Primitive Neuroectodermal Tumour of Pancreas; Second Case from Asia
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Primitive Neuroectodermal Tumour of Pancreas; Second Case from Asia
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Khalid Hamid CHANGAL, Mohmad Hussain MIR, Sheikh Aejaz AZAZ, Sumyra Khurshid QADRI, Abdul Rashid LONE
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Primitive Neuroectodermal Tumour of Pancreas; Second Case from Asia
Year: 2014
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Primitive neuroectodermal tumours (PNETs) are rare and aggressive tumours primarily composed of small round cells of neuroectodermal origin. While PNETs are commonly found in soft tissues and bones, their occurrence in the pancreas is extremely rare, with only 14 documented cases globally before the current report. This paper presents a case of a 60-year-old farmer suffering from a painful pancreatic mass, ultimately diagnosed as PNET after thorough clinical evaluation, imaging, and histopathology.
Rare Occurrence of Pancreatic PNETs
The case highlights the exceptional nature of pancreatic PNETs, emphasizing the significance of accurate diagnosis amidst differential considerations, including other small round cell tumours and pancreatic neoplasms. The diagnostic process relied on a combination of imaging modalities (ultrasound, CECT), histological examination, immunohistochemical staining, and cytogenetic analysis, which confirmed the diagnosis of a primary PNET. Notably, the patient underwent chemotherapy, showing initial improvements and suggesting a potential for future surgical intervention. This case underscores the necessity for healthcare professionals to recognize the possibility of pancreatic PNETs, given their rarity and often aggressive nature.
Conclusion
In conclusion, pancreatic PNETs are an exceedingly rare entity that should remain in the differential diagnosis for pancreatic masses. The presented case is only the second of its kind reported in Asia, reinforcing the need for increased awareness and research into this malignancy. Enhanced understanding of pancreatic PNETs may contribute to better diagnostic, therapeutic, and ultimately prognostic outcomes for affected patients. Further studies are essential to elucidate the disease's characteristics and optimize treatment strategies.
FAQ section (important questions/answers):
What are primitive neuroectodermal tumors (PNETs) and where do they originate?
PNETs are malignant tumors composed of small round cells of neuroectodermal origin. They typically originate in soft tissues and bones, but very rarely in organs like the pancreas, kidney, or bladder.
How rare are pancreatic PNETs compared to other tumors?
Pancreatic PNETs are extremely rare, with only 14 cases documented worldwide before this report, making this instance the fifteenth globally, the second in Asia, and the first in India.
What methods are used to diagnose pancreatic PNETs?
Diagnosis involves a thorough clinical evaluation, imaging techniques, histopathology analysis, immunohistochemistry, and cytogenetic studies to differentiate primary pancreatic PNETs from secondary tumors.
What treatment options are available for pancreatic PNET patients?
Treatment typically involves systemic multi-agent chemotherapy, potentially combined with surgical intervention or radiotherapy. Ongoing assessment and follow-up are essential for managing the disease's progression.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Primitive Neuroectodermal Tumour of Pancreas; Second Case from Asia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In the context of the article, 'Table' refers to a structured presentation of data summarizing markers tested in previously reported cases of primitive neuroectodermal tumors (PNETs) of the pancreas. It provides a quick reference for researchers and clinicians to compare and analyze immunohistochemical characteristics, facilitating better understanding and diagnosis.
2) Chemotherapy:
Chemotherapy is a critical treatment approach for various cancers, including primitive neuroectodermal tumors (PNETs). The article mentions the use of VIDE chemotherapy regimen to manage the patient's condition. Understanding chemotherapy's effects, protocols, and response monitoring is essential for optimizing patient outcomes and managing side effects.
3) Disease:
In medical literature, 'disease' denotes a pathological condition affecting a person. The article discusses primitive neuroectodermal tumors (PNETs) as malignant diseases that require careful diagnosis and treatment. Recognizing the implications of disease terminology is essential for understanding patient prognosis, management strategies, and epidemiological studies.
4) Family:
The term 'family' in the article context refers to a classification of tumors, specifically the Ewing’s sarcoma family, which includes primitive neuroectodermal tumors (PNETs). Understanding the familial relationships of tumors aids in diagnosis, treatment strategies, and identifying shared genetic and biological characteristics across different tumor types.
5) Radiotherapy:
Radiotherapy is mentioned as a potential treatment component alongside chemotherapy for managing PNETs. It utilizes high-energy radiation to target and kill cancerous cells. Understanding radiotherapy's role and effectiveness helps in developing comprehensive treatment plans and managing localized versus disseminated disease.
6) Cancer:
Cancer represents a significant health concern and encompasses a broad range of diseases characterized by uncontrolled cell growth. The article emphasizes the malignant nature of primitive neuroectodermal tumors (PNETs) as a type of cancer, highlighting the need for effective diagnostic and therapeutic approaches critical for patient care.
7) Surrounding:
The word 'surrounding' refers to adjacent tissues and structures around the tumor in question. In cancer diagnosis and treatment, understanding the condition of surrounding tissues is crucial, as it informs surgical resectability, tumor staging, and potential metastasis, influencing the overall treatment strategy.
8) Study (Studying):
In a medical context, 'study' often refers to systematic research or analysis of health conditions. The article reviews cases of PNETs, contributing to the body of knowledge regarding their diagnosis, treatment, and outcomes. Studies enable healthcare professionals to inform practice and improve patient management.
9) Vomiting:
Vomiting is a symptom that may accompany various gastrointestinal diseases, including those related to pancreatic tumors. The article mentions it as a possible clinical manifestation in patients diagnosed with PNETs, emphasizing the need to monitor for such symptoms in diagnosis and treatment plans.
10) Sharman (Sarma, Sharma, Sarman):
Sarman is mentioned as one of the authors cited in the references. This name contributes to the scholarly context of the article, representing the collaborative nature of medical research. Understanding the contributions of various authors is crucial for verifying information and providing appropriate credit in scientific discourse.
11) Lizard:
Lizard appears as the last name of an author cited in the references. Recognizing individual contributors to the literature helps attribute findings and insights accurately within medical research. It underlines the collaborative effort required in the research community to explore rare conditions like PNETs.
12) Blood:
The term 'blood' is relevant in the context of laboratory tests and potential symptoms related to pancreatic tumors, such as anemia or bleeding. Monitoring blood parameters can provide insights into a patient's overall health, tumor burden, and response to treatment, critical for comprehensive patient management.
13) Sang:
'Sang' refers to an author involved in documenting cases of primitive neuroectodermal tumors in the literature. It signifies the collaborative spirit in medical research, indicating how multiple researchers contribute to a comprehensive understanding of rare diseases, including PNETs, impacting future studies and patient care.
14) Pain:
Pain is a critical symptom often associated with pancreatic tumors, influencing the patient's quality of life. The article discusses pain as a significant symptom experienced by a patient with a pancreatic mass, highlighting the importance of effective pain management strategies in cancer treatment plans.
15) Male:
The term 'male' refers to the gender of patients typically studied in medical literature. The article touches on demographics related to primitive neuroectodermal tumors (PNETs), noting that previous cases included both males and females. Gender analysis can inform risk factors and clinical outcomes in research.
16) Discussion:
The 'discussion' section of a research article synthesizes findings and places them in the context of existing literature. It addresses implications for practice and suggests avenues for further research. In this article, it provides insights into the diagnosis, treatment, and understanding of rare tumors like PNETs.
17) Bleeding:
Bleeding, a clinical symptom that may arise from pancreatic tumors, indicates disease severity and potential complications. Monitoring for bleeding is vital in assessing patient status and guiding treatment decisions, showcasing the symptom's relevance in diagnosing and managing pancreatic neoplasms effectively.
18) Account:
The term 'account' may refer to the documented cases or instances explored in the article. It emphasizes the narrative and evidence-based approach taken in medical literature, allowing for cumulative knowledge about rare conditions such as primitive neuroectodermal tumors (PNETs) and informing clinical practice.
19) Farmer:
The word 'farmer' describes the occupation of the patient in the presented case. It illustrates the socioeconomic background of individuals affected by specific health conditions, emphasizing the need for tailored healthcare access and awareness in different occupational demographics, particularly in rural healthcare contexts.
20) India:
India is mentioned as the geographical context of the reported case. The occurrence and epidemiological features of diseases like primitive neuroectodermal tumors (PNETs) may vary by region, making it crucial to document and study cases within specific locales, thus enhancing the global understanding of the disease.
21) Rules:
In a medical research setting, 'rules' could refer to guidelines and criteria used to define diagnostic and treatment standards for conditions like PNETs. Compliance with clinical rules and protocols is essential in ensuring consistent patient management and improving research accuracy in disease documentation.
22) Post:
The term 'post' implies a follow-up or subsequent event or condition, often pertaining to treatment outcomes. The article discusses the necessity for prolonged follow-up after surgery and chemotherapy in monitoring patient responses, indicating the ongoing nature of cancer treatment evaluation and management.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Primitive Neuroectodermal Tumour of Pancreas; Second Case from Asia’. Further sources in the context of Science might help you critically compare this page with similair documents:
Chemotherapy, Radiotherapy, Bone, Abdominal pain, Central nervous system, Clinical picture, Autonomic nervous system, Surgical resection, Histopathology, Magnetic resonance imaging, Malignant tumor, Lymph Node, Serum amylase, Multi-agent chemotherapy, Neoadjuvant chemotherapy, Genetic Analysis, Imaging modalities, Ewing's sarcoma, Fine needle aspiration, Cytogenetic analysis, Chemotherapy treatment, Immunohistochemistry, Serum lipase, Cytogenetics, Malignant Tumour, Chromosomal Translocation, Pathological diagnosis, Ultrasound-guided aspiration, Primary tumor, Multimodal treatment, Soft tissue, Vimentin, Contrast-enhanced computed tomography, Histopathologic analysis, Administrative support, Local radiotherapy.
Concepts being referred in other categories, contexts and sources.
Localized disease, Intellectual content.