H7N9 avian influenza: comparison of recovered vs. fatal cases in Shanghai.
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Clinical comparison of one recovered case and one fatal case of human infection with H7N9 avian influenza in Shanghai Public Health Clinical Center in China
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Yufang ZHENG, Ye CAO, Yunfei LU, Xiuhong XI, Zhiping QIAN, Douglas LOWRIE, Xinian LIU, Yanbing WANG, ZHANG Qi, Shuihua LU, Hongzhou LU
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Clinical comparison of one recovered case and one fatal case of human infection with H7N9 avian influenza in Shanghai Public Health Clinical Center in China
Year: 2013
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
H7N9 avian influenza is a recent subtype of the influenza virus that emerged in China, drawing significant attention due to its severity and high fatality rate. By mid-April 2013, Shanghai had reported 31 confirmed cases, leading to 11 fatalities. Although it is known that this new strain can infect humans, the epidemiological characteristics and clinical outcomes associated with H7N9 remain unclear. The Shanghai Public Health Clinical Center has treated a number of infected patients, revealing stark differences in clinical progress and outcomes among those afflicted.
Variability in Patient Outcomes
Two cases of H7N9 infection that were treated at the Shanghai Public Health Clinical Center illustrate the variability in clinical responses to the virus. Case 1, a 65-year-old male with mild viral pneumonia, rapidly improved following treatment with antiviral and supportive therapies, ultimately leading to his discharge from the hospital within a week. Conversely, Case 2, a 74-year-old male with severe pneumonia and multiple comorbidities, deteriorated following admission and passed away shortly after intubation. Notable differences in laboratory results, such as differential white blood cell counts and C-reactive protein levels, were observed between the two patients, indicating that the host's response to the infection may play a critical role in the clinical trajectory of H7N9 infections.
Conclusion
The stark differences in the clinical outcomes of the two patients highlight the complex nature of H7N9 avian influenza and suggest that laboratory examination results may provide valuable insights for managing and predicting the prognosis of patients. While Case 1 showed an improvement with therapeutic interventions, Case 2's outcomes served as a reminder of the potential severity of the infection, particularly in those with significant underlying health issues. Ongoing research and analysis of additional cases are critical to deepen the understanding of H7N9 infections and to develop effective treatment strategies.
FAQ section (important questions/answers):
What is H7N9 avian influenza and where did it emerge?
H7N9 avian influenza is a new subtype of influenza virus that emerged in China, specifically reported in Shanghai. It has resulted in severe illnesses and fatalities, drawing global attention due to its high fatality rate and unclear characteristics.
What were the outcomes of the two H7N9 cases discussed?
In the reported cases, one patient (Case 1) recovered after treatment, while the other patient (Case 2) deteriorated and died due to complications from severe H7N9 infection, highlighting differences in clinical outcomes despite similar initial conditions.
What treatments were administered to the patients with H7N9?
Both patients received antiviral medication (oseltamivir), antibacterial drugs, and other supportive treatments. However, their responses varied significantly, with Case 1 showing improvement while Case 2's condition worsened, leading to critical respiratory failure.
What differences were noted in laboratory test results of the cases?
Significant differences included white blood cell counts, neutrophil percentages, and renal function indicators. For instance, Case 2 exhibited higher neutrophil levels and renal dysfunction, suggesting a poorer prognosis compared to Case 1.
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