is essential for improving patient management, treatment efficacy, and overall health system effectiveness.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Magnesium, Lung Function, and Asthma Control in Children’. Further sources in the context of Science might help you critically compare this page with similair documents:
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