MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above
Journal name: The Malaysian Journal of Medical Sciences
Original article title: MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Muhammad Fadli EMBONG, Ruwaida YAACOB, Mohd Shafie ABDULLAH, Ahmad Helmy ABDUL KARIM, Anis Kausar GHAZALI, Win Mar @ Salmah JALALUDDIN
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above
Year: 2013
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Hippocampal volume (HCV) is significantly influenced by various psychiatric disorders and the normal aging process. Documenting normative values for HCV in specific populations is crucial for accurate diagnosis and management of conditions such as Alzheimer's disease (AD) and mild cognitive impairment, particularly among older adults. This study aims to establish the normative HCV for the Malay population aged 50 years and above, employing magnetic resonance imaging (MRI) to precisely measure and analyze the data.
Right and Left Hippocampal Volume Discrepancies
The study involved 43 participants, comprising 19 men and 24 women, analyzed using a GE Signa Horizon LX 1.0 Tesla MRI. The average right hippocampal volume was found to be 3.43 cm³, while the left showed a slightly lower mean of 3.26 cm³, indicating a statistically significant difference between the two sides (P < 0.001). Furthermore, while men had marginally larger HCVs than women, the difference was not statistically significant (P = 0.234). Normalized HCV measurements were also conducted to account for variations in intracranial volume, underscoring the importance of standardizing volumetric measures for improved diagnostic accuracy across demographic variables.
Conclusion
The outcomes of this research highlight the significant difference in HCV between the right and left sides, reinforcing the necessity of establishing normative values for hippocampal volume in specific populations. These findings contribute to a deeper understanding of hippocampal morphology in older adults and have implications for the diagnosis and management of neurodegenerative disorders like Alzheimer's disease. As the aging population increases, such studies become vital for early detection and intervention strategies, allowing for better patient care in the context of cognitive health.
FAQ section (important questions/answers):
What is the purpose of this study on hippocampal volume?
The study aims to determine normative hippocampal volumes in normal Malay individuals aged 50 and older, as such data can assist in the diagnosis of psychiatric illnesses related to changes in hippocampal volume.
How was hippocampal volume measured in this study?
Hippocampal volumetry was performed using magnetic resonance imaging (MRI) with manual tracing methods. The volumes were normalized with intracranial volume to account for individual differences.
What were the findings regarding right and left hippocampal volumes?
The study found a significant difference in mean volumes, with the right hippocampal volume averaging 3.43 cm³ and the left at 3.26 cm³, indicating a consistent asymmetry between the two sides.
What is the significance of normalizing hippocampal volume measurements?
Normalizing hippocampal volumes reduces discrepancies between genders and provides a more accurate comparison for diagnosing conditions, as it accounts for differences in overall brain size.
Other Science Concepts:
Discover the significance of concepts within the article: ‘MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above’. Further sources in the context of Science might help you critically compare this page with similair documents:
Data analysis, Different age groups, Aging process, Significant difference, Age-group, Exclusion criteria, Clinical studies, Statistical Significance, Observational study, Paired T test, Cross-sectional study, Meta analysis, Aging Population, Mini Mental State Examination, Study results, Statistically significant difference, Magnetic resonance imaging, Standard deviation, Mean and standard deviation, Independent t-test, Mean Difference, Neurodegenerative disease, Psychiatric illnesses, Sensitivity and Specificity, Signal to noise ratio, Alzheimer Disease, Normal value, Linear regression, Hippocampal volume, Sex difference, Volume measurement, Magnetic field, Temporal lobe epilepsy, Automated method, Hippocampal atrophy, Study material.
Concepts being referred in other categories, contexts and sources.
Right side, Left side, Right and left.