Electrodiagnostic Evaluation of Peripheral Nerve Changes in MS Patients
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Electrodiagnostic Evaluation of Peripheral Nervous System Changes in Patients with Multiple Sclerosis
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Hormoz AYROMLOU, Hadi Mohammad-KHANLI, Mohammad Yazdchi-MARANDI, Reza RIKHTEGAR, Sina ZARRINTAN, Samad EJ GOLZARI, Kamyar GHABILI
Download the PDF file of the original publication
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Electrodiagnostic Evaluation of Peripheral Nervous System Changes in Patients with Multiple Sclerosis
Year: 2013
Copyright (license): CC BY 4.0
Summary of article contents:
Introduction
Multiple sclerosis (MS) is recognized as the most prevalent demyelinating disorder of the central nervous system (CNS), characterized by immune-mediated destruction of myelin, leading to plaque formation in the brain and spinal cord. While the primary focus of MS research has centered on central demyelination, recent studies suggest that it may also impact the peripheral nervous system (PNS). This study aimed to investigate peripheral sensory and motor nerve involvement in patients with MS, particularly those with relapsing-remitting or secondary progressive MS, by conducting nerve conduction velocity tests. The objective was to measure specific electrodiagnostic parameters and compare them with values from a healthy population.
Peripheral Motor Nerve Abnormalities
One significant finding from the results is the observed reduction in the amplitude of various peripheral motor nerves in MS patients. Specifically, there were notable decreases in the right and left tibial, proneal, and left median motor nerve amplitudes compared to the normal population. Although sensory nerve conduction parameters did not show significant differences from normal values, the prolonged H-reflex latencies indicated possible nerve root demyelination. These results suggest that while sensory nerves may remain largely unaffected, motor nerves exhibit considerable abnormalities, reflecting a potential neurodegenerative process affecting motor function in the context of MS.
Conclusion
In summary, the study highlights the presence of significant peripheral motor nerve abnormalities in patients with MS, specifically showing reduced amplitude in the motor nerves. While the findings suggest peripheral involvement, particularly in motor conduction, it remains unclear whether these alterations stem from primary peripheral demyelination or secondary to central demyelination. The results underscore the complexity of MS as a disorder that may simultaneously affect both central and peripheral nervous systems, warranting further research into the clinical implications of these findings and the potential for targeted therapies to address peripheral symptoms.
FAQ section (important questions/answers):
What is the main focus of this study on multiple sclerosis?
The study assesses the involvement of peripheral sensory and motor nerves in patients with multiple sclerosis (MS) by using a nerve conduction velocity test to identify potential abnormalities.
How many patients were involved in the study and what types of MS did they have?
Seventy-five patients were included, diagnosed with either relapsing-remitting or secondary progressive multiple sclerosis (MS) patterns.
What significant findings related to nerve conduction did the study discover?
The study found decreased amplitude in several motor nerves, particularly tibial, proneal, and left median nerves, suggesting peripheral motor nerve abnormalities in MS patients.
What were the study's conclusions regarding sensory nerve conduction in MS patients?
The results indicated no significant differences in nerve conduction velocity parameters of sensory nerves between MS patients and the normal population.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Electrodiagnostic Evaluation of Peripheral Nerve Changes in MS Patients’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Central nervous system, Spinal Cord, Clinical interest, Statistical analysis, Cross-sectional study, Multiple sclerosis, Long term disability, Peripheral neuropathy, Diagnostic value, Magnetic resonance imaging, Nerve conduction velocity, Peripheral Nervous System, Demyelinating disorder, Demyelination, Carpal Tunnel Syndrome, Nerve conduction studies, Systematic random sampling, Demographic variable, Electromyographic Studies, Axonal degeneration, Acute changes, Compound muscle action potential, Hoffmann reflex, Relapsing-remitting, Secondary progressive, Electromyographic changes, Expanded disability status score, Normal population, Controversial issue, Neurodegenerative process, Autoimmune process, Principles of Neurology, Electrophysiological study, Electrodiagnostic tests, Chronic inflammatory demyelinating disease, Gray matter, Motor nerve, Sensory nerve, MS patients, Peripheral motor nerve, Ulnar neuropathy.