Factors Linked to Tuberculosis Recurrence in Northwest Iran

| Posted in: Science

Journal name: The Malaysian Journal of Medical Sciences
Original article title: The Factors Associated with Tuberculosis Recurrence in the Northwest and West of Iran
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Author:

Leyla SAHEBI, Khalil ANSARIN, SEYYEDI Maryam, Amir MONFAREDAN, Hamed SABBGH JADID


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: The Factors Associated with Tuberculosis Recurrence in the Northwest and West of Iran

Year: 2014

Copyright (license): CC BY 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a significant global health challenge, exacerbated by factors such as drug resistance and socioeconomic issues. The recurrence of TB can severely burden healthcare systems, highlighting the importance of identifying factors that contribute to its return, particularly in vulnerable populations. This study focused on TB patients in five border provinces of Iran from 2010 to 2012, aiming to understand clinical, economic, and social factors associated with recurrent TB cases. The results shed light on selected demographic and health-related characteristics, providing insights that could inform future interventions.

Factors Contributing to Tuberculosis Recurrence

One of the pivotal findings of this study was the strong association between migration patterns and TB recurrence. Specifically, the research revealed that individuals migrating from rural villages to urban areas were significantly more likely to experience a recurrence of TB (OR = 8.4). Additionally, weight loss was highlighted as a clinical marker associated with increased recurrence rates (OR = 2.38). These findings suggest that the lifestyle changes and potential socioeconomic stresses accompanying migration contribute to poorer health outcomes among TB patients. The study emphasizes the need for targeted prevention strategies that address the unique challenges faced by this mobile population.

Conclusion

The findings indicate that the studied provinces of Iran had a moderate TB recurrence rate of 8.5%, compared to global estimates which range from 10% to 20%. The factors of migration and weight loss were identified as significantly related to higher recurrence rates of tuberculosis. This suggests the importance of addressing social determinants of health and providing continuous care to vulnerable populations, particularly those on the move. More comprehensive studies are recommended to determine the clinical implications of these associations, particularly regarding the potential role of the BCG vaccination in preventing TB recurrence and improving health outcomes in border regions.

FAQ section (important questions/answers):

What was the main goal of the study on tuberculosis recurrence?

The study aimed to identify factors associated with the recurrence of Mycobacterium tuberculosis (MTB) in patients from five border provinces of Iran to help in tuberculosis prevention and reduce healthcare burdens.

What was the average age of patients in the study?

The average age of the 300 patients involved in the study was 51.9 years, with a standard deviation of 24.2 years, representing a diverse age group across the sample.

Which factors were significantly associated with tuberculosis recurrence?

The study found that migration from a village to a city and weight loss were significantly associated with increased chances of tuberculosis recurrence, highlighting the impact of socioeconomic factors on health outcomes.

What were the study's findings regarding tuberculosis recurrence rates?

The study reported a moderate tuberculosis recurrence rate of 7.2%, which is lower than the global estimates of 10-20%, suggesting the need for continued surveillance and effective public health interventions.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Factors Linked to Tuberculosis Recurrence in Northwest Iran”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Tuberculosis:
Tuberculosis (TB) is a contagious bacterial infection primarily affecting the lungs, caused by Mycobacterium tuberculosis. Its global health burden has increased due to factors like drug resistance, co-infection with HIV, and socio-economic challenges. TB prevention is crucial in healthcare systems, emphasizing control measures, early diagnosis, and effective treatment strategies.

2) Table:
In the context of the study, a table presents organized data that facilitates understanding and analysis of patient demographics, clinical features, and treatment outcomes. It allows for comparison across different variables that influence tuberculosis recurrence, such as gender, province, socio-economic status, and health history, aiding in evidence-based conclusions.

3) Drug:
Drugs are essential in the treatment of tuberculosis. First-line and second-line drugs are utilized to combat drug-sensitive and multidrug-resistant (MDR) strains, respectively. The effectiveness and availability of these medications directly affect the treatment outcomes, recurrence rates, and overall public health response to the TB epidemic.

4) Study (Studying):
The study is a comprehensive investigation aimed at identifying factors associated with the recurrence of tuberculosis. Conducted over a period from 2010 to 2012 across five provinces in Iran, it utilizes cross-sectional data to analyze socio-economic, clinical, and environmental variables that contribute to understanding TB recurrence dynamics.

5) House:
Housing conditions can significantly impact the spread and recurrence of tuberculosis. Overcrowded and poorly ventilated homes contribute to increased transmission risk. The study examines housing factors, such as type and number of rooms in a dwelling, to ascertain their relationship with TB recurrence, emphasizing the importance of safe living environments.

6) Education:
Education level influences health literacy, access to information, and healthcare resources. In the study, educational status is assessed as a socio-economic determinant, helping to understand its potential role in tuberculosis treatment adherence, awareness, and ultimately the recurrence of the disease among affected populations.

7) Disease:
Disease refers to the pathological condition affecting health, in this context primarily focusing on tuberculosis. Understanding the prevalence, recurrence, and affecting factors of tuberculosis diseases is vital for healthcare planning, resource allocation, and effective public health strategies aimed at disease prevention and management.

8) Family:
Family background, including history of tuberculosis infections, can play a role in assessing an individual’s risk for the disease. The study explores the influence of familial patterns on tuberculosis recurrence, suggesting that genetic, environmental, and behavioral factors associated with family can impact treatment outcomes and disease management.

9) Line:
Line pertains to the classification of drugs used in tuberculosis treatment, including first-line and second-line medications. These classifications are essential for tailoring effective treatment regimens, especially in patients with recurrent TB or drug-resistant strains, impacting overall recovery and health outcomes.

10) Village:
Migration from village to urban areas is identified in the study as a significant factor influencing tuberculosis recurrence. This aspect underscores the socio-economic and environmental changes that affect health outcomes, highlighting the need for targeted public health strategies in migrating populations to address TB effectively.

11) India:
India is mentioned to provide a comparative context regarding tuberculosis prevalence and control measures globally. It highlights the challenges faced by countries with high TB rates, emphasizing the importance of tailored approaches to effectively tackle TB recurrence in different socio-cultural and economic contexts.

12) Male:
Gender, specifically the male population, is analyzed in relation to tuberculosis recurrence rates. Variations in health-seeking behaviors, societal roles, and risk factors among males and females can significantly impact TB transmission and treatment outcomes, highlighting the necessity for gender-sensitive health interventions.

13) Rules:
Rules refer to the guidelines and protocols established for the treatment of tuberculosis, such as the DOTS strategy. These rules govern the management of TB patients, ensuring that treatment is consistent and effective while addressing public health concerns related to TB transmission and resistance.

14) Mishra (Misra):
Mishra is likely a reference to a researcher or author associated with findings on tuberculosis recurrence and treatment outcomes. Their work may provide insights into factors affecting TB management and contribute to the broader understanding of the disease within the context of public health initiatives.

15) Sharman (Sarma, Sharma, Sarman):
Sharma denotes another researcher who may focus on tuberculosis, possibly relating to the prevalence of multidrug-resistant strains or treatment outcomes in specific populations. Contributions from Sharma's work can help inform public health policies and measures specific to tuberculosis in the Indian context.

16) Indian:
Indian, in this context, signifies the geographic and cultural setting related to tuberculosis research and the study findings. It encompasses the unique socio-economic, healthcare challenges, and TB management practices prevalent in India, which can differ significantly from other regions in the world.

17) Santha (Samtha, Shantha, Santh):
Santha likely references a researcher whose work pertains to tuberculosis and its management, specifically focusing on risk factors and treatment outcomes. Their research contributes valuable data and insights that can inform strategic approaches to TB prevention and control in various populations.

18) Gupta:
Gupta refers to a researcher involved in tuberculosis studies, whose contributions may emphasize the relationships between socio-demographic factors and TB treatment efficacy. Insights from their work can help shape effective interventions and public health strategies to reduce tuberculosis incidence and recurrence.

19) Fever:
Fever is a common clinical symptom associated with tuberculosis infection and is often used as an indicator of disease activity. Understanding the prevalence and correlation of fever in TB patients is crucial for diagnosing and monitoring treatment responses, thereby informing clinical management and care strategies.

20) Gopi:
Gopi may refer to a researcher focusing on tuberculosis, particularly in India, contributing to knowledge around treatment outcomes and recurrence. Their studies might emphasize the socio-economic dimensions of TB and how they intersect with health policy and program implementation.

21) Pain:
Pain, specifically chest pain, can indicate respiratory issues that may arise during tuberculosis infection. It is an important clinical symptom that may influence patients' health-seeking behavior and treatment adherence, thus playing a vital role in the overall understanding of tuberculosis management.

22) Tiruvallur:
Tiruvallur, a district in India, may represent a study site focusing on tuberculosis treatment outcomes. The context of Tiruvallur helps exemplify local challenges and factors affecting disease management, contributing to the unique epidemiological landscapes of tuberculosis in high-burden areas.

23) Evolution:
Evolution refers to the changes and adaptations of Mycobacterium tuberculosis over time, including the development of drug resistance. Understanding the evolutionary dynamics of this pathogen is essential for informing public health responses and adapting treatment strategies to manage resistant TB strains effectively.

24) Medicine:
Medicine encompasses the clinical practices used to treat tuberculosis, including the application of antibiotics, clinical protocols, and public health measures. The role of modern medicine is pivotal in managing TB, improving patient outcomes, and addressing the growing challenges of drug resistance.

25) Quality:
Quality pertains to the standard of tuberculosis care provided to patients, impacting treatment adherence and outcomes. Assessing healthcare quality is essential for ensuring effective TB management, especially in resource-limited settings where healthcare disparities can affect the success of treatment programs.

26) Thomas:
Thomas likely refers to a researcher involved in tuberculosis studies, offering insights into the predictors of treatment outcomes. Their research can deepen the understanding of tuberculosis prevention strategies and inform health practices regarding disease management in different populations.

27) Farmer:
Farmer, in this context, could signify a researcher focusing on the broader implications of tuberculosis in public health, including the socio-economic determinants influencing treatment outcomes. Their work contributes to understanding how such factors shape health policy and interventions in high-burden areas.

28) Santa (Shanta, Samta, Shamta):
Santa may represent a researcher whose work addresses tuberculosis epidemiology, focusing on factors influencing treatment success and recurrence. Their findings can provide valuable context that informs public health strategies to reduce the burden of TB in diverse populations.

29) Kumar:
Kumar is likely a reference to a researcher associated with the study of tuberculosis management, specifically concerning the influence of socio-economic factors on treatment efficacy. Contributions from their research enhance the understanding of TB dynamics and inform effective interventions in affected communities.

30) Death:
Death, in the context of tuberculosis, highlights the severe outcomes of untreated or poorly managed TB. Understanding mortality rates and risk factors associated with TB-related deaths is crucial for constructing effective preventive strategies and healthcare responses to the TB epidemic.

31) Saha (Shaha):
Saha may refer to a researcher contributing to tuberculosis research, potentially emphasizing the clinical and epidemiological aspects of the disease. Their work may assist in understanding patterns of TB transmission, treatment courses, and factors influencing patient outcomes.

32) Ceta:
Seda relates to a national tuberculosis guideline in Iran, representing health authority efforts to outline effective tuberculosis management strategies. Establishing these guidelines is critical in coordinating effective actions against TB, particularly in lower-income regions struggling with prevalence and treatment challenges.

33) Food supply:
Food supply refers to the availability of nutritional resources critical for maintaining health, particularly for individuals suffering from tuberculosis. Inadequate nutrition can hinder recovery, emphasizing the need for programs that ensure access to sufficient and healthy food for vulnerable TB patients.

34) Discussion:
Discussion sections in research allow authors to interpret findings, contextualize results, and draw connections with existing literature. This exploration of implications can lead to recommendations for future research, policy adjustments, and improvements in tuberculosis treatment protocols based on study outcomes.

35) Suffering:
Suffering pertains to the physical and emotional burden experienced by individuals with tuberculosis. Recognizing the suffering associated with TB is vital for developing compassionate healthcare practices and providing additional support services to enhance patient quality of life during treatment.

36) Toxicity:
Toxicity relates to the side effects associated with tuberculosis medications, particularly second-line treatments for drug-resistant TB. Understanding the toxic effects of these drugs is crucial for managing patient safety, adherence to treatment, and improving overall outcomes in TB care.

37) Cancer:
Cancer represents a significant comorbidity that can complicate tuberculosis treatment. Patients with both conditions may face increased health risks and challenging treatment regimens, necessitating integrated care approaches to adequately address the complexities of dual diagnosis and improve patient outcomes.

38) Medium:
Medium refers to the environment or substrate in which Mycobacterium tuberculosis is cultured for diagnostic purposes. Understanding the culture medium allows for accurate isolation and identification of the bacteria causing tuberculosis, thereby facilitating effective disease management and treatment strategies.

39) Blood:
Blood tests may be utilized in the diagnostic process for tuberculosis, helping to assess immune response and detect co-infections. Analyzing blood parameters can contribute valuable data regarding a patient's overall health and potential complications necessitating integrated patient care.

40) Food:
Food plays a critical role in the health and recovery of tuberculosis patients. Ensuring patients have access to nutritious food is essential for supporting their immune systems, enhancing treatment efficacy, and ultimately improving health outcomes, underlining the interplay between nutrition and disease management.

41) Diet:
Diet encompasses the nutritional intake necessary for supporting immune function and overall health. For tuberculosis patients, a balanced diet helps mitigate the risks of malnutrition, enhances treatment outcomes, and aids in recovery, highlighting the significance of dietary considerations in TB management.

42) Post:
Post refers to the concluding segments of a research study, where recommendations and key insights gathered throughout the research process are highlighted. This section may advocate for improved tuberculosis management strategies, further research, and policies aimed at reducing recurrence rates and enhancing patient care.

43) Viru:
Viru, likely a reference to viral infections alongside tuberculosis, emphasizes the importance of understanding co-infections. The presence of viral illnesses can complicate TB management, affecting treatment outcomes and highlighting the need for comprehensive healthcare strategies to address multiple infectious disease challenges.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Factors Linked to Tuberculosis Recurrence in Northwest Iran’. Further sources in the context of Science might help you critically compare this page with similair documents:

Chronic illness, Chronic disease, Proper treatment, Family history, Loss of appetite, Treatment Success, Healthy diet, Treatment plan, Clinical feature, Chronic cough, Statistical analysis, Socioeconomic status, Environmental factor, Doctoral thesis, Social factor, Pulmonary tuberculosis, BCG Vaccination, Economic factor, Treatment group, Treatment Protocol, World Health Organization, Demographic Data, Cross-sectional study, Health care system, Recurrence Rate, Drug resistance, Pulmonary TB, Weight loss, Treatment of tuberculosis, Treatment regime, Chronic illnesses, Demographic factors, Cigarette smoking, Immunization status, Treatment failure, Mycobacterium tuberculosis, M. tuberculosis, First line drug, Cohort Study, Directly Observed Treatment Short Course, Pulmonary Tuberculosis Patients, Sputum Smear Examination, Average age, Pulmonary infection, Drug-resistant tuberculosis, Second-line drugs, Drug resistance pattern, Tuberculosis infection, Cigarette smokers, Acid-fast bacilli, Average Age of Patients, Sputum positive, Clinical symptom, Opium addiction, Lung disease, Clinical factors, Logistic regression analyses, Preventing recurrence, Maintenance treatment, DOTs program, Study material, Sputum smear, Percentage of patients.

Concepts being referred in other categories, contexts and sources.

Food supply, Neighbouring countries, Common feature.

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