Ten-Year Study of Takayasu's Arteritis: Clinical and Radiologic Findings
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Ten-year Investigation of Clinical, Laboratory and Radiologic Manifestations and Complications in Patients with Takayasu’s Arteritis in Three University Hospitals
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Dalili Nooshin, Pazhouhi Neda, Samangooyi Shahdokht, Jamalian Ali
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Ten-year Investigation of Clinical, Laboratory and Radiologic Manifestations and Complications in Patients with Takayasu’s Arteritis in Three University Hospitals
Year: 2013
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Takayasu arteritis (TA) is a chronic inflammatory disease primarily affecting the aorta and its branches, often resulting in serious vascular complications. This condition, of unknown etiology, has been notably documented in Asia, with varying incidence rates across different regions. The objective of the study was to explore the clinical, laboratory, and angiographic characteristics of TA in Iranian patients over a decade, from 2000 to 2010. These findings aim to establish a baseline understanding of the disease's manifestations in Iran, thereby assisting in early diagnosis and management.
Clinical Manifestations and Findings
The study identified 15 patients, predominantly female (73.3%), with a median age of 36 years at diagnosis. The most common clinical presentation was fever, noted in 66.6% of the patients, and the presence of vascular bruits was observed in 86.7%. Utilizing the modified National Institute of Health criteria, 56% of patients were classified in the acute phase of disease, exhibiting systemic symptoms alongside abnormal laboratory results. Laboratory tests revealed elevated erythrocyte sedimentation rates (ESR) (median of 88 mm/h) and C-reactive protein (CRP) levels, which indicated active disease. Angiographic findings classified the majority of cases as type IV (46.7%), showcasing generalized vascular involvement.
Conclusion
The results highlight that fever and increased ESR levels are critical indicators for clinicians to consider when diagnosing Takayasu arteritis, particularly in young women. The study's findings emphasize the need for heightened awareness and early intervention to prevent serious complications associated with delayed diagnosis. Overall, this research provides significant insights into the clinical profile of TA patients in Iran, presenting valuable data for future studies focused on this disease and improving patient outcomes through timely diagnosis and treatment.
FAQ section (important questions/answers):
What is Takayasu arteritis and who does it affect?
Takayasu arteritis is a chronic inflammatory disease affecting the aorta and its primary branches, primarily recognized in Asia. It often occurs in young women, with symptoms typically presenting in the second or third decade of life.
What were the main findings in Iranian patients with Takayasu arteritis?
In Iranian patients, the study found that fever was the most common symptom, and most patients were females. Angiographic results showed various types of artery involvement, with stenosis being the most frequent finding.
What diagnostic criteria were used to include patients in the study?
Patients were included based on the American College of Rheumatology criteria, requiring at least three criteria, including age of onset under 40, claudication, and significant angiographic findings.
What were the common laboratory findings in patients with this condition?
Common laboratory findings included elevated erythrocyte sedimentation rate (ESR) levels, with a median of 88 mm/h. Other tests showed elevated C-reactive protein and leukocyte counts, while tests for rheumatoid factor and antinuclear antibodies were negative.
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