Hippocampal MRI Volumetry in Normal Malay Children and Adolescents
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Normalised MRI Volumetry of the Hippocampus among Normal Malay Children and Adolescents
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Win Mar @ Salmah Jalaluddin, Norhasiza Mat Jusoh, Izzat Abdulla Ali Basahai, Mohd Shafie Abdullah, Ahmad Helmy Abdul Karim, Anis Kausar Gazali
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Normalised MRI Volumetry of the Hippocampus among Normal Malay Children and Adolescents
Year: 2013
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Magnetic resonance imaging (MRI) is an effective non-invasive tool for assessing brain structure and measuring volumes, particularly in the hippocampus, which has shown volume changes in various neurological conditions. Understanding the normal range of hippocampal volume is essential for clinical assessments, especially in pediatric populations. This study focuses on establishing normalized hippocampal volume references for healthy Malay children and adolescents, thereby contributing valuable data to the existing medical literature.
Hippocampal Volumes and Intracranial Volume Correlation
The findings revealed original right and left hippocampal volumes averaging 3.05 (0.48) cm³ and 2.89 (0.44) cm³, respectively, with total volumes of 5.94 (0.90) cm³. Additionally, volume normalization against total intracranial volume (ICV) showed that the right, left, and total hippocampal volumes were 3.05 (0.41) cm³, 2.89 (0.41) cm³, and 5.94 (0.79) cm³, respectively. A Pearson correlation coefficient indicated a moderate correlation between the hippocampal volumes and ICV, with significant differences in volume between the right and left hippocampal structures observed in 85% of subjects. This study demonstrates robust relationships and essential insights into hippocampal volumetry, highlighting the need for localized normative data across different populations.
Conclusion
The research provides critical normative data on hippocampal volumes within the Malay pediatric population, revealing no significant discrepancies between original and normalized volumes. The findings reaffirm that the right hippocampus tends to be larger than the left, which is consistent with previous studies. This dataset serves as a vital reference point for future assessments of hippocampal volume in children and offers a foundation for understanding neurological conditions related to hippocampal alterations.
FAQ section (important questions/answers):
What was the aim of the study on hippocampal volume?
The study aimed to determine the normalized volume of the hippocampus in normal Malay children and adolescents, as hippocampal volume changes are linked with various diseases.
How were the hippocampal volumes measured in the study?
MRI scans were performed on 81 healthy Malay individuals aged 7 to 18 years. Manual volumetry was utilized to measure the hippocampal volumes, which were normalized against total intracranial volume.
What were the key findings about hippocampal volumes?
The mean original right, left, and total hippocampal volumes were significantly larger on the right side compared to the left, with no significant difference between original and normalized values.
Why is normalizing hippocampal volume important?
Normalizing hippocampal volume with respect to total intracranial volume helps reduce variance, enables better detection of subtle differences in volume, and compensates for growth-related changes in children.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Hippocampal MRI Volumetry in Normal Malay Children and Adolescents”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
[see source text or glossary: #Table#]
2) Study (Studying):
The study aimed to determine the normalized volume of the hippocampus in normal Malay children and adolescents. It involved a cross-sectional approach, gathering data to contribute to understanding hippocampal development and its relevance in various diseases.
3) Epilepsy:
Epilepsy was noted as a condition that can affect hippocampal volume, specifically focusing on mesial temporal sclerosis (MTS). Understanding hippocampal volumetry is crucial in diagnosing and managing epilepsy in pediatric populations.
4) Measurement:
Measurement refers to quantifying the hippocampal volume and intracranial volume through MRI. This includes specific methods of volumetry, manual tracing techniques being the 'gold standard' for reliability in clinical research in this field.
5) Rules:
[see source text or glossary: #Rules#]
6) Line:
[see source text or glossary: #Line#]
7) Disease:
In the context of this text, disease pertains to conditions like epilepsy and MTS, which impact hippocampal volumes. Investigating these relationships helps in understanding the neuroanatomical changes associated with such diseases.
8) Fish:
[see source text or glossary: #Fish#]
9) Reliability:
Reliability is an essential aspect when utilizing manual volumetric measurements, as these methods are considered the gold standard for obtaining accurate hippocampal volumes across various studies in the medical field.
10) Developing:
The study focuses on developing normative data for pediatric populations, emphasizing the growth and changes in hippocampal volume as children age. This information is crucial for clinical assessments and diagnosis.
11) Field:
[see source text or glossary: #Field#]
12) Chan:
[see source text or glossary: #Chan#]
13) Discussion:
The discussion section evaluates the findings of hippocampal volume metrics in relation to existing literature. It analyzes how these results contribute to the understanding of brain morphology in different demographics.
14) Relative:
[see source text or glossary: #Relative#]
15) Quality:
Quality refers to the standards of measurement techniques used in the study, ensuring that the data collected on hippocampal volumes are accurate and contribute meaningfully to the field.
16) Cutting:
[see source text or glossary: #Cutting#]
17) Reason:
Understanding the reason for volumetric changes is crucial in the diagnosis of conditions such as epilepsy. The study highlights how hippocampal volumes can indicate brain health and potential cognitive impairments.
18) Indian:
The comparison to Indian populations demonstrated variability in hippocampal volumes across ethnicities. Understanding these differences aids in establishing a normative framework tailored to specific demographics.
19) Cina:
Comparisons with findings from China showed differences in average ICV and hippocampal volumes, illustrating the importance of geographic and ethnic factors in neuroanatomical research.
20) Noise:
[see source text or glossary: #Noise#]
21) Gold (Golden):
Gold refers to the gold standard of measurement in volumetry, which is the manual tracing of the hippocampus, recognized for its reliability and accuracy in various studies.
22) Post:
[see source text or glossary: #Post#]
23) Male:
The study included both male and female subjects, allowing for comparative analysis of hippocampal volumes across genders. It found no significant differences in overall volumes between sexes, indicating gender does not significantly impact hippocampal metrics.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Hippocampal MRI Volumetry in Normal Malay Children and Adolescents’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Surgical treatment, Statistical analysis, Right and left, Significant difference, Temporal lobe, Sample size, Statistically Significant, Ethics committee, Paired T test, Cross-sectional study, Neuropsychiatric disorders, Paediatric population, Regression analysis, Magnetic resonance imaging, Standard deviation, Cerebrospinal Fluid, Cross Sectional Observational Study, T1 weighted image, Linear Relationship, Geographical variation, Linear regression, Clinical setting, MRI examination, Pearson correlation coefficient, Normative data, Hippocampal volume, Pearson's correlation coefficient, Focal neurological deficit, Study subject, Pearson's correlation test, Research university grant, Temporal lobe epilepsy, Critical revision, Correlation test, Study material, No significant difference, Statistical expertise, Moderate correlation, Mesial temporal sclerosis, Good correlation, Healthy subject, Study revealed, Magnetic resonance image.