Imprint Cytological Diagnosis of Colonic Adenocarcinoma Metastatic to Liver
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Imprint Cytological Diagnosis of Colonic Adenocarcinoma Metastatic to Liver
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Shashikant ADLEKHA, Tandra CHADHA, Prasad KRISHNAN, B SUMANGALA
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The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Imprint Cytological Diagnosis of Colonic Adenocarcinoma Metastatic to Liver
Year: 2013
Copyright (license): CC BY 4.0
Summary of article contents:
Introduction
The liver frequently serves as a site for metastatic tumors, highlighting the importance of accurate pre-operative diagnosis. Various diagnostic techniques, including radiological imaging, fine needle aspiration cytology (FNAC), and histopathological evaluation (HPE), play a crucial role in assessing liver lesions. Intraoperatively, frozen section biopsy is typically employed for quick diagnosis; however, imprint cytology is another valuable technique that can provide rapid and accurate results for intraoperative decisions.
Significance of Imprint Cytology
In the presented case study of a 28-year-old female with colorectal cancer liver metastasis, imprint cytology significantly contributed to the diagnostic process. Following the identification of a 5mm lesion in the left lobe of the liver during surgery, gentle touch smears were prepared and stained for immediate cytological examination. The findings revealed clusters of elongated tumor cells amidst benign liver cells, leading to a diagnosis of metastatic adenocarcinoma, which was later confirmed through histopathological evaluation. This case underscores the utility of imprint cytology as a rapid and effective diagnostic tool, especially for institutions lacking frozen section facilities.
Conclusion
The case study illustrates that colonic adenocarcinoma is a frequent source of liver metastases and reinforces the importance of incorporating various diagnostic methods in evaluating liver lesions. Imprint cytology emerges as a cost-effective and supplementary technique to enhance diagnostic accuracy in the absence of frozen section capabilities. This approach not only aids in the management of liver lesions but also accentuates the crucial role of cytological methods in the overall diagnostic process for metastatic diseases.
FAQ section (important questions/answers):
What role does imprint cytology play during liver surgery?
Imprint cytology is used for rapid intraoperative diagnosis of liver nodules. It helps to determine the nature of the lesions quickly, assisting surgeons in making real-time decisions about patient management.
How is imprint cytology performed on liver nodules?
Imprint cytology involves gently touching the liver nodule to prepare smears, which are then fixed and stained. This method preserves cell shape and allows for accurate diagnosis through microscopy.
What type of cancer commonly metastasizes to the liver?
Colonic adenocarcinoma is a frequent source of metastasis to the liver. It makes up a significant portion of liver metastases, highlighting the importance of timely and accurate diagnosis.
What are the advantages of using imprint cytology?
Imprint cytology is a cost-effective diagnostic tool. It provides rapid results, especially useful in centres where frozen section facilities are unavailable, thus aiding in prompt patient management decisions.
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Chronic diarrhoea, Differential diagnosis, Abdominal pain, CT scan, Surgical Procedure, Cost effective diagnostic tool, Diagnostic tool, Histopathological evaluation, Histopathological examination, Computed tomography scan, Histological evaluation, Colorectal Cancer, Blood investigation, Fine needle aspiration cytology, Core Needle Biopsy, Fine needle aspiration, Diagnostic sensitivity, Tumour cells, Intraoperative diagnosis, Imprint Cytology, Vascular Invasion, Metastatic tumours, Frozen section, Contrast-enhanced computed tomography, Colorectal cancer liver metastasis, Metastatic adenocarcinoma, Lymphatic invasion, Cytological evaluation, Liver parenchyma, Liver lesion, Moderate dysplasia, Liver nodule.