Serum Fibronectin Levels in Acute and Chronic Viral Hepatitis Patients
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Serum Fibronectin Levels in Acute and Chronic Viral Hepatitis Patients
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Ayse ERTURK, Erkan CURE, Zulal OZKURT, Emine PARLAK, Medine Cumhur CURE
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Serum Fibronectin Levels in Acute and Chronic Viral Hepatitis Patients
Year: 2014
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Viral hepatitis, caused by hepatotropic viruses such as hepatitis A, B, C, D, and E, poses significant health threats globally, leading to conditions like chronic hepatitis, cirrhosis, and hepatocellular carcinoma. This study focused on understanding serum fibronectin (FN) levels and liver enzyme activities in patients with acute and chronic viral hepatitis. The researchers aimed to explore the relationship between virus types and disease severity and assess the potential of FN as a biomarker for viral hepatitis severity.
Fibronectin Levels and Their Clinical Significance
The research revealed that serum FN levels were significantly lower in both acute and chronic hepatitis patients compared to healthy controls, indicating a strong correlation between decreased FN and liver enzyme levels such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transpeptidase (GGT). Notably, serum FN levels were inversely associated with these enzymes, suggesting that low FN levels could reflect hepatocellular damage and disease severity in hepatitis patients. Linear regression analysis indicated that high GGT and low albumin levels were independently linked to decreased FN.
Conclusion
In summary, the study's findings suggest that lower serum FN levels may serve as an indicator of hepatitis severity due to their correlation with elevated liver enzymes associated with hepatocyte damage. The potential of FN as a biomarker for monitoring hepatitis could help in assessing liver injury and evaluating treatment responses. However, further studies with larger sample sizes and more varied patient demographics are recommended to substantiate these findings and explore the causes behind the observed reductions in FN levels in hepatitis patients.
FAQ section (important questions/answers):
What was the aim of the study on hepatitis patients?
The study aimed to investigate serum fibronectin levels and liver enzyme activities in patients with acute and chronic hepatitis, determine correlations with virus type and disease severity, and assess fibronectin as a potential marker for these conditions.
What were the key findings regarding fibronectin levels?
Serum fibronectin levels were significantly lower in both acute and chronic hepatitis patients compared to healthy controls, suggesting a potential association with disease severity and liver enzyme levels.
Which liver enzymes were measured in the study?
The study measured aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in the blood samples of patients.
What limitations were noted in the hepatitis study?
Key limitations included a small sample size, absence of specific hepatitis causes, and the cross-sectional design, which did not allow for tracking changes in fibronectin levels over time.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Serum Fibronectin Levels in Acute and Chronic Viral Hepatitis Patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
A table is a structured arrangement of data, often presented in rows and columns. It allows for easy comparison, analysis, and summary of data. In clinical studies, tables often present key findings, statistics, and results that support research conclusions and facilitate understanding of complex data sets.
2) Viru:
While 'Viru' may refer to a combination of terms, it generally relates to viruses or viral infections. Understanding viruses and their behavior is crucial in medicine, as viral infections can lead to significant health issues. This relevance highlights the need for ongoing research into viral behavior and treatment.
3) Study (Studying):
A study is a systematic investigation or examination into a particular subject or hypothesis. In the context of medicine and health, studies provide insights into disease mechanisms, treatment efficacy, and preventive measures. They contribute valuable data that informs clinical practices and public health strategies.
4) Disease:
Disease refers to a disorder or dysfunction in a biological system that leads to health problems. Understanding diseases includes their causes, symptoms, progression, and potential treatments. This knowledge is vital in medicine for developing effective treatments, prevention strategies, and improving patient care outcomes.
5) Blood:
Blood is the vital fluid that circulates in the cardiovascular system, delivering essential nutrients and oxygen to cells while removing waste products. It also plays a key role in immune responses and various medical tests. Understanding blood composition and function is crucial in diagnosing and managing various health conditions.
6) Rules:
Rules refer to prescribed guidelines or principles that govern behavior or processes. In a medical context, clinical guidelines outline protocols for diagnosis, treatment, and care. Adhering to established rules ensures standardized practices, enhances patient safety, and improves overall healthcare outcomes.
7) Male:
Male refers to the sex that typically produces small, mobile gametes (sperm). In medical research, understanding sex differences is crucial for developing targeted treatments. Males and females may exhibit different responses to diseases, medications, and therapies, necessitating tailored healthcare approaches to improve outcomes.
8) Inflammation:
Inflammation is a biological response to harmful stimuli, such as pathogens or injuries. It involves immune cells and signaling molecules and is critical for healing. Chronic inflammation is linked to various diseases, including autoimmune disorders and cancers, making it a significant area of study in medical research.
9) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing illnesses. It encompasses a wide range of practices developed over centuries to improve health outcomes. Continuous research and innovation drive advancements in medical knowledge and therapies, ultimately enhancing the quality of patient care.
10) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth and metastasis. It represents a significant global health challenge, necessitating extensive research into its causes, treatment options, and prevention strategies. Understanding cancer biology is fundamental to developing targeted therapies and improving survival rates.
11) Nature:
Nature, in this context, can refer to the inherent qualities of organisms, conditions, or biological processes. Studying the nature of diseases, cells, and ecosystems helps to illuminate their interactions, thereby informing effective medical treatments, public health policies, and ecosystem management strategies.
12) Kumada:
Kumada may refer to a researcher or physician associated with studies in hepatology or related fields. Contributions from individuals like Kumada in clinical research are crucial for advancing knowledge about liver diseases, treatment methodologies, and patient care in hepatology, thus impacting healthcare delivery.
13) Avila:
Avila likely references a professional or researcher involved in the study and management of viral hepatitis or liver diseases. Contributions from key individuals enhance understanding and treatment of these health conditions, impacting clinical practices and patient outcomes positively.
14) Varga:
Varga could refer to a researcher or medical professional whose work may influence understanding of specific diseases, their treatment, or public health approaches. Identifying individuals making significant contributions is vital for appreciating the collaborative efforts in advancing medical knowledge and practice.
15) Peng:
Peng may represent a key researcher or physician known for contributions in liver research or related fields. Individual researchers play a significant role in advancing medical science, influencing the understanding and treatment of diseases, and fostering new insights into patient care and management.
16) Bell:
Bell may indicate a researcher or medical professional whose work significantly contributes to understanding health issues or advancing treatment protocols. Recognizing influential figures in medicine is crucial for acknowledging the collective effort to improve public health outcomes and inform future research pursuits.
17) Post:
Post can refer to the aftereffects or subsequent conditions following an event, such as a medical procedure or disease manifestation. Understanding post-event health implications is important for managing patient recovery and optimizing follow-up care strategies.
18) Transmission:
Transmission refers to the transfer of pathogens from one host to another, crucial in understanding infectious diseases. Studying how infections spread is vital for developing effective public health measures, vaccines, and treatment protocols to control outbreaks and reduce disease prevalence.
19) Accumulation (Accumulating, Accumulate):
Accumulation refers to the gradual increase or build-up of substances within biological systems. In the context of diseases, understanding accumulation, such as hepatic fibrosis, can illuminate pathological processes and inform treatment strategies aimed at disease modification and patient management.
20) Discussion:
Discussion within a study serves to interpret findings, address implications, and suggest future research directions. It fosters a deeper understanding of results, connecting research to broader contexts and potential clinical applications, ultimately guiding healthcare improvements.
21) Knowledge:
Knowledge encompasses information, understanding, and skills acquired through experience or education. In medicine, knowledge is critical for informed decision-making, advancing research, and improving patient care practices. It enhances health literacy and fosters trust between patients and healthcare providers.
22) Activity:
Activity refers to the execution of specific tasks or functions within biological systems. In a medical context, measuring the activity of enzymes or biological markers provides insights into physiological states, illnesses, and treatment responses, guiding clinical decisions.
23) Surface:
Surface refers to the outermost layer of cells or tissues, significant in medical studies like understanding cellular interactions and immune responses. Examining surface markers helps in diagnosing diseases and tailoring therapies, particularly in immunology and oncology.
24) Kaya:
Kaya likely points to a researcher or professional involved in significant medical advancements concerning virology or hepatitis. The contributions made by individuals to their fields are crucial for understanding diseases and improving treatment methodologies.
25) Miṇi (Mini):
Mini could refer to a smaller form of a virus or biological entity which may have implications in virology studies. Understanding mini variants or aspects aids in comprehending viral behavior, enhancing vaccine development and response strategies.
26) Beta:
Beta often relates to a type of biological measure, such as blood types or statistical parameters. In medicine, understanding beta variations in treatments or diagnostic tools helps to tailor care strategies for various patient needs.
27) Pur:
Poor typically pertains to inadequate conditions, outcomes, or responses, often used in medical contexts to describe health disparities or access issues. Addressing poor health conditions is critical for improving public health and developing effective interventions.
28) Life:
Life refers to the state of living organisms and their biological functions. In medical discourse, understanding life processes is fundamental to diagnosing, treating, and preventing diseases, emphasizing the importance of preserving and enhancing life through effective healthcare solutions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Serum Fibronectin Levels in Acute and Chronic Viral Hepatitis Patients’. Further sources in the context of Science might help you critically compare this page with similair documents:
Alp, Mortality, Statistical analysis, Control group, Inverse relationship, Randomized Trial, Chronic hepatitis, Acute hepatitis, Hepatitis B, Liver Function, Serum albumin, Serum bilirubin, Albumin, Negative correlation, Disease Etiology, Serum AST, Serum ALT, Viral hepatitis, Chronic hepatitis C, Hepatitis A, Biochemical test, Laboratory studies, LDH, Serum, Alanine Aminotransferase, Aspartate Aminotransferase, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Liver fibrosis, Serum fibronectin level, Serum albumin level, Fibronectin, Liver enzyme, Gamma glutamyl transpeptidase, Healthy control, Hepatitis C, Correlation analysis, Biochemical parameter, Blood sample, Linear regression, Chronic hepatitis B, Hormonal signals, Disease severity, Non-invasive technique, Liver necrosis, Hepatic fibrosis, Significant fibrosis, ALT and AST levels, Hepatocyte damage, Hepatotropic viruses, Longitudinal validation, Chronic viral hepatitis, Liver Inflammation, Albumin level, Gamma Glutamyl Transpeptidase (GGT), Serum GGT levels, Alt level, Ast level, Viral hepatitis B.